LOCUS       NM_001150               3662 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens alanyl aminopeptidase, membrane (ANPEP), transcript
            variant 1, mRNA.
ACCESSION   NM_001150
VERSION     NM_001150.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Goltsov,A.A., Maru,D.M., Katkhuda,R., Duose,D.Y., Luthra,R.,
            Correa,A.M., Wang,F., Futreal,P.A. and Hofstetter,W.L.
  TITLE     ANPEP/CD13 Expression as a Marker of Lymphovascular Invasion and
            Survival in Esophageal Adenocarcinoma
  JOURNAL   Ann Thorac Surg 118 (1), 241-251 (2024)
   PUBMED   37806335
  REMARK    GeneRIF: ANPEP/CD13 Expression as a Marker of Lymphovascular
            Invasion and Survival in Esophageal Adenocarcinoma.
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Zhang,W., Blank,A., Kremenetskaia,I., Nitzsche,A., Acker,G.,
            Vajkoczy,P. and Brandenburg,S.
  TITLE     CD13 expression affects glioma patient survival and influences key
            functions of human glioblastoma cell lines in vitro
  JOURNAL   BMC Cancer 24 (1), 369 (2024)
   PUBMED   38519889
  REMARK    GeneRIF: CD13 expression affects glioma patient survival and
            influences key functions of human glioblastoma cell lines in vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Nguyen,J.N., Mohan,E.C., Pandya,G., Ali,U., Tan,C., Kofler,J.K.,
            Shapiro,L., Marrelli,S.P. and Chauhan,A.
  TITLE     CD13 facilitates immune cell migration and aggravates acute injury
            but promotes chronic post-stroke recovery
  JOURNAL   J Neuroinflammation 20 (1), 232 (2023)
   PUBMED   37817190
  REMARK    GeneRIF: CD13 facilitates immune cell migration and aggravates
            acute injury but promotes chronic post-stroke recovery.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Diaz-Alvarez,L., Martinez-Sanchez,M.E., Gray,E., Perez-Figueroa,E.
            and Ortega,E.
  TITLE     Aminopeptidase N/CD13 Crosslinking Promotes the Activation and
            Membrane Expression of Integrin CD11b/CD18
  JOURNAL   Biomolecules 13 (10), 1488 (2023)
   PUBMED   37892170
  REMARK    GeneRIF: Aminopeptidase N/CD13 Crosslinking Promotes the Activation
            and Membrane Expression of Integrin CD11b/CD18.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Watanabe,Y., Yamanaka,G., Morichi,S., Hayashi,K., Suzuki,S.,
            Takeshita,M., Morishita,N., Ishida,Y., Oana,S., Takata,F. and
            Kawashima,H.
  TITLE     Altered serum levels of platelet-derived growth factor receptor
            beta and cluster of differentiation 13 suggest a role for pericytes
            in West syndrome
  JOURNAL   Brain Dev 45 (9), 479-486 (2023)
   PUBMED   37263884
  REMARK    GeneRIF: Altered serum levels of platelet-derived growth factor
            receptor beta and cluster of differentiation 13 suggest a role for
            pericytes in West syndrome.
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   Yeager,C.L., Ashmun,R.A., Williams,R.K., Cardellichio,C.B.,
            Shapiro,L.H., Look,A.T. and Holmes,K.V.
  TITLE     Human aminopeptidase N is a receptor for human coronavirus 229E
  JOURNAL   Nature 357 (6377), 420-422 (1992)
   PUBMED   1350662
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Shapiro,L.H., Ashmun,R.A., Roberts,W.M. and Look,A.T.
  TITLE     Separate promoters control transcription of the human
            aminopeptidase N gene in myeloid and intestinal epithelial cells
  JOURNAL   J Biol Chem 266 (18), 11999-12007 (1991)
   PUBMED   1675638
REFERENCE   8  (bases 1 to 3662)
  AUTHORS   O'Connell,P.J., Gerkis,V. and d'Apice,A.J.
  TITLE     Variable O-glycosylation of CD13 (aminopeptidase N)
  JOURNAL   J Biol Chem 266 (7), 4593-4597 (1991)
   PUBMED   1705556
REFERENCE   9  (bases 1 to 3662)
  AUTHORS   Watt,V.M. and Willard,H.F.
  TITLE     The human aminopeptidase N gene: isolation, chromosome
            localization, and DNA polymorphism analysis
  JOURNAL   Hum Genet 85 (6), 651-654 (1990)
   PUBMED   1977688
REFERENCE   10 (bases 1 to 3662)
  AUTHORS   Look,A.T., Peiper,S.C., Rebentisch,M.B., Ashmun,R.A., Roussel,M.F.,
            Lemons,R.S., Le Beau,M.M., Rubin,C.M. and Sherr,C.J.
  TITLE     Molecular cloning, expression, and chromosomal localization of the
            gene encoding a human myeloid membrane antigen (gp150)
  JOURNAL   J Clin Invest 78 (4), 914-921 (1986)
   PUBMED   2428842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018988.12, BQ879097.1,
            AB209918.1, BC058928.1 and AC079075.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001150.2.
            
            Summary: Aminopeptidase N is located in the small-intestinal and
            renal microvillar membrane, and also in other plasma membranes. In
            the small intestine aminopeptidase N plays a role in the final
            digestion of peptides generated from hydrolysis of proteins by
            gastric and pancreatic proteases. Its function in proximal tubular
            epithelial cells and other cell types is less clear. The large
            extracellular carboxyterminal domain contains a pentapeptide
            consensus sequence characteristic of members of the zinc-binding
            metalloproteinase superfamily. Sequence comparisons with known
            enzymes of this class showed that CD13 and aminopeptidase N are
            identical. The latter enzyme was thought to be involved in the
            metabolism of regulatory peptides by diverse cell types, including
            small intestinal and renal tubular epithelial cells, macrophages,
            granulocytes, and synaptic membranes from the CNS. This
            membrane-bound zinc metalloprotease is known to serve as a receptor
            for the HCoV-229E alphacoronavirus as well as other non-human
            coronaviruses. This gene has also been shown to promote
            angiogenesis, tumor growth, and metastasis and defects in this gene
            are associated with various types of leukemia and lymphoma.
            [provided by RefSeq, Apr 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209918.1, SRR7410570.570202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000300060.7/ ENSP00000300060.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC018988.12        67908-67919         c
            13-16               BQ879097.1         12-15
            17-2558             AB209918.1         1-2542
            2559-3236           BC058928.1         2348-3025
            3237-3238           AC079075.6         14906-14907
            3239-3662           BC058928.1         3028-3451
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..3662
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /note="alanyl aminopeptidase, membrane"
                     /db_xref="GeneID:290"
                     /db_xref="HGNC:HGNC:500"
                     /db_xref="MIM:151530"
     exon            1..81
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            82..918
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1061
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1201
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1328
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1483
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1597
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1741
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1807
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1873
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2046
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2123
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2257
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2313
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2461
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2553
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2664
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2832
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2973
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3055
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3662
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3643..3648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /note="hexamer: AATAAA"
     polyA_site      3662
                     /gene="ANPEP"
                     /gene_synonym="AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1;
                     P150; PEPN"
                     /note="major polyA site"
ORIGIN      
        1 gctggagggg cagggacggc ggcggcgcag ctcggaaccc gccagggtcc agggtccagg
       61 ttccagcgcc cggcggccca ggcacccccc gagcccagct ccacacaccg ttcctggatc
      121 tcctctcccc aggcggagcg tgcccctgcc cagtccagtg accttcgcct gttggagccc
      181 tggttaattt ttgcccagtc tgcctgttgt ggggctcctc ccctttgggg atataagccc
      241 ggcctggggc tgctccgttc tctgcctggc ctgaggctcc ctgagccgcc tccccaccat
      301 caccatggcc aagggcttct atatttccaa gtccctgggc atcctgggga tcctcctggg
      361 cgtggcagcc gtgtgcacaa tcatcgcact gtcagtggtg tactcccagg agaagaacaa
      421 gaacgccaac agctcccccg tggcctccac caccccgtcc gcctcagcca ccaccaaccc
      481 cgcctcggcc accaccttgg accaaagtaa agcgtggaat cgttaccgcc tccccaacac
      541 gctgaaaccc gattcctacc gggtgacgct gagaccgtac ctcaccccca atgacagggg
      601 cctgtacgtt tttaagggct ccagcaccgt ccgtttcacc tgcaaggagg ccactgacgt
      661 catcatcatc cacagcaaga agctcaacta caccctcagc caggggcaca gggtggtcct
      721 gcgtggtgtg ggaggctccc agccccccga cattgacaag actgagctgg tggagcccac
      781 cgagtacctg gtggtgcacc tcaagggctc cctggtgaag gacagccagt atgagatgga
      841 cagcgagttc gagggggagt tggcagatga cctggcgggc ttctaccgca gcgagtacat
      901 ggagggcaat gtcagaaagg tggtggccac tacacagatg caggctgcag atgcccggaa
      961 gtccttccca tgcttcgatg agccggccat gaaggccgag ttcaacatca cgcttatcca
     1021 ccccaaggac ctgacagccc tgtccaacat gcttcccaaa ggtcccagca ccccacttcc
     1081 agaagacccc aactggaatg tcactgagtt ccacaccacg cccaagatgt ccacgtactt
     1141 gctggccttc attgtcagtg agttcgacta cgtggagaag caggcatcca atggtgtctt
     1201 gatccggatc tgggcccggc ccagtgccat tgcggcgggc cacggcgatt atgccctgaa
     1261 cgtgacgggc cccatcctta acttctttgc tggtcattat gacacaccct acccactccc
     1321 aaaatcagac cagattggcc tgccagactt caacgccggc gccatggaga actggggact
     1381 ggtgacctac cgggagaact ccctgctgtt cgaccccctg tcctcctcca gcagcaacaa
     1441 ggagcgggtg gtcactgtga ttgctcatga gctggcccac cagtggttcg ggaacctggt
     1501 gaccatagag tggtggaatg acctgtggct gaacgagggc ttcgcctcct acgtggagta
     1561 cctgggtgct gactatgcgg agcccacctg gaacttgaaa gacctcatgg tgctgaatga
     1621 tgtgtaccgc gtgatggcag tggatgcact ggcctcctcc cacccgctgt ccacacccgc
     1681 ctcggagatc aacacgccgg cccagatcag tgagctgttt gacgccatct cctacagcaa
     1741 gggcgcctca gtcctcagga tgctctccag cttcctgtcc gaggacgtat tcaagcaggg
     1801 cctggcgtcc tacctccaca cctttgccta ccagaacacc atctacctga acctgtggga
     1861 ccacctgcag gaggctgtga acaaccggtc catccaactc cccaccaccg tgcgggacat
     1921 catgaaccgc tggaccctgc agatgggctt cccggtcatc acggtggata ccagcacggg
     1981 gaccctttcc caggagcact tcctccttga ccccgattcc aatgttaccc gcccctcaga
     2041 attcaactac gtgtggattg tgcccatcac atccatcaga gatggcagac agcagcagga
     2101 ctactggctg atagatgtaa gagcccagaa cgatctcttc agcacatcag gcaatgagtg
     2161 ggtcctgctg aacctcaatg tgacgggcta ttaccgggtg aactacgacg aagagaactg
     2221 gaggaagatt cagactcagc tgcagagaga ccactcggcc atccctgtca tcaatcgggc
     2281 acagatcatt aatgacgcct tcaacctggc cagtgcccat aaggtccctg tcactctggc
     2341 gctgaacaac accctcttcc tgattgaaga gagacagtac atgccctggg aggccgccct
     2401 gagcagcctg agctacttca agctcatgtt tgaccgctcc gaggtctatg gccccatgaa
     2461 gaactacctg aagaagcagg tcacacccct cttcattcac ttcagaaata ataccaacaa
     2521 ctggagggag atcccagaaa acctgatgga ccagtacagc gaggttaatg ccatcagcac
     2581 cgcctgctcc aacggagttc cagagtgtga ggagatggtc tctggccttt tcaagcagtg
     2641 gatggagaac cccaataata acccgatcca ccccaacctg cggtccaccg tctactgcaa
     2701 cgctatcgcc cagggcgggg aggaggagtg ggacttcgcc tgggagcagt tccgaaatgc
     2761 cacactggtc aatgaggctg acaagctccg ggcagccctg gcctgcagca aagagttgtg
     2821 gatcctgaac aggtacctga gctacaccct gaacccggac ttaatccgga agcaggacgc
     2881 cacctctacc atcatcagca ttaccaacaa cgtcattggg caaggtctgg tctgggactt
     2941 tgtccagagc aactggaaga agctttttaa cgattatggt ggtggctcgt tctccttctc
     3001 caacctcatc caggcagtga cacgacgatt ctccaccgag tatgagctgc agcagctgga
     3061 gcagttcaag aaggacaacg aggaaacagg cttcggctca ggcacccggg ccctggagca
     3121 agccctggag aagacgaaag ccaacatcaa gtgggtgaag gagaacaagg aggtggtgct
     3181 ccagtggttc acagaaaaca gcaaatagtc cccagccctt gaagtcaccc ggcccccatg
     3241 caaggtgccc acatgtgtcc atcccagcgg ctggtgcagg gcctccattc ctggagcccg
     3301 aggcaccagt gtcctcccct caaggacaaa gtctccagcc cacgttctct ctgcctgtga
     3361 gccagtctag ttcctgatga cccaggctgc ctgagcacct cccagcccct gcccctcatg
     3421 ccaaccccgc cctaggcctg gcatggcacc tgtcgcccag tgccctgggg ctgatctcag
     3481 ggaagcccag ctccagggcc agatgagcag aagctctcga tggacaatga acggccttgc
     3541 tgggggccgc cctgtaccct ctttcacctt tccctaaaga ccctaaatct gaggaatcaa
     3601 cagggcagca gatctgtata tttttttcta agagaaaatg taaataaagg atttctagat
     3661 ga
//
