LOCUS       NM_001115116            1808 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 53 (ANKRD53), transcript variant
            1, mRNA.
ACCESSION   NM_001115116
VERSION     NM_001115116.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Kim,S. and Jang,C.Y.
  TITLE     ANKRD53 interacts with DDA3 and regulates chromosome integrity
            during mitosis
  JOURNAL   Biochem Biophys Res Commun 470 (3), 484-491 (2016)
   PUBMED   26820536
  REMARK    GeneRIF: Thus, ANKRD53 is recruited to the mitotic spindle by DDA3
            and acts as a regulator of spindle dynamics and cytokinesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093479.1 and AC007040.2.
            
            On Nov 24, 2018 this sequence version replaced NM_001115116.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360589.4/ ENSP00000353796.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-993               AK093479.1         22-1014
            994-1808            AC007040.2         132857-133671
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..1808
                     /gene="ANKRD53"
                     /note="ankyrin repeat domain 53"
                     /db_xref="GeneID:79998"
                     /db_xref="HGNC:HGNC:25691"
                     /db_xref="MIM:617009"
     exon            1..186
                     /gene="ANKRD53"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1609
                     /gene="ANKRD53"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 53"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 53
                     isoform a"
                     /protein_id="NP_001108588.1"
                     /db_xref="CCDS:CCDS46321.1"
                     /db_xref="GeneID:79998"
                     /db_xref="HGNC:HGNC:25691"
                     /db_xref="MIM:617009"
                     /translation="MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSL
                     KATWTDAESKQPSQPLPDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAID
                     QTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLV
                     EEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLA
                     ARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFA
                     REMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQAR
                     ATALSKTPEQRESQRSRSFHPSVDARLQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNP
                     ARPPTTQISHSQGIRLGVHPDPTPEHDFSSFLEVRPDGHGGARLHTVDGHWVAPVPRL
                     PFEVLLRMLYPRVWPYRMKVPQGFYPISMREVPRKRHLGDNTFWTDTLAMNLRDTFDE
                     AFLAAVRSHQGLPTLPSPQTNP"
     exon            187..433
                     /gene="ANKRD53"
                     /inference="alignment:Splign:2.1.0"
     exon            434..633
                     /gene="ANKRD53"
                     /inference="alignment:Splign:2.1.0"
     exon            634..798
                     /gene="ANKRD53"
                     /inference="alignment:Splign:2.1.0"
     exon            799..919
                     /gene="ANKRD53"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1808
                     /gene="ANKRD53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD53"
                     /note="hexamer: CATAAA"
     polyA_site      1650
                     /gene="ANKRD53"
                     /note="major polyA site"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD53"
                     /note="hexamer: AATAAA"
     polyA_site      1808
                     /gene="ANKRD53"
                     /note="major polyA site"
ORIGIN      
        1 gagttccagc cccgcgatgg cctccgcggg cagcaccgct cggcgggcgg gctccggaag
       61 ctggcactca gaaaggggag aagggagagg tgctcggccg cagccaactc caagtggctc
      121 catgcagcag gcgaacaaag tctccttgaa ggccacctgg actgacgcgg agtccaagca
      181 gcccagccag cccctgcccg acctcgcaga ccacctcagt gcgcaggcga ctgccctcgc
      241 caggccgcgc cgccctgcct cgctcacccc gccccgcgct gaccccagcc ccagcaagga
      301 gtccgaccag acggcaatcg accagacggc gatcgggagc tactaccagc tgttcgcagc
      361 ggctgtgggc aacgtggaat ggctgcgatt ctgtctgaac cagagcctca gggaaatccc
      421 caccgacgac aagggcttca ctgccatcca cttcgccgcc caatggggca agcttgcatg
      481 cctgcaggtc ctggtagagg agtacaagtt tcccgtggac ctgctgacca acaatagcca
      541 gacacccctg cacctcgtca tccacaggga caacaccacc gtggccctcc cctgcatcta
      601 ctacctgctg gagaaaggcg cagacctcaa tgctcagaca tgcaacggct ccacgcccct
      661 gcacctggca gcccgtgacg gcttgctgga ctgtgtgaag gtcctggtgc agagtggcgc
      721 caacgtccat gcccaagatg ccatgggcta caaacccatt gacttctgca aaatatggaa
      781 ccaccgtgcc tgtgcccggt tcttgaagga tgccatgtgg aaaaaggaca agaaggactt
      841 tgcccgtgag atgacgaaaa tgaagatgtt caagagccag ctgaccctca tggagcacaa
      901 ctacctgatt gagtatcaaa aagagcacaa aattctcaga gaagctgcta tcagaaagtg
      961 gctccacggc aagctgcacc caggccactc tctggtctcc aataccaagc aagcccgggc
     1021 caccgccctc tccaagaccc cagagcaacg ggaatcgcag cgttccagga gcttccaccc
     1081 ctctgtggat gcacgcctgc aatgcattcc acagcccacg gagatgccca agcccatcta
     1141 caggaagccc acggtcaagc ggcccacaat gtggaatgtt agcaacaacc ccgccagacc
     1201 ccccaccacc cagatcagcc actcgcaggg catccgcctg ggcgtgcatc cagaccccac
     1261 tccggagcac gacttcagca gcttcctgga ggtgaggcct gatgggcacg gcggtgcgcg
     1321 gctgcacaca gtggacggcc actgggtggc gcccgtgccg cggctgcctt ttgaggtgct
     1381 gctgcgcatg ctgtacccac gtgtatggcc atacagaatg aaggtgcccc agggctttta
     1441 ccccatcagc atgagggaag tgcccaggaa gcggcacctg ggtgacaaca ccttctggac
     1501 cgacactctg gccatgaacc tgcgtgacac attcgatgaa gccttcctgg cagctgtgcg
     1561 atctcatcaa ggactcccca ccctgccctc cccacaaacc aacccataaa gttattatgg
     1621 ctacctctcc ccctgaggca gcccagtgaa ggctgaagtg tggcaattca cgttgtgggt
     1681 ggcgaggaaa gggggagggg tgcctatggg cttcccactc ccaagctcga ggagtcaccc
     1741 ttcccaatca aaagcccaga ccccaggcct cccttttctc tgcaaataaa tctcttggca
     1801 ccccccca
//
