LOCUS       NM_012404               1064 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens acidic nuclear phosphoprotein 32 family member D
            (ANP32D), mRNA.
ACCESSION   NM_012404
VERSION     NM_012404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1064)
  AUTHORS   Yuzefovych,Y., Blasczyk,R. and Huyton,T.
  TITLE     Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients
            of heat shock protein 90
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2338-2348 (2015)
   PUBMED   26112988
  REMARK    GeneRIF: results highlight that certain malignancies with ANP32C/D
            overexpression or mutation might be specifically targeted using
            Hsp90 inhibitors.
REFERENCE   2  (bases 1 to 1064)
  AUTHORS   Cole,A.M., Petousi,N., Cavalleri,G.L. and Robbins,P.A.
  TITLE     Genetic variation in SENP1 and ANP32D as predictors of chronic
            mountain sickness
  JOURNAL   High Alt Med Biol 15 (4), 497-499 (2014)
   PUBMED   25225945
  REMARK    GeneRIF: results provide independent evidence in support of a role
            for SENP1 in chronic mountain sickness in individuals of Quechua
            ancestry and suggest the SENP1 and ANP32D signatures of selection
            are in tight linkage disequilibrium (LD).
REFERENCE   3  (bases 1 to 1064)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   4  (bases 1 to 1064)
  AUTHORS   Matilla,A. and Radrizzani,M.
  TITLE     The Anp32 family of proteins containing leucine-rich repeats
  JOURNAL   Cerebellum 4 (1), 7-18 (2005)
   PUBMED   15895553
  REMARK    Review article
REFERENCE   5  (bases 1 to 1064)
  AUTHORS   Kadkol,S.S., El Naga,G.A., Brody,J.R., Bai,J., Gusev,Y.,
            Dooley,W.C. and Pasternack,G.R.
  TITLE     Expression of pp32 gene family members in breast cancer
  JOURNAL   Breast Cancer Res Treat 68 (1), 65-73 (2001)
   PUBMED   11678310
REFERENCE   6  (bases 1 to 1064)
  AUTHORS   Kadkol,S.S., Brody,J.R., Pevsner,J., Bai,J. and Pasternack,G.R.
  TITLE     Correction to 'Modulation of oncogenic potential by alternative
            gene use in human prostate cancer'
  JOURNAL   Nat Med 5 (9), 1087 (1999)
   PUBMED   10471270
REFERENCE   7  (bases 1 to 1064)
  AUTHORS   Brody,J.R., Kadkol,S.S., Mahmoud,M.A., Rebel,J.M. and
            Pasternack,G.R.
  TITLE     Identification of sequences required for inhibition of
            oncogene-mediated transformation by pp32
  JOURNAL   J Biol Chem 274 (29), 20053-20055 (1999)
   PUBMED   10400610
REFERENCE   8  (bases 1 to 1064)
  AUTHORS   Kadkol,S.S., Brody,J.R., Pevsner,J., Bai,J. and Pasternack,G.R.
  TITLE     Modulation of oncogenic potential by alternative gene use in human
            prostate cancer
  JOURNAL   Nat Med 5 (3), 275-279 (1999)
   PUBMED   10086381
  REMARK    Erratum:[Nat Med 1999 Sep;5(9):1087]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC089987.26.
            
            On Sep 3, 2019 this sequence version replaced NM_012404.2.
            
            Summary: Phosphoprotein 32 (PP32) is a tumor suppressor that can
            inhibit several types of cancers, including prostate and breast
            cancers. The protein encoded by this gene is one of at least two
            proteins that are similar in amino acid sequence to PP32 and are
            part of the same acidic nuclear phosphoprotein gene family.
            However, unlike PP32, the encoded protein is tumorigenic. The tumor
            suppressor function of PP32 has been localized to a 25 amino acid
            region that is absent in the protein encoded by this gene. This
            gene does not contain introns. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266594.4/ ENSP00000266594.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1064              AC089987.26        137963-139026       c
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..1064
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
                     /note="acidic nuclear phosphoprotein 32 family member D"
                     /db_xref="GeneID:23519"
                     /db_xref="HGNC:HGNC:16676"
                     /db_xref="MIM:606878"
     exon            1..1064
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..502
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
                     /note="pp32 related 2; acidic nuclear phosphoprotein 32D;
                     tumorigenic protein pp32r2; acidic (leucine-rich) nuclear
                     phosphoprotein 32 family, member D; phosphoprotein
                     32-related protein 2"
                     /codon_start=1
                     /product="acidic leucine-rich nuclear phosphoprotein 32
                     family member D"
                     /protein_id="NP_036536.2"
                     /db_xref="CCDS:CCDS31788.1"
                     /db_xref="GeneID:23519"
                     /db_xref="HGNC:HGNC:16676"
                     /db_xref="MIM:606878"
                     /translation="MEMGKWIHLELRNRTPSDVKELFLDNSQSNEGKLEGLTDEFEEL
                     ELLNTINIGLTSIANLPKLNKLKKLELSSNRASVGLEVLAEKCPNLIHLNLSGNKIKD
                     LSTIEPLKKLENLESLDLFTCEVTNLNNY"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
                     /note="hexamer: AAGAAA"
     polyA_site      820
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
                     /note="major polyA site"
     regulatory      1036..1041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
                     /note="hexamer: AATAAA"
     polyA_site      1064
                     /gene="ANP32D"
                     /gene_synonym="PP32R2"
ORIGIN      
        1 gagaacccag cagagctggt tgagctttca aatgtgcggt tgtgggttcg gggtttattg
       61 gttgaattcc gctggctcag gagcctctgc agagaaagcg tgagagatgg agatgggcaa
      121 atggattcat ttagagctgc ggaacaggac gccctccgat gtgaaagaac ttttcctgga
      181 caacagtcag tcaaatgaag gcaaattgga aggcctcaca gatgaatttg aagaactgga
      241 attattaaat acaatcaaca taggcctcac ctcaattgca aacttgccaa agttaaacaa
      301 acttaagaag cttgaactaa gcagtaacag agcctcagtg ggcctagaag tattggcaga
      361 aaagtgtcca aacctcatac atctaaattt aagtggcaac aaaattaaag acctcagcac
      421 aatagagccc ctgaaaaagt tagaaaacct cgagagctta gaccttttca cttgcgaggt
      481 aaccaacctg aacaactact gagaaaagat gttcaagctc ctcctgcaac tcacatatct
      541 caacggctgt gacccggatg acaaggaggc ccctaactcg gatggtgagg gctttgtgga
      601 gtgcctggat gacaaggagg aggatgagga tgaggaggag tatgatgaag atgctcaggt
      661 aatggaagat gaggaggacg aggatgagga ggaggaacgt gaagaggagg acgtgagtgg
      721 agacgaggag gagaaggatg aaggttataa caatggagag gtagatgatg aggaagatga
      781 agaagagctt ggtgaagaag aaaggggtca gaagcgaaaa taagaaactg aagatgaggg
      841 agaagacgat gcctaagtgg aataatctat tttgaaaaat tccttttgtg attttactgt
      901 ttttagccgt atcccctccc ccactccaat cctgccccct gaaacttatt tttttctgat
      961 tgtaacgttg ctgtgggagc aagagaggaa aagtgtactg ggggttgtga gggaagggag
     1021 gggaggaggg ggtggaataa aatactattt ttactgccac tctt
//
