LOCUS       NM_001025356            5998 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens anoctamin 6 (ANO6), transcript variant 1, mRNA.
ACCESSION   NM_001025356 XM_113743
VERSION     NM_001025356.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5998)
  AUTHORS   Lian,Z., Luo,W., Liu,J., Wang,J., Chai,W., Wang,Y., Sethi,S. and
            Ma,X.
  TITLE     Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in Patients with
            Ankylosing Spondylitis in a Chinese Han Population: A Case-Control
            Study
  JOURNAL   Genet Test Mol Biomarkers 28 (10), 385-392 (2024)
   PUBMED   39358671
  REMARK    GeneRIF: Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in
            Patients with Ankylosing Spondylitis in a Chinese Han Population: A
            Case-Control Study.
REFERENCE   2  (bases 1 to 5998)
  AUTHORS   Ousingsawat,J., Schreiber,R. and Kunzelmann,K.
  TITLE     Functional Interdependence of Anoctamins May Influence Conclusions
            from Overexpression Studies
  JOURNAL   Int J Mol Sci 25 (18), 9998 (2024)
   PUBMED   39337485
  REMARK    GeneRIF: Functional Interdependence of Anoctamins May Influence
            Conclusions from Overexpression Studies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5998)
  AUTHORS   Zubia,M.V., Yong,A.J.H., Holtz,K.M., Huang,E.J., Jan,Y.N. and
            Jan,L.Y.
  TITLE     TMEM16F exacerbates tau pathology and mediates phosphatidylserine
            exposure in phospho-tau-burdened neurons
  JOURNAL   Proc Natl Acad Sci U S A 121 (27), e2311831121 (2024)
   PUBMED   38941274
  REMARK    GeneRIF: TMEM16F exacerbates tau pathology and mediates
            phosphatidylserine exposure in phospho-tau-burdened neurons.
REFERENCE   4  (bases 1 to 5998)
  AUTHORS   Liang,P., Zhang,Y., Wan,Y.C.S., Ma,S., Dong,P., Lowry,A.J.,
            Francis,S.J., Khandelwal,S., Delahunty,M., Telen,M.J.,
            Strouse,J.J., Arepally,G.M. and Yang,H.
  TITLE     Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary
            xerocytosis
  JOURNAL   Blood 143 (4), 357-369 (2024)
   PUBMED   38033286
  REMARK    GeneRIF: Deciphering and disrupting PIEZO1-TMEM16F interplay in
            hereditary xerocytosis.
REFERENCE   5  (bases 1 to 5998)
  AUTHORS   Tang,L.H., Dai,M. and Wang,D.H.
  TITLE     ANO6 is a reliable prognostic biomarker and correlates to
            macrophage polarization in breast cancer
  JOURNAL   Medicine (Baltimore) 102 (45), e36049 (2023)
   PUBMED   37960776
  REMARK    GeneRIF: ANO6 is a reliable prognostic biomarker and correlates to
            macrophage polarization in breast cancer.
REFERENCE   6  (bases 1 to 5998)
  AUTHORS   Castoldi,E., Collins,P.W., Williamson,P.L. and Bevers,E.M.
  TITLE     Compound heterozygosity for 2 novel TMEM16F mutations in a patient
            with Scott syndrome
  JOURNAL   Blood 117 (16), 4399-4400 (2011)
   PUBMED   21511967
  REMARK    GeneRIF: Study identified 2 novel mutations in the TMEM16F gene in
            2 patients with Scott syndrome.
REFERENCE   7  (bases 1 to 5998)
  AUTHORS   Hartzell,H.C., Yu,K., Xiao,Q., Chien,L.T. and Qu,Z.
  TITLE     Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels
  JOURNAL   J Physiol 587 (Pt 10), 2127-2139 (2009)
   PUBMED   19015192
  REMARK    Review article
REFERENCE   8  (bases 1 to 5998)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 5998)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of TMEM16E and TMEM16F genes in
            silico
  JOURNAL   Int J Oncol 24 (5), 1345-1349 (2004)
   PUBMED   15067359
REFERENCE   10 (bases 1 to 5998)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK126409.1, BC098410.1,
            AL833405.1 and AA332109.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001025356.2.
            
            Summary: This gene encodes a multi-pass transmembrane protein that
            belongs to the anoctamin family. This protein is an essential
            component for the calcium-dependent exposure of phosphatidylserine
            on the cell surface. The scrambling of phospholipid occurs in
            various biological systems, such as when blood platelets are
            activated, they expose phosphatidylserine to trigger the clotting
            system. Mutations in this gene are associated with Scott syndrome.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098410.1, SRR1660807.198767.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320560.13/ ENSP00000320087.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK126409.1         109-133
            26-2735             BC098410.1         1-2710
            2736-5147           AL833405.1         197-2608
            5148-5183           BC098410.1         5123-5158
            5184-5192           AA332109.1         333-341
            5193-5998           BC098410.1         5168-5973
FEATURES             Location/Qualifiers
     source          1..5998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..5998
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /note="anoctamin 6"
                     /db_xref="GeneID:196527"
                     /db_xref="HGNC:HGNC:25240"
                     /db_xref="MIM:608663"
     exon            1..297
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2960
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane protein 16F; SCAN channel; small-conductance
                     calcium-activated nonselective cation channel"
                     /codon_start=1
                     /product="anoctamin-6 isoform a"
                     /protein_id="NP_001020527.2"
                     /db_xref="CCDS:CCDS31782.1"
                     /db_xref="GeneID:196527"
                     /db_xref="HGNC:HGNC:25240"
                     /db_xref="MIM:608663"
                     /translation="MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHD
                     FRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESN
                     LICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGT
                     LNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSR
                     VKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPR
                     SIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSK
                     EVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLF
                     LEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCI
                     RITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTAT
                     SITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSC
                     FYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEV
                     LLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVA
                     SFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNA
                     MIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYS
                     DLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAI
                     PDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE"
     exon            298..377
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            378..506
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            507..572
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            573..860
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            861..974
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1090
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1225
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1331
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1392
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1535
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1613
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1839
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2009
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2107
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2238
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2444
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2647
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2753
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..5998
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5976..5981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /note="hexamer: AATAAA"
     polyA_site      5998
                     /gene="ANO6"
                     /gene_synonym="BDPLT7; SCTS; TMEM16F"
                     /note="major polyA site"
ORIGIN      
        1 agtctccggg ctccgctcgg caggcgagag gcgtcctccg gctctgggct ccggtcggtg
       61 ggtgcctcgg ctcggctttc cccggcgctg gctgggctca gcggcccctg agcccaagcg
      121 acacacgccc cgcggtcccc gatccggccc ctgggagagc cgcgccgttc tggaacccgg
      181 gagcccccaa cttcgcgcca agttcggagc cgccttctga gggagacatg aaaaagatga
      241 gcaggaatgt tttgctacaa atggaggagg aggaggacga cgacgatggg gatatcgtgt
      301 tggaaaacct tggacagaca attgtccccg atttgggatc actggaaagt cagcatgatt
      361 ttcgaacccc ggagtttgaa gaatttaatg gaaaacctga ctccctcttt tttaatgatg
      421 gccagcgaag aattgacttt gttctagtat atgaggatga aagcagaaaa gagaccaata
      481 aaaagggtac aaatgaaaaa caaaggagga aaagacaagc atacgaatct aaccttatct
      541 gtcatggcct gcagttagaa gcaacaagat cagtattgga tgacaagctt gtatttgtaa
      601 aagtacacgc accatgggag gtgttatgta cgtatgctga gataatgcac atcaaattgc
      661 ctctgaaacc caatgatctg aaaaaccggt cctcagcctt tggtacactc aactggttta
      721 ccaaagtcct cagtgtagac gaaagcatca tcaagccaga gcaagagttt ttcactgccc
      781 catttgagaa gaaccggatg aatgattttt acatagttga tagagatgct ttcttcaatc
      841 cagccaccag aagccgcatt gtttacttca tcctctctcg ggtcaagtat caagtgataa
      901 acaatgttag caagtttggg atcaacagac ttgtaaactc tgggatctac aaggcagctt
      961 tcccactcca tgattgcaaa ttccgccgtc agtcagagga tcccagctgc cctaatgaac
     1021 ggtaccttct gtacagagaa tgggctcatc ctcgaagcat atacaaaaag cagcccttgg
     1081 atcttatcag gaaatactat ggagagaaga ttggaatcta ctttgcttgg ctgggctatt
     1141 acactcagat gcttctcctg gccgcagttg taggagtggc ttgctttctc tatggatatc
     1201 ttaatcaaga taactgtaca tggagcaaag aagtttgtca tcctgatatt ggtggcaaga
     1261 tcataatgtg tcctcagtgt gataggcttt gtccattctg gaaactcaat attacttgcg
     1321 agtcctcaaa gaaattgtgc atcttcgaca gttttggaac cctggtcttt gcagtattta
     1381 tgggagtatg ggttaccttg tttttggagt tttggaagcg acgccaggca gaacttgagt
     1441 atgaatggga tactgttgag ttacagcagg aagaacaagc ccgaccagaa tacgaagcac
     1501 gatgtactca cgtagtgata aatgagatta ctcaggaaga agaacgcatt ccctttactg
     1561 cctggggaaa atgtatacgg ataaccctct gtgccagtgc tgtctttttc tggatcctat
     1621 tgatcatcgc ttcagttatt gggatcattg tctataggct ctcggtgttc attgtatttt
     1681 ctgcaaaact tcccaagaac attaatggaa cagacccaat ccagaaatac ctgactccac
     1741 agacagccac gtccatcacg gcctccatca tcagctttat aattatcatg attctgaaca
     1801 ccatatatga aaaagtggca attatgatta ctaacttcga actcccaagg acccagactg
     1861 attatgagaa cagcctcacc atgaagatgt tcttattcca gtttgtcaac tactactctt
     1921 catgcttcta catagcattc tttaagggca aatttgtagg ctatccagga gacccagttt
     1981 attggttggg aaaatacaga aatgaagagt gtgacccagg tggctgtctt cttgaactga
     2041 caactcagct gacaataatc atgggaggaa aagcaatctg gaataacata caagaagtat
     2101 tattgccctg gatcatgaat ctaattgggc gatttcacag agtttctgga tcagaaaaga
     2161 taaccccacg atgggaacag gactaccatc tgcagcctat gggcaaactg ggattatttt
     2221 atgaatatct tgaaatgatt attcagtttg ggttcgtcac cttatttgtg gcctcttttc
     2281 cactggcccc tctgttggct ctcgtgaaca atatattgga aataagagtg gacgcatgga
     2341 aactgaccac ccagtttaga cgcctggtac cagagaaagc ccaagacatt ggagcatggc
     2401 agcccatcat gcaaggaata gcaattctgg ctgtggtgac caatgccatg atcatagctt
     2461 tcacgtcgga catgatcccc cgcctagtgt actactggtc cttctccgtc cctccctacg
     2521 gggaccacac ttcctacacc atggaagggt acatcaacaa cactctctcc atcttcaaag
     2581 tcgcagactt caaaaacaaa agcaagggaa acccgtactc tgacctgggt aaccatacca
     2641 catgcaggta tcgtgatttc cgatacccac ctggacaccc ccaggagtat aaacacaaca
     2701 tctactattg gcatgtgatt gcagccaagc tggcttttat cattgtcatg gagcacgtca
     2761 tctactctgt gaaatttttc atttcatatg caattcccga tgtatcaaaa cgcacaaaga
     2821 gcaagatcca gagagaaaaa tacctaaccc aaaagcttct tcatgagaat cacctcaaag
     2881 atatgacgaa aaatatgggg gtgatagctg agcggatgat agaagcagta gataacaatt
     2941 tacggccaaa atcagaataa gagctttatg ttctgagaag cactttaagg aatttagctt
     3001 tgtcaaaata tattaggaat cactaatgag aatgtgtaag ttaaatcact ttggcaaata
     3061 tgagtctcaa ctattgccat ttcctcatgt attatttttc agtttcagct agcgatgcag
     3121 aaactggaaa atgtaaaact tagatcatga agggcataaa acttatcacc cggaaaacct
     3181 caatgttacc tttttctgat aaattggaat tttacagaaa aagtccctca gtgtgcttaa
     3241 aaaccacccc ttctaaagta gaatggattc ttttttttct gtttgattat tttcatttct
     3301 gtctattctc aggcgcatga tctcctttat ttttaagcca tgtttcattt cttcacttgg
     3361 ctagatctgt tccagggtca tcttttcctt acagtaccat cattatagat ttaatttaat
     3421 agctttcatg tgattaaaaa tagctaacta gactcaagga ttcacaatat ttaggtgtat
     3481 tttcaatacc tccagaaagg aaacctcagt taatcagagg aaatagtttc agtcttcatt
     3541 tgagcatgtc tttccatctc aaaaaaatac tcttagtagg ttggagtgaa gatagcaagg
     3601 ttttgaagca tatttgtcct aatccacagt gacacttttt atcttccagg agcactccta
     3661 ggaggttccg tgcctaatca atgttgactg ctttgcagat ctcaagggaa taaaatgaca
     3721 aaagcaggga aagttacaga ttcaaacagc attttaactc atgttgatct ggataattaa
     3781 tcttttctaa agatgtgtag tttcttggaa aacagtgata tcacatgatt aaaattacat
     3841 ttttatcaac ataattgtct ggaaaagata agcccctcaa ttttctacca gttgactttt
     3901 attcattaga tacagaaggt gcagtattac acatcaccag ctgcctttgt gaatggctca
     3961 ctacacagcc attggggtac aactgtgtgc atgggcagaa acagcaagtg ccctcattgt
     4021 ggtcattggg tggggagtgc cttttgtcaa ggagtctgca ggaattggct tatttctgta
     4081 tgccaaagtg atcaacacac caaagtctct gccataaaga atgtggcttc cttgcatcct
     4141 ccatcctgtt actctgggcc cagtaatttg atgtaactgt ctgattgtac tagagacagg
     4201 agtataccca gcttattcat aatcaagtaa agagactcag attagatttg attttttagc
     4261 ctcctctaga gccaatcagg cagttaagag taataaagga aaagggtttg gtcacaaacc
     4321 ctaccattat ctggagatta cttcctgctg cactcctgtc ttgccatgca cgtcttgccc
     4381 cctcactttt gctcagccta gcagtctact tcactttatt gccttgtaag tgtcaggcct
     4441 cctgggcgct ctggaaaaga cagggagcca ggccctctca cccctactgg taacaggtca
     4501 ttgctgggtg cacaagaggg aggtgatttg catcatggtc atgctgcatg ggcttcactg
     4561 ggatgctgtt aaacaccaga ggagccaacc tatcagaatc ccagcagcaa aggaaaactc
     4621 agattttaga ggctttttac aataaagtag cgtaactcta ggtcatgatt gatttcaaat
     4681 gcctgccatg aatgatttgt aagtaattat gtaggatcca tcaaagcagt attgtaggct
     4741 tttgaattgt cccagtggat ccgggacccc atttcactgt ctctcttgat cgtgttaatg
     4801 atgcaatcag agttcaagac aggccccatg aagtctgact gcactgggat ggagaaatga
     4861 atttcttccc actgaaggaa actctttctc attcgcagcc aagacgggag tgccactgtt
     4921 cctctcttca ctcctgagat actgcttctg gaagcgggtg tcacttcctc tctagtacct
     4981 cttctcttct ctgaagtgtg tgactatctc ctagtgttta aatttggcag ttactcgcca
     5041 tgtatgtcag catagaaaag gaaatgtttt taccttatct cctgtatgta tgatagaact
     5101 taaaagaaat gtgcatttgt tttcatagcc ccagcagaga aaatcctctt catagattaa
     5161 atgtgctgct gtggacagga ggggaaaaaa aaccctctac atattgaaag gcaccaaatg
     5221 taatatctga cactgttaag atgcccaaaa gagcaaagtt gtagtggaga tgcagggtca
     5281 tttccccatg ccatccacag tgtttgttag tgagtccacg gctgacttgc agtgataaag
     5341 aaaagcatgg agctgtgtct gcagacaatg gtggctgcat ctgtaagtgg cttcagaggc
     5401 agcagccctg gggaaattga tgggtgtggc agtggacctg tgaagaggga gaatctagcc
     5461 ttcagcctgt ccagtgttaa ccactagaga aactgagctt tatatccttt tttaatgcct
     5521 gtgaatttta gcatattgaa acattagagc aaatactcag gggatttttc attaaacatc
     5581 cctcagataa tttagctata tatcattaga aagggaaagc tatcattttt attttaaaac
     5641 taaacaaggc catcttataa actgtcacca aagtcttccc ttttttattg catgtgtgcc
     5701 ttgaatttca taaaacatta attcacaatg ggggtcagaa tgtactcttg ttgaaacact
     5761 tcttgtacca ttttatgttc atattatgtt tgagagggta aaaatgtatg agcagcttaa
     5821 ctgaagtaga actattcatg atgcttttca cacattgtgg cataagatgt aaagtttgta
     5881 attaatgtta atttctgtgc attttaatat tcttttataa ttattaatgt taatttctgt
     5941 gcattttaat attcttttat aattatgagc attttaataa attcattttt acaaacaa
//
