LOCUS       NM_030920               3407 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens acidic nuclear phosphoprotein 32 family member E
            (ANP32E), transcript variant 1, mRNA.
ACCESSION   NM_030920
VERSION     NM_030920.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Dijkwel,Y., Hart-Smith,G., Kurscheid,S. and Tremethick,D.J.
  TITLE     ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent Manner and
            Regulates Its Protein Stability in the Cytoplasm
  JOURNAL   Mol Cell Biol 44 (2), 72-85 (2024)
   PUBMED   38482865
  REMARK    GeneRIF: ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent
            Manner and Regulates Its Protein Stability in the Cytoplasm.
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Sheppard,C.M., Goldhill,D.H., Swann,O.C., Staller,E., Penn,R.,
            Platt,O.K., Sukhova,K., Baillon,L., Frise,R., Peacock,T.P.,
            Fodor,E. and Barclay,W.S.
  TITLE     An Influenza A virus can evolve to use human ANP32E through
            altering polymerase dimerization
  JOURNAL   Nat Commun 14 (1), 6135 (2023)
   PUBMED   37816726
  REMARK    GeneRIF: An Influenza A virus can evolve to use human ANP32E
            through altering polymerase dimerization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Zhu,X., Zou,Y., Wu,T., Ni,J., Tan,Q., Wang,Q. and Zhang,M.
  TITLE     ANP32E contributes to gastric cancer progression via NUF2
            upregulation
  JOURNAL   Mol Med Rep 26 (3) (2022)
   PUBMED   35795988
  REMARK    GeneRIF: ANP32E contributes to gastric cancer progression via NUF2
            upregulation.
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Ruff,G.L., Murphy,K.E., Smith,Z.R., Vertino,P.M. and Murphy,P.J.
  TITLE     Subtype-Independent ANP32E Reduction During Breast Cancer
            Progression in Accordance with Chromatin Relaxation
  JOURNAL   BMC Cancer 21 (1), 1342 (2021)
   PUBMED   34922480
  REMARK    GeneRIF: Subtype-Independent ANP32E Reduction During Breast Cancer
            Progression in Accordance with Chromatin Relaxation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   Zhang,J., Lan,Z., Qiu,G., Ren,H., Zhao,Y., Gu,Z., Li,Z., Feng,L.,
            He,J. and Wang,C.
  TITLE     Over-expression of ANP32E is associated with poor prognosis of
            pancreatic cancer and promotes cell proliferation and migration
            through regulating beta-catenin
  JOURNAL   BMC Cancer 20 (1), 1065 (2020)
   PUBMED   33148205
  REMARK    GeneRIF: Over-expression of ANP32E is associated with poor
            prognosis of pancreatic cancer and promotes cell proliferation and
            migration through regulating beta-catenin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 3407)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 3407)
  AUTHORS   Matilla,A. and Radrizzani,M.
  TITLE     The Anp32 family of proteins containing leucine-rich repeats
  JOURNAL   Cerebellum 4 (1), 7-18 (2005)
   PUBMED   15895553
  REMARK    Review article
REFERENCE   9  (bases 1 to 3407)
  AUTHORS   Jiang,M., Ma,Y., Ni,X., Cao,G., Ji,C., Cheng,H., Tang,R., Xie,Y.
            and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human gene
            (ANP32E alias LANPL) from human fetal brain
  JOURNAL   Cytogenet Genome Res 97 (1-2), 68-71 (2002)
   PUBMED   12438741
  REMARK    GeneRIF: The gene was cloned and identified during large-scale
            sequencing analysis of a human fetal brain cDNA library.
REFERENCE   10 (bases 1 to 3407)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC242988.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030920.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.15628.1,
                                           SRR1660809.123538.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583931.6/ ENSP00000463154.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC242988.1         111920-112299       c
            381-530             AC242988.1         107964-108113       c
            531-653             AC242988.1         106758-106880       c
            654-819             AC242988.1         105259-105424       c
            820-1007            AC242988.1         102795-102982       c
            1008-1062           AC242988.1         99373-99427         c
            1063-3407           AC242988.1         94604-96948         c
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..3407
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="acidic nuclear phosphoprotein 32 family member E"
                     /db_xref="GeneID:81611"
                     /db_xref="HGNC:HGNC:16673"
                     /db_xref="MIM:609611"
     exon            1..380
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..1133
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich acidic nuclear protein like; LANP-like
                     protein; acidic (leucine-rich) nuclear phosphoprotein 32
                     family, member E"
                     /codon_start=1
                     /product="acidic leucine-rich nuclear phosphoprotein 32
                     family member E isoform 1"
                     /protein_id="NP_112182.1"
                     /db_xref="CCDS:CCDS946.1"
                     /db_xref="GeneID:81611"
                     /db_xref="HGNC:HGNC:16673"
                     /db_xref="MIM:609611"
                     /translation="MEMKKKINLELRNRSPEEVTELVLDNCLCVNGEIEGLNDTFKEL
                     EFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKD
                     LSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEE
                     EDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGL
                     SYLMKEEIQDEEDDDDYVEEGEEEEEEEEGGLRGEKRKRDAEDDGEEEDD"
     exon            381..530
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     exon            531..653
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     exon            654..819
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1007
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1062
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..3407
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="hexamer: ATTAAA"
     polyA_site      1446
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="major polyA site"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="hexamer: AATAAA"
     polyA_site      3280
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="major polyA site"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="hexamer: AATAAA"
     polyA_site      3407
                     /gene="ANP32E"
                     /gene_synonym="LANP-L; LANPL"
                     /note="major polyA site"
ORIGIN      
        1 agtctctgag cagccattga aggggaagga actgcgggtg tgtgtgtgta tgtgtgtgtg
       61 tatgtgtgtg cgcgcgtgcg tgcgtgtgtg tgcgcgcgct agtgtgtgga caaggaggtg
      121 ggggcagctg agttagagtc ccaactcttg gactccattt gctattctct tctttctccc
      181 ccacacctat ctggtggtgg tagtgggcgt ttatatttgc gttccttttc attcatttct
      241 aaatctctta aaaattttgg gttgggggta ttggggaagg caggaaaggg aaaaggagag
      301 tagtagctga agagcaagag gaggacatgg agatgaagaa gaagattaac ctggagttaa
      361 ggaacagatc cccggaggag gtgacagagt tagtccttga taattgcctg tgtgtcaatg
      421 gggaaattga aggcctgaat gatactttca aagaactaga atttctgagt atggctaatg
      481 tggaactaag ttcgctggcc cggcttccca gcttaaataa acttcgaaaa ttggagctta
      541 gtgataatat aatttctgga ggcttggaag tcctggcaga gaaatgtcca aatcttacct
      601 acctcaatct gagtggaaac aaaataaaag atctcagtac agtagaagct ctgcaaaatc
      661 ttaaaaattt gaaaagtctt gacctgttta actgtgagat cacaaacctg gaagattata
      721 gagaaagtat ttttgaacta ctgcagcaaa tcacatactt agatggattt gatcaggagg
      781 ataatgaagc gccggactct gaagaggagg atgatgagga tggcgatgaa gatgatgaag
      841 aggaagagga aaatgaagct ggtccaccgg aaggatatga ggaagaggag gaggaagagg
      901 aagaggagga tgaggatgag gatgaagatg aagatgaagc aggttcagag ttgggagagg
      961 gagaagagga agtgggcctc tcatacttaa tgaaagaaga aattcaggat gaagaagatg
     1021 atgatgacta tgttgaagaa ggggaagaag aggaagaaga ggaagaagga ggtcttcgag
     1081 gggagaagag gaaacgagat gctgaagacg atggagagga agaagatgac tagatcattc
     1141 taagaccaga ttctctaatg tttctgggtg tgcaatagag tgatcacatc tttgtttctt
     1201 catgtacgat agctatccct acagaagata atgtgtaact ttttatagga aaagtgtggt
     1261 tttactattt ttgccttatc attccaaata agaactagtc tgttaatgat catattgtat
     1321 gtagagaaaa attttcattg actcccattg tggaattccc tagcaattta tttagactta
     1381 attttttaaa ttcaagctta ctgtattagt catttttagc ccataattaa aacatgatca
     1441 cttttacaca ggtgtagtat ggtgcatttc attccttatt tataaattaa ctgaaattac
     1501 agtttgctat aatataaaat gacaatagtc tcttgagtgg taagttggtt atttttttag
     1561 taggtgatcc aggaatcttt agtttgaagg cagttacctt tttttttttt tttttttgac
     1621 taagagtgtt tggttgcttt tttgtcacaa gtaacttgga aaatagaagc agaatagtaa
     1681 aggttctatt cagcaacata gttcatggat tttgtggagg ttctattcag taatatggtt
     1741 catggattta gtggtgactg ataagatttt atttttgaag gaaaaattgc ttatactaag
     1801 tccagagaca tgcaggtgag cccttttgtc aggctgcaaa tcatgacatg ccgatggttg
     1861 tttattttgt ttttaggtgt gcattctttt tcttcttagc aattccttta tgatcacctt
     1921 cccttcttgt ttcactccct cccgctctct caaaaggaac ttgggaaact tgtgaaaccc
     1981 aggaaaacct ttagtcttat acctcaacta cctttcagtc ctgtctgggt tttaaataag
     2041 tgaagtagaa gaaattgagt attttctgac ataagaatat attatcaata cagttttatg
     2101 cagtaagctc tccttaccat aaatgtttct tggttgacaa catctaagac aatattagtg
     2161 ggatgaagaa agaaaagcag gggtgctttt ggaagcagtg ttagtgttcc tcaaaagtcg
     2221 gaacaattgc ctgttgatat attaataaga cattaaagtc aaattttaat gttggcctct
     2281 caaatgattt ggataccact ctgcaaagta tttctaacct ttaattccca gttttaaaac
     2341 agatataata atagcattta attggaatat actaggcagc tggaaaagta tttgaaacta
     2401 aattgacatt aaaattaaga tttgttttca agtggatgtc cattaaaagt agaaaaatat
     2461 ttgggataag tgagtgtgtg tttccttaca tggctactaa ataaaatata atgagtatac
     2521 aagtatatct cctcttttgc tatggaggct ccatgttcaa ggcaatggct ttttaaatct
     2581 tggctatcta aaattttttc cctttgtttt gaatatttgt aagtttttaa gaagttagtg
     2641 tcagcaaatt aattgaagtt atgcttctat actgggacat atttaaatac tgagtatagt
     2701 actgctgcta ctgcttctac aatgtaaaat gtatgacttg gtgttttaaa gtaaaaatta
     2761 tgatgttact tgtggagaaa ctaaaaatgt tgtacaactg accgaaagaa aacccttggg
     2821 gataagttta gtgaggggat tggaatcccc aaaaagataa catttttctt ctgcttttaa
     2881 aaactgaaat tccctgttct agttcctaac aattctcatt acatactatg ccagattaca
     2941 aaatacttat ttttaaaatg aaatctatat attgactttc ttatcaatca tcttactgtg
     3001 caatcaaaat tagagtactt tggtttgaaa acaacactta gagcctccag ataactttta
     3061 agacttattt agctttgtgg gtggtatttt catgcaaata agtaagggtg ggttttatat
     3121 tttgtagaag ttttcggtcc tattttaatg ctctttgtat ggcagtatgt atatattgtg
     3181 ttaagttcct caagaatctc cttaaaaact ttgaagttaa tacttttgtg caactgtgtt
     3241 ttgaataaag ccatgacagt gttaaaaaca aacaaaaaaa tttgcagtac tcctgattat
     3301 tcttttattg tttttgactg ttccctgttt ttttctgtga ctgctgtaac ttaaagtttt
     3361 tgaaactgaa ttgcttcaaa taaattgaag atttgttata atgatta
//
