LOCUS       NM_138797               2087 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 54 (ANKRD54), transcript variant
            1, mRNA.
ACCESSION   NM_138797
VERSION     NM_138797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Gustafsson,M.O., Mohammad,D.K., Ylosmaki,E., Choi,H., Shrestha,S.,
            Wang,Q., Nore,B.F., Saksela,K. and Smith,C.I.
  TITLE     ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from
            a Human Src-Homology 3 (SH3) domain library
  JOURNAL   PLoS One 12 (4), e0174909 (2017)
   PUBMED   28369144
  REMARK    GeneRIF: the results show that the interaction between BTK and
            ANKRD54 is highly selective, since it was also identified in a
            screen using human SH3-domainome. A novel finding is that BTK not
            only binds to ANKRD54, but stands out as the preferred interactor,
            being highly dominant over all other human SH3-domains.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Gustafsson,M.O., Hussain,A., Mohammad,D.K., Mohamed,A.J.,
            Nguyen,V., Metalnikov,P., Colwill,K., Pawson,T., Smith,C.I. and
            Nore,B.F.
  TITLE     Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine
            kinase (Btk) through a novel SH3-dependent interaction with ankyrin
            repeat domain 54 (ANKRD54)
  JOURNAL   Mol Cell Biol 32 (13), 2440-2453 (2012)
   PUBMED   22527282
  REMARK    GeneRIF: Liar is the first protein identified that specifically
            influences the nucleocytoplasmic shuttling of Btk and Txk and
            belongs to a rare group of known proteins carrying out this
            activity in a Crm1-dependent manner.
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY007929.1, BC066909.1 and BC014641.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138797.3.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014641.1, SRR1163658.175952.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215941.9/ ENSP00000215941.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               HY007929.1         115-505
            392-1258            BC066909.1         371-1237
            1259-2087           BC014641.1         1221-2049
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2087
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /note="ankyrin repeat domain 54"
                     /db_xref="GeneID:129138"
                     /db_xref="HGNC:HGNC:25185"
                     /db_xref="MIM:613383"
     exon            1..424
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..999
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 54;
                     lyn-interacting ankyrin repeat protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 54
                     isoform 1"
                     /protein_id="NP_620152.1"
                     /db_xref="CCDS:CCDS13959.1"
                     /db_xref="GeneID:129138"
                     /db_xref="HGNC:HGNC:25185"
                     /db_xref="MIM:613383"
                     /translation="MAAAAGDADDEPRSGHSSSEGECAVAPEPLTDAEGLFSFADFGS
                     ALGGGGAGLSGRASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLG
                     PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQ
                     LLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKS
                     KLNILQEGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQ
                     VDEVTDLLASFTSLSLQMQSMEKR"
     exon            425..472
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            473..571
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            572..643
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            644..691
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            692..816
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            817..924
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            925..2087
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /note="hexamer: AATAAA"
     polyA_site      2087
                     /gene="ANKRD54"
                     /gene_synonym="LIAR"
                     /note="major polyA site"
ORIGIN      
        1 agctcgctga cagcacgact cagggcggag ggaagtaggt ccgttggtcg gtcgggaacg
       61 aggctcaggc ggccaggccc gcgcggagcc gttgccatgg cagccgccgc cggggacgcg
      121 gacgacgagc cgcgctcagg ccactcgagc tcggagggcg agtgcgcggt ggcgccggag
      181 ccgctgactg acgctgaggg cctcttctcc ttcgctgact tcgggtctgc gctgggcggc
      241 ggcggcgcgg gcctctcggg ccgggcgtcc ggcggggccc agtcgccgct gcgctacttg
      301 cacgtcctgt ggcagcagga tgcggagccg cgcgacgagc tgcgctgcaa gatacccgct
      361 ggccggctga ggcgcgctgc caggccccac cggcggctcg ggcccacggg caaggaggtg
      421 cacgctctga agagactgag ggactcggcc aatgccaatg atgtggaaac agtgcagcag
      481 ctgctggaag atggcgcgga tccctgtgca gctgatgaca agggccgcac agctctacac
      541 tttgcctcat gcaatggcaa tgaccagatt gtgcagctgc tcctggacca tggtgctgat
      601 cctaaccagc gagatgggct ggggaacacg ccactgcacc tggcggcctg caccaaccac
      661 gttcctgtca tcaccacact gctacgagga ggggcccgtg tagatgccct ggaccgagct
      721 ggtcgcacac ccctgcacct ggccaagtca aagctgaata tcctgcagga gggccatgcc
      781 cagtgcctag aggctgtgcg tctggaggtg aagcagatca tccatatgct gagggagtat
      841 ctggagcgcc tagggcaaca tgagcagcga gaacgcctgg atgacctctg cacccgcctg
      901 cagatgacca gtaccaaaga gcaggtggat gaagtgactg acctcctggc cagcttcacc
      961 tccctcagtc tgcagatgca gagcatggag aagaggtagc aagagaggct ccctgccttc
     1021 ctgccactgc cccaccctgc cccactgctg tctcagtacc aagaaaaagc ccaacatctg
     1081 ggacttggag ctgcacttgt ctggtgagga ccttgccctc acccgcagat gccgtggggc
     1141 agagatgctc tctctccacg gcctcagagc cactcccagc cacagtttcc agcatctctg
     1201 tggacaggga ccacagctcc cagcttcttc cagttctcgc agcaccagac cagcctctgc
     1261 agctgcactt cagctccgca gacctgcgct atctcagcag acctcacttg ccccatggcc
     1321 ttcatggcgc gctccaggcc tcagaccctt ctctgtgttc cgtcctggcc atgggcttgt
     1381 tgcagtcagc aggtgtgggc ttaggcgggc accctgtggc caggggtact gcgtgaggcc
     1441 ctcagttggt cctgtgcctc tcaccagcac ttagacagac acgtcaccag actttcaagg
     1501 agatactgca gtgagtttct ctggttggaa ggggagggtt ggtgagtccc agaccttaaa
     1561 aatacaaggt taagagggac cccaaagcaa aaaattccaa cccttttcct cccagtcatt
     1621 gaaacaccaa aactattata ccggagggtg taatagtttt gctgcccagt tgtggtaggc
     1681 cagtagtggc ctcccaagat gcccatgtcc taatcccagg aacctgtcaa aattaccttg
     1741 tatggccaaa ggggctttgc agatgtaatg aagttaagga tctttcgcca ggaagattat
     1801 cccagcttgt tcaggagggc ttgatgtcct cacccgggtc tgtataacag aagagcaggt
     1861 gacgggagag gaggttggag gtgtagcgat ggagcaggaa actggagttg aggagggcag
     1921 ctcaagccac agagtccagg ccacctcaga gccaggaaat gcatcctccc acagagccct
     1981 ggaaggcccc agccctgctc ccacctggac tggctcagtg aggctaattt tataattctg
     2041 gctgatttta gaactctaag ggaataaatt tgtgttgttt taagtca
//
