LOCUS       NM_173595               8681 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 52 (ANKRD52), mRNA.
ACCESSION   NM_173595 XM_001722431
VERSION     NM_173595.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8681)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 8681)
  AUTHORS   Watanabe,K., Morishita,K., Zhou,X., Shiizaki,S., Uchiyama,Y.,
            Koike,M., Naguro,I. and Ichijo,H.
  TITLE     Cells recognize osmotic stress through liquid-liquid phase
            separation lubricated with poly(ADP-ribose)
  JOURNAL   Nat Commun 12 (1), 1353 (2021)
   PUBMED   33649309
  REMARK    GeneRIF: ANKRD52 condensates are not completely colocalized with
            ASK3 condensates, but they move around and grow while sharing their
            phase boundaries.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8681)
  AUTHORS   Lee,T.F., Liu,Y.P., Lin,Y.F., Hsu,C.F., Lin,H., Chang,W.C.,
            Pan,C.M., Chou,T.Y. and Wu,C.W.
  TITLE     TAZ negatively regulates the novel tumor suppressor ANKRD52 and
            promotes PAK1 dephosphorylation in lung adenocarcinomas
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (2), 118891 (2021)
   PUBMED   33096142
  REMARK    GeneRIF: TAZ negatively regulates the novel tumor suppressor
            ANKRD52 and promotes PAK1 dephosphorylation in lung
            adenocarcinomas.
REFERENCE   4  (bases 1 to 8681)
  AUTHORS   Watanabe,K., Umeda,T., Niwa,K., Naguro,I. and Ichijo,H.
  TITLE     A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume
            Regulation under Osmotic Stress
  JOURNAL   Cell Rep 22 (11), 2809-2817 (2018)
   PUBMED   29539411
  REMARK    GeneRIF: ANKRD52 mediates the PP6-ASK3 interaction and,
            consequently, ASK3 inactivation under hyperosmotic stress.
REFERENCE   5  (bases 1 to 8681)
  AUTHORS   Couzens,A.L., Knight,J.D., Kean,M.J., Teo,G., Weiss,A.,
            Dunham,W.H., Lin,Z.Y., Bagshaw,R.D., Sicheri,F., Pawson,T.,
            Wrana,J.L., Choi,H. and Gingras,A.C.
  TITLE     Protein interaction network of the mammalian Hippo pathway reveals
            mechanisms of kinase-phosphatase interactions
  JOURNAL   Sci Signal 6 (302), rs15 (2013)
   PUBMED   24255178
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8681)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8681)
  AUTHORS   Stefansson,B., Ohama,T., Daugherty,A.E. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 regulatory subunits composed of ankyrin
            repeat domains
  JOURNAL   Biochemistry 47 (5), 1442-1451 (2008)
   PUBMED   18186651
REFERENCE   8  (bases 1 to 8681)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 8681)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   10 (bases 1 to 8681)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073896.41, DR002390.1 and AK125379.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173595.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB190990.1, AK125379.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267116.8/ ENSP00000267116.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC073896.41        75398-75422
            26-597              DR002390.1         9-580
            598-960             AK125379.1         590-952
            961-961             AC073896.41        79655-79655
            962-2522            AK125379.1         954-2514
            2523-2523           AC073896.41        88595-88595
            2524-3750           AK125379.1         2516-3742
            3751-8681           AC073896.41        91045-95975
FEATURES             Location/Qualifiers
     source          1..8681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..8681
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /note="ankyrin repeat domain 52"
                     /db_xref="GeneID:283373"
                     /db_xref="HGNC:HGNC:26614"
                     /db_xref="MIM:620862"
     exon            1..142
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3346
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /note="protein phosphatase 6 ankyrin repeat subunit C;
                     CVWG5837; ankyrin repeat domain 33; PP6-ARS-C; ankyrin
                     repeat domain-containing protein 52;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     ARS-C"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory ankyrin repeat subunit C"
                     /protein_id="NP_775866.2"
                     /db_xref="CCDS:CCDS44920.1"
                     /db_xref="GeneID:283373"
                     /db_xref="HGNC:HGNC:26614"
                     /db_xref="MIM:620862"
                     /translation="MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTP
                     LHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA
                     RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL
                     NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ
                     IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPL
                     HVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC
                     ADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL
                     SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLR
                     RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPH
                     TPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL
                     ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFL
                     ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITD
                     VMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAAL
                     LDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWA
                     SYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDA
                     KGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG
                     KADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG
                     LASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDAVSPF
                     SFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAIGLDGCYSE"
     exon            143..226
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            227..305
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            306..376
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            377..577
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            578..665
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            666..808
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1021
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1100
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1215
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1298
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1416
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1485
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1626
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1707
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1819
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1891
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2093
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2181
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2299
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2519
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2607
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2691
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2837
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2920
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3003
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3095
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..8681
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8251..8256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /note="hexamer: AGTAAA"
     polyA_site      8271
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /note="major polyA site"
     regulatory      8661..8666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /note="hexamer: ATTAAA"
     polyA_site      8681
                     /gene="ANKRD52"
                     /gene_synonym="ANKRD33; ARSC"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgctct ccctgcagcc gccaccgcag ccgccgcctg ggccgctccg tgtccccggt
       61 ggagccgccg ccgccgccgc cgggagctcg atgcggacgg agcccgggcc gagccatggg
      121 gatcctcagc atcacggacc agccgcccct ggtccaggcc atctttagcc gagatgtgga
      181 ggaagtgcgt tccctactct cgcagaagga gaacatcaat gtgctggacc aagagaggcg
      241 aactccattg catgctgctg cctacgtagg cgatgtcccc atcctccagt tgctactgat
      301 gtcaggtgct aatgtcaatg ctaaggacac actgtggctg acccctcttc atcgtgctgc
      361 tgcctcccga aacgagaagg tgctggggct gctgctggca cattcagcag atgtgaatgc
      421 ccgggacaag ctgtggcaga caccactgca tgtggctgct gccaaccggg ccaccaagtg
      481 tgctgaggct ctggcacccc tgttgagcag cctcaacgtg gctgacagga gcgggcgcag
      541 tgctctgcac catgcagtgc atagtgggca tcttgagacg gtgaacctgc tcctcaacaa
      601 gggagccagc ctgaatgtct gtgacaaaaa ggagcggcag cctctgcatt gggcagcttt
      661 tctagggcac ttggaggtcc taaaactgct ggtggcacgg ggagcagacc tcggctgcaa
      721 ggaccgcaag ggctatgggc tgctccatac agctgctgcc agtggccaga ttgaagtggt
      781 gaagtacctg cttcggatgg gagcggagat cgatgaaccc aatgcttttg gaaacacagc
      841 tttgcacatc gcctgctacc tgggccagga tgctgtggct attgagctgg tgaatgccgg
      901 agccaatgtc aaccagccga atgacaaggg cttcacgcca ctgcatgtgg ctgcagtctc
      961 caccaatggc gctctctgct tggagctact ggttaataat ggggctgacg tcaactacca
     1021 gagcaaagaa gggaaaagtc ctctgcacat ggctgcaatc catggccgtt tcacacgctc
     1081 ccagatcctc atccagaatg gcagcgagat tgattgtgcc gacaaatttg ggaacacgcc
     1141 actgcatgtg gctgctcgat atggacacga gctgctcatc agcaccctca tgaccaatgg
     1201 cgcagatacc gcccggcgtg gcatccatga catgttcccc ctgcacttag ctgttctctt
     1261 tggattctct gactgttgtc gtaagcttct ttcctcaggt cagttgtaca gcattgtgtc
     1321 ttcactcagc aatgagcatg tgctttcagc tgggtttgac atcaatacac ctgacaacct
     1381 tggccgtacc tgtcttcatg ctgctgcttc cggagggaat gttgaatgtc ttaatttgct
     1441 gttgagcagt ggagctgact tgaggaggag ggacaaattt ggcaggaccc cactgcacta
     1501 tgcagctgct aacggtagct accagtgtgc agtaacattg gtgactgctg gggcaggtgt
     1561 caacgaggcc gactgtaaag gctgctctcc cctccactac gctgccgctt ctgacactta
     1621 caggagagcg gaaccccata caccttccag ccatgatgcc gaagaggacg agccactgaa
     1681 ggagtcccgc aggaaggagg ccttcttctg tctggagttc ttactggata acggtgcaga
     1741 cccctccctg cgggacaggc agggctacac agctgtgcac tatgcagccg cctatggcaa
     1801 cagacagaac ctcgaactgc tcttagaaat gtcctttaac tgcctggagg atgtggagag
     1861 caccattcca gtcagccctt tgcacttagc tgcctacaac ggtcactgtg aagccttgaa
     1921 gacgctggcg gagacgctgg tgaatctgga cgtaagggac cacaagggcc ggaccgcact
     1981 cttcctggcc acggagcgcg gctctactga gtgtgtggag gtgcttacag cccacggcgc
     2041 ctctgccctc atcaaggagc gcaagcgcaa gtggacaccc ctgcacgctg ctgctgcctc
     2101 tggccacact gactccctgc acttgctgat cgacagtggg gaacgagctg acatcacaga
     2161 tgtcatggat gcctatggac agaccccact gatgctggcc atcatgaatg gccatgtgga
     2221 ctgtgtacat ctgctgctag agaaaggatc cacagctgat gctgctgacc tccggggccg
     2281 cactgccctc caccgcgggg cagtgactgg ctgtgaggac tgcctggctg ccctgctgga
     2341 ccacgacgca tttgtgctgt gccgagactt taagggccgc acgcccattc acctggcctc
     2401 agcctgtggc cacactgcag tactgcggac cctgctgcag gctgcccttt ccacagatcc
     2461 cctggatgcc ggggtggatt acagcggata ctcgcccatg cactgggcct cctacactgg
     2521 acatgaagat tgtctggagt tgttacttga acacagcccg ttttcgtacc tggaaggaaa
     2581 ccccttcact cctttgcact gtgcagtgat taataaccaa gacagcacca cagagatgct
     2641 actgggagct ctgggtgcca agattgtgaa cagccgagat gccaaaggac ggacccccct
     2701 tcacgccgct gccttcgcgg acaatgtctc tgggctccgg atgctgctgc agcatcaagc
     2761 tgaggtgaac gccactgacc acactggccg cactgcgctc atgacggcgg ctgagaacgg
     2821 gcagaccgct gctgtggaat ttctgctgta tcgagggaag gcagacctta ctgtgttgga
     2881 tgagaacaag aacacggccc tccacttggc ttgtagcaag ggccatgaga aatgtgccct
     2941 catgatcctg gcagaaaccc aagaccttgg ccttatcaat gctaccaaca gtgcgctgca
     3001 gatgccactc cacattgctg cccggaatgg tctagcttct gtggtacagg ccctgctgag
     3061 tcatggggcc acagtgctgg ctgtggatga agaaggtcac accccagcac tggcctgtgc
     3121 ccccaacaaa gatgtggcag actgcctggc cttgatcctt tccaccatga agcctttccc
     3181 acccaaggac gccgtcagtc ctttcagctt cagcctgctc aagaactgca gcattgcagc
     3241 cgccaagacg gtgggtggct gcggcgccct gccccatggg gcctcctgcc cctacagcca
     3301 ggagcggccc ggcgccattg ggttagatgg ctgctactct gagtagcccc ctccagtgtc
     3361 cctcccccgc cggtggcttg atatctaatt ctatttattt agaaaaagtc taaacattta
     3421 gggcacttta aaggagaaca cgactgggtg gagggggcgg aggggaagga agccctgggg
     3481 agcagctgct cacccctttg ccacaccatc ttggcctggc aggggtctgg gactgacagg
     3541 gagcacccca ggcccttggt acccccaggg cgaccccttc tgccaagtgt cccaaaatga
     3601 ttgctaaatg cctggctccc ccactctttg actccatctc ttggttccct ctttctgctg
     3661 ccagctcccc cgactcttcc ctggggactc ctctctgtgt cccccttctc ccctgcccct
     3721 actgccaggc agatcccctc ttcttccata cccatcactg cctccctgct cggccggtcc
     3781 ctccatcccc gcagcagtga gaagccttaa tttctggtac tgtgtgagca ctctgggggt
     3841 gtccccctcc ccccttcagg ggcagctaga ggatgagggg ggaggatatt tagcactggg
     3901 gcctggagct ttttccccac ttctgtaccc tatcacccct aaagttcaaa tgcaaaacac
     3961 ttgaagcagc aactactgta cctgggcccc aatcctgcac tctcccctgg ctcctcatat
     4021 gcaaatcaag ggctggttct gcccccacag cctgccccct ccccattccc tcccactcct
     4081 agcctggccc ctaaccacgc actttaacct tgcttctttc ttttatcttc ttttgggagg
     4141 gcagagcctg tggtcattcc tgccctggct ctccttccct tgaactttga ggcttgtcat
     4201 gaatttttaa gtaagcgttt tatcctttag gggaagaaac aaattaattt cctgcccatt
     4261 tcaaaaccac agccctagta tgtccactgt gtttcaggca tgtgtttgca tgtatatgga
     4321 gggagggacc atgttcttcc tcctgtgccg ccaagcccat agtttatctg tgctccctat
     4381 ctgcctccac cttccgttat gtccaagagt acccactgcc ccagtcactc ctgatctgaa
     4441 gccaaagatg gtaggagggg cagggccgac aagggaccgt ggctactcgg gacccaggct
     4501 tcccctccag tgtgaggaag aagctctgac ctagagagag atgaataggt actggggctt
     4561 ggtccctgcc ttcccagcag ggaggaaaga tgggattgag ctgggggctg cactgataag
     4621 atttctaaag tcgcacccca aaagccaaac tgggctggag tgaagagggg gcagttttct
     4681 ctctaaatgt agcattgaat ttggccctgg tccctttaag tgctctgtcc acccatctcc
     4741 tagtgcagcc tcctggacag ttggacccac tcctgcagcc cagtgttccc ttcctcacac
     4801 tcaatacctc agccaggggc caagacacag aacttgaata gaggtcatgc cccctccgcc
     4861 cccacactgc atccttgccc agtttggctg ccatcagtat tgtcccctga gaactggaca
     4921 ggcttcgttt acacagtaca gggtctcccc tgagggggga tccttcagcc tccctcccct
     4981 actcaagttt gctttattca cagtcttacc catcttttag ttgtataccc tgaatgtctt
     5041 gccacccttg tcaagggtgg gctgagggga ggggggcgtc ccagggaccc cctccctccc
     5101 caacggatac ctttaaccat acctcatgct ggtttccaga agcctggggt gttgtccaag
     5161 tccttatctt ttcatggtcc cttttgatcc cctgtctctc tgtgttttgc ttctcccaac
     5221 cctcagttcc taaatcattt caaggcttcc aaatgaccat tattgatgag aaggattgtg
     5281 cagcttttag tttttatttt tattttcaaa gccaaagggc cttgtgacgc ccctcttgcc
     5341 cacctccctc cacaccgtgt cctcccctat atgacaatca atgtgacctc tcttaagggc
     5401 tgcagccccc atccccaacc ctgctggctc tgcaaagctt gccttccctt caattctctc
     5461 tcctgaaatc ttcccattcc accccctccc tctcatcttg gtgctgggaa ttaggtggtg
     5521 gggggcaagg ggagtgagaa gatgggtcct ccagagagaa cttgccgggt gtgagtcgtg
     5581 ttctcctttc gtgatgtttg gtgatggcgg gaagcgtctg agtgtcagag ccccgttgtc
     5641 ttgctagatg agatttctgg gggctgtctg cgccctgctg ccctcagcgc actgtcagca
     5701 gtgctgggag gtggtgggga gtcctctgtc cctccatatg tggctgtgag gaagcctggg
     5761 ggacaagcag cctcctctcc ttatgccaaa ggaaacccca cgccccaccc tgggctcccc
     5821 agccctagtg ttttttgaag cattttgacc attctcatgg ccactgcata tttattttaa
     5881 tgttaagatt ttttttaaac ctctttgact taaacgggtg tggagaagta aaacaggcag
     5941 aatgcccccc agtcttcatg ggggagggcg gggagggaac agcgccttcc ctttgccctc
     6001 cccctccccc ctctccccac cgcagcccta aagcacttgc ttcaagtaat aagcactttt
     6061 gtgaaaaggc ctattttaag cgaggaccct gggagcagcc ccaggtccca gcaaaggaaa
     6121 cagagcgagg gcgacatagg agacagggaa acagacgtgt gaatcagagg gtgagatgga
     6181 aagagccagt ttttagtttc tgattttggg ggagctattt ctgattgggc ggtggctctg
     6241 gtagggtcat atactatcct tcagaaaaac gaatggcaca aaccgtgggt cccaggaagg
     6301 accagcagac ccgggtcact gccactgtcc actgagactg acgggccacc tcccctgccc
     6361 cgtggccccc tgagccatag gactgctgaa aaccactgaa tgtacagccc aggttggggt
     6421 ggggagcagc ccctggggga gggggcttct ccttttgttt ggtgctgtgg ggcgtgggag
     6481 agaaaagact gagggactgc caccccacgt agatgtgttt cttggggtgg aggggctgag
     6541 gagggcctac ctccctctcc aaccccagcc atggcccctc ttccttcctc acccctatcc
     6601 gttttgactg taagtccagc tcacctttgc cttcaatatg taaccaaagg aaaactcaat
     6661 actgtttcca ccactgtctg cccacccgag caccttctta ctccctggac ctagaagggg
     6721 agaagaggct ggaggtgggg tggatggggc cagagtgaac ggttctacag ctgtatcccc
     6781 agaacctcct ccagggtctt ggaaggagtc ctgagaggtg ggattggggc cgggctggca
     6841 gggctgagtt tgcgcactgt gtatcttatg cacatgagtg tttttgtcta aatgactcca
     6901 gtgactgctc cagcggggag gccccttcct ccttccctct cagccatttc tcacccactt
     6961 cccataccca gtgttcatcc cctacctccc cttcccaccg caaaggaaaa tagccttaca
     7021 gaccctagcc cagaaaccct actcctgggg caaaccagta tgggccccca tcccgcctag
     7081 tttgaaccct accttttaag aaggagggat aaggaacaaa gcagcccctt cccctctaat
     7141 tgtggtggct ccagccttct gcagccttga cccaggttgg gcaagggcgg aggtgaggaa
     7201 tctttgagga ccaagcccag tggtctggga atcgggaggt agagagggaa gggtctgcct
     7261 tgggggctcc ctcctcccaa cccaacccct agagaagcga ccaaatccca gagatggggt
     7321 gaagctgggg tggggagggt ctgctctttg aattacttga aggtactgac tccaaggctg
     7381 ctgttgccca cttaggtgtg agggggacac tgtcactgca tttgggaggg cagagggtgg
     7441 cgggtaacca gaggatccac cttggccctc acccactcct gctaggccct ttccctgggg
     7501 aatctggaag cctgactttg cccccaggga agttggggac cgccttccct cccttctcca
     7561 cctctcactc tgggcaccct ctccaattgc actaaagtag ctgttgtgcc agtctgcccc
     7621 ccacaagggg ggaggtctct gcttccagtc ttcttccccc gctgcctccg ctcccaccct
     7681 ggacaatctc cttgtttccc ttgtgttcct ggatagctca gctttgtatg tgtgtttggg
     7741 gggtgggggt gggttctggc ttgagtgggt ttggcagggg tttgggaagg gttaggggag
     7801 gatggaggat gaagtctcct acccccttct ccagctccag gccacagaag cctgggaagg
     7861 gagggtgcct actctcgctg ctgtgtgtct tgcagatgtg ccaaaatggg ggtgggtggg
     7921 aggggagggt gcctggcaga gcagcccctg gggtggctct ctcaaagcaa tatagttccc
     7981 ctgcggggga cagcaagaca ggggagaggg ttggggtggg gacctggggg ttccccatgt
     8041 acagctatgt atattcaggg gtgttctccg tctggtaccc gctgtgggca tctatgtgtg
     8101 tgtgaacctc cccttcccca tgccctgcat gacctgtgat gctgcagaca ccaccatcct
     8161 gtgtgcaggt gtgtgttggg gggcacggag gggcatgttc catgtcctgt tgcaccctcc
     8221 accctgtgac ccatgtactc ggttgtagga agtaaagaga actgagcaca attcactgga
     8281 ttctagtgga atctttctct aagcaatttt cccattcctg cctctccctg ccccggaacc
     8341 acctgtggtg ctagtgttgg gatcgggggc gtttaacgct ggtgggcagc aataaggggc
     8401 agatgtgccc agatgcctgc atccccaggg tgccgagggc agcaggaaaa agtggggacc
     8461 tcggtgcatt tgccccaccc ctcccctccc tgggctaaag cacaatgttc tccccgcaga
     8521 ttaatgaccc tgcaccctcc aggcccctac tcacatcctc ccccaaccgg cttcgggtcc
     8581 tcccaccaca ctctggtttt ctatgctgtt ttggtgcaag tacaactgtc gtagtcatgg
     8641 ctttgggatg ggttctgttt attaaaatcc tattgctcct a
//
