LOCUS       NM_182608               1865 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 33 (ANKRD33), transcript variant
            2, mRNA.
ACCESSION   NM_182608
VERSION     NM_182608.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
            Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
            Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of neurocognition as an indicator
            of antipsychotic treatment response in schizophrenia
  JOURNAL   Neuropsychopharmacology 36 (3), 616-626 (2011)
   PUBMED   21107309
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Sanuki,R., Omori,Y., Koike,C., Sato,S. and Furukawa,T.
  TITLE     Panky, a novel photoreceptor-specific ankyrin repeat protein, is a
            transcriptional cofactor that suppresses CRX-regulated
            photoreceptor genes
  JOURNAL   FEBS Lett 584 (4), 753-758 (2010)
   PUBMED   20026326
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC121152.1, AK125517.1, BC121153.2, BX649168.1, AF517120.1 and
            AC025259.49.
            
            On Nov 22, 2018 this sequence version replaced NM_182608.3.
            
            Transcript Variant: This variant (2) has two alternate splice sites
            and lacks an internal exon in the coding region, compared to
            variant 3. The resulting isoform (2) is the longest isoform, which
            is longer at the N-terminus and lacks an internal segment, compared
            to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125517.1, SRR18074967.1323925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301190.11/ ENSP00000301190.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               BC121152.1         95-268
            175-502             AK125517.1         318-645
            503-721             BC121153.2         826-1044
            722-1022            BC121153.2         1075-1375
            1023-1565           BX649168.1         952-1494
            1566-1859           AF517120.1         243-536
            1860-1865           AC025259.49        191994-191999       c
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1865
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /note="ankyrin repeat domain 33"
                     /db_xref="GeneID:341405"
                     /db_xref="HGNC:HGNC:13788"
                     /db_xref="MIM:620857"
     exon            1..229
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1443
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ankyrin repeat domain-containing protein 33; photoreceptor
                     ankyrin repeat protein"
                     /codon_start=1
                     /product="photoreceptor ankyrin repeat protein isoform 2"
                     /protein_id="NP_872414.3"
                     /db_xref="CCDS:CCDS8815.1"
                     /db_xref="GeneID:341405"
                     /db_xref="HGNC:HGNC:13788"
                     /db_xref="MIM:620857"
                     /translation="MKVQPSVTCVASWGGIVHLEAFGDPVIVLRGAWAVPRVDCLIDT
                     LRTPNASCMRKGTHLLVPCLEEEELALHRRRLDMSEALPCPGKETPTPGCRLGALYWA
                     CVHNDPTQLQAILDGGVSPEEATQVDSNGRTGLMVACYHGFQSVVALLSHCPFLDVNQ
                     QDKGGDTALMLAAQAGHVPLVSLLLNYYVGLDLERRDQRGLTALMKAAMRNRCADLTA
                     VDPVRGKTALEWAVLTDSFDTVWRIRQLLRRPQVEQLSQHYKPEWPALSGLVAQAQAQ
                     AQVAPSLLERLQATLSLPFAPSPQEGGVLDHLVTATTSLASPFVTTACHTLCPDHPPS
                     LGTRSKSVPELLGTAPPPPLVPQSPPGSPQRSPWVFVPYQSPQGILSKCLQWLQPRDS
                     TSPRPQVPKILLSKASSSSHQCQPKPSPSGHQSLALPLWRYQELRIEKRKQEEEARMA
                     QK"
     exon            230..480
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /inference="alignment:Splign:2.1.0"
     exon            481..610
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /inference="alignment:Splign:2.1.0"
     exon            611..721
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /inference="alignment:Splign:2.1.0"
     exon            722..1865
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /note="hexamer: GATAAA"
     polyA_site      1865
                     /gene="ANKRD33"
                     /gene_synonym="C12orf7; PANKY"
                     /note="major polyA site"
ORIGIN      
        1 gagacgtgac cacccgcccc gcatggggcc ccagtcccag ctgcttgatc cggctcagcc
       61 ccgaggtgtt tgcagcagct ctttatgaaa gtccagccat ctgttacctg cgttgcttcc
      121 tggggaggga tagtccacct ggaggcattc ggagacccag tgattgtgct ccgcggagcc
      181 tgggctgtgc cccgcgttga ctgcctcata gataccctac gaaccccaaa tgccagctgc
      241 atgagaaaag ggactcacct tctggttccc tgcctggaag aggaagagct ggcattgcac
      301 aggagacggc tggacatgtc tgaggcactg ccctgcccgg gcaaggagac ccccacccca
      361 ggctgcaggc tgggggccct gtattgggcc tgtgtccaca atgatcccac ccagctccaa
      421 gccatactgg atggtggggt ctccccagag gaggccaccc aggtggacag caatgggagg
      481 acaggcctca tggtcgcatg ctaccacggc ttccagagtg ttgtggccct gctcagccac
      541 tgtcctttcc ttgatgtgaa ccagcaggac aaaggagggg acacggccct catgttggct
      601 gcccaagcag gccacgtgcc tctagtgagt ctcctgctca actactatgt gggcctggac
      661 ctggaacgcc gggaccagcg ggggctcacg gcgttaatga aggctgccat gcggaaccgc
      721 tgtgctgacc tgacagcagt ggaccctgtt cggggcaaga cggccctgga atgggcagtg
      781 ctgaccgaca gcttcgacac cgtgtggagg attcggcagc tgctgaggcg gccccaagtg
      841 gagcagctta gccagcacta caagcccgag tggccggcct tgtccgggct cgtggcccag
      901 gcccaggccc aggcccaggt tgccccttca ctcctagaac ggctgcaggc taccttgagc
      961 ctcccctttg ccccgtctcc tcaggagggg ggtgttctgg accaccttgt gactgccaca
     1021 accagcctgg ccagtccctt cgtcaccact gcctgccaca ctctgtgccc tgaccatcca
     1081 ccttcgctgg gcacccgaag caagtccgtg ccagagctgt taggtactgc cccgccccct
     1141 cccctggttc cccagtcccc gccagggagt ccccagaggt ccccgtgggt cttcgtcccc
     1201 taccagagcc ctcagggcat attgagcaag tgccttcagt ggctacaacc cagggatagc
     1261 accagcccca ggccccaagt ccccaagatc ctcctctcca aggcatcctc atcctcccac
     1321 cagtgccagc cgaagcccag tccttcagga caccaaagtc tggcccttcc tctctggcga
     1381 taccaggagc tcaggataga gaagaggaaa caggaggagg aggccagaat ggcacagaag
     1441 taggggaaga tgggatagga caggctggga acaggtaatc aggcccctcc cagggcttct
     1501 ttcccctctg gagtgcctcc ggcctcccca tccacctctg cctaagtaaa tctgctctca
     1561 acctatatat atacaaggtc attcattcta gcattgtttg caagagtgaa agagtggaaa
     1621 cacccgaagt gtccatcagt aagggacagg ctagattgat tacggatgta attgctgtcc
     1681 atccatacag agcatactct acagtgtatt ctaaaataag actaaggaag ctgtttatat
     1741 tctgatatga aactaccatc aagatgtata aagtaaaaat aactaaggag tggaacagtg
     1801 tatatggcat attattattt gtcgaagtaa aattttcacg aagataaaca tgactaagac
     1861 aaata
//
