LOCUS       NM_000700               1401 bp    mRNA    linear   PRI 21-MAR-2025
DEFINITION  Homo sapiens annexin A1 (ANXA1), mRNA.
ACCESSION   NM_000700
VERSION     NM_000700.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1401)
  AUTHORS   Abegunde,S.O., Grieve,S. and Reiman,T.
  TITLE     TAZ downregulated ANXA1 expression to modulate myeloma cell
            interactions with bone marrow mesenchymal stromal cells
  JOURNAL   Exp Hematol 138, 104282 (2024)
   PUBMED   39032857
  REMARK    GeneRIF: TAZ downregulated ANXA1 expression to modulate myeloma
            cell interactions with bone marrow mesenchymal stromal cells.
REFERENCE   2  (bases 1 to 1401)
  AUTHORS   Fang,L., Liu,C., Jiang,Z.Z., Wang,M., Geng,K., Xu,Y., Zhu,Y.,
            Fu,Y., Xue,J., Shan,W., Zhang,Q., Chen,J., Chen,J., Zhao,M.,
            Guo,Y., Siu,K.W.M., Chen,Y.E., Xu,Y., Liu,D. and Zheng,L.
  TITLE     Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and
            prevent obesity
  JOURNAL   Signal Transduct Target Ther 9 (1), 218 (2024)
   PUBMED   39174522
  REMARK    GeneRIF: Annexin A1 binds PDZ and LIM domain 7 to inhibit
            adipogenesis and prevent obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1401)
  AUTHORS   Ge,L., Chen,W. and Wei,F.
  TITLE     Annexin A1 protects epidermal stem cells against ultraviolet-B
            irradiation-induced mitochondrial dysfunction
  JOURNAL   Arch Dermatol Res 316 (7), 385 (2024)
   PUBMED   38874830
  REMARK    GeneRIF: Annexin A1 protects epidermal stem cells against
            ultraviolet-B irradiation-induced mitochondrial dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1401)
  AUTHORS   Xu,L., Zhang,F., Yu,B., Jia,S. and Fan,S.
  TITLE     PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating
            ANXA1
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 69-79 (2024)
   PUBMED   38842205
  REMARK    GeneRIF: PRMT6 Promotes the Immune Evasion of Gastric Cancer by
            Upregulating ANXA1.
REFERENCE   5  (bases 1 to 1401)
  AUTHORS   Kovacic,R.T., Tizard,R., Cate,R.L., Frey,A.Z. and Wallner,B.P.
  TITLE     Correlation of gene and protein structure of rat and human
            lipocortin I
  JOURNAL   Biochemistry 30 (37), 9015-9021 (1991)
   PUBMED   1832554
REFERENCE   6  (bases 1 to 1401)
  AUTHORS   Ando,Y., Imamura,S., Owada,M.K. and Kannagi,R.
  TITLE     Calcium-induced intracellular cross-linking of lipocortin I by
            tissue transglutaminase in A431 cells. Augmentation by membrane
            phospholipids
  JOURNAL   J Biol Chem 266 (2), 1101-1108 (1991)
   PUBMED   1670773
REFERENCE   7  (bases 1 to 1401)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
REFERENCE   8  (bases 1 to 1401)
  AUTHORS   Pepinsky,R.B., Sinclair,L.K., Chow,E.P. and O'Brine-Greco,B.
  TITLE     A dimeric form of lipocortin-1 in human placenta
  JOURNAL   Biochem J 263 (1), 97-103 (1989)
   PUBMED   2532504
REFERENCE   9  (bases 1 to 1401)
  AUTHORS   Varticovski,L., Chahwala,S.B., Whitman,M., Cantley,L.,
            Schindler,D., Chow,E.P., Sinclair,L.K. and Pepinsky,R.B.
  TITLE     Location of sites in human lipocortin I that are phosphorylated by
            protein tyrosine kinases and protein kinases A and C
  JOURNAL   Biochemistry 27 (10), 3682-3690 (1988)
   PUBMED   2457390
REFERENCE   10 (bases 1 to 1401)
  AUTHORS   Wallner,B.P., Mattaliano,R.J., Hession,C., Cate,R.L., Tizard,R.,
            Sinclair,L.K., Foeller,C., Chow,E.P., Browing,J.L.,
            Ramachandran,K.L. et al.
  TITLE     Cloning and expression of human lipocortin, a phospholipase A2
            inhibitor with potential anti-inflammatory activity
  JOURNAL   Nature 320 (6057), 77-81 (1986)
   PUBMED   2936963
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X05908.1, AL359997.8 and
            AA039737.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000700.2.
            
            Summary: This gene encodes a membrane-localized protein that binds
            phospholipids. This protein inhibits phospholipase A2 and has
            anti-inflammatory activity. Loss of function or expression of this
            gene has been detected in multiple tumors. [provided by RefSeq, Dec
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.120863.1,
                                           SRR5189652.240234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257497.11/ ENSP00000257497.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               X05908.1           1-361
            362-362             AL359997.8         156477-156477
            363-1399            X05908.1           363-1399
            1400-1401           AA039737.1         22-23               c
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..1401
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /note="annexin A1"
                     /db_xref="GeneID:301"
                     /db_xref="HGNC:HGNC:533"
                     /db_xref="MIM:151690"
     exon            1..60
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..140
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1115
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /note="annexin I (lipocortin I); annexin-1; calpactin-2;
                     calpactin II; chromobindin-9; phospholipase A2 inhibitory
                     protein; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="annexin A1"
                     /protein_id="NP_000691.1"
                     /db_xref="CCDS:CCDS6645.1"
                     /db_xref="GeneID:301"
                     /db_xref="HGNC:HGNC:533"
                     /db_xref="MIM:151690"
                     /translation="MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNP
                     SSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTG
                     HLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREEL
                     KRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDV
                     NVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPA
                     FFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKGD
                     YEKILVALCGGN"
     exon            141..249
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..344
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..458
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..549
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..629
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..686
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..876
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..935
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1058
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1401
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1379..1384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /note="hexamer: AATAAA"
     polyA_site      1401
                     /gene="ANXA1"
                     /gene_synonym="ANX1; LPC1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgaaat cttcagagaa gaatttctct ttagttcttt gcaagaaggt agagataaag
       61 acactttttc aaaaatggca atggtatcag aattcctcaa gcaggcctgg tttattgaaa
      121 atgaagagca ggaatatgtt caaactgtga agtcatccaa aggtggtccc ggatcagcgg
      181 tgagccccta tcctaccttc aatccatcct cggatgtcgc tgccttgcat aaggccataa
      241 tggttaaagg tgtggatgaa gcaaccatca ttgacattct aactaagcga aacaatgcac
      301 agcgtcaaca gatcaaagca gcatatctcc aggaaacagg aaagcccctg gatgaaacac
      361 tgaagaaagc ccttacaggt caccttgagg aggttgtttt agctctgcta aaaactccag
      421 cgcaatttga tgctgatgaa cttcgtgctg ccatgaaggg ccttggaact gatgaagata
      481 ctctaattga gattttggca tcaagaacta acaaagaaat cagagacatt aacagggtct
      541 acagagagga actgaagaga gatctggcca aagacataac ctcagacaca tctggagatt
      601 ttcggaacgc tttgctttct cttgctaagg gtgaccgatc tgaggacttt ggtgtgaatg
      661 aagacttggc tgattcagat gccagggcct tgtatgaagc aggagaaagg agaaagggga
      721 cagacgtaaa cgtgttcaat accatcctta ccaccagaag ctatccacaa cttcgcagag
      781 tgtttcagaa atacaccaag tacagtaagc atgacatgaa caaagttctg gacctggagt
      841 tgaaaggtga cattgagaaa tgcctcacag ctatcgtgaa gtgcgccaca agcaaaccag
      901 ctttctttgc agagaagctt catcaagcca tgaaaggtgt tggaactcgc cataaggcat
      961 tgatcaggat tatggtttcc cgttctgaaa ttgacatgaa tgatatcaaa gcattctatc
     1021 agaagatgta tggtatctcc ctttgccaag ccatcctgga tgaaaccaaa ggagattatg
     1081 agaaaatcct ggtggctctt tgtggaggaa actaaacatt cccttgatgg tctcaagcta
     1141 tgatcagaag actttaatta tatattttca tcctataagc ttaaatagga aagtttcttc
     1201 aacaggatta cagtgtagct acctacatgc tgaaaaatat agcctttaaa tcatttttat
     1261 attataactc tgtataatag agataagtcc attttttaaa aatgttttcc ccaaaccata
     1321 aaaccctata caagttgttc tagtaacaat acatgagaaa gatgtctatg tagctgaaaa
     1381 taaaatgacg tcacaagaca a
//
