LOCUS       NM_001352185            5962 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens ankyrin repeat and sterile alpha motif domain
            containing 1B (ANKS1B), transcript variant 16, mRNA.
ACCESSION   NM_001352185 XM_006719509
VERSION     NM_001352185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5962)
  AUTHORS   Wang,X., Wang,Y., Cai,Q. and Zhang,M.
  TITLE     AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity
            and Specificity
  JOURNAL   J Mol Biol 436 (12), 168608 (2024)
   PUBMED   38759928
  REMARK    GeneRIF: AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High
            Affinity and Specificity.
REFERENCE   2  (bases 1 to 5962)
  AUTHORS   Kislova,A.V., Zheglo,D., Pozhitnova,V.O., Sviridov,P.S.,
            Gadzhieva,E.P. and Voronina,E.S.
  TITLE     Replication stress causes delayed mitotic entry and chromosome 12
            fragility at the ANKS1B large neuronal gene in human induced
            pluripotent stem cells
  JOURNAL   Chromosome Res 31 (3), 23 (2023)
   PUBMED   37597021
  REMARK    GeneRIF: Replication stress causes delayed mitotic entry and
            chromosome 12 fragility at the ANKS1B large neuronal gene in human
            induced pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5962)
  AUTHORS   Yan,J. and Xu,H.
  TITLE     Regulation of transforming growth factor-beta1 by
            circANKS1B/miR-515-5p affects the metastatic potential and
            cisplatin resistance in oral squamous cell carcinoma
  JOURNAL   Bioengineered 12 (2), 12420-12430 (2021)
   PUBMED   34781814
  REMARK    GeneRIF: Regulation of transforming growth factor-beta1 by
            circANKS1B/miR-515-5p affects the metastatic potential and
            cisplatin resistance in oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 5962)
  AUTHORS   Tao,L.J., Pan,X.Y., Wang,J.W., Zhang,L., Tao,L.S. and Liang,C.Z.
  TITLE     Circular RNA circANKS1B acts as a sponge for miR-152-3p and
            promotes prostate cancer progression by upregulating TGF-alpha
            expression
  JOURNAL   Prostate 81 (5), 271-278 (2021)
   PUBMED   33556191
  REMARK    GeneRIF: Circular RNA circANKS1B acts as a sponge for miR-152-3p
            and promotes prostate cancer progression by upregulating TGF-alpha
            expression.
REFERENCE   5  (bases 1 to 5962)
  AUTHORS   Ghersi,E., Noviello,C. and D'Adamio,L.
  TITLE     Amyloid-beta protein precursor (AbetaPP) intracellular
            domain-associated protein-1 proteins bind to AbetaPP and modulate
            its processing in an isoform-specific manner
  JOURNAL   J Biol Chem 279 (47), 49105-49112 (2004)
   PUBMED   15347684
  REMARK    GeneRIF: the interaction between AbetaPP and AIDA-1 is regulated by
            alternative splicing of the AIDA-1 protein
REFERENCE   6  (bases 1 to 5962)
  AUTHORS   Ghersi,E., Vito,P., Lopez,P., Abdallah,M. and D'Adamio,L.
  TITLE     The intracellular localization of amyloid beta protein precursor
            (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is
            regulated by AbetaPP and alternative splicing
  JOURNAL   J Alzheimers Dis 6 (1), 67-78 (2004)
   PUBMED   15004329
  REMARK    GeneRIF: AbetaPP and the AIDA-1 proteins interact in vitro, in
            living cells and, endogenously, in leukemia cell lines;AIDA-1
            proteins are expressed at high levels in the brain
REFERENCE   7  (bases 1 to 5962)
  AUTHORS   LeBrun,D.P.
  TITLE     E2A basic helix-loop-helix transcription factors in human leukemia
  JOURNAL   Front Biosci 8, s206-s222 (2003)
   PUBMED   12700034
  REMARK    GeneRIF: Evidence pertaining to leukemogenesis by the
            well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its
            mechanistic implications are considered.
            Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5962)
  AUTHORS   Petersen,H.H., Hilpert,J., Militz,D., Zandler,V., Jacobsen,C.,
            Roebroek,A.J. and Willnow,T.E.
  TITLE     Functional interaction of megalin with the megalinbinding protein
            (MegBP), a novel tetratrico peptide repeat-containing adaptor
            molecule
  JOURNAL   J Cell Sci 116 (Pt 3), 453-461 (2003)
   PUBMED   12508107
REFERENCE   9  (bases 1 to 5962)
  AUTHORS   Wiemels,J.L., Leonard,B.C., Wang,Y., Segal,M.R., Hunger,S.P.,
            Smith,M.T., Crouse,V., Ma,X., Buffler,P.A. and Pine,S.R.
  TITLE     Site-specific translocation and evidence of postnatal origin of the
            t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 15101-15106 (2002)
   PUBMED   12415113
  REMARK    GeneRIF: site-specific translocation and evidence of postnatal
            origin of the t(1;19) fusion in childhood acute lymphoblastic
            leukemia
REFERENCE   10 (bases 1 to 5962)
  AUTHORS   Fu,X., McGrath,S., Pasillas,M., Nakazawa,S. and Kamps,M.P.
  TITLE     EB-1, a tyrosine kinase signal transduction gene, is
            transcriptionally activated in the t(1;19) subset of pre-B ALL,
            which express oncoprotein E2a-Pbx1
  JOURNAL   Oncogene 18 (35), 4920-4929 (1999)
   PUBMED   10490826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078916.19, AC141556.5,
            AC141554.5, AC048330.20, AC084374.21, AC079954.18, AC117377.9,
            AC008126.9 and AC011248.8.
            
            On Jun 8, 2017 this sequence version replaced XM_006719509.3.
            
            Summary: This gene encodes a multi-domain protein that is
            predominantly expressed in brain and testis. This protein interacts
            with amyloid beta protein precursor (AbetaPP) and may have a role
            in normal brain development, and in the pathogenesis of Alzheimer's
            disease. Expression of this gene has been shown to be elevated in
            patients with pre-B cell acute lymphocytic leukemia associated with
            t(1;19) translocation. Alternatively spliced transcript variants
            encoding different isoforms (some with different subcellular
            localization, PMID:15004329) have been described for this gene.
            [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               AC078916.19        6384-6934
            552-632             AC078916.19        165649-165729
            633-789             AC141556.5         77504-77660         c
            790-1086            AC141556.5         71753-72049         c
            1087-1162           AC141556.5         47371-47446         c
            1163-1264           AC141556.5         45220-45321         c
            1265-1378           AC141556.5         40897-41010         c
            1379-1545           AC141556.5         38271-38437         c
            1546-1689           AC141554.5         60145-60288         c
            1690-1855           AC048330.20        96269-96434         c
            1856-1992           AC048330.20        35466-35602         c
            1993-2173           AC084374.21        112020-112200       c
            2174-2763           AC079954.18        117445-118034       c
            2764-2836           AC079954.18        115512-115584       c
            2837-2943           AC079954.18        25459-25565         c
            2944-3042           AC117377.9         61218-61316         c
            3043-3195           AC117377.9         29450-29602         c
            3196-3303           AC008126.9         100112-100219
            3304-3483           AC008126.9         102895-103074
            3484-3612           AC008126.9         131123-131251
            3613-3684           AC008126.9         133243-133314
            3685-3696           AC008126.9         150111-150122
            3697-3783           AC008126.9         151045-151131
            3784-3921           AC008126.9         159069-159206
            3922-4089           AC011248.8         7382-7549
            4090-5962           AC011248.8         13058-14930
FEATURES             Location/Qualifiers
     source          1..5962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..5962
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 1B"
                     /db_xref="GeneID:56899"
                     /db_xref="HGNC:HGNC:24600"
                     /db_xref="MIM:607815"
     exon            1..551
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..4197
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="isoform p is encoded by transcript variant 16;
                     E2a-Pbx1-associated protein; amyloid-beta precursor
                     protein intracellular domain associated protein 1; cajalin
                     2"
                     /codon_start=1
                     /product="ankyrin repeat and sterile alpha motif
                     domain-containing protein 1B isoform p"
                     /protein_id="NP_001339114.1"
                     /db_xref="GeneID:56899"
                     /db_xref="HGNC:HGNC:24600"
                     /db_xref="MIM:607815"
                     /translation="MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLL
                     SIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWK
                     GDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSK
                     LETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGM
                     DVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQ
                     IATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDE
                     IKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEE
                     DDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSEN
                     ENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSP
                     PSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPAS
                     PPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFH
                     LYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLE
                     NHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDS
                     DLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNEL
                     KEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIG
                     ILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMD
                     LLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQ
                     LSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPS
                     ITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKM
                     RANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTF
                     AYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPES
                     FENKPSKPIPKPRVSIRKSVIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF"
     exon            552..632
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..789
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1086
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1162
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1264
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1378
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1545
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1689
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1855
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1992
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2173
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2763
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2836
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2943
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3042
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3195
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3303
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3483
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3612
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3684
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3696
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3783
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3921
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4089
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..5962
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5701..5706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="hexamer: ATTAAA"
     polyA_site      5720
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
     regulatory      5940..5945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="hexamer: AATAAA"
     polyA_site      5962
                     /gene="ANKS1B"
                     /gene_synonym="AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgctccc gctccagcta ggactctctc tgccgcctcc tcctcctcct ccgacctcag
       61 tcctcaccac cctcctcccg ctcctcaaaa gcacccccga gtccccaccc cctcacgccg
      121 cacccgcggg aacgaggcct tgggaattca ggggagtggc tgtgggggcg cgtcgcggct
      181 cccagctcgg ccagcccctc tttcaagaca tggtctgatc cccattgtaa aagctgcgcc
      241 ccgaagagga ggagagagtc gtgctccctg cctggggctg cagggagctc tccgtgctga
      301 agctcttgca ttattttagg gtggggcgaa gagggccctg gattttgggg agtgggggtg
      361 ggtggggagg aggacccgag gggggcaagg actctgtggg ggagtcggtg agagactatg
      421 gggaaggacc aggagctgct ggaagctgct cgcactggaa atgtggctct ggtggagaaa
      481 ctcctgtctg gcaggaaagg agggatcctg ggcggtggat ccggacccct gcccctgtct
      541 aatctgctaa gcatctggcg aggccccaat gtgaactgca cagacagttc gggttacact
      601 gctttacacc acgcagcctt aaatggacat aaggacatag ttctcaaact acttcagtat
      661 gaggcatcaa caaatgtagc agacaacaaa gggtattttc ctattcacct ggctgcctgg
      721 aaaggagatg tggaaattgt gaagattctt attcatcatg gaccatcaca ttccagggtc
      781 aatgaacaga acaatgaaaa tgaaactgcc ctacactgtg cagctcaata tggacactca
      841 gaagtagttg ctgttctcct agaagagctc actgacccga caattagaaa tagcaagctg
      901 gaaacacctt tggacttggc ggcactctac ggacggctta gagtggtaaa aatgatcatc
      961 agtgcacatc ctaacttaat gagctgcaac actcgcaagc acacgccact tcaccttgct
     1021 gcgcgcaatg gccacaaagc agtcgtgcag gtgctgctgg aggcaggaat ggatgtgagc
     1081 tgtcaaacag aaaaggggag tgcacttcat gaagcagctt tgtttggaaa ggtggatgtt
     1141 gtacgagttc tgttagaaac aggaattgat gccaacataa aggatagctt aggtagaact
     1201 gtcttggaca ttctgaaaga acatccatct cagaaatctc tccagattgc aacactctta
     1261 caagagtatt tagaaggcgt gggaagatct acagtcctcg aagagcctgt acaggaagat
     1321 gcaacacaag aaacacacat ttcatctcct gttgagtctc cttcccaaaa gaccaaaagt
     1381 gaaaccgtca ctggagaatt atcaaaactc ttggatgaaa taaaactctg tcaagaaaag
     1441 gattattcgt ttgaagactt gtgccacaca atatcagacc actacttaga taatttgagc
     1501 aagatttcag aggaagaact tgggaaaaat ggaagccaga gtgtaagaac ctcatctaca
     1561 atcaatttgt caccaggaga agtggaagaa gaggatgatg atgaaaatac gtgtgggcca
     1621 tcaggacttt gggaagcatt aactccgtgt aatggatgta ggaaccttgg cttccccatg
     1681 cttgcccagg agtcctatcc aaagaagaga aattacacta tggaaattgt accatctgct
     1741 tctctggata catttccttc agaaaatgag aactttctgt gtgatctcat ggacacagct
     1801 gttacaaaga aaccttgctc cttagaaatt gcaagggcac cttccccaag aactgataat
     1861 gcctctgagg tagcagttac tactccagga actagtaacc atagaaacag ctcaacaggc
     1921 ccaacacctg attgttcacc tccatcccct gatactgccc tcaaaaatat tgtaaaagtc
     1981 attcgacccc agcctaaaca gcgaacatcc attgtgtctt ctctggattt tcaccgaatg
     2041 aatcacaacc aagaatattt tgaaatcaac acatctacag ggtgcacaag ctttactgcc
     2101 agtcctcctg ctagtccacc cacctcttct gtgggaacca cagaagtcaa gaatgaggga
     2161 actaaccata cagatgacct ctcccgacag gatgacaatg atcccccaaa agaatatgat
     2221 cctgggcaat ttgcaggcct gctccatgga tcctctccag cctgtgagtc ccctgaaaat
     2281 ccatttcatc tctatgggaa aagagaacaa tgtgaaaaag gacaagatga agtcagtttg
     2341 gcaaacagtc ctttgccttt caagcagtct ccaatagaaa ataactcaga acctttggta
     2401 aagaaaatta aacccaaagt ggtcagtaga acaatttttc acaaaaaaag caaccaactc
     2461 gaaaaccata ccattgttgg cacaagatca accaggagtg gatctcggaa tggggaccag
     2521 tgggttatga acgcaggggg atttgtggag agagcctgta ctctggggag aataaggtca
     2581 ttgcctaaag ccttgatcga catgcatttg tcaaaaagtg tctctaaatc tgattctgat
     2641 ctcattgcct atccttccaa tgagaaaaca tcaagagtta actggagtga atcttccact
     2701 gctgaacaca gttctaaagg gaattctgaa agaacaccat ccttcacatc ggaatgggaa
     2761 gaaattgaca aaataatgag ttccatagat gttggaatca acaacgaact taaagagatg
     2821 aatggtgaga ccacaagacc cagatgccct gtccaaacag tgggacaatg gttggaaagc
     2881 attgggctac ctcagtacga gaaccacctg atggctaatg gatttgacaa tgtgcagttt
     2941 atgggaagca atgttatgga agatcaggat ttgttggaaa ttggaatcct taattctggg
     3001 cacagacaaa gaattctaca ggcaatccag ctccttccaa agatgagacc cattgggcat
     3061 gatggctacc atcccacctc tgtagctgag tggctggatt ccattgaact gggcgactac
     3121 accaaagcct ttctaattaa tggctacact tcgatggacc tgttgaaaaa aatctgggag
     3181 gttgaactta ttaatgtttt aaaaatcaat ttgattggcc acaggaaacg tattttggca
     3241 tctctgggag acaggctgca cgacgatccc ccacagaagc cccctcggtc catcaccctc
     3301 agggaaccca gtggtaatca cactcctcct cagttgtctc catcacttag ccaaagcact
     3361 tacaccactg gtggctccct agacgttcct cacattatca tgcagggcga tgcaaggagg
     3421 agaagaaatg aaaactactt tgatgatatt ccccgatcaa aactggagag gcagatggct
     3481 cagacaggag actggggaga accttccatt accttgcgac ctccgaatga agccacagcc
     3541 tctaccccgg tacagtactg gcagcatcac ccagaaaagc ttatcttcca gtcgtgtgat
     3601 tacaaagctt tttatttagg ttctatgctg ataaaagagc ttagggggac agaatcaacc
     3661 caagatgctt gtgcaaaaat gcgggctaac tgtcagaagt ctacagagca aatgaagaag
     3721 gtccctacta ttattctttc tgtctcatat aaaggagtca aatttattga tgcaacaaat
     3781 aagaacataa ttgctgagca tgaaattcgt aatatctcct gtgctgccca ggacccagaa
     3841 gacctctcaa catttgccta tatcacaaaa gatttgaagt ctaatcacca ctactgtcat
     3901 gtgtttactg cctttgatgt gaatttagcc tatgaaatca tcctaaccct gggacaggca
     3961 ttcgaagtcg cttaccagct agcactacaa gcaagaaaag ggggacactc ctccacactt
     4021 ccagaaagct ttgaaaacaa accctccaaa cccatcccca agccccgcgt tagcattcgc
     4081 aagtccgtga tcgacccatc tgagcaaaag actctggcca atctaccgtg gattgtggag
     4141 ccgggccaag aagccaagag gggcattaat accaagtatg aaaccacgat tttctgatac
     4201 tcgccgtcct cctgtcctcg cggtgccttg ctcgccaagc ggtcccggag caggctttcc
     4261 ttcgcgcctc cgcgtccacc cagcccagga ggaagactgc tctgagcgtg cggccttgtt
     4321 acgggcgaaa ggccactggc cattcctggg gaagttcttt ctgcaccagt gatggaaaac
     4381 gcaagacttt ccagtcgcaa cccctgagag gcgtgagttg agatgggttt tccctgatgc
     4441 tcccgactcc cctccccacc acctcccaag gtatttctga tgactccgcc ccagtacttg
     4501 ctttgcttca tttggggaaa ataatacctt ttctttaaaa aaaaaaaaaa aaaaaaaaaa
     4561 gtaaagggga tctctaatac tgcctaaaag tatgctttca ctgtcagcag ttttaaaggt
     4621 gaaatcagag cagcactacc cctcccacct ccaaagcatc tgtaaaatca ttctatcatt
     4681 gagtatcgtt taatgcaaaa ggacaaaaac aactcccgtg atatgattgc caggagattc
     4741 tgtttcccca tttctatatt tgtggatttt atatgtaatc acctatgtca gagaaagaaa
     4801 acctttcaac caaatgattg gttcaaaagg aaagaatgat tcaaagcaga ggaatttatt
     4861 atgcacagca aaatgtgtct tgtattaaat atttttatta aaagaatgtt tcattaatgc
     4921 attgataaga aaactaggtt agttgcgagg gatgtttctg gtttcatttc aaataattaa
     4981 atttctactg ctactaccaa gaggactggc tcagtggtgg caaaatactg gtgatgctcc
     5041 ctagagcagg aggcccggaa gtgctgacgc agccatcagc ctgccaagat tgttttttaa
     5101 tcttcacagt gttttaaaga acatgttaaa aaaaaaaaaa tctagtgctc ctgctgtcaa
     5161 gatttctgtc atggaaacct tgtttgagaa aggtgttaat aaaattctat tgcaaaaatt
     5221 tctttttcta gaaaaaataa atacaaaaaa aaaaaagaag aaattccaaa gtaataaaac
     5281 ttttcttgag acaaacaaaa aaaaagtttg cttactattt gattaaataa aatttactta
     5341 catttcttta aggtatttta attttttaat gtctctgtgg agtatttgta tgataccata
     5401 atgtatattt atgtagaatc aaattatata aacagtacca atatcattat agaaaaaaat
     5461 aacattttaa tgtatattgt tctaacaatc atattgtgaa tcattttgaa gttcattata
     5521 gcgatattga taaattgtgg aattgtctta atgttttttt attaactgac attattttaa
     5581 acctaactga gatgatcagt tacattcatc agttggtgag ttttgaagaa taactacatt
     5641 ttatttcaaa ctaacaaatg tatacggttt tagttcagtg ttgaagaatt ttaatacaat
     5701 attaaattac ttgaactgaa cagttccttg tatatatttt gcctattcac tgttgatatg
     5761 tatgtagcaa aatgagagtt aaataacact aaaatatggt accaggaggc aattgtatag
     5821 gagcaaagtt aataggagct ttgctgaaac agaagcatat gtgtaaataa gcttgggctt
     5881 ccagttataa attttgtaat ttttgtcatt atttatatcc tataaaaaaa gcacacaaaa
     5941 ataaaacaga agttgtacag ca
//
