LOCUS       NM_058172               8419 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ANTXR cell adhesion molecule 2 (ANTXR2), transcript
            variant 1, mRNA.
ACCESSION   NM_058172
VERSION     NM_058172.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8419)
  AUTHORS   Archana,C.A., Sekar,Y.S., Suresh,K.P., Subramaniam,S., Sagar,N.,
            Rani,S., Anandakumar,J., Pandey,R.K., Barman,N.N. and Patil,S.S.
  TITLE     Investigating the Influence of ANTXR2 Gene Mutations on Protective
            Antigen Binding for Heightened Anthrax Resistance
  JOURNAL   Genes (Basel) 15 (4), 426 (2024)
   PUBMED   38674361
  REMARK    GeneRIF: Investigating the Influence of ANTXR2 Gene Mutations on
            Protective Antigen Binding for Heightened Anthrax Resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8419)
  AUTHORS   Fang,Z., Killick,C., Halfpenny,C., Frewer,N., Frewer,K.A., Ruge,F.,
            Jiang,W.G. and Ye,L.
  TITLE     Sex Hormone-regulated CMG2 Is Involved in Breast and Prostate
            Cancer Progression
  JOURNAL   Cancer Genomics Proteomics 19 (6), 703-710 (2022)
   PUBMED   36316045
  REMARK    GeneRIF: Sex Hormone-regulated CMG2 Is Involved in Breast and
            Prostate Cancer Progression.
REFERENCE   3  (bases 1 to 8419)
  AUTHORS   Castroflorio,E., Perez Berna,A.J., Lopez-Marquez,A., Badosa,C.,
            Loza-Alvarez,P., Roldan,M. and Jimenez-Mallebrera,C.
  TITLE     The Capillary Morphogenesis Gene 2 Triggers the Intracellular
            Hallmarks of Collagen VI-Related Muscular Dystrophy
  JOURNAL   Int J Mol Sci 23 (14), 7651 (2022)
   PUBMED   35886995
  REMARK    GeneRIF: The Capillary Morphogenesis Gene 2 Triggers the
            Intracellular Hallmarks of Collagen VI-Related Muscular Dystrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8419)
  AUTHORS   Yamaguchi,M., Hirai,S., Idogawa,M., Uchida,H. and Sakuma,Y.
  TITLE     Anthrax toxin receptor 2 is a potential therapeutic target for
            non-small cell lung carcinoma with MET exon 14 skipping mutations
  JOURNAL   Exp Cell Res 413 (2), 113078 (2022)
   PUBMED   35189107
  REMARK    GeneRIF: Anthrax toxin receptor 2 is a potential therapeutic target
            for non-small cell lung carcinoma with MET exon 14 skipping
            mutations.
REFERENCE   5  (bases 1 to 8419)
  AUTHORS   Choate,L.A., Barshad,G., McMahon,P.W., Said,I., Rice,E.J.,
            Munn,P.R., Lewis,J.J. and Danko,C.G.
  TITLE     Multiple stages of evolutionary change in anthrax toxin receptor
            expression in humans
  JOURNAL   Nat Commun 12 (1), 6590 (2021)
   PUBMED   34782625
  REMARK    GeneRIF: Multiple stages of evolutionary change in anthrax toxin
            receptor expression in humans.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8419)
  AUTHORS   Dowling,O., Difeo,A., Ramirez,M.C., Tukel,T., Narla,G., Bonafe,L.,
            Kayserili,H., Yuksel-Apak,M., Paller,A.S., Norton,K., Teebi,A.S.,
            Grum-Tokars,V., Martin,G.S., Davis,G.E., Glucksman,M.J. and
            Martignetti,J.A.
  TITLE     Mutations in capillary morphogenesis gene-2 result in the allelic
            disorders juvenile hyaline fibromatosis and infantile systemic
            hyalinosis
  JOURNAL   Am J Hum Genet 73 (4), 957-966 (2003)
   PUBMED   12973667
  REMARK    GeneRIF: identification and characterization of juvenile hyaline
            fibromatosis and infantile systemic hyalinosis disease-causing
            mutations in the capillary morphogenesis factor-2 gene
REFERENCE   7  (bases 1 to 8419)
  AUTHORS   Scobie,H.M., Rainey,G.J., Bradley,K.A. and Young,J.A.
  TITLE     Human capillary morphogenesis protein 2 functions as an anthrax
            toxin receptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5170-5174 (2003)
   PUBMED   12700348
REFERENCE   8  (bases 1 to 8419)
  AUTHORS   Abrami,L., Liu,S., Cosson,P., Leppla,S.H. and van der Goot,F.G.
  TITLE     Anthrax toxin triggers endocytosis of its receptor via a lipid
            raft-mediated clathrin-dependent process
  JOURNAL   J Cell Biol 160 (3), 321-328 (2003)
   PUBMED   12551953
REFERENCE   9  (bases 1 to 8419)
  AUTHORS   Bell,S.E., Mavila,A., Salazar,R., Bayless,K.J., Kanagala,S.,
            Maxwell,S.A. and Davis,G.E.
  TITLE     Differential gene expression during capillary morphogenesis in 3D
            collagen matrices: regulated expression of genes involved in
            basement membrane matrix assembly, cell cycle progression, cellular
            differentiation and G-protein signaling
  JOURNAL   J Cell Sci 114 (Pt 15), 2755-2773 (2001)
   PUBMED   11683410
REFERENCE   10 (bases 1 to 8419)
  AUTHORS   Shieh,J.T.C., Hoyme,H.E. and Arbour,L.T.
  TITLE     Hyaline Fibromatosis Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301698
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB280658.1, DA989889.1,
            DA194583.1, AB209913.1, AL832851.1, AC109518.6 and BM989747.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_058172.5.
            
            Summary: This gene encodes a receptor for anthrax toxin. The
            protein binds to collagen IV and laminin, suggesting that it may be
            involved in extracellular matrix adhesion. Mutations in this gene
            cause juvenile hyaline fibromatosis and infantile systemic
            hyalinosis. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (1) differs in the 3' UTR and
            coding sequence compared to variant 2. The resulting isoform (1)
            has a shorter and distinct C-terminus compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.149032.1,
                                           SRR1803615.28589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403729.7/ ENSP00000385575.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DB280658.1         95-120
            27-515              DA989889.1         37-525
            516-718             DA194583.1         397-599
            719-1075            AB209913.1         401-757
            1076-3993           AL832851.1         1-2918
            3994-7297           AC109518.6         20683-23986         c
            7298-7948           BM989747.1         17-667              c
            7949-8419           AC109518.6         19561-20031         c
FEATURES             Location/Qualifiers
     source          1..8419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..8419
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="ANTXR cell adhesion molecule 2"
                     /db_xref="GeneID:118429"
                     /db_xref="HGNC:HGNC:21732"
                     /db_xref="MIM:608041"
     exon            1..821
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     CDS             670..2136
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; capillary morphogenesis protein 2; capillary
                     morphogenesis gene 2 protein; anthrax toxin receptor 2"
                     /codon_start=1
                     /product="anthrax toxin receptor 2 isoform 1 precursor"
                     /protein_id="NP_477520.2"
                     /db_xref="CCDS:CCDS47085.1"
                     /db_xref="GeneID:118429"
                     /db_xref="HGNC:HGNC:21732"
                     /db_xref="MIM:608041"
                     /translation="MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFD
                     LYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKI
                     SKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAE
                     KEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSC
                     TEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNS
                     MLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGI
                     GLMWWFWPLCCKVVIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRM
                     EVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
                     RLDALWALLRRQYDRVSLMRPQEGDEGRCINFSRVPSQ"
     exon            822..893
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            894..965
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1047
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1155
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1224
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1305
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1366
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1465
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1535
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1614
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1710
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1755
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1848
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2016
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2097
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..8419
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3976..3981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATAAA"
     polyA_site      3994
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="major polyA site"
     regulatory      5338..5343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATAAA"
     polyA_site      5359
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
     regulatory      6901..6906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: ATTAAA"
     polyA_site      6922
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
     regulatory      7439..7444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATAAA"
     polyA_site      7466
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
     regulatory      7926..7931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATAAA"
     regulatory      7938..7943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATAAA"
     polyA_site      7948
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
     polyA_site      7958
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
     regulatory      8361..8366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATGAA"
     regulatory      8384..8389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
                     /note="hexamer: AATAAA"
     polyA_site      8385
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
     polyA_site      8419
                     /gene="ANTXR2"
                     /gene_synonym="CMG-2; CMG2; HFS; ISH; JHF"
ORIGIN      
        1 acacgcagcc cagacccggc ccgagcgggc tcctgccctc ggcgtggctt ctctccagcc
       61 gggagtccca gggccagcta gcctcctccc ctaaagggga cggcctgtca gcgcagtgcc
      121 agagtccagc accgggagga aagtttcgga gtgcggaggg agttggggcc gccggaggag
      181 aagagtctcc actcctagtt tgttctgccg tcgccgcgtc ccagggaccc cttgtcccga
      241 agcgcacggc agcggggggg acttcagccc tccaggcggg gtgggttcca ggtccgggtc
      301 cgaggcgggc gctggaggct cggccccagg ccggagagga actcctttcg cgagctgtcg
      361 ccgtgggccc gcattgtctg caggaactct ccggaatcgg gagggggagg actggatcgc
      421 gcttccactg ggattcgtca agagttccgg cggcagctgc ggcggtggcg gagactccct
      481 ttgtcctctc aggacctccc tctctccctc cctgtcagct ggtgggtccc gctgccgcag
      541 gcgccggcgt ctcagctgct cgccgccccc caccccagag tgcgtgccgg gtgactcccg
      601 ccacctttgc gaccctcctg agcttagggg actgcgagcg ggagggagtc tcaggccccc
      661 ggccgcagga tggtggcgga gcggtccccg gcccgcagcc ccgggagctg gctgttcccc
      721 gggctgtggc tgttggtgct cagcggtccc ggggggctgc tgcgcgccca ggagcagccc
      781 tcctgcagaa gagcctttga tctctacttc gtcctggaca agtctgggag tgtggcaaat
      841 aactggattg aaatttataa tttcgtacag caacttgcgg agagatttgt gagccctgaa
      901 atgagattat ctttcattgt gttttcttct caagcaacta ttattttgcc attaactgga
      961 gacagaggca aaatcagtaa aggcttggag gatttaaaac gtgttagtcc agtaggagag
     1021 acatatatcc atgaaggact aaagctagcg aatgaacaaa ttcagaaagc aggaggcttg
     1081 aaaacctcca gtatcataat tgctctgaca gatggcaagt tggacggtct ggtgccatca
     1141 tatgcagaga aagaggcaaa gatatccagg tcacttgggg ctagtgttta ttgtgttggt
     1201 gtccttgatt ttgaacaagc acagcttgaa agaattgctg attccaagga gcaagttttc
     1261 cctgtcaaag gtggatttca ggctcttaaa ggaataatta attctatact agctcagtca
     1321 tgtactgaaa tcctagaatt gcagccctca agtgtctgtg tgggggagga atttcagatt
     1381 gtcttaagtg gaagaggatt catgctgggc agtcggaatg gcagtgttct ctgcacttac
     1441 actgtaaatg aaacatatac aacgagtgta aaaccagtaa gtgtacagct taattctatg
     1501 ctttgtcctg cacctatcct gaataaagct ggagaaactc ttgatgtttc agtgagcttt
     1561 aatggaggaa aatctgtcat ttcaggatca ttaattgtca cagccacaga atgttctaac
     1621 gggatcgcag ccatcattgt tattttggtg ttactgctac tcctggggat cggtttgatg
     1681 tggtggtttt ggcccctttg ctgcaaagtg gttattaagg atcctccacc accacccgcc
     1741 cctgcaccaa aagaggagga agaagaacct ttgcctacta aaaagtggcc aactgtggat
     1801 gcttcctatt atggtggtcg aggggttgga ggaattaaaa gaatggaggt tcgttggggt
     1861 gataaaggat ctactgagga aggtgcaagg ctagagaaag ccaaaaatgc tgtggtgaag
     1921 attcctgaag aaacagagga acccatcagg cctagaccac ctcgacccaa acccacacac
     1981 cagcctcctc agacaaaatg gtacacccca attaagggtc gtcttgatgc tctctgggct
     2041 ttgttgaggc ggcagtatga ccgggtttct ttgatgcgac ctcaggaagg agatgagggc
     2101 cggtgcataa acttctcccg agttccatct cagtaaaagg gaagcaggaa gaccaagaag
     2161 gtacgaagat ggcacatttt cacatagctg attttcaacc aaatgaaaaa aatcaagtgc
     2221 atttcagaag cttttggaag agcagcttaa ttcctctcag tcgggaaatg ttttctctgc
     2281 cttctgcttt gcttgcacca aacatttcta aacacttgtt ctgccatcta catgggaggt
     2341 gatgaaactc agtggtaact catgatttat gacattgaaa ataaagagga acattgacct
     2401 gcagactatg gtttgtacaa gaaagtttgt ttgaatgtgt agaagaggaa aaagcaacaa
     2461 cagcaacaac acgaagatga taccaaaaca aggaccacaa aacaactagc catgatggga
     2521 gacaggagtt ttttacatgg aaacatggca cttgtgtttt tatgtggcaa gatctttatc
     2581 cataggcaga gtatgaaatt tcccaccagg ctaagcaaat aaagaagtcc attgccttat
     2641 agctatgtca gatcacagaa tccttccaag tgctctatca cagtgtgcct tatgggaagt
     2701 ttctgactgg aaaatcttgt cattctaaca ctgaaaagtg cacacgcatg acaaaatgta
     2761 gacaagatgc ctcaaggtat tggtagcaag caagattttg ccctttagtt ttcgaagaca
     2821 cctttctttc attatgcact cgggacaaga aaattaatag agcgttattc cacagaaggc
     2881 ctctagccag agatcttgag tgtagtgcaa gggactcatt ttttgcgaac ttgtccctgt
     2941 gactagtaga ttcccccttt tcctgtgttt aggatttagt agtgcataaa gcattaatat
     3001 ccataaacat acctagaagt ttgttttgct tttaatttaa aggaagcagt aaccacaaag
     3061 cttccgctca gggttttttc tttcttcaag tctccaaggg ctcttcagcg tcacaagcca
     3121 gcaactctct ttgcattaaa atttcaaagt ttaattaata taattaaaag caacagcaag
     3181 cagcagcctg tgaagatttt gctcatcttt tttatgcctt ttgacattga atgacctatt
     3241 actgtatgcg cattacttgg attttgaggg gcactctacc ttggttatga ttcagtagag
     3301 gaaaaagacc acctttcttc aatttacaaa ttaaatcttc tggagggtcg ctatcacaaa
     3361 acattgacga tgtatgtatt ataatttttt agaaaaacca ccatcgtgtc acgtcgacga
     3421 tgccaaatta tgttagcgtg agcagaaaca ccgtggggga ggaaggcagc agctgaagaa
     3481 aaaagctcaa atgatctagt cactttcgat actgtacttc agatgcgaaa tggatattcg
     3541 agtggaaacc tgacaaagtg cgcctgcttt gatgtgaact ggtatagaca atgaccagtg
     3601 gctgggtcag tgggatgtct ctctgtgagc acaaaggctt atcaaatgac actaaaaata
     3661 agttcaacaa ccatcacatt ggaagggaga aggcgaacat ttcatgtttg gcgggcatgt
     3721 gagtgcacaa gatggaaaga gcgattggag catcctggta taattacccc cattgtgctc
     3781 ttaatggaaa tttcaaagga cgggagtatt ctgttggttg gtgtccaggt ttgtggcact
     3841 gttccaagag gccttacaca cacacacaaa tatataattt tctatacata tatatcctct
     3901 agcttgaaac ttttgctcaa gtttatttat gtcactggct ggctggatcc aaagtcatgt
     3961 gtccacacat tcataaataa aaattttacc tatgcctgtg ctaccatttc tttaagccca
     4021 cataaagcta atgccttctt gggttgaata tgcagttgtt atgcttagtt tcagggatgg
     4081 aattctattc agttccaaaa tgtccctcat gttcacagat gatactattg gcagtagctg
     4141 catatgcaag tgtaacttgg aagcctgata tagtataccc aaccctttct gcaatgagtt
     4201 attgtatccc tttgttctgc atttgcatct ggaacaagac ctaatgtggc ttccttaaat
     4261 gggcacttca tttctgatga gtgcacacca attattgcta ttttaatatc attgagaata
     4321 ctacagaagc taaggctatg tttctttggt aactacttca aatttctcta gaattatgta
     4381 gcatacttac attttgctgc atgaacaatg aaaattaacc tctgccttta aatggaaaaa
     4441 taactttctg tagattgtta tacagctact atgaagagct cttaatgaag aggaagtggc
     4501 agtggtctat atgtagactg aaaaaatatc attaataaag ttcaaagact gatggaattt
     4561 cattgccctt aaagatatga accagatctg ttttatgctt ttctccaatt atactaacta
     4621 gcagttgaaa agaatttgtt ttgaagagtg ttattttctt accaaaagac cagatcaaaa
     4681 atccctatac ttttccacca aaaaaagatt aaaatgaagc catttctata aatttaatgg
     4741 cactttatat tttatataga gaaatagctt ctgtttgatt ttctggacac catgtcagtc
     4801 aagatctact ttctgtgtaa aaatgaataa gtcttgcaca taatccattc gtgttgcata
     4861 aggttgcaaa aacaattaag tgggaaatga ctcctaactt atgtgtctac tctgcctaga
     4921 aagaaagttt tgaaggcatc tatatatatt tcataacaat gtctgttctt tatggatttg
     4981 atccataaat atttatctat ctgaaaactt tgatacttgg aatgttttcc ttagagcatt
     5041 tggtgctcca agaaaaaaca tttggtgcta agagttgcag cactgatgcc tttccctaag
     5101 ttaattctat tttaaaaatt tatatttcct tcccaatgag atgcagagta aaatttgaga
     5161 ccctccattg actagggagc agcatctgtc atctatggtt aattactatt ttgacaaaaa
     5221 tatagaaggt ttaaaccccc atgtatttca gattgttaga gaaagaagta gtttgcttat
     5281 atttcccttg aactttattc taaccattta aataataaat tattcaatat ttgttataat
     5341 aaatccttac tagatacaag atttgggtgt ttctgtgaag ttaactttat tatctaaata
     5401 tcactaacca ttgtttactg ctcagaggca gatacatttg tttagtttaa agttgaaaca
     5461 aattctatat tgtggataat taggtgttta aaacattttg atagaccagc ttatatatgt
     5521 tatttttgaa atttaagaag gcagaatgta attaggtcac atttacaagt agaaggaatt
     5581 ataacttcct actccatgca tatattgtat attggttagc ttttactagc attttctagc
     5641 atcacattac tttagaaagt ttttgagagt ttcattacta ctggaaaagt ttggtgggta
     5701 tatgtacaca ggaaagaaat atatgcatca tttcaatatg aaaggaaata cataatctag
     5761 aaacatagaa taactcttgg tacatctgtt acatagttaa ggaaagaaac aggcaggtga
     5821 ggctggagaa tgttgtctat ttgtaggaaa taaagtcagt gcagacgcat attctagttt
     5881 agagttagat taatattgtg cttagtgaat ttctatgaca tatttctgag aacactttaa
     5941 tatatttcca cacctactgg aatctaattc agtcgatcgg ataaaagaaa gacttttttg
     6001 ttgttgtttt tgaaaatcca taatgtagca ggttctgcgc tggtttttta atgtatttta
     6061 tttttgtgct ctcctgccaa aagaaaaggc tgataagtaa gtacacagta caacatgtaa
     6121 atttgtataa aaatatgctt gtttagattg ctctacaata actatattaa ggtaaattgt
     6181 gtgtgtgtgt gtgagagaga gagagagaga gagaaacaga gggagaattg actcaatgtg
     6241 ttttctatga agagtcttag cttaggaatc aggtaacaga gaggtcctag accatagacc
     6301 cagccatcaa ctagcttgct gatgttgaac agatcaactc tcaaccatag actgaagatg
     6361 gaatgaagat atcaaaagtt ccttttagca ctgactagat tttttttctt ttttttgaaa
     6421 cagagtctca ctctgtcacc caggctggag ttcaatggca tggtctgggc tgactgtaac
     6481 ctcctcttcc tgggttcaag tgattctcat ccctcagcct cctgagtagc tgggattaca
     6541 ggcacataac accacaccca gctaactctt gtatttttgt agaaatgggg tttcgctatg
     6601 ttgctcagac tggtctcaaa cacctggcct caagtgatcc tcctgcctca gtctcccaaa
     6661 tgctgtgatt acaggcacaa gctactgcac caggcctctg actacatttc tattaatatg
     6721 gttaggttgg aggttttagt atttttgtat ctcatatttg tatcaatatg actggcttct
     6781 ttgtctgtag tgtgtggtaa tattagttct gtaaactgtc agttgcaaaa aaaaaaaata
     6841 ccttgaacta tagtatatgt tgataattag ccataataat ttcttagtta atttcttata
     6901 attaaatttg tcaaagagga aacttacagt ttatatctga tgaaatctct aaaaagatgg
     6961 gtaaaacatt gggaaatgta tgcatgtact tcactctggt ttcatagggt tagcaagtgt
     7021 cttaaaaaca tatataaaga agcacagaga ttgttaggag atatttatgc tcccagtttt
     7081 aataattggg atactttgta taccacagaa agaaaaatta ctaaactcct ctttttttag
     7141 tcaaaattgg aaaaaaagtc ttaattgaca gttactatgc ctgtgctacc catagcaagt
     7201 attcagtgga aaatacttta ctaagtaagt aatttgaaca cagcttaaaa tccatagtat
     7261 gttacaattg ctagcctttc acaaagtttg cattgtctta atgtagaagg atactgtgat
     7321 ctaagaattc acaattttaa aaagtggaac ctaaataggg tttcctaatt gccatgaagt
     7381 tatttgtatc ttagatgaat tatatttaca acattgtaaa tgtcagtggg tgatccaaaa
     7441 taaattgtta aagttattaa aatgtacatt taagtaggtt tcagtttgac tagaaataat
     7501 tggcaagaag gcaagaacta gtcttctaga gcagggatcc catcccccag gtcatggact
     7561 ggtactggtc catggcctgt tagaaaccag gccacacagc aggagatgag tggaaagcaa
     7621 gtgaaacttc atgggtattt acagcaattc cccgtcgctc gcattaccac ctgagctgtg
     7681 tctcctgtga gatcagcagc agcattagat tctcaaggag cacaaaccct tttggaactg
     7741 tgtgtgaggg atctaagttg cgcatttctt atgagaatct aatacctgat gatctgttgt
     7801 tgtctcccac cacccccaga tgggaccatc tagttgcagg aaaacaagct caggctccca
     7861 ctgattctac attatagtga gttgtgtaat tatttcatta tatataacaa tgtaataata
     7921 atagaaataa agtacataat aaatgtaatc cacttgaatt atcctgaaac catccccacc
     7981 ccccaccccc cggtctgtgg aaaaattggc ttccacgaaa ctggtccgtg gtgccaaaaa
     8041 tattgggtat ggttgttcta gggtgtagac tatgaaaaag atatgcattg tctccatgaa
     8101 ctaaaaggca aggtgatttt aaacaattta gatgccaaac aaagaaacca aaagcttcca
     8161 aagtaataaa tgatagagaa aggaaattgt tacatcatgt gccaaattag aagcaaatct
     8221 aaacttctta tcatgtactc caccatctga tttgtataag taattgggga aagaaaaact
     8281 cacaatataa aacaagattg actagttcta gcagatgaca cctgtaaata gaatttttac
     8341 tagttgaaat tctgatgtga aatgaagcca ttattattat cacaataaag tgttcttttt
     8401 agttcttttt ttaatatcc
//
