LOCUS       NM_181726                784 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ankyrin repeat domain 37 (ANKRD37), mRNA.
ACCESSION   NM_181726
VERSION     NM_181726.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 784)
  AUTHORS   Xu,J., Xia,X., Li,Q., Dou,Y., Suo,X., Sun,Z., Liu,N., Han,Y.,
            Sun,X., He,Y., Qin,W., Zhang,S., Banaschewski,T., Flor,H.,
            Grigis,A., Gowland,P., Heinz,A., Bruhl,R., Martinot,J.L.,
            Artiges,E., Nees,F., Paus,T., Poustka,L., Hohmann,S., Walter,H.,
            Sham,P.C., Schumann,G., Wu,X., Li,M.J. and Yu,C.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; IMAGEN Consortia
  TITLE     A causal association of ANKRD37 with human hippocampal volume
  JOURNAL   Mol Psychiatry 27 (11), 4432-4445 (2022)
   PUBMED   36195640
  REMARK    GeneRIF: A causal association of ANKRD37 with human hippocampal
            volume.
REFERENCE   2  (bases 1 to 784)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 784)
  AUTHORS   Benita,Y., Kikuchi,H., Smith,A.D., Zhang,M.Q., Chung,D.C. and
            Xavier,R.J.
  TITLE     An integrative genomics approach identifies Hypoxia Inducible
            Factor-1 (HIF-1)-target genes that form the core response to
            hypoxia
  JOURNAL   Nucleic Acids Res 37 (14), 4587-4602 (2009)
   PUBMED   19491311
  REMARK    GeneRIF: ANKRD37 is a direct HIF-1 target that is highly induced in
            hypoxia.
REFERENCE   4  (bases 1 to 784)
  AUTHORS   Li,J., Ji,C., Zheng,H., Fei,X., Zheng,M., Dai,J., Gu,S., Xie,Y. and
            Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human gene
            containing 4 ankyrin repeat domains
  JOURNAL   Cell Mol Biol Lett 10 (1), 185-193 (2005)
   PUBMED   15809689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY296056.1 and BC088376.1.
            
            On Nov 24, 2018 this sequence version replaced NM_181726.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088376.1, SRR5189661.39315.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335174.6/ ENSP00000335147.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               AY296056.1         157-769
            614-784             BC088376.1         715-885
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..784
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /note="ankyrin repeat domain 37"
                     /db_xref="GeneID:353322"
                     /db_xref="HGNC:HGNC:29593"
                     /db_xref="MIM:619021"
     exon            1..110
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..560
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /note="low density lipoprotein receptor-related protein
                     binding protein; low-density lipoprotein receptor-related
                     protein 2-binding protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 37"
                     /protein_id="NP_859077.1"
                     /db_xref="CCDS:CCDS3841.1"
                     /db_xref="GeneID:353322"
                     /db_xref="HGNC:HGNC:29593"
                     /db_xref="MIM:619021"
                     /translation="MLLLDCNPEVDGLKHLLETGASVNAPPDPCKQSPVHLAAGSGLA
                     CFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQIDLCNKNGQTAED
                     LAWSCGFPDCAKFLTTIKCMQTIKASEHPDRNDCVAVLRQKRSLGSVENTSGKRKC"
     exon            111..263
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            264..355
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            356..559
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            560..784
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      764..769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /note="hexamer: ATTAAA"
     polyA_site      784
                     /gene="ANKRD37"
                     /gene_synonym="Lrp2bp"
                     /note="major polyA site"
ORIGIN      
        1 gcgcattctt acctgtcggg gtgcggcgag tgtctcacct ctctgcactt ccaaggactc
       61 ttgtcatctg ccttaggcgg gaaatgctgt tgctggattg caaccccgag gtggatggtc
      121 tgaagcattt gctggagaca ggggcctcgg tcaacgcacc cccggatccc tgcaagcagt
      181 cgcctgtcca cttagccgca ggaagcggcc ttgcttgctt tcttctctgg cagctgcaaa
      241 cgggcgctga cctcaaccag caggatgttt taggagaagc tccactacac aaggcagcaa
      301 aagttggaag cctggagtgc ctaagcctgc ttgtagccag tgatgcccaa attgatttat
      361 gtaataagaa cgggcaaaca gctgaagatc tcgcttggtc atgtggattt ccagactgtg
      421 ccaagtttct tacaacaatt aaatgtatgc agacaataaa agcaagtgaa caccctgaca
      481 ggaatgattg tgttgccgtg ctcagacaga aacggagtct cggaagtgta gaaaatacca
      541 gtgggaaaag gaagtgctga tgtcacgtgg gttatgaaga agtctgaaga acgccttcat
      601 ttcatgcaaa tctataagct cctgcttttg gctttaccat atgttgtgtc taatctcctt
      661 ctgagaagga cgaaaaactt tcttccaagt gaagatccat ttaagaacac atgtatttac
      721 atgcctataa tatgctggtt gtgtatgctt tgtcttttaa gttattaaag gaacgtctaa
      781 aaaa
//
