LOCUS       NM_144698               3359 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 35 (ANKRD35), transcript variant
            1, mRNA.
ACCESSION   NM_144698
VERSION     NM_144698.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   Wang,Y., Peng,M., Zhong,Y., Xiong,W., Zhu,L. and Jin,X.
  TITLE     The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib
            through the ANKRD35-MITD1-ANXA1 axis
  JOURNAL   Oncogene 42 (13), 952-966 (2023)
   PUBMED   36732658
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Ruiz-Arenas,C., Caceres,A., Lopez,M., Pelegri-Siso,D., Gonzalez,J.
            and Gonzalez,J.R.
  TITLE     Identifying chromosomal subpopulations based on their recombination
            histories advances the study of the genetic basis of phenotypic
            traits
  JOURNAL   Genome Res 30 (12), 1802-1814 (2020)
   PUBMED   33203765
  REMARK    GeneRIF: Identifying chromosomal subpopulations based on their
            recombination histories advances the study of the genetic basis of
            phenotypic traits.
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA399526.1, BC101618.1, AK294308.1, AC243547.1 and HY327286.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144698.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.134397.1, AK091120.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355594.9/ ENSP00000347802.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               DA399526.1         1-553
            554-1389            BC101618.1         501-1336
            1390-1882           AK294308.1         1099-1591
            1883-2175           AC243547.1         162226-162518
            2176-3358           AK294308.1         1885-3067
            3359-3359           HY327286.1         35-35               c
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..3359
                     /gene="ANKRD35"
                     /note="ankyrin repeat domain 35"
                     /db_xref="GeneID:148741"
                     /db_xref="HGNC:HGNC:26323"
     exon            1..147
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..3114
                     /gene="ANKRD35"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 35"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 35
                     isoform 1"
                     /protein_id="NP_653299.4"
                     /db_xref="CCDS:CCDS72867.1"
                     /db_xref="GeneID:148741"
                     /db_xref="HGNC:HGNC:26323"
                     /translation="MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKS
                     ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQC
                     VKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA
                     SLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDST
                     GHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSS
                     WRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLE
                     NQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKDLLAESTQELKKQQQAA
                     ATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETIRKATGQQLTTNGAQ
                     TFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQLLLQLREELAAVWREKDA
                     ARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEVPSQES
                     REGALKAAPGSIKQDEEKEKRVPGAQGEPLGALGGEKALGGLAKGQLEKEMSVLRLSN
                     SNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPQAQVQLQQLRQSVGLLTNELAM
                     EKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRH
                     REAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQA
                     TMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKAL
                     LEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKE
                     KMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIISTY
                     RNHLLNAARGYMEHEVYNILLQILSMEEE"
     exon            148..278
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            279..367
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            368..432
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            433..490
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            491..561
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            562..668
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            669..853
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            854..891
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            892..2895
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2985
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3051
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3157
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3359
                     /gene="ANKRD35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD35"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="ANKRD35"
                     /note="major polyA site"
ORIGIN      
        1 gctttttgac agctgtctct tgcacagccg cagccaagtc cggtgggttc gggaacctgt
       61 ggcccggctc tctgcgcgtc cccatccccc gtggccccga ccccggccat gaagcgtatc
      121 ttctcctgct ccagcacaca ggtggcggtg gagagatgga accgccatga tcagaagctg
      181 ctggaggcag tgcacagggg ggatgtggga cgcgtggctg ccctggcctc caggaaatct
      241 gcccgaccca ccaagcttga ctcgaatggc cagtccccgt ttcatctggc agcctccaaa
      301 ggcctgacag aatgtctgac tatcctgctt gcaaatgggg ctgacatcaa cagcaagaat
      361 gaggatggaa gcactgccct acacttggcc accatctcct gccagccaca gtgtgttaag
      421 gttctgcttc agcatggtgc taatgaagat gctgtggatg cagaaaaccg tagtccattg
      481 cactgggcag cctcctctgg ctgtgcctca agtgtgctcc tgctgtgtga ccacgaagcc
      541 ttcctggacg tgttggataa tgatggacgt acacccctga tgatcgcatc gctgggtggg
      601 cacgcagcta tctgctcaca gctgctgcag cgaggcgccc gagttaatgt tacagacaag
      661 aatgacaaat cggctttgat cctggcctgt gagaaaggca gtgccgaggt ggctgaactg
      721 ctcctgagcc acggagctga cgcgggggct gtggacagca cagggcatga tgctctgcac
      781 tatgctctgc acacacaaga caaggcactg tggaggcacc tacagcaggc cctgagccgg
      841 cggcggcggg gcggtcagag gctagtccag cacccagatc tcgcatccca ggcctctcca
      901 tctgagcccc aggcaggttc tcctcctaag agctcatgga gagcagagcc tgaagaggag
      961 caagaggaga aggaggatga agacccgtgc tcggaggagt ggaggtggaa gtatgaagag
     1021 gagcggagga aagttgttcg gctggagcag gagctggtgc aaaagacaga agagtgtaag
     1081 actcaagctg cagcctatct ggaccttgag aaccagattc gagagcaggc gcaggagcta
     1141 ggggtcctcc tatcctggga gcccagagct tcaggaaagc aaggctctag tctccggcct
     1201 ggaggggatg gcatggagca gggttgtcct aaggacctgc tggctgagag tacacaagag
     1261 ctaaagaagc agcagcaggc agcagccaca gtaaatccag tattagctcc aaagaaggct
     1321 gaggactcag ccccaggaaa gatccagtat gaagtccatg gaaggtccca accagaagaa
     1381 caggggccac cccagagccc agcgtctgag accatcagga aagccacagg acagcaactg
     1441 actaccaatg gggcacagac ctttggccct gatcatgctg accagctgcc tgctggtcag
     1501 aaggagagtt cccaggttct aggagttgaa ccaggaggca cagtggctga accagtgggc
     1561 ccagcagcca tgaaccagct tctgcttcaa ctaagggagg agcttgctgc agtgtggcga
     1621 gaaaaggatg ctgcccgggg ggctttgtca agaccggtca tggagggagc cctggggact
     1681 ccccgtgctg aggcagcagc agctgcctgg gagaagatgg aagcccgact ggagcgggtg
     1741 ctggcaaggc tggaatgggc aaaggcagga ctacaggtga aacctgaggt tccttcccag
     1801 gagtccagag agggagccct aaaggcagcc ccagggagca tcaaacagga tgaagagaag
     1861 gagaaaaggg ttcctggggc tcaaggagag cctctagggg cccttggagg ggaaaaggcc
     1921 ctaggaggcc tggcaaaggg acagctggag aaggagatgt cagtactgag actgagcaac
     1981 agtaacttgc tggaggagtt aggggagttg gggcgggagc ggcagaggtt gcagagggag
     2041 ctacagtccc tgagccagcg gctgcagcgg gagtttgtgc ccaagccaca ggcgcaggtc
     2101 cagctacagc agttgcgaca gagtgtgggg ctgctgacaa atgaactggc catggagaag
     2161 gaggccacag agaagctgcg gaagctcctg gcctcccaga gcagcggtct ccgagggctg
     2221 tgggactgcc tgcccgcaga cctagtgggc gagaggagtg cacaaagcaa agcagcggag
     2281 tccctggagg agctgcgggc ctgcatcagc accctggtgg atcggcaccg ggaggcccag
     2341 caggtgctgg ctcggctgca agaagaaaac cagcagttgc gggggtcctt gtccccgtgt
     2401 agggagccag gcacctcctt aaaggcccca gcatcccccc aagtggccgc tctggagcaa
     2461 gacctgggga agctggagga agagctgcgg gcagttcagg ccacgatgag cgggaagagc
     2521 caggagatcg gaaagctgaa gcagctgctc taccaagcca cagaggaagt ggctgagcta
     2581 agggcccggg aggcagccag cctacggcaa cacgagaaaa ctcggggttc gctggtggcc
     2641 caggctcagg cttggggcca ggagctaaag gctctgttgg aaaagtataa tacggcctgc
     2701 cgggaagtgg gtcggctgcg ggaggcggtg gccgaggagc gccgccggag cggggacctg
     2761 gccgctcagg cagccgaaca agagcgccag gccagcgaga tgcgggggcg ctccgagcag
     2821 tttgagaaaa cggcagagct gctgaaagag aagatggagc atctcattgg ggcttgccga
     2881 gacaaggaag ccaagatcaa ggagttgttg aagaagctgg agcagctttc agaagaggtt
     2941 ctagcaattc ggggagaaaa tgctcgcctt gccctgcagc tgcaggattc ccagaagaac
     3001 catgaagaga tcatctccac ctacaggaat catctactga atgctgctcg gggttacatg
     3061 gaacatgaag tgtacaatat cctgctgcaa atccttagca tggaagagga gtgaggcagc
     3121 ctcactgtgt gccctcaggg atacgagatt ctctgttgga ataagaaacc ctggttgaca
     3181 gaggcttcat caggctgtgg tgggcggggg tgttggccac taggcaatgg tatgggcagg
     3241 gcttcacctg acattatgga cctcagacct gagaacctgg accctggaat cagcatggat
     3301 gagaccagag gaggtatgga tggaaacaag ctctatggaa aataaagcat gaggcagga
//
