LOCUS       NM_015245               6350 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ankyrin repeat and sterile alpha motif domain
            containing 1A (ANKS1A), mRNA.
ACCESSION   NM_015245 XM_166478
VERSION     NM_015245.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6350)
  AUTHORS   Lee,J., Lee,H., Lee,H., Shin,M., Shin,M.G., Seo,J., Lee,E.J.,
            Park,S.A. and Park,S.
  TITLE     ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated
            cerebrovascular clearance in brain endothelial cells
  JOURNAL   Nat Commun 14 (1), 8463 (2023)
   PUBMED   38123547
  REMARK    GeneRIF: ANKS1A regulates LDL receptor-related protein 1
            (LRP1)-mediated cerebrovascular clearance in brain endothelial
            cells.
            Erratum:[Nat Commun. 2024 Apr 9;15(1):3062. doi:
            10.1038/s41467-024-47249-w.. PMID: 38594263]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6350)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 6350)
  AUTHORS   Zholudeva,A.O., Lomakina,M.E., Orlova,E.A., Wang,Y., Fokin,A.I.,
            Polesskaya,A., Gautreau,A.M. and Alexandrova,A.Y.
  TITLE     The Role of the Adapter Protein Anks1a in the Regulation of Breast
            Cancer Cell Motility
  JOURNAL   Biochemistry (Mosc) 87 (12), 1651-1661 (2022)
   PUBMED   36717454
  REMARK    GeneRIF: The Role of the Adapter Protein Anks1a in the Regulation
            of Breast Cancer Cell Motility.
REFERENCE   4  (bases 1 to 6350)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   5  (bases 1 to 6350)
  AUTHORS   Fantino,M., Paquette,M., Bernard,S. and Baass,A.
  TITLE     ANKS1A genotype predicts cardiovascular events in patients with
            familial hypercholesterolemia
  JOURNAL   J Clin Lipidol 15 (4), 602-607 (2021)
   PUBMED   34130940
  REMARK    GeneRIF: ANKS1A genotype predicts cardiovascular events in patients
            with familial hypercholesterolemia.
REFERENCE   6  (bases 1 to 6350)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 6350)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 6350)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 6350)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 6350)
  AUTHORS   Pandey,A., Blagoev,B., Kratchmarova,I., Fernandez,M., Nielsen,M.,
            Kristiansen,T.Z., Ohara,O., Podtelejnikov,A.V., Roche,S.,
            Lodish,H.F. and Mann,M.
  TITLE     Cloning of a novel phosphotyrosine binding domain containing
            molecule, Odin, involved in signaling by receptor tyrosine kinases
  JOURNAL   Oncogene 21 (52), 8029-8036 (2002)
   PUBMED   12439753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL033520.16, BC022396.1, D86982.1, AL138721.16 and BF592042.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015245.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86982.1, BC132832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360359.5/ ENSP00000353518.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL033520.16        46484-46489
            7-1539              BC022396.1         1-1533
            1540-2228           D86982.1           1531-2219
            2229-2229           AL138721.16        10923-10923
            2230-2895           D86982.1           2221-2886
            2896-2896           AL138721.16        33502-33502
            2897-3609           D86982.1           2888-3600
            3610-3610           AL138721.16        39439-39439
            3611-6344           D86982.1           3602-6335
            6345-6350           BF592042.1         12-17               c
FEATURES             Location/Qualifiers
     source          1..6350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..6350
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 1A"
                     /db_xref="GeneID:23294"
                     /db_xref="HGNC:HGNC:20961"
                     /db_xref="MIM:608994"
     exon            1..345
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..3553
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /note="ankyrin repeat and SAM domain containing 1; Odin"
                     /codon_start=1
                     /product="ankyrin repeat and SAM domain-containing protein
                     1A"
                     /protein_id="NP_056060.2"
                     /db_xref="CCDS:CCDS4798.1"
                     /db_xref="GeneID:23294"
                     /db_xref="HGNC:HGNC:20961"
                     /db_xref="MIM:608994"
                     /translation="MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGG
                     GGSGGGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRN
                     DALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYG
                     HTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTP
                     LHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIK
                     DNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQ
                     KSQGDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKEAE
                     AAGVKPAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREE
                     DEHPYELLLTAETKKVVLVDGKTKDHRRSSSSRSQDSAEGQDGQVPEQFSGLLHGSSP
                     VCEVGQDPFQLLCTAGQSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRV
                     GYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDRSGARSRAPPTSKPKAELKLSRSLS
                     KSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGI
                     DFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRD
                     IGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSS
                     IDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLLSQT
                     SSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERFRIQEEHREAKLTLR
                     PPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKST
                     EHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQ
                     TSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAEMIETKSSK
                     PVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTN"
     exon            346..426
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..583
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..880
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..956
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1058
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1160
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1357
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1450
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1571
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2158
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2225
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2332
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2431
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2584
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2692
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2857
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2983
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3055
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3142
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3280
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3451
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3549
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..6350
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6325..6330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /note="hexamer: AATAAA"
     polyA_site      6350
                     /gene="ANKS1A"
                     /gene_synonym="ANKS1"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgcgc tcgtggggaa aaggcaggga gggggtggtg tccccagccg gtttgggggg
       61 tgcgttgccc ggagacggaa agtttgggag cccgagcagg ctcggctgca gcctcgggga
      121 gggggtccag cgggtggcgg ccctggggat ggggaaggag caggagctgc tggaggcggc
      181 ccgcaccggg cacctcccgg cggtggagaa gctgctgtcc gggaagcggc tctcctcagg
      241 ctttgggggc ggcggcggcg gtggctctgg gggcggcggc ggcggcagcg gcggcggcgg
      301 cggcggcctc ggctcttcca gccaccccct ctccagtctg ctcagcatgt ggagagggcc
      361 aaatgtgaac tgtgttgaca gcactggcta cacacccctg caccatgctg ctttgaatgg
      421 ccataaggat gtggtcgagg ttcttctgag gaacgatgcg ctgaccaacg tggctgactc
      481 aaaaggctgc taccctctgc atttggcagc ctggaaagga gatgcccaga tagtgcggtt
      541 gctcatccat caagggcctt cacacaccag agtcaatgaa cagaacaatg acaacgagac
      601 agccctgcat tgtgcagcgc agtatggcca cacagaggtg gtgaaggtgc tcttagagga
      661 gctgacggac cccaccatgc gcaacaacaa attcgagacc cctttggacc tggcagcact
      721 gtacgggcga ctggaggtgg tgaaaatgct ccttaatgca caccccaacc tcctgagctg
      781 caacactaag aagcacaccc ctctgcactt ggcagcaagg aatggccaca aagccgtggt
      841 ccaggtcctc ctcgatgctg gcatggacag caactaccag acggagatgg gcagtgcttt
      901 gcatgaggct gctttgtttg gcaagaccga tgtggtgcaa atcctgctgg ctgcaggaac
      961 tgacgtcaac ataaaagata accatggact gactgcccta gacactgttc gggaactgcc
     1021 ttctcaaaag agccagcaaa tagcagcatt aattgaagat cacatgactg gaaaaagaag
     1081 tacaaaagaa gtagataaaa cccccccacc ccagccacct ctcatctcca gtatggactc
     1141 catatcacag aagtctcagg gtgacgtgga gaaagcagtg actgaactga ttatagattt
     1201 tgatgcaaat gctgaagaag agggtcccta cgaagctctg tataatgcca tctcctgcca
     1261 ttcgttggac agcatggcca gcgggcgatc atctgaccaa gactccacga acaaggaggc
     1321 tgaggcagca ggagtgaaac ctgctggagt gaggcctagg gaacgtccac cacctccagc
     1381 aaagccaccg cccgatgaag aggaagaaga ccacatagat aagaagtatt ttcccttgac
     1441 agcttctgag gttctgtcca tgagacctag gattcatggg agtgcagccc gggaagaaga
     1501 cgaacaccct tatgaactgt tgttaacagc agagacaaag aaagtggtgt tggtggatgg
     1561 aaaaacaaaa gaccacaggc ggagcagcag cagccggagc caggactctg cggaggggca
     1621 ggacgggcag gtcccagagc agttctcagg cctcctccac ggctcctccc cggtgtgcga
     1681 ggtggggcag gaccctttcc agctgctctg taccgctggc cagagccatc cagacgggtc
     1741 cccccagcag ggcgcctgcc acaaggccag catgcagctg gaggagacgg gtgtgcatgc
     1801 tcctggagcc tcccagccca gtgccctgga ccagagcaag agagtgggct acctcacagg
     1861 cctgcccacc accaacagcc gctcgcaccc tgaaactttg actcacacag catctccgca
     1921 ccctggtggt gctgaggaag gagaccggag tggggccagg agccgagcgc ctcccactag
     1981 caaacccaaa gctgaactca aactcagccg cagcttgtcc aagtctgact ctgatctcct
     2041 gacctgctca cccacagagg acgctaccat ggggagtcgg agtgagtcct tatccaactg
     2101 cagcattggg aagaaaaggc tagagaagtc accctccttc gcctcggagt gggatgagat
     2161 tgagaaaatc atgagttcta ttggagaagg gattgacttt tctcaggaac ggcagaagat
     2221 ctcaggttta cggacgctgg agcagagtgt cggggagtgg ctggagtcga ttgggctgca
     2281 gcagtatgag agcaagttgc ttctgaatgg ctttgacgat gtccacttcc tggggtctaa
     2341 tgtgatggaa gagcaggacc tgcgggacat cggcatcagc gacccacagc accggcggaa
     2401 gctgctccag gcggcacgct ccctacccaa ggtgaaggct ctgggttatg acgggaacag
     2461 cccccctagc gtgccctcct ggctggactc cctggggctg caggactacg tccattcctt
     2521 cttgtcaagt ggttacagct ccattgacac cgtgaagaac ctctgggagc tagagctcgt
     2581 caatgtcctg aaggtccagc tgctcggcca tcgcaagcgc atcatcgcct ccctcgcaga
     2641 cagaccgtac gaggagccgc cccagaagcc ccccagattc tcccagctga ggtgccaaga
     2701 tttgctctcc cagacgtcat ccccactgag tcagaatgat tcctgcactg ggcggtcggc
     2761 agatctgctg ctgcctccag gggacacagg caggaggcgc catgacagtc tccatgaccc
     2821 tgcggcaccc tcccgagcgg agcgcttcag gatccaggag gagcaccgtg aggccaagct
     2881 gaccctgcgg cccccgagcc tggcagcccc ctacgcccca gtgcagagtt ggcaacacca
     2941 gccagagaaa ctcatcttcg agtcctgtgg ttatgaagcc aattatctgg gctccatgct
     3001 gatcaaagat ctgcgaggga cagaatccac gcaagacgcc tgtgccaaga tgcggaaatc
     3061 tacggagcac atgaagaaga tccccaccat catcctgtcc atcacataca aaggtgtcaa
     3121 gttcatcgat gcctccaaca agaacgtcat tgcagagcac gagatccgga acatttcctg
     3181 tgcggcccag gacccggagg acctctgtac ctttgcctac atcaccaagg acctgcagac
     3241 cagccaccac tattgccatg tgttcagcac cgtggatgtg aacctgacct acgagatcat
     3301 cctgacgctg gggcaggcct tcgaagtggc ctatcagttg gccctgcagg cccagaagtc
     3361 cagggcgacg ggcgcctctg cagctgagat gattgaaaca aaatcttcca aaccggtgcc
     3421 taagcctcgg gtcggcgtga ggaaatccgc actggaacca cctgatatgg accaagatgc
     3481 ccaatcccat gccagtgtct cctgggttgt ggaccccaaa ccagactcta agcggagcct
     3541 cagcaccaac tgagccactg aggaaccaca ctgtgctgcg gaaacataga cgtgggggca
     3601 taggctccca ctgccaccac cgccatcgcc tcacctgcag ctctgaagac ccaggcctca
     3661 cctccgcctg caggacctcc tcttggccac ttggcctggg cctgccacca ccacgtcctg
     3721 cagaacgagc cctgccttgg ctgtggagaa gcactccagg ccgctagcag atgggactgg
     3781 cattccagag ggtcaagaag tgacttgttc agaacacatt gtttttaaca gaaaaaaaat
     3841 ctttttataa aatgaacttt taacacttgg ctcaaacctc taggtcatac tgccaatctt
     3901 tagacaaatg gccatggggc agaggacagg ggagctgagg ttggttcaga ggccagcctg
     3961 catagcctct gtcctcagga cggaacttgg gtgcagctca gtgggtcgga agagaaggcg
     4021 gtggcctgtg ggtgagggga acggagcagg ctcaggcaga attgagtacg gtgcgtctgc
     4081 ttttcaaacc caaccatatc agctgctgct ctttatgaac tgcccaactt cctgtccctt
     4141 tcaggggcta gacacaggct tctcgtaaga acacagcctt agaggcacct gagcaactca
     4201 aaggtttccg gtccatttct ggggttcccg atgggaaggt tcagtggcca aatgaagata
     4261 agtgtgcagt ttctagtgct gggaagtctt agccagcacc agagcgccag gcctctccct
     4321 ggcctcttac ctgtcagtga tcggagcact gccctgggct ggccggcgcc gtactgcctg
     4381 cgttgtgtca gagaatagga aaagcagctt tgtttggggc attaatgctt ggagtggggt
     4441 cagctaaggt tgctacttgc caatttgtga tttgtctaat cagcctgtgt gattggggct
     4501 cattttgatt ctctgaatta tcggtttgac ggttacactt ggctgctggg cccatccctg
     4561 gcccccggtg tggaaaaggc taaataaggt gacagtgcat cgatgctccc ccgcgtggcc
     4621 tttggggcag gctggcatcc cggtgcgcct ctgcttctta agctttcctg ctgctcgctt
     4681 tgtttttaaa agtaacttgg gttgcattct tccctctgga ctagagtaga aatgcagggg
     4741 aaactgctgt ggatttgaga ggcaaagttg gctcagctgt gtgcccagtt cctcctgtgg
     4801 gcactttagc aggctccgag ctttcctggc ataggtcaat caggtcccag gatgaataat
     4861 ccaggcttca gcaacactcc tctttcccag ccagcaaagg ctgtgaattt gaattctttg
     4921 ttggtatgta tgtgcaggga gtactgttag gcacattctt aacccatgtg gttggccaga
     4981 aatcagaagt ggggctgtgt ctctgactgg ctagaggcca ggccttgtgg gtttctatct
     5041 gctaagcacc cagcaggttg gggcctggga ctcagctctc tctgcggtag aggcaggccc
     5101 tcctccactt cttggtacta aacgaagatc tcgacacctt gcagttttac ttcatttcct
     5161 gcccctttca gggcctgtga ggatgcccat gagctaccgc tgtacagttc tcggccccgg
     5221 ctttcttcca agagttgacc aggaacccta aagcatccag agtagactgc gctgccactg
     5281 cgcacatgct ggtgcccgtc ttcctcctaa ggggccaggc cacatccaag tgggcctctg
     5341 tcgggggcgg ggcggtaggt ccgaaagaaa ccgcagacac tacgatgcac tcctcaagct
     5401 gtcttttgtg cttagatcat ccataggtgt ttcttctgct tgaagctgct atatcatctt
     5461 tatttattca gggtattttc atattggaag ccttggctag tctgctctag ctctgggttc
     5521 tgtttagaga ttggtttatt tctgaatatt caagaaagga aaatgactgg gcctttcttt
     5581 cttttcttct cctctgggat gggtagtctc cctttcctag aaaggttatt ataactttaa
     5641 ggacaggctt caagtgggaa ggcccctact tttgcacttc tccaagtgca ggtcacacca
     5701 ggggcagacc ctgtcgctgc gtttctgaac tgtgaaggag cccattcggg tgggagactt
     5761 cagatgggct cagtacctgt cccagccaca ggcttcttgt ccacctcttc tcccctgccc
     5821 accagctgct cagcgcataa gaccttcccg acaggctctg cgtgtgcagc tctctgcgtc
     5881 cctcctgggc cctccagcgt cagacactaa tgggagttcc cgagatgctc gggtttgagc
     5941 agggagcagg cagagctgca gtcagagaca ttagaaaacc agtctgaatt gggtctgtct
     6001 ttgagatgcc caggccagca gaaagcagct cagaagtatt gttgctcatg gtgtggcaat
     6061 ggactgaact gtaatgaaaa tgttatttaa tctttgtctc tgtattttga tacttgaatg
     6121 actttccctt ttgttttact gtatataaaa ttgttaatct gtctgatttt gtctgaatta
     6181 taaacacttt gaggtaccaa acataaccaa tctgtgcaac aacatagact gacctcagta
     6241 cccaagagag tgtaaatatt tctgggcttc cagctttggt tttgttattt tcataactgt
     6301 acacaactta gaacagactg aattaataaa tgagaagcga catgaacgca
//
