LOCUS       NM_001352186            6322 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens ankyrin repeat and sterile alpha motif domain
            containing 1B (ANKS1B), transcript variant 13, mRNA.
ACCESSION   NM_001352186 XM_017019651
VERSION     NM_001352186.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6322)
  AUTHORS   Wang,X., Wang,Y., Cai,Q. and Zhang,M.
  TITLE     AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity
            and Specificity
  JOURNAL   J Mol Biol 436 (12), 168608 (2024)
   PUBMED   38759928
  REMARK    GeneRIF: AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High
            Affinity and Specificity.
REFERENCE   2  (bases 1 to 6322)
  AUTHORS   Kislova,A.V., Zheglo,D., Pozhitnova,V.O., Sviridov,P.S.,
            Gadzhieva,E.P. and Voronina,E.S.
  TITLE     Replication stress causes delayed mitotic entry and chromosome 12
            fragility at the ANKS1B large neuronal gene in human induced
            pluripotent stem cells
  JOURNAL   Chromosome Res 31 (3), 23 (2023)
   PUBMED   37597021
  REMARK    GeneRIF: Replication stress causes delayed mitotic entry and
            chromosome 12 fragility at the ANKS1B large neuronal gene in human
            induced pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6322)
  AUTHORS   Yan,J. and Xu,H.
  TITLE     Regulation of transforming growth factor-beta1 by
            circANKS1B/miR-515-5p affects the metastatic potential and
            cisplatin resistance in oral squamous cell carcinoma
  JOURNAL   Bioengineered 12 (2), 12420-12430 (2021)
   PUBMED   34781814
  REMARK    GeneRIF: Regulation of transforming growth factor-beta1 by
            circANKS1B/miR-515-5p affects the metastatic potential and
            cisplatin resistance in oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 6322)
  AUTHORS   Tao,L.J., Pan,X.Y., Wang,J.W., Zhang,L., Tao,L.S. and Liang,C.Z.
  TITLE     Circular RNA circANKS1B acts as a sponge for miR-152-3p and
            promotes prostate cancer progression by upregulating TGF-alpha
            expression
  JOURNAL   Prostate 81 (5), 271-278 (2021)
   PUBMED   33556191
  REMARK    GeneRIF: Circular RNA circANKS1B acts as a sponge for miR-152-3p
            and promotes prostate cancer progression by upregulating TGF-alpha
            expression.
REFERENCE   5  (bases 1 to 6322)
  AUTHORS   Ghersi,E., Noviello,C. and D'Adamio,L.
  TITLE     Amyloid-beta protein precursor (AbetaPP) intracellular
            domain-associated protein-1 proteins bind to AbetaPP and modulate
            its processing in an isoform-specific manner
  JOURNAL   J Biol Chem 279 (47), 49105-49112 (2004)
   PUBMED   15347684
  REMARK    GeneRIF: the interaction between AbetaPP and AIDA-1 is regulated by
            alternative splicing of the AIDA-1 protein
REFERENCE   6  (bases 1 to 6322)
  AUTHORS   Ghersi,E., Vito,P., Lopez,P., Abdallah,M. and D'Adamio,L.
  TITLE     The intracellular localization of amyloid beta protein precursor
            (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is
            regulated by AbetaPP and alternative splicing
  JOURNAL   J Alzheimers Dis 6 (1), 67-78 (2004)
   PUBMED   15004329
  REMARK    GeneRIF: AbetaPP and the AIDA-1 proteins interact in vitro, in
            living cells and, endogenously, in leukemia cell lines;AIDA-1
            proteins are expressed at high levels in the brain
REFERENCE   7  (bases 1 to 6322)
  AUTHORS   LeBrun,D.P.
  TITLE     E2A basic helix-loop-helix transcription factors in human leukemia
  JOURNAL   Front Biosci 8, s206-s222 (2003)
   PUBMED   12700034
  REMARK    GeneRIF: Evidence pertaining to leukemogenesis by the
            well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its
            mechanistic implications are considered.
            Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6322)
  AUTHORS   Petersen,H.H., Hilpert,J., Militz,D., Zandler,V., Jacobsen,C.,
            Roebroek,A.J. and Willnow,T.E.
  TITLE     Functional interaction of megalin with the megalinbinding protein
            (MegBP), a novel tetratrico peptide repeat-containing adaptor
            molecule
  JOURNAL   J Cell Sci 116 (Pt 3), 453-461 (2003)
   PUBMED   12508107
REFERENCE   9  (bases 1 to 6322)
  AUTHORS   Wiemels,J.L., Leonard,B.C., Wang,Y., Segal,M.R., Hunger,S.P.,
            Smith,M.T., Crouse,V., Ma,X., Buffler,P.A. and Pine,S.R.
  TITLE     Site-specific translocation and evidence of postnatal origin of the
            t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 15101-15106 (2002)
   PUBMED   12415113
  REMARK    GeneRIF: site-specific translocation and evidence of postnatal
            origin of the t(1;19) fusion in childhood acute lymphoblastic
            leukemia
REFERENCE   10 (bases 1 to 6322)
  AUTHORS   Fu,X., McGrath,S., Pasillas,M., Nakazawa,S. and Kamps,M.P.
  TITLE     EB-1, a tyrosine kinase signal transduction gene, is
            transcriptionally activated in the t(1;19) subset of pre-B ALL,
            which express oncoprotein E2a-Pbx1
  JOURNAL   Oncogene 18 (35), 4920-4929 (1999)
   PUBMED   10490826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078916.19, AC141556.5,
            AC141554.5, AC048330.20, AC084374.21, AC079954.18, AC117377.9,
            AC008126.9 and AC011248.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 19, 2020 this sequence version replaced NM_001352186.1.
            
            Summary: This gene encodes a multi-domain protein that is
            predominantly expressed in brain and testis. This protein interacts
            with amyloid beta protein precursor (AbetaPP) and may have a role
            in normal brain development, and in the pathogenesis of Alzheimer's
            disease. Expression of this gene has been shown to be elevated in
            patients with pre-B cell acute lymphocytic leukemia associated with
            t(1;19) translocation. Alternatively spliced transcript variants
            encoding different isoforms (some with different subcellular
            localization, PMID:15004329) have been described for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (13) represents the longest
            transcript and encodes the longest isoform (m).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683438.2/ ENSP00000508105.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-833               AC078916.19        6102-6934
            834-914             AC078916.19        165649-165729
            915-1071            AC141556.5         77504-77660         c
            1072-1368           AC141556.5         71753-72049         c
            1369-1444           AC141556.5         47371-47446         c
            1445-1546           AC141556.5         45220-45321         c
            1547-1660           AC141556.5         40897-41010         c
            1661-1827           AC141556.5         38271-38437         c
            1828-1971           AC141554.5         60145-60288         c
            1972-2137           AC048330.20        96269-96434         c
            2138-2274           AC048330.20        35466-35602         c
            2275-2455           AC084374.21        112020-112200       c
            2456-3045           AC079954.18        117445-118034       c
            3046-3118           AC079954.18        115512-115584       c
            3119-3225           AC079954.18        25459-25565         c
            3226-3324           AC117377.9         61218-61316         c
            3325-3477           AC117377.9         29450-29602         c
            3478-3585           AC008126.9         100112-100219
            3586-3765           AC008126.9         102895-103074
            3766-3840           AC008126.9         124330-124404
            3841-3969           AC008126.9         131123-131251
            3970-4041           AC008126.9         133243-133314
            4042-4053           AC008126.9         150111-150122
            4054-4140           AC008126.9         151045-151131
            4141-4278           AC008126.9         159069-159206
            4279-4446           AC011248.8         7382-7549
            4447-6322           AC011248.8         13055-14930
FEATURES             Location/Qualifiers
     source          1..6322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..6322
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 1B"
                     /db_xref="GeneID:56899"
                     /db_xref="HGNC:HGNC:24600"
                     /db_xref="MIM:607815"
     exon            1..833
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             700..4557
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="isoform m is encoded by transcript variant 13;
                     E2a-Pbx1-associated protein; amyloid-beta precursor
                     protein intracellular domain associated protein 1; cajalin
                     2"
                     /codon_start=1
                     /product="ankyrin repeat and sterile alpha motif
                     domain-containing protein 1B isoform m"
                     /protein_id="NP_001339115.1"
                     /db_xref="CCDS:CCDS91740.1"
                     /db_xref="GeneID:56899"
                     /db_xref="HGNC:HGNC:24600"
                     /db_xref="MIM:607815"
                     /translation="MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLL
                     SIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWK
                     GDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSK
                     LETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGM
                     DVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQ
                     IATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDE
                     IKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEE
                     DDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSEN
                     ENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSP
                     PSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPAS
                     PPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFH
                     LYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLE
                     NHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDS
                     DLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNEL
                     KEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIG
                     ILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMD
                     LLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQ
                     LSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQQSSVCEIW
                     TNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYK
                     AFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATN
                     KNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLG
                     QAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANL
                     PWIVEPGQEAKRGINTKYETTIF"
     exon            834..914
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1071
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1368
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1444
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1546
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1660
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1827
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1971
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2137
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2274
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2455
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..3045
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3118
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3225
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3324
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3477
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3585
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3765
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3840
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3969
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4041
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4053
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4140
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4278
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4446
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..6322
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6061..6066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="hexamer: ATTAAA"
     polyA_site      6080
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
     regulatory      6300..6305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="hexamer: AATAAA"
     polyA_site      6322
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="major polyA site"
ORIGIN      
        1 agcccgccac ccaactcggg ccgcaccagg ggccgcacct gcccgcgcgc acacgccccc
       61 cgcgcgccag gcctcgccgc cgccgccgcc ctcggcacgc gcccgctgcg gctgcccccc
      121 accgccctgc ctcggcgcgg gccacagcgc acgagccgcc gccgccgccg ccgcgctcct
      181 ccccgccgcg gacgccgccc ccgcgtaacc gccgaggaag ccgaggcgag cccgggtcgg
      241 gcgcgagggc gcgcgggccg ctgctgccac cgcgggtgtt ccctgcgctc ccgctccagc
      301 taggactctc tctgccgcct cctcctcctc ctccgacctc agtcctcacc accctcctcc
      361 cgctcctcaa aagcaccccc gagtccccac cccctcacgc cgcacccgcg ggaacgaggc
      421 cttgggaatt caggggagtg gctgtggggg cgcgtcgcgg ctcccagctc ggccagcccc
      481 tctttcaaga catggtctga tccccattgt aaaagctgcg ccccgaagag gaggagagag
      541 tcgtgctccc tgcctggggc tgcagggagc tctccgtgct gaagctcttg cattatttta
      601 gggtggggcg aagagggccc tggattttgg ggagtggggg tgggtgggga ggaggacccg
      661 aggggggcaa ggactctgtg ggggagtcgg tgagagacta tggggaagga ccaggagctg
      721 ctggaagctg ctcgcactgg aaatgtggct ctggtggaga aactcctgtc tggcaggaaa
      781 ggagggatcc tgggcggtgg atccggaccc ctgcccctgt ctaatctgct aagcatctgg
      841 cgaggcccca atgtgaactg cacagacagt tcgggttaca ctgctttaca ccacgcagcc
      901 ttaaatggac ataaggacat agttctcaaa ctacttcagt atgaggcatc aacaaatgta
      961 gcagacaaca aagggtattt tcctattcac ctggctgcct ggaaaggaga tgtggaaatt
     1021 gtgaagattc ttattcatca tggaccatca cattccaggg tcaatgaaca gaacaatgaa
     1081 aatgaaactg ccctacactg tgcagctcaa tatggacact cagaagtagt tgctgttctc
     1141 ctagaagagc tcactgaccc gacaattaga aatagcaagc tggaaacacc tttggacttg
     1201 gcggcactct acggacggct tagagtggta aaaatgatca tcagtgcaca tcctaactta
     1261 atgagctgca acactcgcaa gcacacgcca cttcaccttg ctgcgcgcaa tggccacaaa
     1321 gcagtcgtgc aggtgctgct ggaggcagga atggatgtga gctgtcaaac agaaaagggg
     1381 agtgcacttc atgaagcagc tttgtttgga aaggtggatg ttgtacgagt tctgttagaa
     1441 acaggaattg atgccaacat aaaggatagc ttaggtagaa ctgtcttgga cattctgaaa
     1501 gaacatccat ctcagaaatc tctccagatt gcaacactct tacaagagta tttagaaggc
     1561 gtgggaagat ctacagtcct cgaagagcct gtacaggaag atgcaacaca agaaacacac
     1621 atttcatctc ctgttgagtc tccttcccaa aagaccaaaa gtgaaaccgt cactggagaa
     1681 ttatcaaaac tcttggatga aataaaactc tgtcaagaaa aggattattc gtttgaagac
     1741 ttgtgccaca caatatcaga ccactactta gataatttga gcaagatttc agaggaagaa
     1801 cttgggaaaa atggaagcca gagtgtaaga acctcatcta caatcaattt gtcaccagga
     1861 gaagtggaag aagaggatga tgatgaaaat acgtgtgggc catcaggact ttgggaagca
     1921 ttaactccgt gtaatggatg taggaacctt ggcttcccca tgcttgccca ggagtcctat
     1981 ccaaagaaga gaaattacac tatggaaatt gtaccatctg cttctctgga tacatttcct
     2041 tcagaaaatg agaactttct gtgtgatctc atggacacag ctgttacaaa gaaaccttgc
     2101 tccttagaaa ttgcaagggc accttcccca agaactgata atgcctctga ggtagcagtt
     2161 actactccag gaactagtaa ccatagaaac agctcaacag gcccaacacc tgattgttca
     2221 cctccatccc ctgatactgc cctcaaaaat attgtaaaag tcattcgacc ccagcctaaa
     2281 cagcgaacat ccattgtgtc ttctctggat tttcaccgaa tgaatcacaa ccaagaatat
     2341 tttgaaatca acacatctac agggtgcaca agctttactg ccagtcctcc tgctagtcca
     2401 cccacctctt ctgtgggaac cacagaagtc aagaatgagg gaactaacca tacagatgac
     2461 ctctcccgac aggatgacaa tgatccccca aaagaatatg atcctgggca atttgcaggc
     2521 ctgctccatg gatcctctcc agcctgtgag tcccctgaaa atccatttca tctctatggg
     2581 aaaagagaac aatgtgaaaa aggacaagat gaagtcagtt tggcaaacag tcctttgcct
     2641 ttcaagcagt ctccaataga aaataactca gaacctttgg taaagaaaat taaacccaaa
     2701 gtggtcagta gaacaatttt tcacaaaaaa agcaaccaac tcgaaaacca taccattgtt
     2761 ggcacaagat caaccaggag tggatctcgg aatggggacc agtgggttat gaacgcaggg
     2821 ggatttgtgg agagagcctg tactctgggg agaataaggt cattgcctaa agccttgatc
     2881 gacatgcatt tgtcaaaaag tgtctctaaa tctgattctg atctcattgc ctatccttcc
     2941 aatgagaaaa catcaagagt taactggagt gaatcttcca ctgctgaaca cagttctaaa
     3001 gggaattctg aaagaacacc atccttcaca tcggaatggg aagaaattga caaaataatg
     3061 agttccatag atgttggaat caacaacgaa cttaaagaga tgaatggtga gaccacaaga
     3121 cccagatgcc ctgtccaaac agtgggacaa tggttggaaa gcattgggct acctcagtac
     3181 gagaaccacc tgatggctaa tggatttgac aatgtgcagt ttatgggaag caatgttatg
     3241 gaagatcagg atttgttgga aattggaatc cttaattctg ggcacagaca aagaattcta
     3301 caggcaatcc agctccttcc aaagatgaga cccattgggc atgatggcta ccatcccacc
     3361 tctgtagctg agtggctgga ttccattgaa ctgggcgact acaccaaagc ctttctaatt
     3421 aatggctaca cttcgatgga cctgttgaaa aaaatctggg aggttgaact tattaatgtt
     3481 ttaaaaatca atttgattgg ccacaggaaa cgtattttgg catctctggg agacaggctg
     3541 cacgacgatc ccccacagaa gccccctcgg tccatcaccc tcagggaacc cagtggtaat
     3601 cacactcctc ctcagttgtc tccatcactt agccaaagca cttacaccac tggtggctcc
     3661 ctagacgttc ctcacattat catgcagggc gatgcaagga ggagaagaaa tgaaaactac
     3721 tttgatgata ttccccgatc aaaactggag aggcagatgg ctcagcagtc gtctgtctgt
     3781 gaaatatgga cgaatcagaa cgcaggattt cctttctcag cgatccatca ggttcataat
     3841 acaggagact ggggagaacc ttccattacc ttgcgacctc cgaatgaagc cacagcctct
     3901 accccggtac agtactggca gcatcaccca gaaaagctta tcttccagtc gtgtgattac
     3961 aaagcttttt atttaggttc tatgctgata aaagagctta gggggacaga atcaacccaa
     4021 gatgcttgtg caaaaatgcg ggctaactgt cagaagtcta cagagcaaat gaagaaggtc
     4081 cctactatta ttctttctgt ctcatataaa ggagtcaaat ttattgatgc aacaaataag
     4141 aacataattg ctgagcatga aattcgtaat atctcctgtg ctgcccagga cccagaagac
     4201 ctctcaacat ttgcctatat cacaaaagat ttgaagtcta atcaccacta ctgtcatgtg
     4261 tttactgcct ttgatgtgaa tttagcctat gaaatcatcc taaccctggg acaggcattc
     4321 gaagtcgctt accagctagc actacaagca agaaaagggg gacactcctc cacacttcca
     4381 gaaagctttg aaaacaaacc ctccaaaccc atccccaagc cccgcgttag cattcgcaag
     4441 tccgtgcaga tcgacccatc tgagcaaaag actctggcca atctaccgtg gattgtggag
     4501 ccgggccaag aagccaagag gggcattaat accaagtatg aaaccacgat tttctgatac
     4561 tcgccgtcct cctgtcctcg cggtgccttg ctcgccaagc ggtcccggag caggctttcc
     4621 ttcgcgcctc cgcgtccacc cagcccagga ggaagactgc tctgagcgtg cggccttgtt
     4681 acgggcgaaa ggccactggc cattcctggg gaagttcttt ctgcaccagt gatggaaaac
     4741 gcaagacttt ccagtcgcaa cccctgagag gcgtgagttg agatgggttt tccctgatgc
     4801 tcccgactcc cctccccacc acctcccaag gtatttctga tgactccgcc ccagtacttg
     4861 ctttgcttca tttggggaaa ataatacctt ttctttaaaa aaaaaaaaaa aaaaaaaaaa
     4921 gtaaagggga tctctaatac tgcctaaaag tatgctttca ctgtcagcag ttttaaaggt
     4981 gaaatcagag cagcactacc cctcccacct ccaaagcatc tgtaaaatca ttctatcatt
     5041 gagtatcgtt taatgcaaaa ggacaaaaac aactcccgtg atatgattgc caggagattc
     5101 tgtttcccca tttctatatt tgtggatttt atatgtaatc acctatgtca gagaaagaaa
     5161 acctttcaac caaatgattg gttcaaaagg aaagaatgat tcaaagcaga ggaatttatt
     5221 atgcacagca aaatgtgtct tgtattaaat atttttatta aaagaatgtt tcattaatgc
     5281 attgataaga aaactaggtt agttgcgagg gatgtttctg gtttcatttc aaataattaa
     5341 atttctactg ctactaccaa gaggactggc tcagtggtgg caaaatactg gtgatgctcc
     5401 ctagagcagg aggcccggaa gtgctgacgc agccatcagc ctgccaagat tgttttttaa
     5461 tcttcacagt gttttaaaga acatgttaaa aaaaaaaaaa tctagtgctc ctgctgtcaa
     5521 gatttctgtc atggaaacct tgtttgagaa aggtgttaat aaaattctat tgcaaaaatt
     5581 tctttttcta gaaaaaataa atacaaaaaa aaaaaagaag aaattccaaa gtaataaaac
     5641 ttttcttgag acaaacaaaa aaaaagtttg cttactattt gattaaataa aatttactta
     5701 catttcttta aggtatttta attttttaat gtctctgtgg agtatttgta tgataccata
     5761 atgtatattt atgtagaatc aaattatata aacagtacca atatcattat agaaaaaaat
     5821 aacattttaa tgtatattgt tctaacaatc atattgtgaa tcattttgaa gttcattata
     5881 gcgatattga taaattgtgg aattgtctta atgttttttt attaactgac attattttaa
     5941 acctaactga gatgatcagt tacattcatc agttggtgag ttttgaagaa taactacatt
     6001 ttatttcaaa ctaacaaatg tatacggttt tagttcagtg ttgaagaatt ttaatacaat
     6061 attaaattac ttgaactgaa cagttccttg tatatatttt gcctattcac tgttgatatg
     6121 tatgtagcaa aatgagagtt aaataacact aaaatatggt accaggaggc aattgtatag
     6181 gagcaaagtt aataggagct ttgctgaaac agaagcatat gtgtaaataa gcttgggctt
     6241 ccagttataa attttgtaat ttttgtcatt atttatatcc tataaaaaaa gcacacaaaa
     6301 ataaaacaga agttgtacag ca
//
