LOCUS       NM_001012302            2867 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens anoctamin 9 (ANO9), transcript variant 1, mRNA.
ACCESSION   NM_001012302 XM_374860
VERSION     NM_001012302.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Schreiber,R., Talbi,K., Ousingsawat,J. and Kunzelmann,K.
  TITLE     A TMEM16J variant leads to dysregulated cytosolic calcium which may
            lead to renal disease
  JOURNAL   FASEB J 37 (1), e22683 (2023)
   PUBMED   36520003
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Katsurahara,K., Shiozaki,A., Kosuga,T., Shimizu,H., Kudou,M.,
            Arita,T., Konishi,H., Komatsu,S., Kubota,T., Fujiwara,H.,
            Okamoto,K., Kishimoto,M., Konishi,E. and Otsuji,E.
  TITLE     ANO9 regulates PD-L2 expression and binding ability to PD-1 in
            gastric cancer
  JOURNAL   Cancer Sci 112 (3), 1026-1037 (2021)
   PUBMED   33404124
  REMARK    GeneRIF: ANO9 regulates PD-L2 expression and binding ability to
            PD-1 in gastric cancer.
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Katsurahara,K., Shiozaki,A., Kosuga,T., Kudou,M., Shoda,K.,
            Arita,T., Konishi,H., Komatsu,S., Kubota,T., Fujiwara,H.,
            Okamoto,K., Kishimoto,M., Konishi,E., Marunaka,Y. and Otsuji,E.
  TITLE     ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell
            Carcinoma
  JOURNAL   Ann Surg Oncol 27 (9), 3218-3230 (2020)
   PUBMED   32227267
  REMARK    GeneRIF: ANO9 Regulated Cell Cycle in Human Esophageal Squamous
            Cell Carcinoma.
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Kim,H., Kim,H., Lee,J., Lee,B., Kim,H.R., Jung,J., Lee,M.O. and
            Oh,U.
  TITLE     Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA
            signal
  JOURNAL   Cell Calcium 71, 75-85 (2018)
   PUBMED   29604966
  REMARK    GeneRIF: ANO9 is a cation channel activated by a cAMP/PKA pathway
            and could play a role in intestine function.
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Scudieri,P., Sondo,E., Ferrera,L. and Galietta,L.J.
  TITLE     The anoctamin family: TMEM16A and TMEM16B as calcium-activated
            chloride channels
  JOURNAL   Exp Physiol 97 (2), 177-183 (2012)
   PUBMED   21984732
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Gfeller,D., Butty,F., Wierzbicka,M., Verschueren,E., Vanhee,P.,
            Huang,H., Ernst,A., Dar,N., Stagljar,I., Serrano,L., Sidhu,S.S.,
            Bader,G.D. and Kim,P.M.
  TITLE     The multiple-specificity landscape of modular peptide recognition
            domains
  JOURNAL   Mol Syst Biol 7, 484 (2011)
   PUBMED   21525870
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Hartzell,H.C., Yu,K., Xiao,Q., Chien,L.T. and Qu,Z.
  TITLE     Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels
  JOURNAL   J Physiol 587 (Pt 10), 2127-2139 (2009)
   PUBMED   19015192
  REMARK    Review article
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TP53I5 and mouse
            Tp53i5 genes in silico
  JOURNAL   Int J Oncol 25 (1), 225-230 (2004)
   PUBMED   15202010
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB140066.1, BC128557.1,
            AC138230.5 and AI986229.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001012302.2.
            
            Summary: The protein encoded by this gene is a member of the TMEM16
            (anoctamin) family of proteins, some of which form integral
            membrane calcium-activated chloride channels. The function of the
            encoded protein has yet to be elucidated, although it may have
            channel-forming abilities and also may have phospholipid scramblase
            activity. This gene has been observed to be upregulated in stage II
            and III colorectal cancers. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026923.1, BC128557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332826.7/ ENSP00000332788.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DB140066.1         1-32
            33-1255             BC128557.1         1-1223
            1256-1256           AC138230.5         145290-145290       c
            1257-1279           BC128557.1         1225-1247
            1280-1280           AC138230.5         145186-145186       c
            1281-2542           BC128557.1         1249-2510
            2543-2867           AI986229.1         13-337              c
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..2867
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /note="anoctamin 9"
                     /db_xref="GeneID:338440"
                     /db_xref="HGNC:HGNC:20679"
                     /db_xref="MIM:619963"
     exon            1..91
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2434
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 16J; p53-induced gene 5 protein;
                     tumor protein p53-inducible protein 5"
                     /codon_start=1
                     /product="anoctamin-9 isoform 1"
                     /protein_id="NP_001012302.2"
                     /db_xref="CCDS:CCDS31326.1"
                     /db_xref="GeneID:338440"
                     /db_xref="HGNC:HGNC:20679"
                     /db_xref="MIM:619963"
                     /translation="MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHT
                     QRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAP
                     HAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRL
                     KKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSL
                     FEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMAL
                     WATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVIL
                     VLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIII
                     MTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHP
                     GKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRA
                     SESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLAL
                     FSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFI
                     PRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRD
                     YRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKY
                     QRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARSTDV"
     exon            92..166
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            167..289
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            290..435
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            436..491
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            492..550
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            551..624
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..759
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            760..856
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            857..917
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1000
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1105
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1270
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1307
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1419
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1477
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1575
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1718
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1871
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2019
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2121
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2215
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2867
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2850..2855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /note="hexamer: AGTAAA"
     polyA_site      2867
                     /gene="ANO9"
                     /gene_synonym="PIG5; TMEM16J; TP53I5"
                     /note="major polyA site"
ORIGIN      
        1 acgcggaagt caggtaggag cacccgccgc tggcagccac tctcctggcc gccaaacccc
       61 agctggaact ccggccacag ccagcatgca gggcgaagag agcctccgga tcctggtgga
      121 gcccgaaggg gacagcttcc cgctgatgga gatcagcacc tgtgagaccg aggcctccga
      181 gcagtgggac tatgtcctcg tggcccaacg tcacacccag agagaccccc ggcaggcgcg
      241 gcagcaacag ttcctggagg agctcaggag aaagggcttc cacattaagg tgatccggga
      301 ccagaaacag gtcttctttg ggatccgtgc tgacaacagt gtctttggcc tgtaccgcac
      361 tctcctcctg gagcctgagg ggcctgcccc ccacgccgag ctggccgcgc cgaccaccat
      421 cccggtcacc acgagtctca gaatccgaat cgtgaacttc gttgtcatga acaacaagac
      481 ctcggctggt gagaccttcg aggatctgat gaaggacggg gtctttgagg ccaggttccc
      541 cctgcacaag ggggagggac gcctgaagaa gacgtgggcg cggtggagac acatgttccg
      601 ggagcagcca gttgatgaaa tcaggaacta ctttggggaa aaggtggccc tgtacttcgt
      661 ctggctgggc tggtacacct acatgctggt gccggccgcc ctgacgggcc tcttagtctt
      721 tctgagcgga ttctcgctgt ttgaggccag ccagatcagc aaggagatct gtgaggccca
      781 cgacatcctc atgtgtcccc tcggcgacca cagccgcagg taccagcggc tctcggaaac
      841 ctgcactttt gccaagctca cccacctctt tgacaatgat ggcacggtgg tgttcgccat
      901 cttcatggct ctctgggcca cggtgttcct ggagatctgg aagcggcagc gcgcccgcgt
      961 ggtcctgcac tgggacctgt acgtgtggga cgaggaacag gaggaaatgg cacttcagct
     1021 cattaactgc cccgactaca agctccggcc ataccagcac tcctacctac gcagcaccgt
     1081 catcctcgtc ctgaccctgc tcatgatctg cctcatgatc ggcatggccc acgtcctggt
     1141 ggtctaccgc gtcctggcct ccgcgctctt cagcagctcg gccgtgccct tcctggagga
     1201 gcaggtgacc acggccgtgg tggtgaccgg ggctctggtg cactatgtga ccatcatcat
     1261 catgaccaag atcaacaggt gcgtggccct gaagctttgt gacttcgaga tgcccaggac
     1321 cttctcggag cgagagagca ggttcaccat ccgcttcttc acactgcagt tcttcaccca
     1381 tttctcgtct ctcatctaca tcgccttcat cctgggcagg atcaacggcc accccgggaa
     1441 gtccacgcgc ctggcgggct tgtggaagct ggaagagtgc cacgccagcg gctgcatgat
     1501 ggacctcttc gtgcagatgg ccatcatcat gggcctgaag cagacgctca gcaactgcgt
     1561 cgagtacctg gtcccgtggg tgacccacaa gtgccgctct ctgcgggcct ccgagtccgg
     1621 gcacctgccc cgggaccccg agctcaggga ctggcggcgc aactaccttc tgaacccggt
     1681 caacaccttc agcctgttcg acgagttcat ggagatgatg atccagtacg gcttcaccac
     1741 catcttcgtg gccgccttcc cgctggcgcc gctgctcgcg ctcttcagca acctcgtgga
     1801 gatccgcctg gacgccatca agatggtctg gttgcagcgg cgcctggtgc cgcgcaaggc
     1861 caaggacatc gggacctggc tgcaggtgct ggagaccatc ggtgtgctgg cggtcattgc
     1921 caatgggatg gtcattgcct tcacatctga gttcatcccc cgagtggtct acaagtaccg
     1981 ctatagccca tgcctgaaag aaggcaactc tactgtcgac tgcctcaagg gctacgtcaa
     2041 ccacagcctg tccgtcttcc acaccaagga cttccaggac cctgatggga ttgagggctc
     2101 agaaaacgtg actctgtgca gatacaggga ctaccgcaat ccccccgatt acaacttctc
     2161 cgagcagttc tggttcctcc tggccatccg cctggccttc gtcatcctct ttgagcacgt
     2221 ggccttgtgc atcaagctca tcgccgcctg gttcgtgccc gacatccctc agtcggtgaa
     2281 gaacaaggtt ctggaggtga agtaccagag gctgcgtgag aagatgtggc atggaaggca
     2341 gaggctgggt ggggtggggg caggctctcg gcccccaatg cctgcccatc ccaccccagc
     2401 atccatcttc agtgccagga gcacagacgt gtagggccag agcccgtcca gaggccacca
     2461 ggagctgaga cagtgccacc accagcacct cccacaagcc caccgctgtg cgtgttgagg
     2521 ggtgctgtga gaaggctgtg cccatgtggg gccgcaggaa tcccctgtat gttcagggct
     2581 gtgagctgcc accctattcc gcctgctccg tctttgtggg ggctctcagg cttggcacag
     2641 ccctgacttg aactctgggt gaccctgggc acccacagaa ctgggagtga gggctcctca
     2701 ggcagccaca aggcaggaaa actggcgcaa atttcctggg cctccctctg acttctgggc
     2761 gccagatcct gccgtgcccc catcctggct gttgggggtg tcctgagccc acctcgctgg
     2821 cctgttccct tcagccaacc cgtttctgca gtaaaattaa gcctgtc
//
