LOCUS       NM_001271700            1423 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 61 (ANKRD61), mRNA.
ACCESSION   NM_001271700
VERSION     NM_001271700.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1423)
  AUTHORS   Li,J., Mahajan,A. and Tsai,M.D.
  TITLE     Ankyrin repeat: a unique motif mediating protein-protein
            interactions
  JOURNAL   Biochemistry 45 (51), 15168-15178 (2006)
   PUBMED   17176038
  REMARK    Review article
REFERENCE   2  (bases 1 to 1423)
  AUTHORS   Mosavi,L.K., Cammett,T.J., Desrosiers,D.C. and Peng,Z.Y.
  TITLE     The ankyrin repeat as molecular architecture for protein
            recognition
  JOURNAL   Protein Sci 13 (6), 1435-1448 (2004)
   PUBMED   15152081
  REMARK    Review article
REFERENCE   3  (bases 1 to 1423)
  AUTHORS   Hryniewicz-Jankowska,A., Czogalla,A., Bok,E. and Sikorsk,A.F.
  TITLE     Ankyrins, multifunctional proteins involved in many cellular
            pathways
  JOURNAL   Folia Histochem Cytobiol 40 (3), 239-249 (2002)
   PUBMED   12219834
  REMARK    Review article
REFERENCE   4  (bases 1 to 1423)
  AUTHORS   Sedgwick,S.G. and Smerdon,S.J.
  TITLE     The ankyrin repeat: a diversity of interactions on a common
            structural framework
  JOURNAL   Trends Biochem Sci 24 (8), 311-316 (1999)
   PUBMED   10431175
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005995.3 and AI221268.1.
            
            On May 17, 2019 this sequence version replaced NM_001271700.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.184976.1,
                                           ERR3218366.287039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409061.2/ ENSP00000386502.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC005995.3         11962-12177         c
            217-314             AC005995.3         10617-10714         c
            315-1294            AC005995.3         7130-8109           c
            1295-1423           AI221268.1         6-134               c
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..1423
                     /gene="ANKRD61"
                     /note="ankyrin repeat domain 61"
                     /db_xref="GeneID:100310846"
                     /db_xref="HGNC:HGNC:22467"
     CDS             1..1257
                     /gene="ANKRD61"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 61"
                     /protein_id="NP_001258629.1"
                     /db_xref="CCDS:CCDS64590.1"
                     /db_xref="GeneID:100310846"
                     /db_xref="HGNC:HGNC:22467"
                     /translation="MGNITRKGSRDLVVDSAKSLEDGPSAALHSKLYEAIMREDCTTI
                     EVLLRNHPVNQPITILPNSASNRLLLTQPTESIIPIHLAAKYHKAQSLLCLLRHGADP
                     EVRDTTGLTTLNLMLLHWPVTSTTWAKPGNRTHRILTDIQNSSITCLRILCAHGAQVN
                     TQGEISNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMME
                     TLIAYGANVNCAVSSTGNTPLKLAVCTASSKAGRLLGAGVSCIRLLLTHGAKVNAQDY
                     KGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPIYMYLQRSCNVRDTALLARL
                     LYHTYPLRMTNNQGILPAGIMLPEFRLLRDTLIKQSQKPLSLQGICKRNIRNIYGEKY
                     KQHLKQFLPVTIWNSVYCCYDLAYTS"
     exon            1..216
                     /gene="ANKRD61"
                     /inference="alignment:Splign:2.1.0"
     exon            217..314
                     /gene="ANKRD61"
                     /inference="alignment:Splign:2.1.0"
     exon            315..1423
                     /gene="ANKRD61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD61"
                     /note="hexamer: AATACA"
     polyA_site      1423
                     /gene="ANKRD61"
                     /note="major polyA site"
ORIGIN      
        1 atggggaata taaccaggaa aggaagcaga gacctggtgg ttgacagtgc caagtccctg
       61 gaagatggcc catctgcagc acttcactcg aaactctatg aagccatcat gagagaagac
      121 tgcactacga tcgaggtact cctgagaaat caccctgtca accagcccat caccattctg
      181 cccaactccg ccagcaacag attacttctg acccagccga cagagtctat catccccatc
      241 catctggctg ccaagtacca caaggcccag agtctgctct gcctgttacg gcacggtgct
      301 gacccagaag tcagggacac gacaggcctc accacactca acttaatgct actgcactgg
      361 ccagtcactt ccaccacgtg ggcaaaacca ggcaacagaa cgcacaggat cctgacagac
      421 attcagaata gcagcatcac atgtctccgc atcttgtgtg cgcacggagc tcaagtgaac
      481 actcaagggg aaatcagcaa caaacgttca ccactccacc tggccatagc atatggttgc
      541 tatccagttc tctccatttt gacccaaaat ggtgccgatg tcaatgctat taatgaagcc
      601 agcatgacac cccttcacat ggccgcaaac atgctgaata aggagatgat ggaaacgctc
      661 attgcctatg gagcaaacgt caactgtgct gtctcttcca cggggaacac gcccctgaag
      721 cttgcagtgt gcactgcatc aagcaaagca ggccgactcc tcggggcggg ggtcagctgc
      781 atccgtctgc tactcactca cggagccaaa gtcaacgccc aggactacaa gggccaaaca
      841 gccatccatg aggcatgctt tggaggcaga gaggcaatca tcaatctcct gcttgaattt
      901 gaagcaaatg ttaacatttt aacaagaaac ggggaatctc caatttatat gtaccttcag
      961 cgcagttgca atgtaagaga tacggcactt ctggccaggc tactttatca cacttatcct
     1021 ctgagaatga ccaataacca aggaattcta cctgcaggaa tcatgctacc agaattccgc
     1081 ctcttaaggg acaccctaat aaagcaatcg caaaaacctt tatccctaca gggtatctgc
     1141 aaaagaaaca tcaggaatat ttatggtgag aaatacaaac agcacttgaa gcaattcctc
     1201 ccagtgacaa tatggaattc tgtctactgc tgttatgact tggcatatac ctcttgaaat
     1261 aagacctccc agtttcacag cagagggact ttcagccact caaactgcat tttctggcta
     1321 gacatgtccc agaaaatgct tcacctatca cctgtgacat cccaaatgta caaactactg
     1381 attcttgaac atgttccaaa atacaaagtg atttgtctat taa
//
