LOCUS       NM_001145210            2024 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat domain 65 (ANKRD65), transcript variant
            1, mRNA.
ACCESSION   NM_001145210 XR_040433 XR_040434 XR_040435
VERSION     NM_001145210.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Tomita,N., Horii,A., Doi,S., Yokouchi,H., Ogawa,M., Mori,T. and
            Matsubara,K.
  TITLE     Transcription of human endogenous retroviral long terminal repeat
            (LTR) sequence in a lung cancer cell line
  JOURNAL   Biochem Biophys Res Commun 166 (1), 1-10 (1990)
   PUBMED   2302192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC094869.1, BC063445.1, AL391244.11 and BC018095.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001145210.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304716.358711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537107.6/ ENSP00000445688.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BC094869.1         169-221
            54-353              BC063445.1         1-300
            354-894             AL391244.11        36480-37020
            895-2024            BC018095.1         342-1471
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2024
                     /gene="ANKRD65"
                     /note="ankyrin repeat domain 65"
                     /db_xref="GeneID:441869"
                     /db_xref="HGNC:HGNC:42950"
     exon            1..144
                     /gene="ANKRD65"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1344
                     /gene="ANKRD65"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 65"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 65
                     isoform 1"
                     /protein_id="NP_001138682.1"
                     /db_xref="CCDS:CCDS55558.1"
                     /db_xref="GeneID:441869"
                     /db_xref="HGNC:HGNC:42950"
                     /translation="MDSQRPEPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGH
                     LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA
                     VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL
                     EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAA
                     LRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA
                     AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWL
                     RKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGGGEKEC
                     EGIESTG"
     exon            145..353
                     /gene="ANKRD65"
                     /inference="alignment:Splign:2.1.0"
     exon            354..894
                     /gene="ANKRD65"
                     /inference="alignment:Splign:2.1.0"
     exon            895..2024
                     /gene="ANKRD65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD65"
                     /note="hexamer: AATAAA"
     polyA_site      2024
                     /gene="ANKRD65"
                     /note="major polyA site"
ORIGIN      
        1 attcagcttt tcagcagcag acactccacc ccaaagcctg cagaagggat tttgtgaaga
       61 gggtcaccag gctgagcctc ggccagaacc cgtctacaga ggaccctcag ccagagcaga
      121 aagctcctga gccagctccc ttggatggac tcccagaggc ctgagcccag agaggaggag
      181 gaggaggaac aggaactgcg gtggatggag ctggactccg aagaggccct gggaaccagg
      241 acagaggggc ctagtgttgt ccagggctgg gggcacctgc tccaggccgt gtggaggggc
      301 cctgcaggcc tggtgacgca gctgctgcgg caaggtgcca gcgtggagga gagggaccac
      361 gcaggccgga ccccgctcca cctggccgtg ctgcggggcc acgcgcccct ggtgcgtctc
      421 ctgctgcagc gaggggcccc ggtgggcgcg gtggaccggg cggggcgcac cgcgctgcac
      481 gaggccgcct ggcacggaca ctcgcgggtg gccgagctgc tgctgcagcg cggggcctcg
      541 gcggcggctc gctccgggac gggcctcacg ccgctgcact gggccgctgc cctgggccac
      601 acgctgctgg ccgcgcgcct gctggaggct ccgggcccgg gacccgcggc agcggaggcg
      661 gaggacgcgc gcggctggac ggcggcgcac tgggcggccg cgggcgggcg gctggcggtg
      721 ctggagctgc tggcggccgg cggcgcgggc ctggacggcg ccctgctcgt ggctgccgct
      781 gcggggcgcg gggcggcgct gcgcttcctc ctggcgcgcg gggcgcgggt ggacgcccgg
      841 gatggcgcgg gggccacagc gctgggtctg gcggccgccc taggccgctc ccaggacatt
      901 gaggtgctgc tgggccacgg ggcagaccca ggcatcaggg acaggcatgg ccgctctgcg
      961 ctgcacaggg ctgccgcccg aggacacctg cttgccgtcc agttgctggt cacccagggg
     1021 gccgaggtgg atgcgcggga caccctgggc ctcacacccc tgcatcacgc ctctcgggaa
     1081 ggccacgtgg aggttgccgg ctgcctgctg gacaggggtg cccaggtgga tgctaccggc
     1141 tggctccgaa agacccccct acacctggct gcagagcgag ggcatgggcc taccgtgggg
     1201 cttctgctga gccgaggggc cagccccact ctgcggacgc agtgggccga ggtggcccag
     1261 atgcctgagg gggacctgcc ccaggcgctg cctgaacttg gaggggggga gaaggagtgt
     1321 gagggcatag agtccacggg ctgagccaga cagcaggctc caggctccac cgccccagtg
     1381 atttccaggc tctctggctg aggctgcctg cctggagggg acatcaggga agaggcttcc
     1441 ggaggagggg atgggagaaa gtaggggatg tggcttgagc tgcagtcaca ggccttggct
     1501 ggaccaggga tggcccccag ctcccaggag ggcccactga ccctgcagct ccagccttct
     1561 ccatacttca acaaagaatg agttgtggca atgagggaag agagaccctc tcatagtgtt
     1621 ttatactcag tacctgtttt aagaaaaaac aacaaggaag taaaaccaaa gacaggcagg
     1681 cagcctggcg ctaggcccga aaccaggcct gcgcctgcct ggcctaaacc cagtagttga
     1741 aaatcaattc ataacttaga aaccgatgtt attcatagat tccagacatt gtatagaaga
     1801 acatttgtga aactccctgc cgtgttctgt ttctctctga ccgccggtgc atgcagcccc
     1861 tgtcacgtac cgcctgcttg ctcaaatcaa tgacgaccct ttcatgtgaa atcttcggtg
     1921 ttgtgagccc ttaaaaggga cagaaattgt gcacttgggg agctcggatt ttaaggcagt
     1981 agcttgccga tgctcccagc tgaataaagc ccttccttct acaa
//
