LOCUS       NM_001242809            5368 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 6 (ANKRD6), transcript variant
            1, mRNA.
ACCESSION   NM_001242809
VERSION     NM_001242809.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5368)
  AUTHORS   Luan,L., Li,N., Zhang,K., Wang,X. and Pan,H.
  TITLE     Diversin upregulates the proliferative ability of colorectal cancer
            by inducing cell cycle proteins
  JOURNAL   Exp Mol Pathol 129, 104850 (2023)
   PUBMED   36623636
  REMARK    GeneRIF: Diversin upregulates the proliferative ability of
            colorectal cancer by inducing cell cycle proteins.
REFERENCE   2  (bases 1 to 5368)
  AUTHORS   Allache,R., Wang,M., De Marco,P., Merello,E., Capra,V. and Kibar,Z.
  TITLE     Genetic studies of ANKRD6 as a molecular switch between Wnt
            signaling pathways in human neural tube defects
  JOURNAL   Birth Defects Res A Clin Mol Teratol 103 (1), 20-26 (2015)
   PUBMED   25200652
  REMARK    GeneRIF: missense mutations in ANKRD6 are associated with neural
            tube defects.
REFERENCE   3  (bases 1 to 5368)
  AUTHORS   Jones,C., Qian,D., Kim,S.M., Li,S., Ren,D., Knapp,L., Sprinzak,D.,
            Avraham,K.B., Matsuzaki,F., Chi,F. and Chen,P.
  TITLE     Ankrd6 is a mammalian functional homolog of Drosophila planar cell
            polarity gene diego and regulates coordinated cellular orientation
            in the mouse inner ear
  JOURNAL   Dev Biol 395 (1), 62-72 (2014)
   PUBMED   25218921
REFERENCE   4  (bases 1 to 5368)
  AUTHORS   Wang,M., Yu,X., Dong,Q. and Wang,Y.
  TITLE     Diversin is overexpressed in human gliomas and its depletion
            inhibits proliferation and invasion
  JOURNAL   Tumour Biol 35 (8), 7905-7909 (2014)
   PUBMED   24833088
  REMARK    GeneRIF: diversin is overexpressed in human glioma and regulates
            glioma cell proliferation and invasion, possibly through MMP9
REFERENCE   5  (bases 1 to 5368)
  AUTHORS   Yu,X., Wang,M., Dong,Q. and Jin,F.
  TITLE     Diversin is overexpressed in breast cancer and accelerates cell
            proliferation and invasion
  JOURNAL   PLoS One 9 (5), e98591 (2014)
   PUBMED   24858714
  REMARK    GeneRIF: study demonstrated that diversin was overexpressed in
            human breast cancers. Diversin could contribute to breast cancer
            cell proliferation and invasion.
            Erratum:[PLoS One. 2014;9(12):e116045]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5368)
  AUTHORS   Li,J., Liu,F., Wang,H., Liu,X., Liu,J., Li,N., Wan,F., Wang,W.,
            Zhang,C., Jin,S., Liu,J., Zhu,P. and Liu,Y.
  TITLE     Systematic mapping and functional analysis of a family of human
            epididymal secretory sperm-located proteins
  JOURNAL   Mol Cell Proteomics 9 (11), 2517-2528 (2010)
   PUBMED   20736409
REFERENCE   7  (bases 1 to 5368)
  AUTHORS   Haribaskar,R., Putz,M., Schupp,B., Skouloudaki,K., Bietenbeck,A.,
            Walz,G. and Schafer,T.
  TITLE     The planar cell polarity (PCP) protein Diversin translocates to the
            nucleus to interact with the transcription factor AF9
  JOURNAL   Biochem Biophys Res Commun 387 (1), 212-217 (2009)
   PUBMED   19591803
  REMARK    GeneRIF: Diversin, containing several nuclear localization signals,
            translocates to the nucleus, where it interacts with the
            transcription factor AF9.
REFERENCE   8  (bases 1 to 5368)
  AUTHORS   Miyasaka,K.Y., Kida,Y.S., Sato,T., Minami,M. and Ogura,T.
  TITLE     Csrp1 regulates dynamic cell movements of the mesendoderm and
            cardiac mesoderm through interactions with Dishevelled and Diversin
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11274-11279 (2007)
   PUBMED   17592114
REFERENCE   9  (bases 1 to 5368)
  AUTHORS   Schwarz-Romond,T., Asbrand,C., Bakkers,J., Kuhl,M., Schaeffer,H.J.,
            Huelsken,J., Behrens,J., Hammerschmidt,M. and Birchmeier,W.
  TITLE     The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon
            to the beta-catenin degradation complex and acts in both canonical
            Wnt and Wnt/JNK signaling
  JOURNAL   Genes Dev 16 (16), 2073-2084 (2002)
   PUBMED   12183362
REFERENCE   10 (bases 1 to 5368)
  AUTHORS   Tissir,F., Bar,I., Goffinet,A.M. and Lambert De Rouvroit,C.
  TITLE     Expression of the ankyrin repeat domain 6 gene (Ankrd6) during
            mouse brain development
  JOURNAL   Dev Dyn 224 (4), 465-469 (2002)
   PUBMED   12203740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138717.6, DN999929.1, AK295731.1 and AL096678.8.
            
            On Nov 23, 2018 this sequence version replaced NM_001242809.1.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.11198.1,
                                           SRR1803616.2790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339746.9/ ENSP00000345767.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL138717.6         101779-101804
            27-642              DN999929.1         10-625
            643-1407            AK295731.1         917-1681
            1408-1585           AL096678.8         16420-16597
            1586-1738           AL096678.8         17079-17231
            1739-1852           AL096678.8         20123-20236
            1853-1979           AL096678.8         21652-21778
            1980-5368           AL096678.8         22973-26361
FEATURES             Location/Qualifiers
     source          1..5368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..5368
                     /gene="ANKRD6"
                     /note="ankyrin repeat domain 6"
                     /db_xref="GeneID:22881"
                     /db_xref="HGNC:HGNC:17280"
                     /db_xref="MIM:610583"
     exon            1..224
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            225..487
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..2551
                     /gene="ANKRD6"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 6; diversin;
                     diego homolog; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 6
                     isoform a"
                     /protein_id="NP_001229738.1"
                     /db_xref="CCDS:CCDS56441.1"
                     /db_xref="GeneID:22881"
                     /db_xref="HGNC:HGNC:17280"
                     /db_xref="MIM:610583"
                     /translation="MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRT
                     PLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD
                     RQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVL
                     LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALN
                     HKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRK
                     KRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAK
                     DDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQ
                     LYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQM
                     ENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCML
                     KIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKAL
                     NSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSG
                     KSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKW
                     YERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN"
     exon            488..586
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            587..685
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            686..784
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..883
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            884..982
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1081
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1159
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1264
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1399
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1585
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1738
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1852
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1979
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..5368
                     /gene="ANKRD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD6"
                     /note="hexamer: AATAAA"
     polyA_site      3045
                     /gene="ANKRD6"
                     /note="major polyA site"
     regulatory      5329..5334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD6"
                     /note="hexamer: ATTAAA"
     polyA_site      5368
                     /gene="ANKRD6"
ORIGIN      
        1 agagggccct gcggcggcgg acgcggcggg ctcggccaca ggtaacccgc aggagccgag
       61 agcgctgcct ggcgcgcggg cggctggagg cacggcgctg ggcggcgccg aggccctggg
      121 gccgccggag ccagcgggag ccagtccccg tcttcgcccc tcgcccccca ccgtgtcgcc
      181 ggccttggtc cctgcggcgc ggacgtccgg cgcgggagag aaaggtcccg aagatggcat
      241 attcataaag acatcttctg atgattgtga acatctttac ctctgggtgc caggccgggc
      301 cagtgacttc gtgttgagct gaaggaactt gtctaccgct tccctgaaaa cctttctttc
      361 ctaattcatg agccagcaag atgcggtcgc tgcactttca gagcgccttc tcgtagctgc
      421 gtacaaaggc caaacagaga atgtggttca gctcatcaac aagggcgcca gggtagcggt
      481 taccaagcat ggccggactc ccctgcatct tgctgccaat aagggccatc ttcctgtggt
      541 ccagatcttg ctgaaggctg gctgcgacct tgatgtccag gatgatgggg accagaccgc
      601 cttgcaccgg gccacagtgg tggggaacac ggagatcatc gcggcgctca tccacgaagg
      661 gtgtgccctg gacagacaag acaaggatgg gaatacagcc ttgcatgaag catcctggca
      721 tggtttcagc cagtcagcca agctgctcat taaagcagga gccaacgtgc ttgccaagaa
      781 caaggcgggg aacacagctc tgcacctggc ctgccagaac agccactccc agagcacgcg
      841 cgtcctcctg ctggccgggt cccgcgctga cctcaaaaat aatgcaggag acacctgttt
      901 gcacgttgct gcgcgctata atcacttgtc catcattagg ctcctcctca ctgctttctg
      961 ttctgtccat gaaaagaacc aggctggaga cacagcactt cacgttgctg ctgccctaaa
     1021 tcacaagaag gtggccaaaa tcttactgga agccggagca gatacgacca ttgttaacaa
     1081 tgcaggccag actccgctgg agactgcccg ctaccacaat aacccggaag ttgctcttct
     1141 ccttactaaa gctccccagg tcttgcgctt cagtcgtggg cgaagcctga ggaaaaagag
     1201 agagaggctc aaggaagaga ggagagccca gtctgtgcca agagatgagg tggcccaaag
     1261 caagggcagt gtctcagcag gagacacccc cagcagtgaa caggctgtgg ccagaaaaga
     1321 agaagccaga gaagagttcc tgtcagcctc cccagaaccc agagcaaagg atgacaggag
     1381 gagaaagtca aggcccaagg tgtcagcatt ttctgacccc accccaccag ccgaccaaca
     1441 gcctggacac cagaagaacc tgcatgctca taatcaccct aaaaagagga acaggcatcg
     1501 gtgttcatcc ccacccccac cccatgagtt cagggcgtat cagctctaca cattgtaccg
     1561 gggcaaggat gggaaagtga tgcaggcacc aataaatggt tgtcgatgtg aacctctaat
     1621 caacaagctg gagaatcagt tggaggctac tgtggaggag ataaaagcag agctgggatc
     1681 ggttcaggac aaaatgaata caaagctggg gcagatggag aataagaccc agcaccaaat
     1741 gcgtgttttg gacaagctga tggttgagcg actttctgca gagaggacgg agtgcctgaa
     1801 ccgcctgcaa cagcactcag acacagagaa gcatgagggg gagaaacgac agatatcctt
     1861 ggtggatgaa ttaaaaacct ggtgcatgtt aaagattcag aatctggagc agaagctttc
     1921 tggagattct agggcctgca gagctaaatc cacaccatct acttgtgagt cctctacagg
     1981 tgtggaccaa ttagtggtga ctgcaggtcc agcagcagct tccgacagct cccctccagt
     2041 ggttaggccc aaagagaagg ccctcaactc cactgctacc cagagactcc agcaggagct
     2101 gtcgtcttct gactgtacag gctcccgact gagaaacgtc aaggtccaga cagccttgct
     2161 acccatgaat gaggcagcca gatctgatca gcaggctggg ccctgcgtca acagaggcac
     2221 tcaaactaag aagtctggga agagtgggcc aacaaggcat cgtgcccagc aacccgcagc
     2281 cagcagcacc tgtgggcagc cgccaccagc cacaggcagc gagcagactg gccctcacat
     2341 tcgggacacc tcccaagctc tggagcttac ccagtatttt tttgaggctg tttctaccca
     2401 gatggaaaag tggtatgaaa ggaagattga agaagcacga agccaagcca atcagaaagc
     2461 ccagcaagat aaggctacat tgaaggaaca cattaaaagt ttagaagagg aacttgccaa
     2521 actaaggact agggtgcaga aggaaaatta gcaccaataa agaggaaata tgaaaggatt
     2581 cttgaagatt tccagttttg caactgcata atagctatgc ccaaggagtc aactattgta
     2641 tatattgcag atttgccttt ttaaaaaaat cactaattct acaatgtgcc agatacatgt
     2701 ttcctatgcc caggaagtta tgaagacttc aacaattaaa ctgaaaccag gggaagcttg
     2761 cttagttttg ggtttcatta taaactctta gcctcagtcc aggttaatct gaagtttgaa
     2821 agctcagatt aagcaagcca tgccaagaaa ctggacgatg tgtaagccta gactctaaaa
     2881 ttcaagatgt gtgaaataat ataagtcaaa agcaagaaaa acgtaatccc gtctgaactc
     2941 aagtagtcat tcatataaat ttgaacacac ctgctgtgcc tagacaagtg tctttctgta
     3001 agagctgtaa ctctgagatg tgctaaataa accctctttc tcaaattcgt aattctccaa
     3061 ctgttgacat tttaatcaca tgaaaagtta tcagattttt gaggagaaat attttcatga
     3121 tgtcacaaga tccaatatat cttatgataa aatttattga aaagtcagtt tatttaaata
     3181 atgaataatt ggctaacagc tctggaaaca atgagatcaa atgagaaaga ttcaaattgt
     3241 ttgttatttt ctgtattttc agtcaaaaaa tcagttatat agtgatttta aagcagatta
     3301 atggaaaaaa attcatgtaa caattacctg aaaatttata acctattcct aatcaaaccc
     3361 aattatatca gaataccttt ctgaatttga gatttttgct ctacatttta taatgaataa
     3421 ggctattttt tgaaagtatt tcattttgaa ttctgtcatt aacctcaaaa gctttctact
     3481 gctttgcggt gaaggcaaaa tattcgataa ctcaacttag gccccactgt tccccaactt
     3541 catggaggcc agaagacttt actttgttcc ataatgaaat ataaacacag aacaaagttg
     3601 taaaagtagc atggatatgt tgaaactttg gacaagcttc ttgtcctttg gaatatggga
     3661 tttatattca tctcctcaat atcccatgta tgcacagaaa cttcagttct atttctatag
     3721 acacaggaac ctagtgacta ttgaacgtaa ttgtaataaa atgctgctca ttgagccaaa
     3781 gagaagaaat gatttattaa catggggaca ccaagaaaaa caaagtatgc ttttattccc
     3841 tttgtcaagc tcagttttag ggttttttct tttttttata gtgacaatcc atagatatag
     3901 acattcctaa aagaaaaata attcagtaga tatatgtcac tgttacctga atatggaatg
     3961 aatttgatgt tttttatttt gttgagacag ggtcttgctc tgtcacccag actggagtgc
     4021 agtggcatga tcacacctca ctgcagcctt ggcctctcag gctcgtgatc ctcctgcctc
     4081 aacctcgcaa gtagcttggg actacaggcg tgtgccacca gtcctggcta attttttgta
     4141 gatataaggt ctcatgatat tgcccaggct gaatttgatg ttatttcaag ttgattttca
     4201 tgtgtttggg agcttgtctt gttctcaact actacgcagg tagacagtct tcccccagag
     4261 actcattaga ttgcaatata gaggcacttt ctcatttccc tattgttcct aatacagaat
     4321 tgtagagctg gagagtacct tcagttttct aaatctattc tcaaacagga tatcactaac
     4381 ctctttagaa tcattcctca gtatacatca atttattgag aactgcctaa tactcaagaa
     4441 attaaatcct gagttcagta ggctgtgttc caagcaggaa ttattttcac ttaccaaaat
     4501 atctcctatt acctcaaggt atccttgttg aggaatgctg aaaactaaat tttaagtatc
     4561 aagtctagac catagagtgc tttggtggga gtattttgat tacctcctac ccatcagaag
     4621 caggcagcta atattgtgaa ctgagtattt ttgtcaaaag tcacagggaa gagactacag
     4681 aagaatgaga agggtcaaaa ggacctagtg tggcttacta catggatctt gtctcttgga
     4741 ggtctgtcgt agaagaagaa acaaatagag gtgatgaaga cacagaacag gctcagtcag
     4801 catcctcacc cagagatggc aacatctatt aagaccaatg caataccttt tcatcttcag
     4861 caaatgttgt ttcatctgtt tttgatcctt ggcattgtca aaaacttaac tgcaggtcca
     4921 gtgtatattt ttccttattt ttccctttta gctatctgct aaagtgagta aatgccacaa
     4981 ctgtactttt ccaaagaaaa agaactattg acaacttata gcctgtcatg caggtcatgt
     5041 ttcaaatcaa ggctgaaatt ttcaacagct gtgggaaaaa ctaaaacaca gaaatactgt
     5101 acagtattag tgttttttta aagaaattgt tagtgcatta ttgagtatac taaatatctg
     5161 tgattaaata aattagttct aacttttgat tttgggagcc caaaataaag ggagtgttgt
     5221 tttcatggtt atgccttgtt tgtggagtca agtgttgata tacttgaggc atgttatgtg
     5281 tcttctaatt aatattttta tcaccttgaa tttgtgtctc ttccaagcat taaagatact
     5341 atggatctta aattccttat taaaaaaa
//
