LOCUS       NM_006305               2440 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens acidic nuclear phosphoprotein 32 family member A
            (ANP32A), mRNA.
ACCESSION   NM_006305
VERSION     NM_006305.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Schmelter,C., Fomo,K.N., Brueck,A., Perumal,N., Markowitsch,S.D.,
            Govind,G., Speck,T., Pfeiffer,N. and Grus,F.H.
  TITLE     Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal
            Explants through Molecular Interaction with Acidic Leucine Rich
            Nuclear Phosphoprotein 32A (ANP32A)
  JOURNAL   Biomolecules 13 (7), 1161 (2023)
   PUBMED   37509196
  REMARK    GeneRIF: Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in
            Retinal Explants through Molecular Interaction with Acidic Leucine
            Rich Nuclear Phosphoprotein 32A (ANP32A).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Quintiens,J., De Roover,A., Cornelis,F.M.F., Escribano-Nunez,A.,
            Sermon,A., Pazmino,S., Monteagudo,S. and Lories,R.J.
  TITLE     Hypoxia and Wnt signaling inversely regulate expression of
            chondroprotective molecule ANP32A in articular cartilage
  JOURNAL   Osteoarthritis Cartilage 31 (4), 507-518 (2023)
   PUBMED   36370958
  REMARK    GeneRIF: Hypoxia and Wnt signaling inversely regulate expression of
            chondroprotective molecule ANP32A in articular cartilage.
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Swann,O.C., Rasmussen,A.B., Peacock,T.P., Sheppard,C.M. and
            Barclay,W.S.
  TITLE     Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins
            To Support cRNA but Not vRNA Synthesis
  JOURNAL   mBio 14 (1), e0339922 (2023)
   PUBMED   36645303
  REMARK    GeneRIF: Avian Influenza A Virus Polymerase Can Utilize Human ANP32
            Proteins To Support cRNA but Not vRNA Synthesis.
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Ding,H., Li,X., Zhou,L., Cui,Z., Meng,H. and Wang,J.
  TITLE     [Silenced ANP32A inhibits the growth, invasion and migration of
            colorectal cancer in vitro via the inactivation of AKT pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (1), 52-59 (2023)
   PUBMED   36856210
  REMARK    GeneRIF: [Silenced ANP32A inhibits the growth, invasion and
            migration of colorectal cancer in vitro via the inactivation of AKT
            pathway].
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Matilla,A. and Radrizzani,M.
  TITLE     The Anp32 family of proteins containing leucine-rich repeats
  JOURNAL   Cerebellum 4 (1), 7-18 (2005)
   PUBMED   15895553
  REMARK    Review article
REFERENCE   6  (bases 1 to 2440)
  AUTHORS   Matilla,A., Koshy,B.T., Cummings,C.J., Isobe,T., Orr,H.T. and
            Zoghbi,H.Y.
  TITLE     The cerebellar leucine-rich acidic nuclear protein interacts with
            ataxin-1
  JOURNAL   Nature 389 (6654), 974-978 (1997)
   PUBMED   9353121
  REMARK    Erratum:[Nature 1998 Feb 19;391(6669):818]
REFERENCE   7  (bases 1 to 2440)
  AUTHORS   Li,M., Makkinje,A. and Damuni,Z.
  TITLE     Molecular identification of I1PP2A, a novel potent heat-stable
            inhibitor protein of protein phosphatase 2A
  JOURNAL   Biochemistry 35 (22), 6998-7002 (1996)
   PUBMED   8679524
REFERENCE   8  (bases 1 to 2440)
  AUTHORS   Fink,T.M., Vaesen,M., Kratzin,H.D., Lichter,P. and Zimmer,M.
  TITLE     Localization of the gene encoding the putative human HLA class II
            associated protein (PHAPI) to chromosome 15q22.3-q23 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 29 (1), 309-310 (1995)
   PUBMED   8530098
REFERENCE   9  (bases 1 to 2440)
  AUTHORS   Vaesen,M., Barnikol-Watanabe,S., Gotz,H., Awni,L.A., Cole,T.,
            Zimmermann,B., Kratzin,H.D. and Hilschmann,N.
  TITLE     Purification and characterization of two putative HLA class II
            associated proteins: PHAPI and PHAPII
  JOURNAL   Biol Chem Hoppe Seyler 375 (2), 113-126 (1994)
   PUBMED   8192856
REFERENCE   10 (bases 1 to 2440)
  AUTHORS   Schraven,B., Kirchgessner,H., Gaber,B., Samstag,Y. and Meuer,S.
  TITLE     A functional complex is formed in human T lymphocytes between the
            protein tyrosine phosphatase CD45, the protein tyrosine kinase
            p56lck and pp32, a possible common substrate
  JOURNAL   Eur J Immunol 21 (10), 2469-2477 (1991)
   PUBMED   1655467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA825897.1, BC007200.1 and BC064969.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006305.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.396748.1,
                                           SRR3476690.937833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000465139.6/ ENSP00000417864.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA825897.1         28-38
            12-1109             BC007200.1         1-1098
            1110-2440           BC064969.1         81-1411
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..2440
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="acidic nuclear phosphoprotein 32 family member A"
                     /db_xref="GeneID:8125"
                     /db_xref="HGNC:HGNC:13233"
                     /db_xref="MIM:600832"
     exon            1..198
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..894
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="leucine-rich acidic nuclear protein; putative human
                     HLA class II associated protein I; cerebellar leucine rich
                     acidic nuclear protein; inhibitor-1 of protein
                     phosphatase-2A; mapmodulin; acidic nuclear phosphoprotein
                     pp32; putative HLA-DR-associated protein I; potent
                     heat-stable protein phosphatase 2A inhibitor I1PP2A;
                     hepatopoietin Cn; acidic (leucine-rich) nuclear
                     phosphoprotein 32 family, member A; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="acidic leucine-rich nuclear phosphoprotein 32
                     family member A"
                     /protein_id="NP_006296.1"
                     /db_xref="CCDS:CCDS45292.1"
                     /db_xref="GeneID:8125"
                     /db_xref="HGNC:HGNC:13233"
                     /db_xref="MIM:600832"
                     /translation="MEMGRRIHLELRNRTPSDVKELVLDNSRSNEGKLEGLTDEFEEL
                     EFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKD
                     LSTIEPLKKLENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDA
                     EGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEEEEGEEEDVSGEEEEDEEGYNDGE
                     VDDEEDEEELGEEERGQKRKREPEDEGEDDD"
     exon            199..348
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     exon            349..471
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     exon            472..670
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     exon            671..768
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     exon            769..832
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     exon            833..2440
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1079..1084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="hexamer: AATAAA"
     polyA_site      1102
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="major polyA site"
     regulatory      2050..2055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="hexamer: AATAAA"
     polyA_site      2068
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="major polyA site"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
                     /note="hexamer: AACAAA"
     polyA_site      2440
                     /gene="ANP32A"
                     /gene_synonym="C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1;
                     PHAPI; PP32"
ORIGIN      
        1 agtgtgcgcc gcgggtgctg ggggctcgag aaccgagcgg agctggttga gccttcaaag
       61 tcctaaaacg cgcggccgtg ggttcggggt ttattgattg aattccgccg gcgcgggagc
      121 ctctgcagag agagagcgcg agagatggag atgggcagac ggattcattt agagctgcgg
      181 aacaggacgc cctctgatgt gaaagaactt gtcctggaca acagtcggtc gaatgaaggc
      241 aaactcgaag gcctcacaga tgaatttgaa gaactggaat tcttaagtac aatcaacgta
      301 ggcctcacct caatcgcaaa cttaccaaag ttaaacaaac ttaagaagct tgaactaagc
      361 gataacagag tctcaggggg cctggaagta ttggcagaaa agtgtccgaa cctcacgcat
      421 ctaaatttaa gtggcaacaa aattaaagac ctcagcacaa tagagccact gaaaaagtta
      481 gaaaacctca agagcttaga ccttttcaat tgcgaggtaa ccaacctgaa cgactaccga
      541 gaaaatgtgt tcaagctcct cccgcaactc acatatctcg acggctatga ccgggacgac
      601 aaggaggccc ctgactcgga tgctgagggc tacgtggagg gcctggatga tgaggaggag
      661 gatgaggatg aggaggagta tgatgaagat gctcaggtag tggaagacga ggaggacgag
      721 gatgaggagg aggaaggtga agaggaggac gtgagtggag aggaggagga ggatgaagaa
      781 ggttataacg atggagaggt agatgacgag gaagatgaag aagagcttgg tgaagaagaa
      841 aggggtcaga agcgaaaacg agaacctgaa gatgagggag aagatgatga ctaagtggaa
      901 taacctattt tgaaaaattc ctattgtgat ttgactgttt ttacccatat cccctctccc
      961 ccccccctcc aatcctgccc cctgaaactt atttttttct gattgtaacg ttgctgtggg
     1021 aacgagaggg gaagagtgta ctgggggttg cggggggagg gatggcgggt gggggtggaa
     1081 taaaatacta tttttactgc cactctttat ttttttcccc tactttttct ttgtgtccgg
     1141 tttttgtccc tgtaaatgcg atagctaagt acacactaag tgagcatttg ttcctgactc
     1201 tcaaagagga tggtttggag ttctcttacg tttcctggta tttcccaagt ctcttgggtt
     1261 ggttggaagg ctgtggctgg tctcagtttg gttactcaat gcccaggagg ggctgagcac
     1321 cagccatatc ttttgctttg gttcacatga tgatacctgc ttttctcagg cctgctagag
     1381 gcatccaacg ccctggtttg taaatagcaa cctaaaggcg tattttggca ctggtctggg
     1441 gacattcccc atctctcatc ccttttcccc cttcacagat ggtggtgggc ttcgctctac
     1501 aaagaggact ctgatgttac tcttgagctt atgagccaga gagctgaaaa ccgcaggctt
     1561 gttgtgttaa gttacaagga aaatggattt ggtaattaaa attagaagaa acacaccttc
     1621 aaacttcaac ttctttaaaa gaaaaaaaaa actgtcctat cttgttctgt aaaatattag
     1681 aacgctttgt tttacaaaaa atgatgagag aattcttcca catgtacttc tgtgcttaga
     1741 acatttttac ggacctaagc gctggagacg ttgctgcatg tcggctgggt tttttttttc
     1801 atacacccga gcacggaaaa actaacgcaa aattgtattt tcttacctag tggaaatctg
     1861 aaatgactgc aaattcctag tgaatgtaca ggtttgcttt cgtgtccctc ttctggttgc
     1921 tttagaagtg acgtgtaatt tctgaaccca tgtttcatct gtataaaaga acatctgcac
     1981 cagtttttct cctgcccctc agaagagcca aactttgagt tttatgtctg tttgtcattg
     2041 ataaatttca ataaatcttt ttatacaatt tttttgggga tggcttcttt gagtccaaca
     2101 ggccattgat cttttcaaga tgcattccag atgaactgct aggtgagggg gaagcttcat
     2161 ttttgttacc tgatagaata gcttttctta tgagatatat ataatgtgat actatgtttg
     2221 gatatttttg gtcttaaagc aagactcagt ggtgtatctt cattaaaagc ttcctttaaa
     2281 aaagttacag agttactaaa aaaacaagta cccaaacaat caagttgggc caaccttgga
     2341 accttgtttt gaatatcttt cattgttttg tttgtcgtat tgtaaaaaga atgtatggtt
     2401 gaaaactcag gaatgtttat aaaacaaatt atttcacaaa
//
