LOCUS       NM_006401               1483 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acidic nuclear phosphoprotein 32 family member B
            (ANP32B), mRNA.
ACCESSION   NM_006401
VERSION     NM_006401.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Staller,E., Carrique,L., Swann,O.C., Fan,H., Keown,J.R.,
            Sheppard,C.M., Barclay,W.S., Grimes,J.M. and Fodor,E.
  TITLE     Structures of H5N1 influenza polymerase with ANP32B reveal
            mechanisms of genome replication and host adaptation
  JOURNAL   Nat Commun 15 (1), 4123 (2024)
   PUBMED   38750014
  REMARK    GeneRIF: Structures of H5N1 influenza polymerase with ANP32B reveal
            mechanisms of genome replication and host adaptation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Zhou,C., Ma,H., Yu,W., Zhou,Y., Zhang,X., Meng,Y., Chen,C.,
            Zhang,J. and Shi,G.
  TITLE     ANP32B inhibition suppresses the growth of prostate cancer cells by
            regulating c-Myc signaling
  JOURNAL   Biochem Biophys Res Commun 698, 149543 (2024)
   PUBMED   38266312
  REMARK    GeneRIF: ANP32B inhibition suppresses the growth of prostate cancer
            cells by regulating c-Myc signaling.
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Mandemaker,I.K., Fessler,E., Corujo,D., Kotthoff,C., Wegerer,A.,
            Rouillon,C., Buschbeck,M., Jae,L.T., Mattiroli,F. and Ladurner,A.G.
  TITLE     The histone chaperone ANP32B regulates chromatin incorporation of
            the atypical human histone variant macroH2A
  JOURNAL   Cell Rep 42 (10), 113300 (2023)
   PUBMED   37858472
  REMARK    GeneRIF: The histone chaperone ANP32B regulates chromatin
            incorporation of the atypical human histone variant macroH2A.
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Li,T., Wang,N., Li,S., Yan,H., Gao,S., Gao,W. and Xu,R.
  TITLE     ANP32B promotes lung cancer progression by regulating VDAC1
  JOURNAL   Gene 859, 147200 (2023)
   PUBMED   36642319
  REMARK    GeneRIF: ANP32B promotes lung cancer progression by regulating
            VDAC1.
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Matilla,A. and Radrizzani,M.
  TITLE     The Anp32 family of proteins containing leucine-rich repeats
  JOURNAL   Cerebellum 4 (1), 7-18 (2005)
   PUBMED   15895553
  REMARK    Review article
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Gallouzi,I.E. and Steitz,J.A.
  TITLE     Delineation of mRNA export pathways by the use of cell-permeable
            peptides
  JOURNAL   Science 294 (5548), 1895-1901 (2001)
   PUBMED   11729309
  REMARK    Erratum:[Science 2002 Apr 5;296(5565):47]
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Brennan,C.M., Gallouzi,I.E. and Steitz,J.A.
  TITLE     Protein ligands to HuR modulate its interaction with target mRNAs
            in vivo
  JOURNAL   J Cell Biol 151 (1), 1-14 (2000)
   PUBMED   11018049
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Mencinger,M., Panagopoulos,I., Contreras,J.A., Mitelman,F. and
            Aman,P.
  TITLE     Expression analysis and chromosomal mapping of a novel human gene,
            APRIL, encoding an acidic protein rich in leucines
  JOURNAL   Biochim Biophys Acta 1395 (2), 176-180 (1998)
   PUBMED   9473664
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Zhu,L., Perlaky,L., Henning,D. and Valdez,B.C.
  TITLE     Cloning and characterization of a new silver-stainable protein
            SSP29, a member of the LRR family
  JOURNAL   Biochem Mol Biol Int 42 (5), 927-935 (1997)
   PUBMED   9285060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW296974.1, BC019658.1 and BP395780.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006401.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.903297.1,
                                           SRR3476690.857482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339399.5/ ENSP00000345848.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AW296974.1         135-161
            28-1353             BC019658.1         1-1326
            1354-1483           BP395780.1         111-240
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..1483
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /note="acidic nuclear phosphoprotein 32 family member B"
                     /db_xref="GeneID:10541"
                     /db_xref="HGNC:HGNC:16677"
                     /db_xref="MIM:619823"
     exon            1..269
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..971
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /note="acidic protein rich in leucines; silver-stainable
                     protein SSP29; putative HLA-DR-associated protein I-2;
                     acidic (leucine-rich) nuclear phosphoprotein 32 family,
                     member B"
                     /codon_start=1
                     /product="acidic leucine-rich nuclear phosphoprotein 32
                     family member B"
                     /protein_id="NP_006392.1"
                     /db_xref="CCDS:CCDS6732.1"
                     /db_xref="GeneID:10541"
                     /db_xref="HGNC:HGNC:16677"
                     /db_xref="MIM:619823"
                     /translation="MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNL
                     EFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKD
                     ISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDA
                     EVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGL
                     DEEDEDEDEDEEEEEGGKGEKRKRETDDEGEDD"
     exon            270..419
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            420..542
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            543..732
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            733..851
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            852..903
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1483
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /note="major polyA site"
     regulatory      1460..1465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="ANP32B"
                     /gene_synonym="APRIL; PHAPI2; SSP29"
                     /note="major polyA site"
ORIGIN      
        1 cttttccctc catggtttct ctccgctccc gtgagtaact tggctccggg ggctccgctc
       61 gcctgcccgc acgccgcccg ccacccagga ccgcgccgcc ggcctccgcc gctagcaaac
      121 ccttccgacg gccctcgctg cgcaagccgg gacgcctctc ccccctccgc ccccgccgcg
      181 gaaagttaag tttgaagagg ggggaagagg ggaacatgga catgaagagg aggatccacc
      241 tggagctgag gaaccggacc ccggcagctg ttcgagaact tgtcttggac aattgcaaat
      301 caaatgatgg aaaaattgag ggcttaacag ctgaatttgt gaacttagag ttcctcagtt
      361 taataaatgt aggcttgatc tcagtttcaa atctccccaa gctgcctaaa ttgaaaaagc
      421 ttgaactcag tgaaaataga atctttggag gtctggacat gttagctgaa aaacttccaa
      481 atctcacaca tctaaactta agtggaaata aactgaaaga tatcagcacc ttggaacctt
      541 tgaaaaagtt agaatgtctg aaaagcctgg acctctttaa ctgtgaggtt accaacctga
      601 atgactaccg agagagtgtc ttcaagctcc tgccccagct tacctacttg gatggctatg
      661 accgagagga ccaggaagca cctgactcag atgccgaggt ggatggtgtg gatgaagagg
      721 aggaggacga agaaggagaa gatgaggaag acgaggacga tgaggatggt gaagaagagg
      781 agtttgatga agaagatgat gaagatgaag atgtagaagg ggatgaggac gacgatgaag
      841 tcagtgagga ggaagaagaa tttggacttg atgaagaaga tgaagatgag gatgaggatg
      901 aagaggagga agaaggtggg aaaggtgaaa agaggaagag agaaacagat gatgaaggag
      961 aagatgatta agaccccaga tgacctgcag aaacagaact gttcagtatt ggttggactg
     1021 ctcatggatt ttgtagctgt ttaaaaaaaa aaaaaaggta gctgtgatac aaaccccagg
     1081 acacccaccc acccaaagag ccaaagaata gttcctgtga cattccgcct tccttccatg
     1141 tagtccctct tggtaatcta ccaccaagct tgtggacttc accccaacaa aattgtaagc
     1201 gttgttaggt ttttgtgtaa gattcttgct gtagcgtgga tagctgtgat tggtgagtca
     1261 accgtctgtg gctaccagtt acactgagat tgtaacagca tttttacttt ctgtacaaca
     1321 aaaaagcttt gtaaataaaa tcttaacatt ttgggtctgt tttttcatgc tttgcttttt
     1381 aattattatt attatttttt ttacattagg acattttatg tgacaactgc caaaaaagta
     1441 tttttaagaa tttaagcgaa ataaacagtt actctttggt aaa
//
