LOCUS       NM_001270377            2649 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 46 (ANKRD46), transcript variant
            1, mRNA.
ACCESSION   NM_001270377
VERSION     NM_001270377.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Cheng,L., Wang,P., Yang,S., Yang,Y., Zhang,Q., Zhang,W., Xiao,H.,
            Gao,H. and Zhang,Q.
  TITLE     Identification of genes with a correlation between copy number and
            expression in gastric cancer
  JOURNAL   BMC Med Genomics 5, 14 (2012)
   PUBMED   22559327
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2649)
  AUTHORS   Yan,L.X., Wu,Q.N., Zhang,Y., Li,Y.Y., Liao,D.Z., Hou,J.H., Fu,J.,
            Zeng,M.S., Yun,J.P., Wu,Q.L., Zeng,Y.X. and Shao,J.Y.
  TITLE     Knockdown of miR-21 in human breast cancer cell lines inhibits
            proliferation, in vitro migration and in vivo tumor growth
  JOURNAL   Breast Cancer Res 13 (1), R2 (2011)
   PUBMED   21219636
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2649)
  AUTHORS   Li,J., Mahajan,A. and Tsai,M.D.
  TITLE     Ankyrin repeat: a unique motif mediating protein-protein
            interactions
  JOURNAL   Biochemistry 45 (51), 15168-15178 (2006)
   PUBMED   17176038
  REMARK    Review article
REFERENCE   5  (bases 1 to 2649)
  AUTHORS   Mosavi,L.K., Cammett,T.J., Desrosiers,D.C. and Peng,Z.Y.
  TITLE     The ankyrin repeat as molecular architecture for protein
            recognition
  JOURNAL   Protein Sci 13 (6), 1435-1448 (2004)
   PUBMED   15152081
  REMARK    Review article
REFERENCE   6  (bases 1 to 2649)
  AUTHORS   Tkatchenko,A.V., Pietu,G., Cros,N., Gannoun-Zaki,L., Auffray,C.,
            Leger,J.J. and Dechesne,C.A.
  TITLE     Identification of altered gene expression in skeletal muscles from
            Duchenne muscular dystrophy patients
  JOURNAL   Neuromuscul Disord 11 (3), 269-277 (2001)
   PUBMED   11297942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA503253.1, AK095235.1,
            AP000424.3 and AB077205.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001270377.1.
            
            Summary: This gene encodes a protein containing multiple ankyrin
            repeats. Ankyrin domains function in protein-protein interactions
            in a variety of cellular processes. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) encodes the shorter protein
            (isoform 1). Variants 1, 2, and 3 encode the same protein (isoform
            1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060843.1, SRR3476690.1082506.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335659.7/ ENSP00000335287.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DA503253.1         28-65
            39-84               AK095235.1         41-86
            85-85               AP000424.3         101746-101746       c
            86-405              AK095235.1         88-407
            406-406             AP000424.3         98077-98077         c
            407-982             AK095235.1         409-984
            983-2649            AB077205.1         1113-2779
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..2649
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /note="ankyrin repeat domain 46"
                     /db_xref="GeneID:157567"
                     /db_xref="HGNC:HGNC:27229"
     exon            1..49
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /inference="alignment:Splign:2.1.0"
     exon            50..152
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /inference="alignment:Splign:2.1.0"
     exon            153..490
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..866
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 46; ankyrin
                     repeat small protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 46
                     isoform 1"
                     /protein_id="NP_001257306.1"
                     /db_xref="CCDS:CCDS6287.1"
                     /db_xref="GeneID:157567"
                     /db_xref="HGNC:HGNC:27229"
                     /translation="MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSR
                     GRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKID
                     ICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAME
                     SHSLLNPNLQQGEGVLSSFRTTWQEFVEDLGFWRVLLLIFVIALLSLGIAYYVSGVLP
                     FVENQPELVH"
     exon            491..649
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /inference="alignment:Splign:2.1.0"
     exon            650..2649
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /note="hexamer: AATAAA"
     polyA_site      2649
                     /gene="ANKRD46"
                     /gene_synonym="ANK-S; GENX-115279"
                     /note="major polyA site"
ORIGIN      
        1 accgcctcct tgaagctgcc gctgtcgctg ctgctcgttc gagtcgcaga tccttgccag
       61 cacattacag aatatttttg ttgaaccttc ttgagaattc agagaaactg ctgagtgacc
      121 actgaacgaa aagatctaat cttaaggctt acgcgtgttc catccaccac atcagaacaa
      181 tgtcgtatgt ttttgtaaat gattcttctc agactaacgt gcccttgctg caagcctgta
      241 ttgatgggga ctttaattat tccaagcggc ttttggaaag tggctttgac ccaaatattc
      301 gtgacagcag gggcagaaca ggccttcacc ttgcagcagc tcgagggaat gtagacatct
      361 gccagttact gcataaattc ggtgccgatc ttctggccac agattatcaa ggaaacacag
      421 ctcttcacct ctgtggccat gtggatacta tccaattttt ggtttccaat ggactcaaaa
      481 ttgatatttg caatcatcaa ggtgctaccc ctttagttct ggcaaagcgc agaggagtaa
      541 ataaagatgt catccgattg ctggaatctt tggaagaaca ggaggtgaaa ggatttaaca
      601 gaggaaccca ctcgaaactg gagaccatgc aaacagctga gagtgaaagt gccatggaaa
      661 gccattcact cctcaatccc aacctgcagc aaggtgaagg agtcctctcc agcttccgaa
      721 ccacgtggca ggagtttgtg gaggatctgg gcttctggag agtattgctg ttgatcttcg
      781 tcattgcttt gctgtctctt ggcattgctt attatgtgag tggggtgcta cccttcgtgg
      841 aaaaccagcc tgaactggtg cattaaagga gctcatggaa gatgaggcaa ttaattgcct
      901 gtttcctggc ttccaatgtt tgttctcagt ttctcagaat ttttcttagc gcaaagcagt
      961 gagggcagta catgttcttt ttgcattttt aattattgta atccttttag ataatgatgt
     1021 gttcatttga actaactaca tactatgatc aagtatattg catcctaacg ctacctctga
     1081 ctcaacctga ctttgtagga aagcctacac gtagccttgt ttgataaaaa cacggaagtg
     1141 actagagaat ggaagataaa ggaagaagct aggaagtcct tgctatcaaa accttatcct
     1201 aatataggac caattgaagt attcaaaaag aaaaacagta tcttatatga ttagtttttg
     1261 ttggtggttt tgttttcatt tatttttgca agagccactt tttatttact ttctctaggg
     1321 ataagagata aaacttgaag tacttttttc aaatcttgtg tgcaaattag tattgttagc
     1381 atctatttgg cttattttag tatttttaag tctagtcaca aaccaaacaa aacttttgaa
     1441 aatgagctat attttgttca aagataattg atttgatctt atatttattt gtttttagga
     1501 taatttttga tctttttgta aactgctttg cttgttaata tctgtgaaaa ataaatgagt
     1561 tcattttgtt cactttccaa ttttcccgag tatcctagtc atcaaagata acagttcatc
     1621 agaattacag tcagaaaatc ctttttctac tgaatagtta gcagggaaaa ataattctga
     1681 tatttaactg tcataattct gtagtgctat tatagtgaaa aactcagttc tataagctag
     1741 ctgtgttgtc acagttttat catagttcat aattatttca tgtgcaatcc tatttggagg
     1801 ccctgttaga cttttaacaa tcccatccat atctgtaatt ctctgatggc aagaatggat
     1861 ggagcatttc tgagttaaca gtgctggaca gtatcgtact gggtgtcata aactctttat
     1921 gaatggtaat attatgtaaa ttgaaatctg gccctcaaac tatattgcag ctttcagcag
     1981 tatgtttgaa ggcctctttt gttaatgatt ctgtaatgta tgaattatgt tcttgagtgg
     2041 ttaaaaaaga atatgaaggc ttgataatta tttattgggt aaagtcagga aattgtagtg
     2101 aaagaactaa tggttttgtt ttttggaata aaggcaccta agctattgct aattgaattg
     2161 ctgctagaat tagaaattat gctttagaat agaattggta tttctgtgat tctttttgct
     2221 tcttggtatt ttctcttgta tctatgtatc tagtattgag gcttgctctt tcatgtggct
     2281 ttatcctctc tttaatagct gttgtaaaat tcctgagtaa ctggctgctt caggatcagc
     2341 ttgcagagtc ttgcttttag gttagataca aacaaagtaa atcatagttg gtgtaaatcc
     2401 agcaaaaaac agctggcttt ggaatggaga acactacaat tcaaatttga agtatattca
     2461 gaagaaaact ttggaattag ctttacattt gtttgtaaat ctaaacaaat atgcaaaatt
     2521 ggtcaaaatg taagtatata gcatttttaa agattaatgg ttccttttat gtgctgattt
     2581 ctttgtattc tgttctctgc attcatcatt caggaatacc accaataaat gtatttatat
     2641 atcccttaa
//
