LOCUS       NM_018089               2540 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ankyrin repeat and zinc finger peptidyl tRNA hydrolase
            1 (ANKZF1), transcript variant 1, mRNA.
ACCESSION   NM_018089
VERSION     NM_018089.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Li,G., Wang,Z., Gao,B., Dai,K., Niu,X., Li,X., Wang,Y., Li,L.,
            Wu,X., Li,H., Yu,Z., Wang,Z. and Chen,G.
  TITLE     ANKZF1 knockdown inhibits glioblastoma progression by promoting
            intramitochondrial protein aggregation through mitoRQC
  JOURNAL   Cancer Lett 591, 216895 (2024)
   PUBMED   38670305
  REMARK    GeneRIF: ANKZF1 knockdown inhibits glioblastoma progression by
            promoting intramitochondrial protein aggregation through mitoRQC.
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Zhang,J., Wang,Y., Hou,S., Chi,X., Ding,D., Xue,M., Zhang,M.,
            Wang,J., Shuai,J., Sun,H., Gao,Q. and Kang,C.
  TITLE     Overexpression of ZNF169 promotes the growth and proliferation of
            colorectal cancer cells via the upregulation of ANKZF1
  JOURNAL   Oncol Rep 51 (6) (2024)
   PUBMED   38666541
  REMARK    GeneRIF: Overexpression of ZNF169 promotes the growth and
            proliferation of colorectal cancer cells via the upregulation of
            ANKZF1.
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Yip,M.C.J., Savickas,S., Gygi,S.P. and Shao,S.
  TITLE     ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality
            Control
  JOURNAL   Cell Rep 30 (7), 2106-2114 (2020)
   PUBMED   32075755
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Zhou,X., Shang,Y.N., Lu,R., Fan,C.W. and Mo,X.M.
  TITLE     High ANKZF1 expression is associated with poor overall survival and
            recurrence-free survival in colon cancer
  JOURNAL   Future Oncol 15 (18), 2093-2106 (2019)
   PUBMED   31257922
  REMARK    GeneRIF: High ANKZF1 is an independent factor of poor survival
            (overall survival and recurrence-free survival) in colon cancer by
            taking part in angiogenesis and some cancer signaling pathways.
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Yip,M.C.J., Keszei,A.F.A., Feng,Q., Chu,V., McKenna,M.J. and
            Shao,S.
  TITLE     Mechanism for recycling tRNAs on stalled ribosomes
  JOURNAL   Nat Struct Mol Biol 26 (5), 343-349 (2019)
   PUBMED   31011209
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Stapf,C., Cartwright,E., Bycroft,M., Hofmann,K. and Buchberger,A.
  TITLE     The general definition of the p97/valosin-containing protein
            (VCP)-interacting motif (VIM) delineates a new family of p97
            cofactors
  JOURNAL   J Biol Chem 286 (44), 38670-38678 (2011)
   PUBMED   21896481
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA226194.1, BC008948.2, BC028334.1 and AC068946.4.
            
            On May 17, 2019 this sequence version replaced NM_018089.2.
            
            Transcript Variant: This variant (1)represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008948.2, SRR1803613.62256.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323348.10/ ENSP00000321617.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DA226194.1         50-89
            41-2509             BC008948.2         1-2469
            2510-2530           BC028334.1         2087-2107
            2531-2540           AC068946.4         131028-131037
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2540
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /note="ankyrin repeat and zinc finger peptidyl tRNA
                     hydrolase 1"
                     /db_xref="GeneID:55139"
                     /db_xref="HGNC:HGNC:25527"
                     /db_xref="MIM:617541"
     exon            1..95
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            96..273
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2306
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and zinc finger domain-containing protein
                     1; zinc finger protein 744; tRNA endonuclease ANKZF1;
                     ankyrin repeat and zinc finger domain containing 1"
                     /codon_start=1
                     /product="tRNA endonuclease ANKZF1 isoform 1"
                     /protein_id="NP_060559.2"
                     /db_xref="CCDS:CCDS42821.1"
                     /db_xref="GeneID:55139"
                     /db_xref="HGNC:HGNC:25527"
                     /db_xref="MIM:617541"
                     /translation="MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAP
                     RTSCSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQ
                     RLKDKPLLSALDFEKQSSTGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGF
                     YPHRVLFQNAQGQFLYAYRCVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFA
                     GAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVR
                     DLLAGPSWAKALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQ
                     ELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEAL
                     GQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQ
                     EAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVG
                     VLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDS
                     RARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAA
                     RRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAI
                     VNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQAGRPSS"
     exon            274..386
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            387..489
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            490..683
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            684..796
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            797..944
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1173
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1329
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1816
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1928
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2096
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2182
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2540
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /note="hexamer: AATAAA"
     polyA_site      2512
                     /gene="ANKZF1"
                     /gene_synonym="Vms1; ZNF744"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcgctg ctccgtagtg acggggattg ttgtgttgca gaaatccggc aatcgacctg
       61 aggacttgcg agccgctcag ctcccgggac gtttggagct gctgctaaat aatttctgct
      121 cagccatgtc gccggctcca gatgcagccc cggctcctgc gtcgatctcc ctgtttgacc
      181 tcagcgcgga tgctccggtc tttcagggcc tgagcctggt gagccacgcg cctggggagg
      241 ctctggcccg ggctccgcgt acttcctgtt caggctcagg ggagagagaa agcccagaaa
      301 gaaagctact ccagggtcct atggatattt cagagaagtt attttgttca acttgtgacc
      361 agaccttcca gaaccaccaa gaacagaggg aacattataa gcttgactgg catcggttta
      421 acctaaagca acgtctcaag gacaagcctc tcctgtctgc cctggacttt gaaaagcaga
      481 gctccacagg agatctttcc agcatctcgg gatcagaaga ctcagactca gccagtgagg
      541 aggacttgca gacactggat cgggagaggg ctacatttga gaagttgagc cgacccccag
      601 gcttttaccc tcatcgagtt cttttccaga atgcccaggg ccagtttctt tatgcctacc
      661 gctgtgtcct aggccctcat caggatcccc cagaagaggc agaactgctg ctacagaacc
      721 tgcaaagtag aggtcccaga gactgcgtgg tgctcatggc tgcagctggg cactttgctg
      781 gtgctatatt tcaaggaaga gaagtggtga cacacaaaac ttttcaccgc tatacggttc
      841 gggccaagcg gggcacagcc caggggcttc gggatgcccg aggtgggcca tcacactctg
      901 ctggagccaa cctgaggcgc tacaatgaag ccacactata taaggatgtt cgtgacctgc
      961 tggcagggcc aagctgggct aaggcgctgg aggaggctgg tacaatactg ttgcgtgctc
     1021 cccgctctgg ccggtctttg ttctttggag gcaagggagc acccctgcaa aggggggatc
     1081 cccgactttg ggatatcccc ctcgccaccc gcagacccac cttccaagag ctacagcgtg
     1141 tgctccataa gctgaccact ttgcatgtct atgaagaaga ccctcgggaa gcagtcagac
     1201 tgcactcacc tcagacacac tggaaaacag taagagagga gagaaagaag cctactgagg
     1261 aagaaataag aaagatctgc agggatgaaa aggaagcgct ggggcagaat gaggaatctc
     1321 ccaaacaggg ttcagggtcg gagggagaag atggctttca ggtagagttg gagctagtgg
     1381 agttgactgt ggggactctg gatctttgtg agtctgaagt attgcccaag cggaggagga
     1441 gaaaaaggaa taagaaggag aaaagccgag accaggaggc tggggcacat cggactcttc
     1501 tccagcaaac tcaagaagag gagccttcca cacagtcatc ccaggcagtt gctgccccct
     1561 tgggcccttt gctggatgag gccaaagccc ctggtcagcc agagctctgg aatgcactgc
     1621 ttgctgcttg ccgagctgga gatgttggag tgctaaagct gcagctagct cccagccctg
     1681 cagaccctag agttctgtct ctgctcagtg cccccttggg ctccggtggc tttactctcc
     1741 tgcatgcagc agctgcagct ggaagaggct cagtggttcg tctgctgctg gaagcaggtg
     1801 ctgaccccac tgtgcaggac tctcgggccc ggccacctta tactgttgcg gctgacaaat
     1861 caacacgtaa tgagttccga aggttcatgg agaagaatcc agatgcctac gattacaaca
     1921 aggctcaggt gccaggacca ttgacaccag aaatggaggc acggcaggct acacggaaaa
     1981 gggagcagaa ggcagcccgg cggcaacggg aggaacagca gcagaggcag caggagcagg
     2041 aggagcgtga acgagaagag cagcggcgat ttgccgccct cagtgaccga gagaagagag
     2101 ctctggctgc agagcgccga ctcgctgccc agttgggagc ccctacctct ccaatccctg
     2161 actctgcaat cgtcaatact cgacgctgct ggagttgtgg ggcatccctc caaggcctga
     2221 ctccctttca ctacctcgac ttctctttct gctccacacg ttgcctccag gatcatcgcc
     2281 gtcaggcagg gaggccctct tcctgatctc ttacagctct acctggggcc aactcaggga
     2341 cctgagaggg cacattcaca gcagccctag gttttttctt ccccgtgaaa ccagagatga
     2401 tttggaagat gggggtgaag gacactcggg aactagggca aagacagggc tagaggtatg
     2461 tggagctggt actgtctctg gaattttaat cacaataaag tttggcaagg aatgtgtact
     2521 tgtacttaca ttcagaggca
//
