LOCUS       NM_020337               8798 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain containing 50 (ANKRD50),
            transcript variant 1, mRNA.
ACCESSION   NM_020337 XM_048747
VERSION     NM_020337.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8798)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 8798)
  AUTHORS   Kvainickas,A., Orgaz,A.J., Nagele,H., Diedrich,B., Heesom,K.J.,
            Dengjel,J., Cullen,P.J. and Steinberg,F.
  TITLE     Retromer- and WASH-dependent sorting of nutrient transporters
            requires a multivalent interaction network with ANKRD50
  JOURNAL   J Cell Sci 130 (2), 382-395 (2017)
   PUBMED   27909246
  REMARK    GeneRIF: ANKRD50 simultaneously engages multiple parts of the
            SNX27-retromer-WASH complex machinery in a direct and co-operative
            interaction network that is needed to efficiently recycle the
            nutrient transporters.
REFERENCE   3  (bases 1 to 8798)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 8798)
  AUTHORS   McGough,I.J., Steinberg,F., Gallon,M., Yatsu,A., Ohbayashi,N.,
            Heesom,K.J., Fukuda,M. and Cullen,P.J.
  TITLE     Identification of molecular heterogeneity in
            SNX27-retromer-mediated endosome-to-plasma-membrane recycling
  JOURNAL   J Cell Sci 127 (Pt 22), 4940-4953 (2014)
   PUBMED   25278552
REFERENCE   5  (bases 1 to 8798)
  AUTHORS   Khadka,S., Vangeloff,A.D., Zhang,C., Siddavatam,P., Heaton,N.S.,
            Wang,L., Sengupta,R., Sahasrabudhe,S., Randall,G., Gribskov,M.,
            Kuhn,R.J., Perera,R. and LaCount,D.J.
  TITLE     A physical interaction network of dengue virus and human proteins
  JOURNAL   Mol Cell Proteomics 10 (12), M111.012187 (2011)
   PUBMED   21911577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295135.1, AK291068.1, CX871714.1, AK127496.1, AB033049.2 and
            AA628892.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020337.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291068.1, SRR1660807.63981.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504087.6/ ENSP00000425658.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AK295135.1         1-158
            159-686             AK291068.1         159-686
            687-978             CX871714.1         568-859
            979-1170            AK291068.1         979-1170
            1171-1349           AK127496.1         22-200
            1350-4368           AK291068.1         1350-4368
            4369-8794           AB033049.2         2313-6738
            8795-8798           AA628892.1         5-8                 c
FEATURES             Location/Qualifiers
     source          1..8798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..8798
                     /gene="ANKRD50"
                     /note="ankyrin repeat domain containing 50"
                     /db_xref="GeneID:57182"
                     /db_xref="HGNC:HGNC:29223"
                     /db_xref="MIM:619856"
     exon            1..275
                     /gene="ANKRD50"
                     /inference="alignment:Splign:2.1.0"
     exon            276..1550
                     /gene="ANKRD50"
                     /inference="alignment:Splign:2.1.0"
     CDS             1039..5328
                     /gene="ANKRD50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 50; ankyrin
                     repeat domain 50"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 50
                     isoform 1"
                     /protein_id="NP_065070.1"
                     /db_xref="CCDS:CCDS34060.1"
                     /db_xref="GeneID:57182"
                     /db_xref="HGNC:HGNC:29223"
                     /db_xref="MIM:619856"
                     /translation="MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCC
                     NSAVNAPSLVMNSGNNASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRG
                     LHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGE
                     CERNPAEAFKRCVLLPLLGMKPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALL
                     AGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQ
                     EEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLY
                     LWLCQRLFVRKQFAKVQPILNVILAACRPLTITELYHAVWTKNMSLTLEDFQRKLDIL
                     SKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPL
                     EAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVN
                     SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVS
                     RGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHT
                     EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALI
                     AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE
                     VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVN
                     TLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF
                     EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGR
                     NALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANV
                     EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL
                     LIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKN
                     GHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDM
                     QPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTV
                     PIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKPSL
                     KSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPK
                     QMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGR
                     VSVPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL"
     exon            1551..1780
                     /gene="ANKRD50"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..5331
                     /gene="ANKRD50"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..8798
                     /gene="ANKRD50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8338..8343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD50"
                     /note="hexamer: AATAAA"
     regulatory      8342..8347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD50"
                     /note="hexamer: AATATA"
     polyA_site      8360
                     /gene="ANKRD50"
                     /note="major polyA site"
     polyA_site      8363
                     /gene="ANKRD50"
                     /note="major polyA site"
     regulatory      8767..8772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD50"
                     /note="hexamer: AATAAA"
     polyA_site      8798
                     /gene="ANKRD50"
                     /note="major polyA site"
ORIGIN      
        1 agttactgcc ctgacggcgg cggcggcggc ggttggccgg tgggggctgg ggcgagcacg
       61 accgattctg ctgggaaagc tggaactggc agccgccggg ggccaagagg aggatccgga
      121 gctgggagcg tgccccgggc ccggcggagg aggcggctgc agttggagtg gagtcttggg
      181 agcgctgctg gcagcgactt ctcagcgaag caagtgtctg agactgagag tccctaacag
      241 cggcagcggc ggccacggcg gcggctgggg ccgagttact tgtggaaatt gttgattacc
      301 cggacgtctt aaaaccaaga aacctgtgaa caggttcatt aagaatctgc tgtcttgaaa
      361 aatgcatatt atgaatgctt tgaattaaga aggtgttaac agtggttgtc atttctgcca
      421 cataagagac tataatctga aacagttcct ggcagttgcc cagatgcctg aaactggcac
      481 gatctagtac tcttgagtga tcatccttca acgagaaata cagagctact tacatactgt
      541 acctcatacc gtataaatgt aatctctctg atgccattta atgcagtgga cctcttttca
      601 gaatctaatt gtcagatgca gaattaacac ttggaatctg gagaagcatt ttgtacaaat
      661 tgaaagattg ggttttttct ttagttttcc acatgtattg tctcatctct gttcttgaaa
      721 catccacaat cacataaact ccagttataa ccatggagtt atgtgactca ttaaaattta
      781 ggaaaagtgt tgctgagctg tggaatcagg cgtttctccc tcagttcaac aactaataca
      841 tagactgctg atcaagaata aggaaccaaa taaagtcatg cacgttctgt tgacagagga
      901 actctgtggc tgttgaattt tactgtaact agttactctg tcttcagagt caacttaata
      961 tacaagttat gtcataatgg atggaaagac ctgtgttgat gtatccagac tctagcaaat
     1021 gaagataaaa aacccgttat gactaatcct tgggaagaga aagtctgcaa aatggctcaa
     1081 accagtttac tgcaagggaa gcagttttac tgtagggagt gggttttcca caagcttcag
     1141 cattgcctcc aggagaaaag taactgctgc aatagtgctg tcaatgcacc atcacttgta
     1201 atgaattctg ggaataatgc tagtggtgtc tctggaaagg gagctgcctg gggtgtgttg
     1261 ttggtaggag ggcctggcag tggcaagacg gccctatgta ctgaactctt atggccaagt
     1321 tcacctgcaa gtttgcagag aggtttacat cgccaagctt tggcctttca tttctgcaaa
     1381 gcccaggact ctgatacttt gtgtgttgga gggtttatta gaggtctagt agcccagatc
     1441 tgccgcagtg gactactcca aggatatgag gacaagctaa gggatccagc agtccaaagc
     1501 ctcttacagc ctggggagtg cgagagaaac ccagccgaag catttaaaag gtgtgttcta
     1561 ctccctcttc tgggaatgaa gcctccccag caaagcctat acctgcttgt tgattctgtt
     1621 gatgaagggt gtaacattac tgaaggtgaa caaacgtcta ccagcttatc tgggactgtt
     1681 gcagcacttt tagctggtca ccatgagttc tttccaccat ggctattgct tctctgttct
     1741 gcccgaaagc agagtaaggc tgttactaaa atgtttactg gttttcgaaa aataagttta
     1801 gatgaccttc ggaaggcata tatcgtcaag gatgttcagc agtacattct tcatcgttta
     1861 gatcaagaag aagctttgcg acaacacctc acaaaagaaa ctgcagagat gttaaatcaa
     1921 ctgcacatta aaagcagtgg atgctttctt tacctagaac gagttttaga tggagttgta
     1981 gaaaatttta ttatgttaag agaaattcgt gacatcccag gaactctaaa tggtttatat
     2041 ctctggctgt gccaaagact ttttgtaaga aaacaatttg caaaggttca gcctattttg
     2101 aatgtgattc ttgcagcctg ccgacctttg accataacgg aattatatca cgcagtatgg
     2161 accaaaaaca tgtcgttaac tttggaagat tttcaacgca agttagatat cctctccaaa
     2221 cttcttgttg atggactagg aaatacaaaa atactgtttc attatagttt tgccgagtgg
     2281 cttctggatg tgaaacactg tactcagaag tatttatgta atgcagcaga aggacacaga
     2341 atgttggcta tgagttatac ctgtcaagcc aagaatttaa caccattgga agcacaagaa
     2401 tttgcattgc acttaattaa ctcaaactta caattagaga cagcggagtt agctctgtgg
     2461 atgatatgga atggtacacc tgtcagagat tccctttcta ctttgatacc caaggaacaa
     2521 gaagtgctac agctgttggt taaagctggg gctcatgtca acagtgaaga cgatcgcaca
     2581 tcatgcatag ttcgacaagc cttagaaaga gaggattcca ttcggacatt attagataat
     2641 ggagcttcag taaatcagtg tgattcaaat gggagaacat tattggctaa tgctgcatat
     2701 agtggcagtc ttgatgtagt caatttactt gtctctaggg gagcagattt agagatagaa
     2761 gatgctcatg gacatacacc actcactcta gcggctagac agggacatac caaggtggtt
     2821 aattgtttga ttgggtgtgg agcaaatatt aatcatactg atcaagatgg ttggacagca
     2881 ttaagatctg ctgcttgggg tggccatact gaggtagttt ctgcactact ttatgctggc
     2941 gtaaaagtgg attgtgcaga tgctgatagc cgaacagctt tgagagcagc agcatgggga
     3001 ggacacgagg atattgtact gaatttgcta caacatggcg ctgaagtgaa caaagctgat
     3061 aatgaaggta gaactgcttt gatagcagca gcatacatgg gacatagaga gattgtggaa
     3121 cacctactgg accatggagc agaagtaaat catgaggatg ttgatggcag gactgcactc
     3181 tctgtagctg cactttgtgt gcctgcaagt aaagggcacg catcagttgt tagcctttta
     3241 attgatcgag gtgctgaagt agatcattgt gataaagatg gcatgactcc actgctggta
     3301 gctgcctatg aaggacatgt tgatgtggtt gacttgcttc tagaaggggg agcagatgta
     3361 gatcacacag ataacaatgg ccgtacaccc ctcttagcag cagcgtctat gggtcatgca
     3421 tcagttgtaa atacactttt gttttggggt gcagctgtgg atagtattga tagtgaaggt
     3481 aggacagtcc tcagtatagc ttcagcacaa ggaaatgttg aggtggtacg tactctactg
     3541 gatagagggt tagatgaaaa tcacagagat gatgctggat ggacaccttt gcacatggca
     3601 gcttttgaag ggcacagatt gatatgtgaa gcacttattg aacaaggtgc tagaacaaat
     3661 gagattgaca atgatggacg aatccctttc atattagctt cacaagaggg tcattatgat
     3721 tgtgttcaaa tattactgga aaacaaatcc aacattgatc aaagaggtta tgatggaaga
     3781 aatgcactgc gggttgctgc attagaaggg cacagggaca ttgttgaatt gctttttagc
     3841 catggtgctg atgttaactg caaagatgct gatggtcggc ctacacttta tatcttggcc
     3901 ttagaaaatc agcttacaat ggccgaatat tttttagaaa atggtgcaaa cgtagaagca
     3961 agtgatgctg aaggaaggac agcacttcat gtgtcttgtt ggcaaggcca tatggaaatg
     4021 gtgcaggtcc tgatagcata ccatgctgac gtcaatgctg cagacaatga aaagcgctct
     4081 gctttgcagt ctgcagcctg gcagggccat gtaaaagtgg ttcagcttct gattgagcat
     4141 ggtgctgtag ttgaccatac atgtaaccaa ggtgcaactg cactctgtat tgcagcccag
     4201 gaagggcaca ttgatgttgt tcaggtctta ttagagcatg gtgctgatcc aaaccatgct
     4261 gatcaatttg gacgcactgc tatgcgtgtt gcagccaaaa atggacattc tcagataatt
     4321 aaattattag aaaaatatgg tgcatctagt ttgaatggct gttccccatc tcctgttcac
     4381 acaatggagc aaaaacctct acagtcattg tcttcaaaag tgcagtcatt aacaattaaa
     4441 tcaaatagct ctggtagtac tggtggaggg gatatgcagc cttcgttacg tggtttacct
     4501 aatgggccta ctcatgcttt tagttctcct tcagaatctc cagattctac agttgaccgg
     4561 cagaagtcat cactgtcaaa taattccctg aaaagctcaa aaaattcatc tttgagaact
     4621 acttcatcta cagcaacggc tcaaacagtg ccaattgata gctttcataa cttgtcattt
     4681 acagaacaaa ttcagcagca ttcattgcca cgcagtagaa gtcgacagtc aattgtttcc
     4741 ccatcttcca caacacagtc cttaggacag agtcataatt caccaagtag tgaatttgag
     4801 tggagtcaag taaagcccag tttgaagtca actaaagcaa gtaaaggggg gaaatcagaa
     4861 aattctgcca agtctggatc agctgggaaa aaagcgaaac aaagtaattc ttcacagcca
     4921 aaggttttag aatatgaaat gactcagttt gatagaagag gacctatagc caaatccggg
     4981 actgctgcac cacctaaaca aatgccagca gaatctcaat gcaaaattat gataccttca
     5041 gctcagcagg aaattggtcg atctcaacag cagtttctta ttcaccaaca aagtggggaa
     5101 cagaagaaga gaaatggaat aatgacaaat ccaaattatc atcttcagag caaccaggtt
     5161 tttcttggta gggtttcagt cccacgaaca atgcaagata gagggcatca ggaagtgttg
     5221 gagggatacc cttcctcaga gacagaatta agccttaaac aagctctgaa gcttcagatt
     5281 gaaggttctg accctagctt caactataaa aaggaaacac cattataaaa gtttcctatt
     5341 ctgtgaaaca gaagacattg tgatggagtg gttcttcagc tactggatgg aaacatatgc
     5401 ctgttgattt gctgaaaaaa caaaaaaaat gaagaatgtg atctctgcag tacagttacc
     5461 ttaattactg taatgtgcct aaatagtaag gctgccttct caatgtaacc ctctgtgctt
     5521 aaaaaatttc attttgtgtg ctttgtattc actacacagg aataagcact ttttaaaaat
     5581 gcagatacat actgcagttc cctgataaaa gctgaaaaga aaatttgagt attttaagtt
     5641 aagatgtgat aaaaaatgtg catgtgccat aatcaaatat atatgaaaag gcagtgttcc
     5701 ttgtatttat ttttttttct ttttgtggca aaagaaactt aaacatactg tttcagtcac
     5761 attgcattgt agtgtatggc ctgtttcttg tatctttaaa gacgttgctc aataaaacaa
     5821 atcttgcaac tgttctatgt tcactacacc ttcagcattg gataaaaatc attttctata
     5881 taaatatcac attgaaatga aaaaatgatt tcttggcagt ttaaaaaaaa tattttatag
     5941 tagtttaggg agctgcttta agtagtttaa atctggattt tcccagtaga attcttctca
     6001 tctctggcta aacatgtcag aacaaacaac caaccagtct gtaggcagaa caaagtccta
     6061 tttcatccgc tgggatacaa tttcatcttc cattcacttt gtcattccac ctctaagaag
     6121 acagactatc attcctgagg catgaaaatt ctcagggaca aagccatgcc tcagtcacat
     6181 gtgtgtgcag agagaaatgc acctgtctat ctaagggtag atttttgatc cctgaataat
     6241 tcattgacta aactgacctc ttcctcctgg ctaaataaat taattttgct ggcttctctc
     6301 tcagcggttt ctattttgta aattgctgca tgaccaaaat agccccactc aaaatcaatt
     6361 ggattaattt taatggtttg gttggatgaa tattctggat gaatataaaa tgtgctgccc
     6421 ttcacagatg acaccactcc cctgtcaatc atagcacatg tgtacttttt attgttactt
     6481 aatagtgatg gatttgcact tttctatcct catactcttt cctgttttct tctttgtaca
     6541 attgcatgca ggagggctgg atgccagggt taagagagaa attcatgaca aggaaggtaa
     6601 aattggttca aatgagcatg tgtcccacag ccttagtctc cttactctta aatcagtgga
     6661 gctgtagctt agatgggtcg tttatatgtc tggaaaagtt gtcataacag tttagaagcc
     6721 aaggttgtgg atttgatctt agaatgggcc tgttaatctt atagaaccca gaaattctgt
     6781 tcttttcatg tactgttgat gaggaatgag gaaagagaat ttggagattc agcacaaaac
     6841 cattgctact tctagaacaa aatctttaga atatgtccta ataacaaagg tcagtaatgt
     6901 catcttcata tatgaaggac acatgtgata cattgttcgt ggaaatagaa atgtataatt
     6961 atgataaatg tttcacttga atcttattgt aaggcttttc ttgcttttat tttttaaagt
     7021 cagcaaaact cattttgtct gtcatctata agtcatagtg aggactacga gataagttga
     7081 taagttcaat tgatattaag gtgacatggc aatattaata actcaaatgt gaatgtttca
     7141 agtattgaat tcttgtccct atgggacatt tattaaataa aattaatggg actcttgcaa
     7201 agtagcctta aaagtgttaa tgagtctatt aataaatatg aacacatact attattagaa
     7261 ccaactttac tcatatctca aatacagtac atttacatta ctgtagagga tgaagctcta
     7321 atttctatta catgtaattt tctttagaaa gagaaccctg aaagctgcca gtttttctat
     7381 taactttgaa ttattgaaat tgtatttatt taattttatt gtttttacaa aattgcacct
     7441 tgtgtccaaa gggcgaagat atgacattgc ataagggatt tatgtttttc aaagagctaa
     7501 ctgttttcat atccatacta tatacacttg aagcaattgg taggaagaga acctattgga
     7561 aaaatacgat tttcaaaagt aagtattcct cgggatgttt ttatataaat tatgttttgg
     7621 aatagaacat aaatgacttt gagttaggat aaggatgata ggatgggtgc tggagatgcc
     7681 ctgccttgct tatttgtttc tgtgggggat ttaatactat aaatgaaaat ggcttctgct
     7741 ccattaaaaa gtaaaaattg tcctccaaat ataaaactcc ttaatagata tttttgaaat
     7801 taaaatcttt aaattttata aatcagctgt tgccactaca caactatgat ggcatgtgct
     7861 tataacattt ttataacatt ccgtctgtgt ctattcccta aatatcatga gtttataata
     7921 aggaaagtga taaaaataca gtaatgaaat aaaaatctga atgtttctaa gaaaggtttt
     7981 ggaaggaaaa atgacctgaa atcagtgcgt actgcaaagt acagccaata atttttgttc
     8041 tttgttttca cccccaccct cactggaatt ctcaccaaaa atagtttgat acttaaaaaa
     8101 cagaagtaaa tacttttctc aatattgttt tggctatgca aatatttgtt ttgcttaatg
     8161 tcctccattt acacttctca gcaaatgtag ttgcaaacaa atgctttctt tttatttttc
     8221 ccttggtttg aggtatgtaa atagccaaaa atgtacattg aatttcacat tgtaaaagtt
     8281 ttattttatc ccttgtatga tattactcaa aaaatccctg tgtatatgaa agtgcataat
     8341 aaatatattt gctttacaga gaagatcttg ttttaatttt gtccttgaac cagtagaaca
     8401 tgcatgatat gcatatagca taaacaactg ttagttgttt taagttatta tcttaaataa
     8461 atcctgagca aatgaatttg gaaacatttt gcaaagaaga aagtgaaata taacactgtc
     8521 caaaggaagg tagaaaaaca aagatttact gtttatgtct tcctaagcct ttttaaagac
     8581 ttaatgttct tttccccccc gtgactgatt atatactata tcacaccatg tcaggttttg
     8641 tgcctctgag aattgcagta atccaataac ttttgtatat gtgtgctcct tgatcatcag
     8701 aatattatgg ccatcttatg gcggatattt tgggagttta ttgcaaacat ggtcattcat
     8761 tttctaaata aaatttgtgt gtttcttcac tcagtaaa
//
