LOCUS       NM_173551               7190 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens ankyrin repeat and sterile alpha motif domain
            containing 6 (ANKS6), mRNA.
ACCESSION   NM_173551 XM_940697 XM_944734 XM_944735 XM_944737 XM_944739
VERSION     NM_173551.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7190)
  AUTHORS   Schwarz,H., Popp,B., Airik,R., Torabi,N., Knaup,K.X., Stoeckert,J.,
            Wiech,T., Amann,K., Reis,A., Schiffer,M., Wiesener,M.S. and
            Schueler,M.
  TITLE     Biallelic ANKS6 mutations cause late-onset ciliopathy with chronic
            kidney disease through YAP dysregulation
  JOURNAL   Hum Mol Genet 31 (9), 1357-1369 (2022)
   PUBMED   34740236
  REMARK    GeneRIF: Biallelic ANKS6 mutations cause late-onset ciliopathy with
            chronic kidney disease through YAP dysregulation.
REFERENCE   2  (bases 1 to 7190)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7190)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7190)
  AUTHORS   Grampa,V., Delous,M., Zaidan,M., Odye,G., Thomas,S.,
            Elkhartoufi,N., Filhol,E., Niel,O., Silbermann,F., Lebreton,C.,
            Collardeau-Frachon,S., Rouvet,I., Alessandri,J.L., Devisme,L.,
            Dieux-Coeslier,A., Cordier,M.P., Capri,Y., Khung-Savatovsky,S.,
            Sigaudy,S., Salomon,R., Antignac,C., Gubler,M.C., Benmerah,A.,
            Terzi,F., Attie-Bitach,T., Jeanpierre,C. and Saunier,S.
  TITLE     Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia
            through YAP Dysregulation
  JOURNAL   PLoS Genet 12 (3), e1005894 (2016)
   PUBMED   26967905
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7190)
  AUTHORS   Hoff,S., Halbritter,J., Epting,D., Frank,V., Nguyen,T.M., van
            Reeuwijk,J., Boehlke,C., Schell,C., Yasunaga,T., Helmstadter,M.,
            Mergen,M., Filhol,E., Boldt,K., Horn,N., Ueffing,M., Otto,E.A.,
            Eisenberger,T., Elting,M.W., van Wijk,J.A., Bockenhauer,D.,
            Sebire,N.J., Rittig,S., Vyberg,M., Ring,T., Pohl,M., Pape,L.,
            Neuhaus,T.J., Elshakhs,N.A., Koon,S.J., Harris,P.C., Grahammer,F.,
            Huber,T.B., Kuehn,E.W., Kramer-Zucker,A., Bolz,H.J., Roepman,R.,
            Saunier,S., Walz,G., Hildebrandt,F., Bergmann,C. and Lienkamp,S.S.
  TITLE     ANKS6 is a central component of a nephronophthisis module linking
            NEK8 to INVS and NPHP3
  JOURNAL   Nat Genet 45 (8), 951-956 (2013)
   PUBMED   23793029
  REMARK    GeneRIF: ANKS6 as a new NPHP family member that assembles a
            distinct module of nephronophthisis-associated proteins,
            encompassing NEK8, INVS and NPHP3.
REFERENCE   6  (bases 1 to 7190)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7190)
  AUTHORS   Kaisaki,P.J., Bergmann,C., Brown,J.H., Outeda,P., Lens,X.M.,
            Peters,D.J., Gretz,N., Gauguier,D. and Bihoreau,M.T.
  TITLE     Genomic organization and mutation screening of the human ortholog
            of Pkdr1 associated with polycystic kidney disease in the rat
  JOURNAL   Eur J Med Genet 51 (4), 325-331 (2008)
   PUBMED   18434273
  REMARK    GeneRIF: Location, sequence and structure of the gene encoding
            human SamCystin have been determined.
REFERENCE   8  (bases 1 to 7190)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 7190)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   10 (bases 1 to 7190)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807776.1, BX462630.2,
            BM552108.1, BY994327.1, BC012981.2, AK127702.1, CR749472.1,
            BC064367.1 and AK074328.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_173551.4.
            
            Summary: This gene encodes a protein containing multiple ankyrin
            repeats and a SAM domain. It is thought that this protein may
            localize to the proximal region of the primary cilium, and may play
            a role in renal and cardiovascular development. Mutations in this
            gene have been shown to cause a form of nephronophthisis (NPHP16),
            a chronic tubulo-interstitial nephritis. [provided by RefSeq, Jul
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353234.5/ ENSP00000297837.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL807776.1         38933-38945         c
            14-43               BX462630.2         5-34
            44-222              BM552108.1         1-179
            223-906             BY994327.1         52-735
            907-926             BC012981.2         1857-1876
            927-1993            AK127702.1         501-1567
            1994-2485           CR749472.1         1332-1823
            2486-2916           BC064367.1         1460-1890
            2917-3673           CR749472.1         2255-3011
            3674-3779           BC064367.1         2648-2753
            3780-4606           CR749472.1         3118-3944
            4607-7190           AK074328.1         704-3287
FEATURES             Location/Qualifiers
     source          1..7190
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..7190
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 6"
                     /db_xref="GeneID:203286"
                     /db_xref="HGNC:HGNC:26724"
                     /db_xref="MIM:615370"
     exon            1..423
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2680
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /note="ankyrin repeat domain 14; samCystin; SAM
                     domain-containing protein 6"
                     /codon_start=1
                     /product="ankyrin repeat and SAM domain-containing protein
                     6"
                     /protein_id="NP_775822.3"
                     /db_xref="CCDS:CCDS43856.1"
                     /db_xref="GeneID:203286"
                     /db_xref="HGNC:HGNC:26724"
                     /db_xref="MIM:615370"
                     /translation="MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPE
                     AGAEPAGAEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGA
                     SVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVV
                     KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPN
                     HAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY
                     LDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAA
                     VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKN
                     GYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSKVRQPWSIPVLPD
                     DKGGLKSWWNRMSNRFRKLKLMQTLPRGLSSNQPLPFSDEPEPALDSTMRAAPQDKTS
                     RSALPDAAPVTKDNGPGSTRGEKEDTLLTTMLRNGAPLTRLPSDKLKAVIPPFLPPSS
                     FELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVRPVKFPSLPRSPAS
                     SANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKKAAGLLEQK
                     PSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTTSKSTSPTLTPS
                     PSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQE
                     VDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFE
                     SSASNTRAPGNSPCA"
     exon            424..926
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            927..971
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1176
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1283
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1432
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1631
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1681
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1885
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2036
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2206
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2390
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2458
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2575
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..7190
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7163..7168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /note="hexamer: AATAAA"
     polyA_site      7190
                     /gene="ANKS6"
                     /gene_synonym="ANKRD14; NPHP16; PKDR1; SAMD6"
                     /note="major polyA site"
ORIGIN      
        1 atccgggggc ggagccgacg cggccggcgg ggcggacggg agcgggccgc gcgtggcggc
       61 ggcgatgggc gagggcgggc tgcccccggc cttccagctg ctgctgcgcg cgtgtgacca
      121 gggcgacacg gagacggcgc ggcggctgct ggagccgggg gcggcggagc cagccgagcg
      181 cggcgcggag ccggaggcgg gcgcggagcc ggcgggggcc gaggtggccg ggcccggggc
      241 cgcagcggcg ggggcagtcg gggctccggt gcccgtggat tgctcggacg aggcgggcaa
      301 caccgcactg cagttcgccg cggccggggg ccacgaaccg ctggtgcgct tcctgctgcg
      361 ccgcggtgcc tcggtcaaca gccgcaacca ctacggctgg agcgcgctca tgcaggcggc
      421 cagatttggg catgtgagtg tggcacacct cctgttggat cacggggctg atgtcaatgc
      481 ccagaaccgg ctgggggcca gtgtgctcac tgtggcttct cggggcggcc acctgggtgt
      541 ggtgaagctg ctcctggaag ccggtgcctt tgtggaccat caccaccctt caggcgagca
      601 actggggttg ggcggcagca gggatgagcc cttggacatc acagccctga tggctgccat
      661 ccagcacggg cacgaggccg tggtgcgtct actgatggag tggggcgcgg accccaacca
      721 cgcagcccgg accgtgggct ggagcccgct gatgctggcc gcactcactg ggcggcttgg
      781 agtggcccag cagctggtgg agaagggcgc caaccctgac cacctcagcg tgctggagaa
      841 gaccgccttc gaggttgcac tggactgcaa gcacagggac cttgtagact acctggaccc
      901 gctgaccacc gtcaggccca aaacagatga ggagaaaagg cgacctgata ttttccatgc
      961 attgaaaatg ggaaacttcc agctggtcaa agagattgcc gatgaagacc ccagccacgt
     1021 gaacttggtc aatggggacg gggcgacgcc actgatgcta gcagctgtta cggggcagct
     1081 ggctctggtg cagctgctgg tggagaggca cgcggatgtt gacaagcagg acagcgtgca
     1141 tggctggacg gccctcatgc aggcaaccta ccatgggaat aaggaaattg tgaaatatct
     1201 gctaaaccaa ggggccgatg tcactcttcg tgcaaaaaat ggatacacgg cctttgacct
     1261 ggtgatgctg ctgaatgatc ccgacacgga acttgttcga ctgctggcat ctgtctgcat
     1321 gcaggtgaat aaagacaaag gccggccgag ccaccagcct cccctgcccc actcgaaggt
     1381 ccgacagccc tggagcatcc cagtgctgcc cgatgacaag ggtggactga agtcctggtg
     1441 gaaccgaatg tccaatcggt tccgaaagct caaactgatg cagacgctgc cccgtgggct
     1501 gtccagcaac cagcctttgc ctttctctga cgagcctgag ccagctctgg actccacaat
     1561 gagggctgcc ccccaggaca agacaagccg ctctgcactc cctgatgcgg cccctgtgac
     1621 caaagacaat ggtcctggga gcacaagagg agaaaaggaa gacacgttat tgacaaccat
     1681 gcttcgaaac ggagctcccc tcaccagact cccgagtgac aagctgaaag cagtcatccc
     1741 cccattccta cccccttcca gttttgagct gtggagctct gatcggtccc ggacgcgtca
     1801 caacgggaag gcagacccca tgaagactgc gctgccccag agagccagca ggggccaccc
     1861 cgtgggcggc gggggcacag acactacacc cgtcaggcct gttaaatttc caagcctccc
     1921 cagaagccca gcctcttctg ccaattctgg aaacttcaac cactcgcctc attcatcggg
     1981 cggctccagt ggggtaggtg tgagccggca cggtggggag ctgcttaacc gctcaggtgg
     2041 cagcatagac aatgtcttgt cccaaatcgc tgcccagagg aaaaaagcag ccggattatt
     2101 ggagcagaaa cccagccatc ggtcaagccc tgtggggcca gcaccggggt ccagcccgtc
     2161 tgagcttcca gcctcccctg caggtggcag cgctcctgtt ggcaagaaat tggagaccag
     2221 caaaaggcct ccatctggaa cttccactac ctccaagagc acctctccaa ccctcacgcc
     2281 ctccccctca cccaaagggc acactgcaga gtcctcagtg tcttcctcgt catcccatcg
     2341 gcagtccaag agcagtgggg gctccagcag tggcaccatc acagatgagg atgaactgac
     2401 tggaatcctt aagaaattat cacttgagaa atatcagccc atttttgagg aacaagaggt
     2461 ggacatggaa gcgttcctca cactgactga cggtgacttg aaggagctgg gaattaagac
     2521 agatgggtcc aggcagcaga ttctggcagc gatttctgaa ctgaacgcag gcaagggacg
     2581 cgagagacaa attttacagg aaaccattca caactttcac tcttcctttg agagcagtgc
     2641 cagcaacacc agggcccctg gcaacagccc ctgtgcgtga tcctccttcc cgcagccacc
     2701 agcgtgagct ctctgaatcc cgggacccct tcacgtggcc acagccccag ccctgccccc
     2761 gtcacactgc tgtgccttag tcatgttgtt ccctttgctc gggatgccca cttcacgtcg
     2821 acggcattca ttggtagtac ttcttgctgc aacaaacttc aacacacaga gacagattcc
     2881 catgtaacag tccagtgggg gtgcttctgc ttggcaggtt ggttcacaca gtgatgcagg
     2941 gactcagctc ctttcatcct gtgctctgcc ctccccggga gcctcagagt ttgcttctgg
     3001 ctggcggcaa gggaaaggga cgatggagaa ggcacggctg cttcttacct gccttgctct
     3061 taactgacac acatcactcc tgctcacgtc ctcttggcca ctggtagtca tgtggcccca
     3121 cctggatgca gaggaggcca ggatgtgcag tctccacata gtggcttccc agcaacaact
     3181 tttgacttag atggggggta tgtattatgg tgagaggtta gccttcctgg cacatcttcc
     3241 cttaaaactt ctaacttgcc cctcctagtc caagtcacct ctcagatgaa gtcttttttg
     3301 accccctttc agccactggg tcccttagtg ctgtgtatgt gactgctgta gcattccact
     3361 gcacctgctg catacagctt acattggaga tgtgtatgtc aaacgcattt ttctttattg
     3421 caaagagagt ctattataga aggaaagaag tggaggcctg ctgtgtggat cccttcttct
     3481 tcctagcttt cagtttcctt atctgcaaag tggaaggtca gaccagatga tgctctggta
     3541 ctccacagtg ctcacctgta tcactgcagg gctttctgca ctgaaagtgg aagcagaagg
     3601 ctaatgggtc acattgtgta aaggtctctg gtgctcaaag tttctaggca aagaagtgaa
     3661 aatttggaat tttgtctaca tcctattaat gctgtgttcc tcaaaaggga attggcttgt
     3721 gtagtttcct accatatcat attttattaa attagagggg ccctgacttt taaaacccac
     3781 tggctttctg aagtgttttc cagtgaatga ctcattcagc cagtgcttgt tgcatttatg
     3841 ttagctacca ggtgccaagt gtgcagacac aatacagagc cttcaggctc tcgacaggca
     3901 agagaacacc tgtaaataga tggtcccgac attgagaggc agcatggtag agtgggcaga
     3961 ccttgtgctc tggactcagg ttcaaagttc agatgaagct caatggcctc ttagttggag
     4021 cttagaacca gtatgcccaa agtgctgggt ctgcaggaag tacccagtcg atggtaggct
     4081 gcacagaatt ctgatctcta ccttgagcca tgctgagcca caagttggtc tccttgggag
     4141 gtgccatctc tcatctgtcc ctcccccagc catgaaagcc cattccccta tgctggcttt
     4201 cagaggctgt cgttaactta ctgcccagag cctcgtagtt ttcttcccct gccctgatgg
     4261 ttgggtgttt ttcctttaaa ttctctcagc cttacactca cagaagccaa ctttccacag
     4321 gactgaagac aaagtgtttc atttagctgt tactgataga cacctttaca aaggttacta
     4381 atgtcccagc ctttttaagg agacacactc attcatcccc tactatgtgc tggcagcttt
     4441 acctttgtca tttcatcctc atggccaccc tggaggtggc attgtgtaac ctcatcttgc
     4501 acattcggga aacggatgct taggagaggg aagcagcttg ccagttaaac agcccagaag
     4561 gagcagatct ggggtcagaa ccggacctgg tgggcttgca agcctgtgcc ttttccacta
     4621 actcctatag actcctggag ctagaagcac ttgtgattct tgttttaatt tactgatggc
     4681 ttcaggggtt aacagtaggc ctagaattgt ttgcctctga aattcatggc ccctgacgtt
     4741 atgtgctttg aggttttgtg cctgcttttt gctgtggtcc tgtttttttc ataacaatat
     4801 actggtatag cttccactca ggtaagtttg attgaacaat gatacacagc tgcaccgggg
     4861 ggtcaccttt tcacaaatgt agacctccat gaactcattg gatgaccctg gacagagcgg
     4921 ggctattccc attttgcaga caggacagca gaggctccag acaatgcctt tcctttcttt
     4981 ttcactggac tcaagtgtcc aaggcttttc atcctaggaa gtttgtgtgc tggttcacaa
     5041 gaggtccctg gcaccctttc tggggatgtt tggatgcggc tggtaggcag ggaagagaaa
     5101 gggcacccca gcgggggcat gtgtggaggc agcacggaac atgtaggtta tagatcgtca
     5161 gggaggaggg gtcagttggg tgcttgtttt tctgattttt ggtccttgat cacccccttc
     5221 ccttcccaca cgtgtcccca gcctgcctgt ggctgttccc cccacaagaa gcacctccct
     5281 tgcttggcaa ccttcaccag catttcccaa aagtatgctc ctgggaaccc tagttccaca
     5341 ggataatagg tttttcataa agaaacgtag ggtgtgtatg tgaaagtggg gtgaggttcc
     5401 ctggttgagt aggtttggca gacactaaag cgagctacac gatcatcttt gctacaggcc
     5461 tctcacaacc ttcagcatgc cagcatgggt caggcctctt cacagggcca agaaactcat
     5521 agcatctccc acattactct catcacttct ccaaggtgct tttgcaagac tggaattcct
     5581 tggacaccat tggagaagcc ccgctttttc tggaacagcg gcaaccaaga ggccttgcag
     5641 ccctggaagt gggtcagggc ccttggtggt cacctttttc tccccagcag ctctgcagag
     5701 gtggcctgct tggcagtggg acatcagggg accggtcctg ctttgagatg gcagggtccc
     5761 tgttctgaga gctctccagc ctgagggcat tgagctgagg ctccaccctg agctctcctg
     5821 cagggtggag ggcattgttt cccagcaccc aggcagtgtc ttgctggtgt gtcgtgagtg
     5881 ctggatgtcc aagtccctgc tggccacgga gggctcctgc ctctcttctt cagcgccaca
     5941 aaattacatg gaggccagct ggttttgtga ggagattgtt tattttttaa ttcttttgtt
     6001 taccgaacgt ttactgagca tctaccctgt gccagcccta ctcgtacgct ctgtctccaa
     6061 agatgaaaaa ggacttctct gccctcaagg gaaccccaca gtatcttaga ggagacaatc
     6121 atgtcggtga gatggtgtgg tgatgaagcc tgctgggtat acagctcagg gaaagtcatc
     6181 gatgatggct caggctcagc ctgggcacgc cccagaggag agagatggag tggggcctca
     6241 aagggcaggt ttaggcagaa aagaaaaagg gcattccagc tggggcatgt gcaaaggcag
     6301 cacgtaatgt gtaagttcta gatcgtcagg gaggaagggt cagttgggtg cctgtttttc
     6361 tgtttttagt cctttaaaat gagtagaagc aacctgttac cctggaaaga gcactggaca
     6421 tagacctagt gctgcgtgat gttgagcacg tttcttcttc cctttgagtc ccagtttccc
     6481 ttttggttac agggggatag tagcccccag ggatcatgtg aaagtgagaa agcccttttc
     6541 acactgtgga gcggtgcaga tgtgggaaac ctcaaagatg gttgcccatt ttaaatcctt
     6601 tcatctctca tctctctttc ttctctccct tctgccctga cgtagccatg gttgggtggg
     6661 tgaggccaga agaaactgcc tccggcaaga ggtagcagcc gctcaggtgg ctctgctggc
     6721 atcggagccc acagaagtga ggagtggccg atggacctgc cctccaaatg tgcctgactc
     6781 tgggtcttgc tgtcactgga tttcctggca tggcagacag aaagaaagat agtttgacca
     6841 agtcgtagaa gctgatccag cgggtaaaaa gggggcaggg aactcgtccc ttttattctt
     6901 gcctcagagc tgcctgaaga catgggccag gccggaggct ggacaacttt ggataacgct
     6961 gacctgtact tccaagtaaa tgcctcctga agagcccggg acccttcctg ggagaattct
     7021 gcagccagaa tgaaggtgcc atcagcagga ggcactgtga agcaccatcc tgtcgctgtc
     7081 cttgtccatt cctagcaagt taatcgtgtc ttgttaacca gcagttcctg ttcaacgtgt
     7141 aaagagacct gatgttttcc ctaataaagc tgataacaga ttttgcagga
//
