LOCUS       NM_001004441            3730 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ankyrin repeat domain 34B (ANKRD34B), mRNA.
ACCESSION   NM_001004441 XM_293976
VERSION     NM_001004441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3730)
  AUTHORS   Serth,J., Peters,I., Hill,B., Hubscher,T., Hennenlotter,J.,
            Klintschar,M. and Kuczyk,M.A.
  TITLE     Age-Related DNA Methylation in Normal Kidney Tissue Identifies
            Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1
            Genes
  JOURNAL   Int J Mol Sci 23 (10), 5327 (2022)
   PUBMED   35628134
  REMARK    GeneRIF: Age-Related DNA Methylation in Normal Kidney Tissue
            Identifies Epigenetic Cancer Risk Susceptibility Loci in the
            ANKRD34B and ZIC1 Genes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3730)
  AUTHORS   Al-Shaibi,N. and Ghosh,S.K.
  TITLE     A novel phosphoprotein is induced during bone marrow commitment to
            dendritic cells
  JOURNAL   Biochem Biophys Res Commun 321 (1), 26-30 (2004)
   PUBMED   15358210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008434.5, BC137441.1 and CR749535.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001004441.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749535.1, BC137441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338682.8/ ENSP00000339802.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC008434.5         90905-90920
            17-2689             BC137441.1         1-2673
            2690-3730           CR749535.1         2689-3729
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..3730
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /note="ankyrin repeat domain 34B"
                     /db_xref="GeneID:340120"
                     /db_xref="HGNC:HGNC:33736"
                     /db_xref="MIM:618581"
     exon            1..127
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /inference="alignment:Splign:2.1.0"
     exon            128..275
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /inference="alignment:Splign:2.1.0"
     exon            276..361
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /inference="alignment:Splign:2.1.0"
     exon            362..442
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /inference="alignment:Splign:2.1.0"
     exon            443..3730
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..2010
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /note="dendritic phosphoprotein 58 kDa; cytosolic
                     phosphoprotein DP58"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 34B"
                     /protein_id="NP_001004441.2"
                     /db_xref="CCDS:CCDS34194.1"
                     /db_xref="GeneID:340120"
                     /db_xref="HGNC:HGNC:33736"
                     /db_xref="MIM:618581"
                     /translation="MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGE
                     TPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVS
                     LLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKLPCGK
                     HTTKQYLNMPPVDIDGCHSPATCTTPSEIDIKTASSPLSHSSETELTLFGFKDLELAG
                     SNDDTWDPGSPVRKPALAPKGPKLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEE
                     LSYKTNGLALSKRFITRHQSIDVKDTAHLLRAFDQASSRKMSYDEINCQSYLSEGNQQ
                     CIEVPVDQDPDSNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTSEDGKALIG
                     KKKILSPSPSQLSESKELLENIPPGPLSRRNHAVLERRGSGAFPLDHSVTQTRQGFLP
                     PLNVNSHPPISDINVNNKICSLLSCGQKVLMPTVPIFPKEFKSKKMLLRRQSLQTEQI
                     KQLVNF"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /note="hexamer: AATAAA"
     polyA_site      3730
                     /gene="ANKRD34B"
                     /gene_synonym="DP58"
                     /note="major polyA site"
ORIGIN      
        1 gattcgaggc gccgaggagc cgaagaccac agctcagctc agacggcgcc ctagggccgc
       61 acagagggtc gggcagtgcc ggagagaggt ttgaaagcgc cgccgccaac tcgacagcgc
      121 gtcccagcgc cttgagctcg cttcctcctg ctctcaggaa aaactgagga aacgcgcctg
      181 gttccagggg tcggcgggga ccgtggagac gctgccagca tcctcaacag cttggaaatc
      241 ccatcacctt ggttccctga gacttggagg actagtagga actgacagct ggctgacaga
      301 aaacttatcc agggagagaa gagacaaaag tgaagtgtga aattttgaat aatgttttca
      361 gatgctttgc attcagaata gacctctgag ttgggaccca agctgtcaac tgatcccaaa
      421 ttcctaagtt cctgacttgc aggtattgag ttctaacctc cgaagatgga tgaaggtatg
      481 gaaatttcaa gtgaaggaaa ttccttgatc aaagcagtcc atcagagccg gcttcgcctc
      541 acaagacttt tgctagaagg cggtgcctac attaatgaga gcaacgaccg tggggaaacc
      601 cctttaatga tcgcttgtaa gaccaaacat gtcgatcacc agagtgtcag taaagccaaa
      661 atggtgaaat acctgttaga gaacaatgcc gatcccaaca tacaggacaa atctgggaaa
      721 acggctctga tgcatgcttg cttagaaaaa gctggccctg aagttgtttc cttgctcctc
      781 aagagtgggg ctgacctcag cttgcaagac cattctagtt actcagctct tgtttatgct
      841 ataaattcag aagatacaga gaccctgaaa gttcttctta gtgcttgcaa ggcaaaaggg
      901 aaagaggtca tcatcatcac aacagcaaag ttgccctgtg ggaagcatac tactaaacaa
      961 tacttaaata tgcctcctgt ggatatagat gggtgtcatt ccccagctac ctgcaccact
     1021 ccttcagaaa tagacatcaa aactgcctca tcgccacttt cacattcttc tgaaacggaa
     1081 ctgacgcttt ttggctttaa agatcttgag cttgctggaa gcaatgatga tacctgggac
     1141 ccaggttccc ctgtgaggaa acctgcattg gcccctaagg ggcccaagct cccccacgct
     1201 ccaccctggg tcaagagtcc cccattatta atgcaccaga acagagtggc ttcattgcaa
     1261 gaggagctcc aggatattac accagaggaa gaactatcct ataaaaccaa tgggctggca
     1321 ctttccaagc ggttcatcac taggcaccaa agcattgatg taaaagacac tgcacatttg
     1381 ctaagagcct ttgatcaggc cagctcaagg aagatgtcat atgatgaaat aaattgtcaa
     1441 tcttatcttt cagaaggaaa tcagcaatgc attgaagtcc ctgttgacca ggacccagat
     1501 tctaaccaga caatatttgc ttccacctta agaagtatag ttcaaaaaag aaacttgggg
     1561 gcaaatcact acagctctga ttcccagctc tcagctggcc ttacccctcc aacttcagaa
     1621 gacggcaaag cacttatagg aaagaaaaag atcctctcac catctccttc ccaattgtca
     1681 gagtccaaag aattgttgga gaatatcccc ccaggtcccc tgagcaggag aaatcatgca
     1741 gttttagaaa ggcgaggttc aggagctttc cctttagatc acagtgttac ccaaaccaga
     1801 caagggtttc tcccaccctt aaatgtaaat tctcaccctc ccatctcaga tatcaatgtc
     1861 aacaacaaga tttgcagcct tctttcttgt ggtcaaaaag tgcttatgcc aacagttccg
     1921 attttcccta aagaattcaa aagtaagaaa atgttgttaa ggagacaatc attgcaaact
     1981 gaacaaatta agcaattagt aaacttctag gagatgggta taaaacacat cttcttcaaa
     2041 tgtttatatc agagaaacaa agaactagag aagaaatctt aaatgttcat tcttttaaat
     2101 ctcgtgattg gttagtccat aatggctaga tggattaaaa tgtaatgtga tttgtactag
     2161 gcgtcatgag cataaaaaat aatacatagt ttctgttaag ggaattctct caaacaaaag
     2221 gaaagcgatt tttctcaatg cttctaatat ttaacaatct ccatgtagtc caaatttgtc
     2281 attaaaaaaa aatcaaagaa agaaggccac gtatgttggg gtaattttta aaaattttca
     2341 gattggctaa atattttatt aggaaacagt tttcaagtca ataatttttt taacatttca
     2401 tgttaataaa tgagattgaa attttttatg atctctaaac cataaaagaa aacaccgaca
     2461 gctgtaaaat gttctaagat aaaaaaactc gagctacaaa gaaagaatga actaattctt
     2521 tacaaatgtt gactgaagat agataaaact ctaattaaaa atttaaaagg ttaaacactg
     2581 tattagaatg ggcaactaaa atattcgtgg tgtcagttta attagtgtca aactggcaag
     2641 tcagagtttt acaacctact agtaatctat gccgggtctt gttgtttgtg cactgtgttt
     2701 tgctttgctt tgttttggtt tttaaacaga cttacctgta aagttatctt acggaattat
     2761 tctttctcca tatcttttaa ggaattattc tttctccata tcatctttta attcctgtta
     2821 ttagttttgg aagcttatcc ataagtttcc aaagacaaga tgatataaaa gttaaaaagc
     2881 attcctcttt acttatatca aattattctt gtctttcaaa aagaaccaaa aaaaaaaaat
     2941 tcatcatgga taaaaactaa gcgcttgcct tcttttaaaa agaaaaactg atgattagat
     3001 taggttagct aaaattaata gaggcagtag aaacttaatc acaaaatgta ctaaatattt
     3061 ggcaatatta aacaatgcct ttttatttct gatatgtagt tattagacat ttatatatta
     3121 aggataactt ccttagtgtg acattccaat catttagtat tttaggacct gtgaataact
     3181 tccaacaaaa ttaatgaata ccatattagt attataaaat attataaagt aataattata
     3241 tcatctatat aacttcaaag tatgatgttt atacaaagaa tccttatttc agtctagcag
     3301 cttaacaaca aaggataaat cagactatac aaaacctaag tgtattaatt tgatgattgt
     3361 cacgtacaac tttctttgcc ttccaagtag aggtgatcct aacaattggc atgatgcttt
     3421 tcttggtaat ttgatataag caagttgtaa tgtacatagt aattatttaa ttactgtggc
     3481 ttttatttta aaaagtaatt agaggttttt ccatttcatg tcttgaacaa cattaatatt
     3541 aattacacta gaaatatttt ttgattcaga acttagaatt gtacctgata tttataggta
     3601 tttaaatgct ttctgcaagt taaatatcga gaaaagtact tgacttcaag ttgtaaggat
     3661 acaatttgga agggtatgta aatagattag ttcataaaca aaatggtatc aataaagatt
     3721 ttaaatatca
//
