LOCUS       NM_001393982            7501 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens ankyrin repeat domain 36C (ANKRD36C), transcript
            variant 2, mRNA.
ACCESSION   NM_001393982
VERSION     NM_001393982.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Basu,M.K., Massicano,F., Yu,L., Halkidis,K., Pillai,V., Cao,W.,
            Zheng,L. and Zheng,X.L.
  TITLE     Exome Sequencing Identifies Abnormalities in Glycosylation and
            ANKRD36C in Patients with Immune-Mediated Thrombotic
            Thrombocytopenic Purpura
  JOURNAL   Thromb Haemost 121 (4), 506-517 (2021)
   PUBMED   33184803
  REMARK    GeneRIF: Exome Sequencing Identifies Abnormalities in Glycosylation
            and ANKRD36C in Patients with Immune-Mediated Thrombotic
            Thrombocytopenic Purpura.
REFERENCE   2  (bases 1 to 7501)
  AUTHORS   Kumar,R., Haugen,J.D., Wieben,E.D., Londowski,J.M. and Cai,Q.
  TITLE     Inhibitors of renal epithelial phosphate transport in tumor-induced
            osteomalacia and uremia
  JOURNAL   Proc Assoc Am Physicians 107 (3), 296-305 (1995)
   PUBMED   8608414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013272.5 and AC073995.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000295246.7/ ENSP00000295246.7
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC013272.5         110971-111283
            314-428             AC013272.5         115589-115703
            429-602             AC013272.5         115871-116044
            603-709             AC013272.5         120433-120539
            710-847             AC013272.5         122010-122147
            848-915             AC013272.5         124606-124673
            916-944             AC013272.5         140248-140276
            945-1017            AC013272.5         140371-140443
            1018-1046           AC013272.5         142128-142156
            1047-1119           AC013272.5         142250-142322
            1120-1148           AC013272.5         144010-144038
            1149-1221           AC013272.5         144132-144204
            1222-1252           AC013272.5         145979-146009
            1253-1319           AC013272.5         148790-148856
            1320-1380           AC013272.5         151387-151447
            1381-1411           AC013272.5         152016-152046
            1412-1478           AC013272.5         154199-154265
            1479-1539           AC013272.5         157621-157681
            1540-1607           AC013272.5         158101-158168
            1608-1647           AC013272.5         161596-161635
            1648-1676           AC013272.5         163780-163808
            1677-1749           AC013272.5         163894-163966
            1750-1778           AC013272.5         167151-167179
            1779-1851           AC013272.5         167269-167341
            1852-1880           AC073995.6         97174-97202         c
            1881-1953           AC073995.6         97007-97079         c
            1954-1982           AC073995.6         95316-95344         c
            1983-2055           AC073995.6         95149-95221         c
            2056-2084           AC073995.6         93454-93482         c
            2085-2157           AC073995.6         93287-93359         c
            2158-2186           AC073995.6         91596-91624         c
            2187-2259           AC073995.6         91430-91502         c
            2260-2288           AC073995.6         89717-89745         c
            2289-2361           AC073995.6         89542-89614         c
            2362-2390           AC073995.6         87827-87855         c
            2391-2463           AC073995.6         87668-87740         c
            2464-2492           AC073995.6         85949-85977         c
            2493-2565           AC073995.6         85790-85862         c
            2566-2594           AC073995.6         84078-84106         c
            2595-2667           AC073995.6         83915-83987         c
            2668-2696           AC073995.6         82210-82238         c
            2697-2769           AC073995.6         82043-82115         c
            2770-2798           AC073995.6         80342-80370         c
            2799-2871           AC073995.6         80179-80251         c
            2872-2900           AC073995.6         78475-78503         c
            2901-2973           AC073995.6         78308-78380         c
            2974-3002           AC073995.6         76604-76632         c
            3003-3075           AC073995.6         76437-76509         c
            3076-3104           AC073995.6         74729-74757         c
            3105-3177           AC073995.6         74566-74638         c
            3178-3206           AC073995.6         72859-72887         c
            3207-3279           AC073995.6         72696-72768         c
            3280-3308           AC073995.6         70988-71016         c
            3309-3381           AC073995.6         70821-70893         c
            3382-3410           AC073995.6         69113-69141         c
            3411-3483           AC073995.6         68950-69022         c
            3484-3512           AC073995.6         67243-67271         c
            3513-3585           AC073995.6         67080-67152         c
            3586-3614           AC073995.6         65372-65400         c
            3615-3687           AC073995.6         65205-65277         c
            3688-3716           AC073995.6         63497-63525         c
            3717-3789           AC073995.6         63334-63406         c
            3790-3818           AC073995.6         61631-61659         c
            3819-3891           AC073995.6         61468-61540         c
            3892-3920           AC073995.6         59767-59795         c
            3921-3993           AC073995.6         59600-59672         c
            3994-4022           AC073995.6         57901-57929         c
            4023-4095           AC073995.6         57734-57806         c
            4096-4124           AC073995.6         56027-56055         c
            4125-4197           AC073995.6         55860-55932         c
            4198-4226           AC073995.6         54151-54179         c
            4227-4299           AC073995.6         53983-54055         c
            4300-4328           AC073995.6         52275-52303         c
            4329-4401           AC073995.6         52108-52180         c
            4402-4430           AC073995.6         50404-50432         c
            4431-4503           AC073995.6         50237-50309         c
            4504-4532           AC073995.6         48530-48558         c
            4533-4605           AC073995.6         48362-48434         c
            4606-4679           AC073995.6         44374-44447         c
            4680-4821           AC073995.6         35375-35516         c
            4822-5035           AC073995.6         27796-28009         c
            5036-5219           AC073995.6         25244-25427         c
            5220-6134           AC073995.6         23201-24115         c
            6135-6287           AC073995.6         21644-21796         c
            6288-6358           AC073995.6         20061-20131         c
            6359-6452           AC073995.6         19629-19722         c
            6453-6482           AC073995.6         19101-19130         c
            6483-7501           AC073995.6         17483-18501         c
FEATURES             Location/Qualifiers
     source          1..7501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..7501
                     /gene="ANKRD36C"
                     /note="ankyrin repeat domain 36C"
                     /db_xref="GeneID:400986"
                     /db_xref="HGNC:HGNC:32946"
     exon            1..313
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..6476
                     /gene="ANKRD36C"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein immuno-reactive with anti-PTH polyclonal
                     antibodies; ankyrin repeat domain-containing protein 36C"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 36C
                     isoform 2"
                     /protein_id="NP_001380911.1"
                     /db_xref="CCDS:CCDS92809.1"
                     /db_xref="GeneID:400986"
                     /db_xref="HGNC:HGNC:32946"
                     /translation="MDDKEPKRWPTLRDRLCSDGFLFPQYPIKPYHLKGIHRAVFYRD
                     LEELKFVLLTRYDINKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPL
                     IKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLLSYGANIEEC
                     SEDEYPPLFLAVSQRKVKMVEFLLKKKANINAVDYLGRSALIHAVTLGEKDIVILLLQ
                     HNIDVFSRDVYGKLAEDYASEAKNRVIFELIYEYERKKHEELSINSNPVSSQKQPALK
                     ATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKGTSDKNDSVSNTATEIKDEQKSGT
                     VSSQKQPALKDTSDKNDSVSNTATEIKDEQKSGTVLPAVEQCLNRSLYRPDAVAQPVT
                     EDEFALESEIISKLYIPKRKIISPRSIEDVLPPVEEAVDRCLYLLDRFAQAVTKDKFA
                     LESENISEPYFTNRRTISQQSAEKLDAACGIDKTENGTLFEDQNVDKEGKALPATGQK
                     ANVSPEQPPLFTHTVKDSDHISTRFLGSMDSLTSSEESSERPPLSTLTLKEADPSSKA
                     AMRRKDSPPPGKVSSQKQPAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKAT
                     SDEKDSVSNIATEIKEGQQSGTVSPQKQSAWKVIFKKKVSLLNIATRITGGGKSGTVS
                     SQKQPPSKATSDKTDSALNIATEIKDGLQCGTVSSQKQPALKATTDEEDSVSNIATEI
                     KDGEKSGTVSSQKQPALKATTDEEDSVLNIATEIKDGEKSETVSSQKQPALKATTDEE
                     DSVSIIATEIKDGEKSGTVSSRKKPALKATSDEKDSFSNITREKKDGEISRTVTSEKP
                     AGLKATSDEEDSVLNIARGKEDGEKTRRVSSRKKPALKATSDEKDSFSNITREKKDGE
                     TSRTVSSQKPPALKATSDEEDSVLSIAREEKDGEKSRTVSSEQPPGLKATRDEKDSLL
                     NIARGKKHGEKTRRVSSRKKAALKATSDEKDSFSNITRERKDGETSRTVSSQKPPALK
                     ATSDEEDSVLNIAREKKDGEKSRTVSSEQPPGLKATRDEKDSLLNIARGKKYGEKTRR
                     VSSRKKAALKATSDEKDSFSNITRERKDGETSRTVSSQKPPALKATSDEEDSVLNIAR
                     EKKDGEKSRTVSSEQPPGLKATRDEKDSLLNIARGKKHGEKTRRVSSRKKAALKATSD
                     EKDSFSNITRERKDGETSRTVSSQKPPALKATGDEEDSVLNIAREKKDGEKSRTVSSE
                     KPSGLKATSDEKDSVLNIARGKKHGEKTRRVSSHKQPALKATSDKENSVPNMATETKD
                     EQISGTVSSQKQPALKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQLAWKATSVKKDS
                     VSNIATEIKDGQIRGTVSSQRQPALKATGDEKDSVSNIAREIKDGEKSGTVSPQKQSA
                     QKVIFKKKVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTS
                     TPAEQDLEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCN
                     CKNVILLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASV
                     LQKRLSEKEEIKSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITE
                     EQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLR
                     LEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNEETLAETIACYSGQLAALTDEN
                     TTLRSKLEKQRESGQRLETEMQSYRCRLNAALCDHDQSHSSKRDQELAFQGTVDKCCH
                     LQENLNSHVLILSLQLSKAESKFRVLETELHYTGEALKEKALVFEHVQSELKQKQSQM
                     KDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQAR
                     CDARVENLQAECRKHRLLLEEDNKMLVNELNHSKEKKCQYEKEKAEREVAVRQLQQKQ
                     DDVLNKRSATKALLDASSRHCIYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKE
                     MEGDAQKLEVENVMMRKIIKKQDEQIERFEKILQHSSLMLQVFES"
     exon            314..428
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            429..602
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            603..709
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            710..847
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            848..915
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            916..944
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1017
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1046
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1119
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1148
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1221
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1252
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1319
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1380
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1411
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1478
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1539
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1607
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1647
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1676
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1749
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1778
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1851
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1880
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1953
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..1982
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2055
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2084
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2157
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2186
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2259
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2288
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2361
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2390
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2463
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2492
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2565
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2594
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2667
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2696
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2769
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2798
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2871
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2900
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..2973
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3002
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3075
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3104
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3177
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3206
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3279
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3308
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3381
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3410
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3483
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3512
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3585
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3614
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3687
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3716
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3789
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3818
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3891
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..3920
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..3993
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4022
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4095
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4124
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4197
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4226
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4299
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4300..4328
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4401
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4430
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4503
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..4532
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4605
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4679
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4821
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            4822..5035
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            5036..5219
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            5220..6134
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            6135..6287
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            6288..6358
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..6452
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            6453..6482
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     exon            6483..7501
                     /gene="ANKRD36C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7479..7484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD36C"
                     /note="hexamer: AATAAA"
     polyA_site      7501
                     /gene="ANKRD36C"
                     /note="major polyA site"
ORIGIN      
        1 gagtctgtgc gaaggtccgt ggacagactg ctttgcctgt tgttgctctt cggaggcggc
       61 gatccccgaa ggcgagctga aatacggctg caggctacaa tttgcagccg accattatgg
      121 atgacaagga gccgaagagg tggcccaccc tcagggaccg cttgtgctcg gatggcttct
      181 tatttcccca ataccccatt aaaccgtatc atctgaaggg gatccacaga gctgtcttct
      241 atcgtgatct ggaggaactg aagttcgttc tgctcacgcg ttatgacatc aataagagag
      301 acaggaagga aaggaccgcc ctacatttgg cctgtgccac tggccaaccg gaaatggtac
      361 atctcctggt gtccagaaga tgtgagctta acctctgcga ccgtgaagac aggacacctc
      421 tgatcaaggc tgtacaactg aggcaggagg cttgtgcaac tcttctgctg caaaatggcg
      481 ccgatccaaa tattacggat gtctttggaa ggactgctct gcactacgct gtgtataatg
      541 aagatacatc catgatagaa aaacttcttt catatggtgc aaatattgaa gaatgcagcg
      601 aggatgaata tccgccactg ttccttgctg tgagtcaaag aaaagtgaaa atggtggaat
      661 ttttattaaa gaaaaaagca aatataaatg ccgttgatta tcttggcaga tcagccctca
      721 tacatgctgt tactcttgga gaaaaagata tagtcattct tcttctgcag cacaatattg
      781 atgtgttttc tcgagatgtg tatggaaagc ttgcagaaga ttatgccagc gaggctaaga
      841 acagagtcat ttttgaacta atttatgaat atgaaagaaa gaaacatgaa gagctttcta
      901 taaatagcaa tccagtgtct tctcagaaac aaccagcctt gaaggctaca agtggcaagg
      961 aagattctat ctcgaatata gccacagaaa taaaggatgg acaaaaatct gggacagtgt
     1021 cttctcagaa acaaccggcc ttgaagggta caagtgacaa gaacgattct gtttcgaaca
     1081 cagccacaga aataaaagat gaacaaaaat ctgggacagt gtcttctcag aaacaaccgg
     1141 ccttgaagga tacaagtgac aagaacgatt ctgtttcgaa cacagccaca gaaataaaag
     1201 atgaacaaaa atctgggaca gtgcttcctg ctgttgaaca gtgtttaaac aggagtctct
     1261 acagaccgga tgctgttgca cagcctgtga cagaggatga gtttgctttg gaatctgaga
     1321 ttatttcaaa actatacatc ccaaagagaa agattatttc tccacgatct atagaagatg
     1381 tgcttcctcc tgttgaagag gctgttgaca ggtgtctcta cctactggac cgttttgcac
     1441 aggctgtgac aaaggataag tttgctttgg aatctgagaa tatttcagaa ccatacttta
     1501 caaacagaag gactatttct caacaatctg cagaaaagtt agatgctgca tgtggcattg
     1561 acaaaacaga aaatggaacc ttgtttgaag accaaaatgt tgataaggaa ggaaaagcac
     1621 taccagcaac tggacaaaaa gcaaatgtgt ctcctgagca accgccttta ttcacgcata
     1681 cggtgaaaga cagtgatcac atttcaacta gattcttagg aagtatggat tcactaactt
     1741 ccagtgaaga atcttctgag cgacctcctt tatccacgct tactctgaaa gaggcagatc
     1801 ccagttcaaa agcagccatg agaaggaagg attcaccacc tccaggaaaa gtgtcttctc
     1861 agaaacaacc agctgagaag gctacaagtg acgacaaaga ttctgtttca aatatagcca
     1921 cagaaataaa ggagggacca atatctggga cagtgtcttc tcagaaacaa ccagctgaga
     1981 aggctacaag tgatgagaaa gattctgttt caaatatagc cacagaaata aaggagggac
     2041 aacaatctgg gacagtgtct cctcagaaac aatcagcctg gaaggttata tttaaaaaga
     2101 aagtttctct tttgaatatt gccacaagaa taacgggcgg tgggaaatct ggaacagtgt
     2161 cttctcagaa acaaccaccc tcaaaggcta caagtgacaa gacagattct gctttgaata
     2221 tagctacaga aataaaggat ggactacaat gtgggacagt gtcttctcag aaacaaccag
     2281 ccttgaaggc tacaactgac gaggaagatt ctgtttcgaa tatagccaca gaaataaagg
     2341 atggagaaaa atctgggaca gtgtcttctc agaaacaacc agccttgaag gctacaactg
     2401 acgaggaaga ttctgttttg aatatagcca cagaaataaa ggatggagaa aaatctgaga
     2461 cagtgtcttc tcagaaacaa ccagccttga aggctacaac tgacgaggaa gattctgttt
     2521 cgattatagc cacagaaata aaggacggag aaaaatctgg gacagtgtct tctcggaaaa
     2581 aaccagcctt gaaggctaca agtgatgaga aagattcttt ttcgaatata accagagaaa
     2641 aaaaggatgg agaaatatct aggacagtga cttctgagaa accagcaggc ttgaaggcta
     2701 caagtgacga ggaagattct gttttgaata tagccagagg aaaagaggat ggagaaaaaa
     2761 ctaggagagt gtcttctcgg aaaaaaccag ccttgaaggc tacaagtgat gagaaagatt
     2821 ctttttcgaa tataaccaga gaaaaaaagg atggagaaac atctaggaca gtgtcttctc
     2881 agaaaccacc agccttgaag gctacaagtg acgaggaaga ttctgttttg agtatagcca
     2941 gagaagaaaa ggatggagaa aaatctagga cagtgtcttc tgagcaacca ccaggcttga
     3001 aggctacaag agatgagaaa gattctcttt tgaatatagc cagaggaaaa aagcatggag
     3061 aaaaaactag gagagtgtct tctcggaaaa aagcagcctt gaaggctaca agtgatgaga
     3121 aagattcttt ttcaaatata accagagaaa gaaaggatgg agaaacatct aggacagtgt
     3181 cttctcagaa accaccagcc ttgaaggcta caagtgacga ggaagattct gttttgaata
     3241 tagccagaga aaaaaaggat ggagaaaaat ctagaacagt gtcttcagag caaccaccag
     3301 gcttgaaggc tacaagagac gagaaagatt ctcttttgaa tatagccaga ggaaaaaagt
     3361 atggagaaaa aactaggaga gtgtcttctc ggaaaaaagc agccttgaag gctacaagtg
     3421 atgagaaaga ttctttttca aatataacca gagaaagaaa ggatggagaa acatctagga
     3481 cagtgtcttc tcagaaacca ccagccttga aggctacaag tgacgaggaa gattctgttt
     3541 tgaatatagc cagagaaaaa aaggatggag aaaaatctag aacagtgtct tctgagcaac
     3601 caccaggctt gaaggctaca agagatgaga aagattctct tttgaatata gccagaggaa
     3661 aaaagcatgg agaaaaaact aggagagtgt cttctcggaa aaaagcagcc ttgaaggcta
     3721 caagtgatga gaaagattct ttttcaaata taaccagaga aagaaaggat ggagaaacat
     3781 ctaggacagt gtcttctcag aaaccaccag ccttgaaggc tacaggtgac gaggaagatt
     3841 ctgttttgaa tatagccaga gaaaaaaagg atggagaaaa atctagaaca gtgtcttctg
     3901 agaaaccatc aggcttgaag gctacaagtg acgagaaaga ttctgttttg aatatagcca
     3961 gaggaaaaaa gcatggagaa aaaactagga gagtgtcttc tcataaacaa ccagccttga
     4021 aggctacaag tgacaaggaa aattctgttc cgaatatggc cacagaaaca aaggatgaac
     4081 aaatatctgg gacagtgtct tctcagaaac aaccagcctt gaaggctaca agtgacaaga
     4141 aagattctgt ttcgaatata cccacagaaa taaaggatgg acaacaatct ggaacagtgt
     4201 cttctcagaa acaactggcc tggaaggcta caagtgtcaa gaaagattct gtttcgaata
     4261 tagccacaga gataaaggat ggacaaatac gtgggacagt gtcttctcag agacaaccag
     4321 ccttgaaggc tacaggtgat gagaaagatt ctgtttcgaa tatagccaga gaaataaagg
     4381 atggagaaaa atctgggaca gtgtctcctc agaaacaatc ggcccagaag gttatattta
     4441 aaaagaaagt ttctcttttg aatattgcca caagaataac gggcggttgg aaatctggaa
     4501 cagagtatcc tgagaatctg cccaccttga aggctacaat tgaaaataaa aattctgttc
     4561 tgaatacagc caccaaaatg aaagatgtac aaacatccac accagcagaa caagacttag
     4621 aaatggcatc agagggagag caaaagaggc ttgaagaata tgaaaataac cagccacagg
     4681 tgaaaaacca aatacattct agggatgacc ttgatgacat aattcagtca tctcaaacag
     4741 tctcagagga cggtgactcg ctttgctgta attgtaagaa tgtcatatta ctcattgatc
     4801 aacatgaaat gaagtgtaaa gattgtgttc acctattgaa aattaaaaag acattttgtt
     4861 tatgtaaaag attaacagaa cttaaagata atcactgtga gcaacttaga gtaaaaattc
     4921 gaaaactgaa aaataaggct agtgtactac aaaagagact atctgaaaaa gaagaaataa
     4981 aatcgcagtt aaagcatgaa acacttgaat tggaaaaaga actctgtagt ttgagatttg
     5041 ccatacagca agaaaaaaag aaaagaagaa atgttgaaga gttgcaccaa aaagttaggg
     5101 aaaagttaag aatcacagaa gagcaatata ggatagaagc tgatgtgaca aaaccaatta
     5161 aaccggctct caaatcagca gaggtggaat tgaagacagg aggaaataat tcaaatcagg
     5221 tttctgaaac tgatgaaaaa gaagacctgc tgcatgaaaa ccgcttgatg caagatgaaa
     5281 ttgccaggct caggctggaa aaagacacaa taaaaaacca aaacctggaa aagaaatact
     5341 taaaagactt tgaaattgtg aaaagaaagc atgaagacct tcaaaaggct ctaaaacgga
     5401 atgaggaaac attagcagaa acgatagcct gttatagtgg acagcttgct gctctgacgg
     5461 atgaaaacac aacgctccgt tctaaactgg agaagcaaag agagagcggg caaagactgg
     5521 aaacagaaat gcaatcatac cgttgtagac tgaatgctgc tctatgtgat catgatcaaa
     5581 gtcactcatc aaaaagagac caagagcttg ctttccaggg cacagtagat aaatgttgtc
     5641 atttacagga aaatttgaat tctcatgttc tgattctttc tctgcaactt tctaaagctg
     5701 agagtaagtt cagagtcctc gaaactgagc tccattacac aggagaggct ctgaaagaaa
     5761 aggctttggt ttttgaacac gtgcaaagtg agctaaagca aaaacagagt caaatgaagg
     5821 acattgaaaa aatgtacaaa agtggataca atacaatgga aaaatgcata gaaaagcagg
     5881 aaagattttg tcaactaaaa aaacaaaata tgttgcttca acagcaactg gatgatgctc
     5941 gcaacaaagc tgacaatcaa gaaaaagcaa tacttaatat tcaagccaga tgtgatgcta
     6001 gagtagaaaa ccttcaagct gagtgcagaa agcaccgtct cttactagaa gaagacaata
     6061 aaatgttggt gaatgaattg aatcattcga aagaaaaaaa atgccaatat gaaaaagaga
     6121 aagcagaaag agaagtagct gtgagacagc ttcaacaaaa acaagatgat gtcttaaaca
     6181 aacgatcagc aacaaaagct ttgctggatg cttcatcgcg tcactgcatc tatttagaaa
     6241 atgggatgca ggattcaagg aagaaattag accagatgag aagtcaattt caagaaatac
     6301 aggatcaact tacagctact ataagatgta ctaaggagat ggaaggcgac gcacaaaagc
     6361 ttgaagtaga aaatgtcatg atgagaaaaa ttattaaaaa acaggatgaa caaattgagc
     6421 ggtttgagaa aatcctgcag cattcaagtt tgatgctgca ggtgtttgag agctagatga
     6481 agcatccagc caaactagac tacatggagc tccacagtga tcgtcttcac ctccagctgt
     6541 ttgcatttac ttcttccctc tatcctacat gtgttttcct tccccttcag atatcaacct
     6601 atgaattgcc tctaccaaaa agcctacaat attgacacaa acctgggcta gtatcccttc
     6661 tatgtcttcc aataagtgct gtcttatgcc tgtcattgta tgtatgactc tgtacgggaa
     6721 ttgcctgttt gttttttcag attatagcat acagttgttg aggggtggac tgtatcatct
     6781 ttatcttgta attccagtgc ttgtcctagt accttagcac atggttgctg aatacatgaa
     6841 tgaagagtga gaaaccagaa gctctgatac ttaactgcca tgataatgaa ttcagtgtgc
     6901 aactatgggc aaattatatt taatagtaat tgcatattgt acatattttt cattcttatt
     6961 aacactgata aacttttcaa catatactga ctttctctta gttaactgtg aaatcattta
     7021 gataaagaat ataattcttt ttcattgtaa cttctgaatt taaatctgaa tcctctatag
     7081 caggggtccc caacccccag gtcacagaca ggtccatgac ctgttaggaa ccaggctgca
     7141 cagcaggagg tgagtggcag gcaagcgagt gaagcttcat ctgtatttcc agccactgcc
     7201 cgttgctcac attatcacct gagctctgcc tcctgtcaga tcagcaaagc cattagattc
     7261 tcacaggagt gaaaatccta ttgtgaactg cacgttcaag ggatctaggt cacatgctcc
     7321 ttatgagact ctaatgcctg atgatatgtc attgtctcct ttctcttcac gatgggacca
     7381 tctagttaca gaaaaacaag ctcaggactc ccattgattc tccattatga tgagttgtgt
     7441 aattatttca ttatgtatta caatgtagta ataataggaa taaagtgcac aatagatgta
     7501 a
//
