LOCUS       NM_001278688            2207 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens ANTXR like (ANTXRL), transcript variant 1, mRNA.
ACCESSION   NM_001278688 XR_159066 XR_159158 XR_159198 XR_171854
VERSION     NM_001278688.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Szot,C., Saha,S., Zhang,X.M., Zhu,Z., Hilton,M.B., Morris,K.,
            Seaman,S., Dunleavey,J.M., Hsu,K.S., Yu,G.J., Morris,H.,
            Swing,D.A., Haines,D.C., Wang,Y., Hwang,J., Feng,Y., Welsch,D.,
            DeCrescenzo,G., Chaudhary,A., Zudaire,E., Dimitrov,D.S. and St
            Croix,B.
  TITLE     Tumor stroma-targeted antibody-drug conjugate triggers localized
            anticancer drug release
  JOURNAL   J Clin Invest 128 (7), 2927-2943 (2018)
   PUBMED   29863500
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450388.13 and AC244230.3.
            
            On Nov 20, 2020 this sequence version replaced NM_001278688.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY947541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620264.5/ ENSP00000480615.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               AL450388.13        129064-129577
            515-586             AL450388.13        134125-134196
            587-658             AL450388.13        135896-135967
            659-740             AL450388.13        138086-138167
            741-774             AL450388.13        138286-138319
            775-851             AL450388.13        139319-139395
            852-920             AL450388.13        139473-139541
            921-1001            AL450388.13        139898-139978
            1002-1062           AL450388.13        140069-140129
            1063-1161           AL450388.13        144789-144887
            1162-1231           AL450388.13        148870-148939
            1232-1310           AL450388.13        149469-149547
            1311-1400           AL450388.13        151180-151269
            1401-1439           AL450388.13        152528-152566
            1440-1595           AL450388.13        153577-153732
            1596-1676           AL450388.13        155303-155383
            1677-2207           AC244230.3         42592-43122
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..2207
                     /gene="ANTXRL"
                     /note="ANTXR like"
                     /db_xref="GeneID:195977"
                     /db_xref="HGNC:HGNC:27277"
     exon            1..514
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2162
                     /gene="ANTXRL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; anthrax toxin receptor like"
                     /codon_start=1
                     /product="anthrax toxin receptor-like isoform 1 precursor"
                     /protein_id="NP_001265617.1"
                     /db_xref="CCDS:CCDS60524.1"
                     /db_xref="GeneID:195977"
                     /db_xref="HGNC:HGNC:27277"
                     /translation="MGSHESLGPYFLVFLLLLLLPPPLFRAGSLRYHGPDWRIFHRLA
                     LGSRRAHHHHGPGWRQHWRQGQAGHRCQGSFDLYFILDKSGSVNNNWIDLYMWVEETV
                     ARFQSPNIRMCFITYSTDGQTVLPLTSDKNRIKNGLDQLQKIVPDGHTFMQAGFRKAI
                     QQIESFNSGNKVPSMIIAMTDGELVAHAFQDTLREAQKARKLGANVYTLGVADYNLDQ
                     ITAIADSPGHVFAVENGFKALRSTIDALTSKVCLDVTSVEPSSECVGEPYHVVIHGNG
                     FQNLKKRDEVICRFIFNESTIIDEKPTSIDNNSMNCPGPKLEKPGEEYSIEVSLNKGK
                     TFFKSNVSITSTTCGIFRNWLYFVPLLLLVPLLLCCVWRLCRKQTVKEPPPVQKPEKE
                     PEQEKPPSPPPPPPPPPPPLPPPPPAPVNTCPTVIICCCGCQGVGGMRRIEGNLDTFC
                     DLSHASCHQVPWMCCQSRDQGRYLSLALAQSQYAQAPCCPRICFPHSQECLSLPQAPC
                     SPRMCLRHSRECLALKQARCSPNICLRHSQHSRECLARKQAPCSPRICLRHSPEYFSQ
                     AQTLCNPKSCLQPSRECLPLTCSSRCRLPPARCLRPPSRMLPLLSPLLRHTAEPPLSL
                     PPSEPNF"
     exon            515..586
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            587..658
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            659..740
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            741..774
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            775..851
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            852..920
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1001
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1062
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1161
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1231
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1310
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1400
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1439
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1595
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1676
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..2207
                     /gene="ANTXRL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cataacagag aattctgtcc ccagggtggg ggaagggcca ggcaggtagc tggaagcaag
       61 tctcccagag ccagctgctg accctagtcc ctgcgatctg gggaggtacc tggtggaggg
      121 ccatagtgtg cactggtgaa agggcaggag gaggggtgtg gccccgggca taaggggagg
      181 cggcaaagaa ggggcctgtg ctcagcctct ctgggccctg gcacaggcac ccaagagtga
      241 ggtggggtca cagggacagc cagataatgg ggagccatga gtccctgggg ccctacttcc
      301 tggtcttcct gctgctgctg ctgcttcctc caccgctttt tagagcagga agccttcggt
      361 accatggacc tgactggaga atatttcacc gcctggccct gggctccagg agagcccacc
      421 accaccatgg cccaggatgg aggcagcact ggcgccaggg gcaagcaggt cacagatgcc
      481 agggctcatt tgacctctac ttcatcttgg acaagtctgg cagcgtgaac aataactgga
      541 ttgaccttta tatgtgggtg gaggaaacag tggcgaggtt ccaaagccca aatattcgga
      601 tgtgcttcat cacctactcc acagacggcc agactgtctt gccactcacc tcagacaaga
      661 atagaataaa aaacggtctt gaccaacttc agaaaattgt gcctgacggt cacacattca
      721 tgcaggcagg atttagaaag gcaattcaac agatcgaaag tttcaactcc ggaaacaagg
      781 ttcccagcat gattattgct atgactgatg gagaactggt ggcacatgca tttcaggaca
      841 ctctcagaga agctcaaaag gctcggaaac tgggggccaa cgtttacacc ctgggtgtgg
      901 ctgattataa tctggatcag ataacagcaa ttgcagacag ccctggccac gtgtttgcag
      961 tggagaatgg cttcaaggcc ctgagaagca ccattgatgc cctcacgtca aaggtctgtc
     1021 ttgatgtgac atcggtggag ccttcctctg agtgtgtagg agaaccctac catgtggtta
     1081 ttcatggaaa tggctttcag aatctaaaga aacgggatga agttatttgc agatttatct
     1141 tcaatgaaag cactatcatt gatgaaaagc caaccagtat cgacaataat tccatgaatt
     1201 gccctgggcc aaaactagaa aaacctggag aggagtactc tattgaagtc agcttgaaca
     1261 aaggcaaaac attcttcaag agcaatgtca gcatcaccag caccacatgt ggcattttcc
     1321 gcaactggct ctattttgtg ccactcctgc tgcttgtgcc actgctgctg tgttgtgtct
     1381 ggcggctgtg ccgcaagcag actgtcaagg agccaccacc tgtgcagaag ccagaaaagg
     1441 agccagagca ggaaaaacca ccatcaccac caccaccgcc tccgcctcca ccacctccac
     1501 tcccgcctcc gcccccagct cctgtaaaca cctgccccac tgtgattatt tgttgctgtg
     1561 gatgccaagg agtgggcggg atgagaagga tagagggcaa tctggatacc ttttgtgacc
     1621 tctctcacgc aagctgccac caggtgccat ggatgtgttg tcagagcagg gaccagggga
     1681 ggtacctcag cttagccctt gcacagtccc aatatgcaca ggctccctgc tgcccaagga
     1741 tctgctttcc acacagccag gagtgccttt ccctaccaca ggctccctgc agcccaagga
     1801 tgtgcctgag acacagccgg gagtgcctcg ccctcaaaca ggctcgctgc agcccaaaca
     1861 tctgcctgag acacagccaa cacagcaggg agtgccttgc ccgcaaacag gctccctgca
     1921 gcccaaggat ctgcctgaga cacagcccgg agtacttttc ccaagcacag actctgtgca
     1981 acccaaagag ctgccttcaa cccagccggg agtgcctccc cctcacctgc tcctccaggt
     2041 gccgcctccc cccagctagg tgcttgaggc ctccctccag gatgctgccg ctgctgtccc
     2101 cactgctcag gcacacggca gaaccccctt tgtcactccc cccctcagag cccaacttct
     2161 aaggcaccaa acacccaaga ttaacaggct tttgttgctg aactgga
//
