LOCUS       NM_023933                870 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens adenine nucleotide translocase lysine
            methyltransferase (ANTKMT), transcript variant 1, mRNA.
ACCESSION   NM_023933
VERSION     NM_023933.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Malecki,J.M., Willemen,H.L.D.M., Pinto,R., Ho,A.Y.Y., Moen,A.,
            Eijkelkamp,N. and Falnes,P.O.
  TITLE     Human FAM173A is a mitochondrial lysine-specific methyltransferase
            that targets adenine nucleotide translocase and affects
            mitochondrial respiration
  JOURNAL   J Biol Chem 294 (31), 11654-11664 (2019)
   PUBMED   31213526
  REMARK    GeneRIF: FAM173A is the long-sought mitochondrial lysine-specific
            methyltransferase responsible for adenine nucleotide translocase
            methylation at Lys-52, and point out the functional significance of
            Lys-52 methylation in adenine nucleotide translocase.
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI597021.1, BC002624.2 and AI492179.1.
            
            On Nov 22, 2018 this sequence version replaced NM_023933.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001181.1, BU632070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000569529.6/ ENSP00000454380.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               BI597021.1         10-155
            147-861             BC002624.2         103-817
            862-870             AI492179.1         8-16                c
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..870
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /note="adenine nucleotide translocase lysine
                     methyltransferase"
                     /db_xref="GeneID:65990"
                     /db_xref="HGNC:HGNC:14152"
                     /db_xref="MIM:618566"
     exon            1..291
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..837
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM173A; protein N-lysine methyltransferase
                     FAM173A; family with sequence similarity 173 member A;
                     adenine nucleotide translocase lysine N-methyltransferase"
                     /codon_start=1
                     /product="adenine nucleotide translocase lysine
                     N-methyltransferase isoform 1"
                     /protein_id="NP_076422.1"
                     /db_xref="CCDS:CCDS10423.1"
                     /db_xref="GeneID:65990"
                     /db_xref="HGNC:HGNC:14152"
                     /db_xref="MIM:618566"
                     /translation="MEQDDPVEALTELRERRLGALELLQAAAGSGLAAYAVWALLLQP
                     GFRRVPLRLQVPYVGASARQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRPAV
                     GYELNPWLVALARLHAWRAGCAGSVCYRRKDLWKVSLRDCRNVSVFLAPSVLPLLEDK
                     LRTELPAGARVVSGRFPLPTWQPVTAVGEGLDRVWAYDVPEGGQAGEAASSRIPIQAA
                     PGPSSAPIPGGLISQAS"
     exon            292..396
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /inference="alignment:Splign:2.1.0"
     exon            397..537
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /inference="alignment:Splign:2.1.0"
     exon            538..588
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /inference="alignment:Splign:2.1.0"
     exon            589..870
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      849..854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /note="hexamer: GATAAA"
     polyA_site      870
                     /gene="ANTKMT"
                     /gene_synonym="ANT-KMT; C16orf24; FAM173A"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtg tcgcgcggcg gctcccggca ggaggcagag ggcacaccgc cagccccagg
       61 ccaggctgcg agggccgcgg acccgagccg ggaaggacct tgggcggacg agccgcgcgt
      121 cccgcagcca tggagcagga cgacccggtc gaggcgctga cggagctgcg cgagcggcgg
      181 ctgggcgcgc tggagctgct gcaggcggcg gccggctcgg gcttggcagc ctacgcggtg
      241 tgggcgctgc tgctccagcc cggcttccgg cgcgtgccgc tgcggctgca ggtgccctac
      301 gtcggcgcga gcgcgcggca ggtggagcac gtgttgtcgc tgctgcgagg acgccccgga
      361 aaaacggtgg atctgggctc tggcgacggc aggatcgtgc tggcggccca caggtgcggc
      421 ctccgcccgg ccgtgggcta cgagctgaac ccctggctgg tggcgctggc gcggctgcac
      481 gcctggaggg ccggctgtgc cggcagcgtc tgctatcgcc gcaaggatct ctggaaggtg
      541 agcctgaggg actgccgcaa cgtgtctgtg ttcctggccc ctagcgtgct cccgctgctg
      601 gaggacaagc tgcggacaga gctgcctgct ggggcccgcg tggtgtctgg gcgcttccca
      661 ctccccacct ggcagcctgt gaccgcggtt ggcgagggcc tggaccgagt atgggcttat
      721 gatgttcctg agggtgggca ggctggggag gccgcctcct cgcggatacc catccaggct
      781 gcccccggac ctagttctgc ccccatcccg gggggcctta tttctcaggc cagctgagta
      841 ttagacacga taaagactct gtgggttcta
//
