LOCUS       NM_001195144            6087 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 44 (ANKRD44), transcript variant
            A, mRNA.
ACCESSION   NM_001195144
VERSION     NM_001195144.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6087)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6087)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6087)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6087)
  AUTHORS   Kariuki,S.N., Ghodke-Puranik,Y., Dorschner,J.M., Chrabot,B.S.,
            Kelly,J.A., Tsao,B.P., Kimberly,R.P., Alarcon-Riquelme,M.E.,
            Jacob,C.O., Criswell,L.A., Sivils,K.L., Langefeld,C.D.,
            Harley,J.B., Skol,A.D. and Niewold,T.B.
  TITLE     Genetic analysis of the pathogenic molecular sub-phenotype
            interferon-alpha identifies multiple novel loci involved in
            systemic lupus erythematosus
  JOURNAL   Genes Immun 16 (1), 15-23 (2015)
   PUBMED   25338677
REFERENCE   6  (bases 1 to 6087)
  AUTHORS   Kapoor,M., Wang,J.C., Wetherill,L., Le,N., Bertelsen,S.,
            Hinrichs,A.L., Budde,J., Agrawal,A., Almasy,L., Bucholz,K.,
            Dick,D.M., Harari,O., Xiaoling,X., Hesselbrock,V., Kramer,J.,
            Nurnberger,J.I. Jr., Rice,J., Schuckit,M., Tischfield,J.,
            Porjesz,B., Edenberg,H.J., Bierut,L., Foroud,T. and Goate,A.
  TITLE     Genome-wide survival analysis of age at onset of alcohol dependence
            in extended high-risk COGA families
  JOURNAL   Drug Alcohol Depend 142, 56-62 (2014)
   PUBMED   24962325
REFERENCE   7  (bases 1 to 6087)
  AUTHORS   Couzens,A.L., Knight,J.D., Kean,M.J., Teo,G., Weiss,A.,
            Dunham,W.H., Lin,Z.Y., Bagshaw,R.D., Sicheri,F., Pawson,T.,
            Wrana,J.L., Choi,H. and Gingras,A.C.
  TITLE     Protein interaction network of the mammalian Hippo pathway reveals
            mechanisms of kinase-phosphatase interactions
  JOURNAL   Sci Signal 6 (302), rs15 (2013)
   PUBMED   24255178
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6087)
  AUTHORS   Stefansson,B., Ohama,T., Daugherty,A.E. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 regulatory subunits composed of ankyrin
            repeat domains
  JOURNAL   Biochemistry 47 (5), 1442-1451 (2008)
   PUBMED   18186651
REFERENCE   9  (bases 1 to 6087)
  AUTHORS   Dechamps,C., Bach,S., Portetelle,D. and Vandenbol,M.
  TITLE     The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with
            two components of the cytoskeleton
  JOURNAL   Biotechnol Lett 28 (4), 223-231 (2006)
   PUBMED   16555005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010746.8, AC013264.4 and AC017035.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001195144.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. There are no full-length human transcripts representing
            this variant; the genomic coordinates used for the transcript
            record are predicted based on partial human transcript alignments
            and on full-length homologous transcript and protein alignments
            with mouse NP_001074902.2 and chicken NP_001012933.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.240231.1,
                                           SRR1660807.82774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282272.15/ ENSP00000282272.9
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC010746.8         46194-46396         c
            204-287             AC013264.4         124458-124541       c
            288-366             AC013264.4         84462-84540         c
            367-437             AC013264.4         74027-74097         c
            438-638             AC013264.4         63272-63472         c
            639-726             AC013264.4         62816-62903         c
            727-869             AC013264.4         60085-60227         c
            870-1082            AC013264.4         58767-58979         c
            1083-1161           AC013264.4         48201-48279         c
            1162-1276           AC013264.4         37251-37365         c
            1277-1359           AC013264.4         27385-27467         c
            1360-1423           AC013264.4         26146-26209         c
            1424-1492           AC013264.4         24115-24183         c
            1493-1633           AC013264.4         20804-20944         c
            1634-1714           AC013264.4         19080-19160         c
            1715-1826           AC013264.4         16138-16249         c
            1827-1898           AC017035.6         115498-115569       c
            1899-2100           AC017035.6         103813-104014       c
            2101-2188           AC017035.6         99246-99333         c
            2189-2306           AC017035.6         98108-98225         c
            2307-2523           AC017035.6         95996-96212         c
            2524-2611           AC017035.6         92055-92142         c
            2612-2695           AC017035.6         90721-90804         c
            2696-2841           AC017035.6         89209-89354         c
            2842-2924           AC017035.6         88639-88721         c
            2925-3007           AC017035.6         85681-85763         c
            3008-3099           AC017035.6         83885-83976         c
            3100-6087           AC017035.6         76964-79951         c
FEATURES             Location/Qualifiers
     source          1..6087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..6087
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /note="ankyrin repeat domain 44"
                     /db_xref="GeneID:91526"
                     /db_xref="HGNC:HGNC:25259"
                     /db_xref="MIM:620861"
     exon            1..203
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3158
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /note="isoform A is encoded by transcript variant A;
                     serine/threonine-protein phosphatase 6 regulatory ankyrin
                     repeat subunit B; ankyrin repeat domain-containing protein
                     44; serine/threonine-protein phosphatase 6 regulatory
                     subunit ARS-B"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory ankyrin repeat subunit B isoform A"
                     /protein_id="NP_001182073.1"
                     /db_xref="CCDS:CCDS74619.1"
                     /db_xref="GeneID:91526"
                     /db_xref="HGNC:HGNC:25259"
                     /db_xref="MIM:620861"
                     /translation="MAVLKLTDQPPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTP
                     LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA
                     RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL
                     AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ
                     INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPL
                     HFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC
                     VDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLL
                     SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH
                     FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKE
                     KEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA
                     TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGA
                     SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH
                     IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL
                     HYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFR
                     KFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQ
                     LLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLAC
                     SKGHEKCALLILDKIQDESLINEKNNALQTPLHVAARNGLKVVVEELLAKGACVLAVD
                     ENASRSNGPRSTPGTAVQKEE"
     exon            204..287
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            288..366
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            367..437
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            438..638
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            639..726
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            727..869
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1082
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1276
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1359
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1423
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1492
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1633
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1714
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1826
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1898
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2100
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2188
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2306
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2523
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2611
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2695
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2841
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2924
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3007
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3099
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..6087
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6060..6065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /note="hexamer: AATAAA"
     polyA_site      6087
                     /gene="ANKRD44"
                     /gene_synonym="ARSB; PP6-ARS-B"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcagcc tctcggcggg aggaggcggc ggcggaggag gagcaggggg agggctgtca
       61 aattcgggag ccagattttt tcccttctcc tggcaatccc ttccgcttcc ccggctcccg
      121 gcgtgacatc tgcgggccgg ggacctgcat gtgtgtgcgc gcgaaggagc ggaagaatgg
      181 cagtgctcaa actcaccgac cagccaccat tggttcaggc aatcttcagc ggtgatccag
      241 aggagatccg gatgctcatc cataaaactg aagatgtgaa tactctggat tctgagaaac
      301 gaacccctct tcatgtggcc gcatttctgg gagatgcaga gatcattgaa ctcctgattt
      361 tgtcaggagc tcgtgtaaat gccaaggaca acatgtggct gactccactg caccgggctg
      421 ttgcttccag aagtgaagaa gcagtacagg ttttgattaa gcactcagct gatgtcaatg
      481 caagggacaa gaactggcag acccctcttc atgtggcagc agccaacaag gctgtcaaat
      541 gtgcagaagt gatcattccc ctgctgagca gtgtcaatgt ctccgaccga ggggggcgca
      601 cagccttgca ccatgcggct ctgaacggcc acgtggagat ggtcaattta ctcttggcca
      661 aaggggcaaa tatcaatgca tttgacaaga aggaccggcg tgctctgcac tgggcagcat
      721 acatgggcca cttggatgtt gtagcattgc tcattaacca tggcgcagaa gtgacctgta
      781 aggataagaa gggttatacc cctctgcatg ctgcagcctc caatggacag attaatgttg
      841 tcaagcatct cctgaacctg ggggtggaga ttgatgaaat caatgtctat ggaaatacag
      901 cgcttcacat cgcctgctac aatggacagg atgctgtggt taacgagttg attgactacg
      961 gtgctaacgt gaaccagcca aacaataatg ggttcacccc tttgcatttt gctgctgcct
     1021 ccactcatgg tgctttgtgt cttgaattgt tagtaaacaa cggggcagat gttaacattc
     1081 agagtaaaga tggcaaaagt ccactgcaca tgacagctgt ccatggaagg ttcacacggt
     1141 cacagaccct cattcagaat ggaggtgaaa ttgactgtgt ggataaggac ggcaacactc
     1201 ctctccatgt ggctgcaaga tacggtcatg agcttttgat taacacctta ataaccagcg
     1261 gagctgacac agccaagtgt ggaatccata gcatgttccc tttacattta gctgccctaa
     1321 atgctcactc tgactgctgc agaaagttgt tatcatcggg ctttgaaata gacaccccag
     1381 ataaatttgg aagaacgtgc cttcatgctg ctgctgcagg aggtaatgtg gaatgtataa
     1441 aactcttgca gagcagcgga gcagatttcc ataaaaagga caagtgtggg aggacccctt
     1501 tgcactatgc agctgcgaat tgtcatttcc actgtattga gacattagtg accacagggg
     1561 ccaacgttaa tgaaacagat gactggggac gcacagcttt gcattacgcc gctgcatcag
     1621 acatggatag aaataagact atcttaggaa atgcccatga taattcagaa gaacttgaaa
     1681 gagccaggga gctgaaggaa aaggaagcca cactatgtct agagtttctg cttcaaaatg
     1741 atgcaaatcc atctatccgg gacaaggaag gttacaatag catacattat gctgccgcct
     1801 atgggcacag gcagtgtctg gaattgcttt tggaaagaac aaacagtgga tttgaagaat
     1861 cagattctgg tgctactaag agtccactcc acttagctgc ctacaatggg caccatcaag
     1921 ccttggaagt ccttctgcag tcgttggtgg acctggacat cagggatgag aaaggccgca
     1981 ctgctctgga tctggctgcc tttaaaggac acacagaatg tgtggaagcg cttatcaatc
     2041 agggcgcatc catctttgtg aaagacaatg taaccaaaag aaccccactt catgcctcag
     2101 taattaatgg tcacacactg tgtttacggc tgttgctaga aattgcagac aacccggagg
     2161 cggtcgatgt gaaagatgcc aaaggacaaa caccactgat gcttgcagta gcatatggac
     2221 atattgacgc tgtttcattg ttacttgaaa aggaagccaa cgtagacact gttgacatcc
     2281 taggatgcac agctttacac agagggatta tgacaggaca cgaggaatgt gtgcaaatgc
     2341 tgctggaaca agaagtgtca attctctgta aagattccag agggaggacg cccttgcact
     2401 atgcagctgc tcgtggccac gccacgtggc tgagcgagct gctccaaatg gctctttctg
     2461 aggaggactg ttgtttcaaa gataaccaag gctacacgcc gctgcactgg gcttgttaca
     2521 atggtaatga aaactgtata gaggtacttt tggagcaaaa atgttttcgc aaatttatcg
     2581 gtaatccctt tactccactg cactgtgcaa taatcaatga tcatgggaat tgtgcatcat
     2641 tgctgcttgg ggccatagat tccagtatcg tcagttgtag agatgacaaa ggcaggacac
     2701 cccttcatgc ggcagcattt gctgatcatg tggagtgctt gcagcttctt ctgagacaca
     2761 gtgctccagt gaacgcagta gataattcag ggaaaacagc actgatgatg gctgctgaga
     2821 atgggcaggc aggcgctgtg gatattttgg tgaacagtgc ccaggctgat ctgactgtaa
     2881 aggataagga cttgaataca cccttacatt tggcttgtag taaaggtcat gaaaaatgtg
     2941 ccttgttaat acttgacaag atacaagacg agagccttat taatgaaaaa aataatgcac
     3001 tgcagacacc cctccacgtc gctgcgcgca atggcttaaa ggtggtagtt gaggagttgc
     3061 tggccaaagg ggcctgtgta cttgctgtag atgaaaatgc ttctaggtca aatggacccc
     3121 gttccacacc tggaaccgct gtacaaaaag aagaatgaga ctctttaaaa attatgcaca
     3181 tacacatgca cacatatatg tgtgcgtgtg tatatatata tatatgtgtg tgtgtgtgta
     3241 gttcatcagc cagctacaca tgaggaccaa aatgcttcag tctaaaatgg aagatacaca
     3301 tttttttcct tcaaaatgca agtgagaact gaagtagctt ttttatggag ttaaatgtaa
     3361 tctttctgtg taccagtctt tgttgtattt tatatttctt aggacacaga tttctagttg
     3421 accacttaac atttgtaact gatgatgtgc tgaccttttt tttttttttt gccaaactag
     3481 agaaaatgtc catatacttt tgctgtaaat gtgtttatat ttatttgaaa tgaaacaaat
     3541 ggtgaggaaa catccattat ttgttctcta ttttaattgc tatgtatctt atttagaata
     3601 acaaaaaaaa agtgaaaaaa aaaacacttg accctgggct agccaaaagc ccaagggcca
     3661 aacctagcat ttccactgct aaggtttcca gatgaccctc aggttcttcc gcgttggtta
     3721 gagagggcta cgcatcttct actgctcagc cacagtctgt agccagctta gagcttagaa
     3781 gacattgcag tctggatgcc cttctgcgag atgaaaactc agatgtgtag tggatcatat
     3841 acacaaaggc agcacaaaga aatatctaga aattacccta agtacactga aaagctcaca
     3901 tagtctcagt aacctgatga gaaatgatgg cagtgtgtgg gcacatgtgc caaaaggaga
     3961 aataaaaatc accagctcaa gtgctatttt ctacttgagg aagagacaga aaagaaatgt
     4021 gtcgaattag agcagtactc tctgacgttt tataatgagt tccatttcca ccctggaaat
     4081 tgctatttta tagtgtatgt gagatatttc aaaaataatg ttctatcata tctggatcaa
     4141 agacagataa ctgtattata tttttcatct agctataaaa ctttaatctt actcttaata
     4201 tcctggattt aattaaaact cctgttgggt tcttcacaaa tgagaacttg ttcaaaggat
     4261 ttattgaact ggtattgatt tcactgaaaa ttttccacac caccaccatt gtttttttga
     4321 attcttggtg ttgtgcttcc caccttctgt ccttttcgtt tgtttagaga agatgaattt
     4381 ttaaaaagca gataaattgc taatgagcaa taatgacctt atctttacca aaacactgaa
     4441 aattaagaga ggttcagtgt tgaagaagca caatatgctg cggtgtcttt ttctagaagt
     4501 gaatggaaat cttgctcagt tggcatttca agcaggaaat gaaatgcttg ctttaatggc
     4561 aaagcagcgt taacattttt cctgtcgtgt agcagagagt acaagaatca tttcagcaaa
     4621 gcagtgactc accatgagac gttatctcca tggagctgcg ttttgacttt tcccactctc
     4681 ttactcatag aaggaggaca aaggaacgaa atgaaatcat gctcacaatg aactgttcat
     4741 tacatcaact gatctctctc tctctctctt cctctctttc tctttctccc ataccccaag
     4801 gcaaaatttt tttaaagaaa tgactttaaa aactatcatt tctgtatttt aattacatct
     4861 cttagaaata aaattatgtt tgcaccatag ctttctaaga aaaaaaaatg tgtttttaac
     4921 tgagtcttag ttgcttagtg cttttatttg tgttattttt agactgtatt ttaaccacaa
     4981 ctacaaggat catgtttcat tgcacttact tatttgccag tgtctgcctg tctttgctaa
     5041 atacattact atctccaaat tgcctaaaat ctgctatgat tctacagtaa atagctcagg
     5101 gtatttctat ttatcactac taaaagggca ccatagtatg ttttggtact ttaggcagta
     5161 aacactgctt ggtttatcat tttgttatta aattagaaca agaacatcaa atggatttgc
     5221 tgcactagtt attctttgta ctgttgagca acttggtgtg cttatatgtt gtgttggttg
     5281 aagaactcat ccgttttatt gtcttgtaat atgaagttag agtgcctttt tatatttgta
     5341 tattctgaaa atgttctgtg gaatgttttg tattttttca tttgagtgtt atcagagcaa
     5401 tatgatacca gtgagttttc atttcaactt ttctttgaat gtataaagtg tcttttttcc
     5461 tatttcccct tgtacttgca ttgaaatgaa tatgaaaatg cttaagtttt ctataggaat
     5521 tgtttgattt tgcagtgcta aaatgctttc gtcttacgaa actataaacc ataggtcagt
     5581 attatagggg aaaagcattt taagatagtg acaatctgag tgtttgtata aaatgtaatt
     5641 ctatgcgttt cttatgtgat ctaaaaattc aatgcaaata tcttttattt ggtagttttg
     5701 tctacatatt ttatgctcta gcatgtgcaa tatatctttg taaagcacga tgatacaaat
     5761 ctggtgccag tgttatattt tgcataacat atttgtaaca gcataaaata ttgtttgatg
     5821 atttcagtgg gattttgtct ataatgtttt cttatgtaaa ttggagttga atgactctgg
     5881 taaatgtcat gactgtaaaa atggggaaaa tgacttttag ttcagtgaat gactttgaaa
     5941 caatctgaat cttctcaagc acagtttaat acttttgcaa ctactgaatg ctctaataac
     6001 gtaatgaagt acttaactgt aatatactat ggaaatgcat tcagatggtt atttttacaa
     6061 ataaaaacgg tacaaatatt gttggaa
//
