LOCUS       NM_001300975            3310 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ankyrin repeat domain 42 (ANKRD42), transcript variant
            1, mRNA.
ACCESSION   NM_001300975
VERSION     NM_001300975.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3310)
  AUTHORS   Liu,S., Zhang,Z., Wang,Z., Li,J. and Shen,L.
  TITLE     Genome-wide CRISPR screening identifies the pivotal role of ANKRD42
            in colorectal cancer metastasis through EMT regulation
  JOURNAL   IUBMB Life 76 (10), 803-819 (2024)
   PUBMED   38822625
  REMARK    GeneRIF: Genome-wide CRISPR screening identifies the pivotal role
            of ANKRD42 in colorectal cancer metastasis through EMT regulation.
REFERENCE   2  (bases 1 to 3310)
  AUTHORS   Browne,G.J., Fardilha,M., Oxenham,S.K., Wu,W., Helps,N.R., da Cruz
            E Silva,O.A., Cohen,P.T. and da Cruz E Silva,E.F.
  TITLE     SARP, a new alternatively spliced protein phosphatase 1 and DNA
            interacting protein
  JOURNAL   Biochem J 402 (1), 187-196 (2007)
   PUBMED   17123353
  REMARK    GeneRIF: the cloning and characterization of a new protein, termed
            SARP (several ankyrin repeat protein), which is shown to interact
            with all isoforms of PP1 by a variety of techniques.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000873.5, BC045621.1 and BC171752.1.
            
            On May 17, 2019 this sequence version replaced NM_001300975.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.88923.1,
                                           SRR1660803.215653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533342.6/ ENSP00000435790.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AP000873.5         63804-63830
            28-933              BC045621.1         1-906
            934-2515            BC171752.1         1-1582
            2516-3310           AP000873.5         118269-119063
FEATURES             Location/Qualifiers
     source          1..3310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..3310
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /note="ankyrin repeat domain 42"
                     /db_xref="GeneID:338699"
                     /db_xref="HGNC:HGNC:26752"
                     /db_xref="MIM:619778"
     exon            1..1017
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             960..2543
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     several ankyrin repeat protein; ankyrin repeat
                     domain-containing protein 42; protein phosphatase 1,
                     regulatory subunit 79"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 42
                     isoform 1"
                     /protein_id="NP_001287904.1"
                     /db_xref="CCDS:CCDS76459.1"
                     /db_xref="GeneID:338699"
                     /db_xref="HGNC:HGNC:26752"
                     /db_xref="MIM:619778"
                     /translation="MPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSE
                     IVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAI
                     RGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREW
                     RPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSA
                     TQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGD
                     LGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP
                     SDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVKYFIRHGVEGSTDAKDDLCLSDL
                     DKTDARMRAYKKIVELRHLLEIAESNYKHLGGITEEDLKQKKEQLESEKTIKELQGQL
                     EYERLRREKLECQLDEYRAEVDQLRETLEKIQVPNFVAMVGVLFNTFIFLKKYIQEWP
                     RVQALGWGSLDLNPGYSLF"
     exon            1018..1181
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1289
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1409
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1545
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1746
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1872
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1978
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2154
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2281
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..3310
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /note="hexamer: AATAAA"
     polyA_site      2886
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /note="major polyA site"
     regulatory      3055..3060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /note="hexamer: ATTAAA"
     polyA_site      3073
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
                     /note="hexamer: AATATA"
     polyA_site      3254
                     /gene="ANKRD42"
                     /gene_synonym="PPP1R79; SARP"
ORIGIN      
        1 actcgtttcc aaggcgacgg ccctgctgcc tctccagcca agtggctgga gtcgggaggc
       61 tggaaagaga ctccgagaaa gtaccagcgg aaggcggccg ccgctacggc gattcgcagg
      121 gagtagcaga cgaagacggt ggccgccgca ctagccacca cgtgtggagg ataaacggtc
      181 tacacggcca ttccggcgcc gagtctaggg aaagagttag cgacgacggg gaaagaaaat
      241 gtgaagagag cgaccgccgc tccagggtcg ctgcaggaag cctaagtgca gacgccggct
      301 tctcccgcag tgacttgaga agggtcagtg aaaacctcgg ccactgccgc agcgtctcta
      361 gggagagagt taggggagat agtggccaca gtcacagctg ctcttgggag agagttaggg
      421 gagacagcac cttctgcagc agcgacgtga attttagtga agttggaggc caccaaacta
      481 ccgactccag gggaacagcc agagaagacc gaggcctccg cctcagtggt ccttgggagg
      541 gagtcagtga cattcgggac ccgcgaacta gtgacttcgg ggatagagtc agtgacgatc
      601 gcagtcgccg cttcagtggc tcctgggagg gagggagtgt cgaaggcggc cacagcgttg
      661 gtagttcttg ggaggaagta agtggagacc gcggctacgc agccagcgac tcctctggtg
      721 tgagcggcag tgaagacgcc agctaccgct tcagtggctt ttgggagaga gaaagtgaag
      781 acgaaggttt ccgctgcagc ttctgggaga gagcaagaga ggaccttggg ccccgtccta
      841 gtgacgacgg agaagagggc cgctgccgct gcagtggctc gtgggtgaga gcaagtgaag
      901 accgccgcag catcaggggc ctggactcaa ctcctcccca gagtcggagg tgttgcgcca
      961 tgcccggggt ggccaattca ggcccctcca cttcctctag ggagactgca aacccctgtt
     1021 ccaggaagaa ggtgcatttt ggcagcatac atgatgcagt acgagctgga gatgtaaagc
     1081 agctttcaga aatagtggta cgtggagcca gcattaatga acttgatgtt ctccataagt
     1141 ttaccccttt acattgggca gcacattctg gaagtttgga gtgtcttcat tggctgctct
     1201 ggcatggagc tgatatcaca cacgtaacaa cgagaggttg gacagcatct cacatagctg
     1261 caatcagggg tcaggatgct tgtgtacagg ctcttataat gaatggagca aatctgacag
     1321 cccaggatga ccggggatgc actcctttac atcttgctgc aactcatgga cattctttca
     1381 ctttacaaat aatgctccga agtggagtgg atcccagtgt gactgataag agagaatgga
     1441 gacctgtgca ttatgcagct tttcatgggc ggcttggctg cttgcaactt cttgttaaat
     1501 ggggttgtag catagaagat gtggactaca atggaaacct tccagttcac ttagcagcca
     1561 tggaaggcca ccttcactgt ttcaaattcc tagtcagtag aatgagcagt gcgacgcaag
     1621 ttttaaaagc tttcaatgat aatggagaaa atgtactgga tttggcccag aggttcttca
     1681 agcagaacat tttacagttt atccaggggg ctgagtatga aggaaaagac ctagaggatc
     1741 aggaaacttt agcatttcca ggtcatgtgg ctgcctttaa gggtgatttg gggatgctta
     1801 agaaattagt ggaagatgga gtaatcaata ttaatgagcg tgctgataat ggatcaactc
     1861 ctatgcataa agctgctgga caaggccaca tagagtgttt gcagtggtta attaaaatgg
     1921 gagcagacag taatattacc aacaaagcag gggagagacc cagtgatgtg gcaaagaggt
     1981 ttgcccattt ggcagcagtg aagctgttag aggagctaca gaaatatgat atagatgacg
     2041 aaaatgaaat tgatgaaaat gatgtgaaat attttataag acatggtgtt gagggaagca
     2101 ctgatgccaa ggatgattta tgtctgagtg acttggataa aacagatgcc agaatgagag
     2161 cttacaagaa aattgtagaa ttgagacacc tcctggaaat tgccgagagc aactataaac
     2221 acttgggagg cataacagaa gaagatttaa agcagaagaa agaacagctt gagtctgaaa
     2281 agaccatcaa agaactgcag ggccagctgg agtatgaacg actacgtaga gaaaaattag
     2341 aatgtcagct tgatgaatat cgagcagaag ttgatcaact cagggaaaca ctggaaaaaa
     2401 ttcaagtccc aaactttgtg gctatggttg gtgtcctttt taatacattt atttttctca
     2461 agaagtatat acaagagtgg ccaagagtac aagctttggg ctggggctct ttggacttga
     2521 atcctggcta tagtcttttt tgatttgggc tactcattta acctttttgt gcctcaacta
     2581 taaactggag atgataactt atactttcta gagctgatga caggattaaa ggaatacaca
     2641 cacacacaca cacacacaca cacacacaca cacactctat atgtaactat aactttctag
     2701 atacatacac acatctgtct atctatcttc aaacagcagc ctagttcata agtattattg
     2761 ttaacattgt accatagaag gagaaaatgt tttcataagt aatcaatcag aattctaaga
     2821 cagctagagg atatgtatat tttaatattc taaataacca aaataaagtg ctttgaatgg
     2881 aatccatatt ttctttccat agggaagttt cttcatcaat catcatggat gaattaattc
     2941 tgtttgaggc ttgtgtcacc tcaaatctga tctattaata ttatagaatc ttcctggctt
     3001 ctttttattt tgcacaaact agtcattggt ctctttaata accactttaa aaatattaaa
     3061 ataataaaac atgtttgttg tatagtgtta aaaacaagat agatgttcct tctgacacta
     3121 agttccactc tccagaggaa gctattgtta acaatttagt acataccata ttagacaaaa
     3181 ttctatttat ctgcaaacat gtatgtgtat ttctatgcat atgcaaatat aaccacttcc
     3241 tcagtttctc tgggttttgg tgtctcacca gtggttgatt ttccaagaaa tataattaac
     3301 tataataatt
//
