LOCUS       NM_198493               2660 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 45 (ANKRD45), transcript variant
            1, mRNA.
ACCESSION   NM_198493 XM_290882
VERSION     NM_198493.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Kang,Y., Xie,H. and Zhao,C.
  TITLE     Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell
            Proliferation
  JOURNAL   Genes (Basel) 10 (6), 462 (2019)
   PUBMED   31208154
  REMARK    GeneRIF: we show that the distribution of ANKRD45 protein was
            highly dynamic during mitosis. ANKRD45 is preferably localized to
            the midbody ring during cytokinesis. Together, our results suggest
            that Ankrd45 is a novel ankyrin repeat protein with a conserved
            role during cell proliferation in both zebrafish embryos and
            mammalian cells
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC126355.1, AK127170.1 and AL139142.10.
            
            On May 17, 2019 this sequence version replaced NM_198493.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127170.1, SRR1803611.300185.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333279.3/ ENSP00000331268.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1045              BC126355.1         12-1056
            1046-1987           AK127170.1         1057-1998
            1988-2581           AL139142.10        134282-134875       c
            2582-2660           AK127170.1         2592-2670
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..2660
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /note="ankyrin repeat domain 45"
                     /db_xref="GeneID:339416"
                     /db_xref="HGNC:HGNC:24786"
                     /db_xref="MIM:618712"
     exon            1..35
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /inference="alignment:Splign:2.1.0"
     exon            36..378
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..851
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /note="cancer/testis antigen 117"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 45"
                     /protein_id="NP_940895.1"
                     /db_xref="CCDS:CCDS1309.1"
                     /db_xref="GeneID:339416"
                     /db_xref="HGNC:HGNC:24786"
                     /db_xref="MIM:618712"
                     /translation="MESEGPPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPAL
                     TGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN
                     LNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVE
                     FLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEAS
                     INELFEQRQQLEDIVTPIFTKMTTPCQVKSAKSVTSHDQKRSQDDTSN"
     exon            379..546
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /inference="alignment:Splign:2.1.0"
     exon            547..641
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /inference="alignment:Splign:2.1.0"
     exon            642..780
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /inference="alignment:Splign:2.1.0"
     exon            781..2660
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /note="hexamer: AATAAA"
     polyA_site      1435
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
                     /note="major polyA site"
     polyA_site      1668
                     /gene="ANKRD45"
                     /gene_synonym="CT117"
ORIGIN      
        1 gctatggtaa ccgaggaggc cggggcccgg gtgtggtatt tttggagtta atggagtcag
       61 aaggacctcc agagtcagag agttcagaat ttttctcaca gcaagaagag gaaaatgaag
      121 aagaagaagc ccaagaacca gaggaaacag gccctaagaa ccccctttta caacctgctc
      181 tcacagggga tgtagagggt ttgcagaaga tatttgagga tcctgagaat cctcatcatg
      241 aacaggccat gcagcttctc ttagaagaag acatcgttgg gagaaatttg ttgtatgcag
      301 cttgcatggc tgggcaaagt gacgtgatta gagctttggc aaaatatggt gtgaatctga
      361 atgaaaaaac caccagaggg tacacactct tacattgtgc tgcagcctgg ggtcgtttgg
      421 aaactttgaa agcactggta gaactggatg ttgatataga agctttgaac ttccgggaag
      481 aaagggctcg agatgttgct gctagatatt ctcagactga gtgtgttgaa ttcctggact
      541 gggcagatgc aaggctgact ctgaaaaaat atattgcaaa agtctcttta gctgttactg
      601 acacagaaaa gggatcaggg aaactcctta aggaagacaa gaataccatc ctcagtgcat
      661 gccgtgcaaa aaatgagtgg ttggaaaccc atacagaagc ttccattaat gagctttttg
      721 agcagagaca acaactggaa gatattgtga ctcctatctt cacaaaaatg actacaccat
      781 gtcaagtgaa aagtgccaaa tctgtaacaa gccatgacca gaagagaagt caagatgata
      841 cctccaactg aacatacgtt ctgtaaaagg ccacattttc ttttagtatc tgaaaggcaa
      901 acctattcat gccatttgaa atcgagaaaa cagatgtggg tttctttaag tatttaagta
      961 caacattaca tcgcccttgt tttgtttgac ctgttcagca tgcttatgtc cggactctgg
     1021 cctcgcctct gctcctccaa gcacagcccc atgtgagttt cacgtgctcc ttcaggaaag
     1081 cacttgggta taaatcattc gtgaagacca tgtggaggct ttaagaacta ctcagagaat
     1141 ctaataattt tctgtgtaat tgaggcattc catataaaag gacatatttg gctatttcca
     1201 gagaaaaaat ttgttctccc tgcctaaaaa ggaaatctta tggaatgaca cttggagcaa
     1261 ggaaatatta agaccagctt ggattaggag cctctgggta caactatcac tttttatgtc
     1321 caaaattaaa tttcacctgt gaggtggggt atacctctga gtaaaacccc tctttatctt
     1381 tgacctcctt ctatctgtaa attaataaac acaaatctgt atagttttat acttagaaga
     1441 gttctcctat tctgtaaggc tggcaataca gatattgtaa ctggactgaa gaccatttcc
     1501 cctcccattc tgttttatat ttcctaggtt ttaagtacga tagttggttt catattggtg
     1561 gtttggaaag ccttttttct aatttattta atcaggcgcc tcaaccttct cttacgttgt
     1621 gactttatgg aaaagtttta tagaaaagaa gatggttttt aaaaagcact tattgttcgt
     1681 tcttatggct ttctcttctt tgtcctgttc tgaaagctag ttttccctta tggggagaag
     1741 gaaaaggaat gggtaattca gtaatacttt gtcagttgac atttatttaa ccatggtttt
     1801 gagataaccc tgttttaaat gtctcccaaa gtttttagtt ttttatcctt ttaatgtatg
     1861 agcaattcag tttcaatttt ttaaagcaaa agaacactgc aataactttc agccaccttt
     1921 ttggccgacc cagtgggtgt ttatggagca gtacaaagaa gacctgtgtt tgctcctttt
     1981 ttttttttac cctccttctc ccttctccct tttcccttcc cttccccttc tccttcctct
     2041 cccttcctct cccttcccct cccttcccct cccttcccct cccttcctct cccttcctct
     2101 cccctcccct cccttcctct cccctcccct cccttcctct cccctcccct ccccctcctc
     2161 ttctctctcc tcctcctctt ccctctccaa ctccttcttc ttcctctctt atctctctct
     2221 ctctctccac ccccgcaacc ttcttgacag ggtctgcctc tcctgcccag gctggaatgc
     2281 agtggagtta tcatgatcat agctcactgt aacctgtaac tcctgcactc aagtgatcct
     2341 cccaccatgc ttgggtaatt gaaaaaataa acatttgcag gctgggtgct ggctcacacc
     2401 tgtaatccaa gaactttggg aggccaaggc aggcggatca cctgaggtca gcggtttgag
     2461 acaagcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa tttagctgta
     2521 tgtggtggca cgtgcctgta atcccagtga cttgggaggc tgaggcagga gaatcacctg
     2581 agcccgggag gtggaggttg cagtgagccg agatcgcacc actgcattcc agcctgggtg
     2641 acagagtgag actccatctc
//
