LOCUS       NM_001372053            6207 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 31 (ANKRD31), transcript variant
            1, mRNA.
ACCESSION   NM_001372053 XM_011543299
VERSION     NM_001372053.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6207)
  AUTHORS   Wang,Y., Guo,T., Ke,H., Zhang,Q., Li,S., Luo,W. and Qin,Y.
  TITLE     Pathogenic variants of meiotic double strand break (DSB) formation
            genes PRDM9 and ANKRD31 in premature ovarian insufficiency
  JOURNAL   Genet Med 23 (12), 2309-2315 (2021)
   PUBMED   34257419
  REMARK    GeneRIF: Pathogenic variants of meiotic double strand break (DSB)
            formation genes PRDM9 and ANKRD31 in premature ovarian
            insufficiency.
REFERENCE   2  (bases 1 to 6207)
  AUTHORS   Boekhout,M., Karasu,M.E., Wang,J., Acquaviva,L., Pratto,F.,
            Brick,K., Eng,D.Y., Xu,J., Camerini-Otero,R.D., Patel,D.J. and
            Keeney,S.
  TITLE     REC114 Partner ANKRD31 Controls Number, Timing, and Location of
            Meiotic DNA Breaks
  JOURNAL   Mol Cell 74 (5), 1053-1068 (2019)
   PUBMED   31003867
REFERENCE   3  (bases 1 to 6207)
  AUTHORS   Lucariello,M., Vidal,E., Vidal,S., Saez,M., Roa,L., Huertas,D.,
            Pineda,M., Dalfo,E., Dopazo,J., Jurado,P., Armstrong,J. and
            Esteller,M.
  TITLE     Whole exome sequencing of Rett syndrome-like patients reveals the
            mutational diversity of the clinical phenotype
  JOURNAL   Hum Genet 135 (12), 1343-1354 (2016)
   PUBMED   27541642
  REMARK    GeneRIF: We determined that the other patients harbored mutations
            in genes that have not previously been linked to RTT or other
            neurodevelopmental syndromes, such as the ankyrin repeat containing
            protein ANKRD31 or the neuronal acetylcholine receptor subunit
            alpha-5 (CHRNA5).
REFERENCE   4  (bases 1 to 6207)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008769.7 and AC093259.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2019 this sequence version replaced XM_011543299.1.
            
            Summary: This gene encodes a protein containing multiple ankyrin
            repeats. Ankyrin domains function in protein-protein interactions
            in a variety of cellular processes. Mutations in this gene are
            associated with a Rett syndrome (RTT)-like phenotype. [provided by
            RefSeq, Apr 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000506364.6/ ENSP00000427262.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC008769.7         104776-105071       c
            297-370             AC008769.7         98755-98828         c
            371-480             AC008769.7         90442-90551         c
            481-518             AC008769.7         79021-79058         c
            519-595             AC008769.7         74604-74680         c
            596-639             AC008769.7         67824-67867         c
            640-1209            AC008769.7         63824-64393         c
            1210-1490           AC008769.7         61504-61784         c
            1491-1600           AC008769.7         60860-60969         c
            1601-1756           AC008769.7         56686-56841         c
            1757-1899           AC008769.7         37172-37314         c
            1900-2044           AC008769.7         22394-22538         c
            2045-2097           AC008769.7         16769-16821         c
            2098-3616           AC008769.7         14180-15698         c
            3617-3787           AC008769.7         12194-12364         c
            3788-3925           AC008769.7         7039-7176           c
            3926-4068           AC093259.2         182837-182979       c
            4069-4231           AC093259.2         163116-163278       c
            4232-4347           AC093259.2         161547-161662       c
            4348-4435           AC093259.2         157494-157581       c
            4436-4532           AC093259.2         152502-152598       c
            4533-5523           AC093259.2         149209-150199       c
            5524-5664           AC093259.2         136242-136382       c
            5665-5767           AC093259.2         129253-129355       c
            5768-5839           AC093259.2         125549-125620       c
            5840-6207           AC093259.2         113278-113645       c
FEATURES             Location/Qualifiers
     source          1..6207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..6207
                     /gene="ANKRD31"
                     /note="ankyrin repeat domain 31"
                     /db_xref="GeneID:256006"
                     /db_xref="HGNC:HGNC:26853"
                     /db_xref="MIM:618423"
     exon            1..296
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..5985
                     /gene="ANKRD31"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 31; putative
                     ankyrin repeat domain-containing protein 31"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 31
                     isoform 1"
                     /protein_id="NP_001358982.1"
                     /db_xref="CCDS:CCDS93735.1"
                     /db_xref="GeneID:256006"
                     /db_xref="HGNC:HGNC:26853"
                     /db_xref="MIM:618423"
                     /translation="MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASL
                     KSEFSLHPDTRGMCKGMPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETE
                     RNQALLQTRKNCSMFIGSFRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEV
                     SLLSGTAITVSDTVAVKETSLVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLE
                     TFVSALESLLTSPESTQEERLFELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDL
                     LEDAKDDALPAELLEALNTLSEAKVETICHRKEGGSSLIARNECLEVEFNTSQTNEDC
                     TQIAETLQDPNPSGLQTLAHQNITSCEPLSNKRNSNSVTNSSDQETACVLRRSSRLEK
                     LKVSRDAKYSDHMYKMPEKILPKILGCEDLTNNNSSAQNFRMQDPALMIDGKEKNMHS
                     ARFKNGKQIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHC
                     IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNG
                     HYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSID
                     PLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEHVKVNKGSKASLFINKEDVYEYY
                     QKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDPNTNVPKGIGRRKTQHKRTQV
                     DDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEELCEPSSLTLSSLRNGLDSS
                     TEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGLLLHKEIKLPVVTTDKQ
                     PHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDNDDDDDCSTSEKAIT
                     SKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKAVSLTTLPEQEAV
                     NFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHEASKLTNHVEL
                     FKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEPLSIVAHSQ
                     VIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPDEELT
                     NNISGDEITIRNCEEIKEKTESEIHMPTNSQEHKTVQNFRKRQSFLKTTCNLGMKAGR
                     INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV
                     ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADD
                     EKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQER
                     SRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQK
                     AERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTS
                     LPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYS
                     QNTNICLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFI
                     GQTEYSQKENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLS
                     NYDPKRGNRKTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQ
                     ISSSSGSGQQDTIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKAS
                     ILLNGKLKVESGQIYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPI
                     LPEPNSVPQQYQPCLPEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINE
                     ILLISDQEFLPCHIMDQHWKFCVECEELTP"
     exon            297..370
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            371..480
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            481..518
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            519..595
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            596..639
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1209
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1490
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1600
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1756
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1899
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2044
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2097
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..3616
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3787
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3925
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4068
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4231
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4347
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4435
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4532
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..5523
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            5524..5664
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            5665..5767
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..5839
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     exon            5840..6207
                     /gene="ANKRD31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6180..6185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD31"
                     /note="hexamer: AATAAA"
     polyA_site      6207
                     /gene="ANKRD31"
                     /note="major polyA site"
ORIGIN      
        1 agactgctac cccgccgcgc tcgcggccgc ctgcgtcctc ctcagcagcc ctgcgacaag
       61 tcccggctcc tgctgcgatt atattatttt tatttttaat tcacaatttc ccctggccct
      121 caaagcgttt ttttgtttgc gggcaagagg gagttagagg agggtaaaaa agactttgaa
      181 tgtgaggcaa agatggagga aggcgtccag gccccagact gggacagtga tgaaactgtg
      241 atagagggtt cagtgacgga gagcgacctg gaagaaaagg agctgccctg gagaaggttg
      301 ctgtttgatc aagacgcatc tcttaaatct gagttcagtc tgcatcctga tacaagagga
      361 atgtgcaaag gcatgccttc tcctgagatt caacttggat ttaagctcag agaggatctg
      421 caagagcaaa tgaataaaaa taagatgatg cctgttctta gcgaggatac aatattacag
      481 tctcaagatg aaacagaacg aaatcaagct ctgttacaga ctagaaaaaa ctgttcaatg
      541 ttcattgggt cgtttcgcca gtctggactt tcattgaacc accaaaatat tgaagggcca
      601 gaggctgaaa gtcctgaagt tttgccacac atagaaaagg aactaagtga aggcagagat
      661 tctcctgaag ttagccttct ctcaggcact gctattacag tatctgatac agttgctgta
      721 aaggagacat cattagtaga gccagagaag attttagcag caccaaatac attttttgag
      781 cctagaaagg aagtcacaat gaccatgact tctgaagaaa ctaaggatga agaaagctct
      841 cttgaaacct ttgtgtctgc cttagaaagt ttacttacat caccagaaag cacccaggag
      901 gaaagattgt ttgaattagt aagtgatttt gatcgtaaag aattgatgaa cccattgagt
      961 gactctctta gttccatatc aatacctttg aattcctggt cggcatgtca tagagattta
     1021 ctagaagatg caaaagatga tgcattgcca gctgagttat tggaagccct gaacacattg
     1081 tcagaagcca aggtggaaac catctgtcac agaaaagagg gaggtagcag tctcattgcc
     1141 agaaatgaat gtttagaagt ggagttcaat acgtctcaga ccaatgaaga ttgtacacaa
     1201 atagcagaga ctctgcaaga cccaaatcca tctggattgc aaactttggc tcatcaaaat
     1261 atcacttctt gtgagccact aagtaataag agaaattcaa attcagtgac aaatagctct
     1321 gatcaggaaa ctgcgtgtgt gttgaggaga tcatccagac tagaaaaact gaaagtaagc
     1381 agagatgcaa agtactcaga tcacatgtat aagatgccag aaaagatttt accaaaaatc
     1441 cttggctgtg aggacctaac aaataataac tcttcagctc agaatttcag aatgcaggat
     1501 ccggctttaa tgattgatgg taaagagaag aatatgcatt cagcaaggtt caagaatgga
     1561 aaacagatca ggaaaaatga acaattttca ggaaaaaaag aaaaaatgaa ggtgaacaaa
     1621 atatctcttc atagcattaa ccggagaaac atttttggag agaacttagt atataaggct
     1681 gctctacacg atgatgctga tcttgttcat cattgtataa aaaaaggtgg aaatgttaat
     1741 cagccaagtt atgctggttg gacagcactt catgaagcta gtgtaggagg attttatcgg
     1801 acagcaagtg aactattaaa aggtggagca gatgtaaata tcaaaggatt ataccagatt
     1861 actcccctac atgatgcagt gatgaatgga cattataagg tggcagagtt acttcttctg
     1921 aatggagctg atccattatt tagaaatgat gatggaaaat gtgctttgga tgaggccaag
     1981 gatttatgta tgaagcgtct ccttgagaga tatatcccta aacatcaaaa atgccttaca
     2041 tcagctcaaa ggagtagcat tgacccacta gacatagagg atgtgtacca acacaagaaa
     2101 ccaaagttca gttctaaaag tcacatttgg catgtttata atgaaaattc caacagacag
     2161 aagctggaac atgtaaaagt caataaagga agcaaagcga gtttatttat aaataaagaa
     2221 gatgtatatg aatattacca aaaagatccc aaaaacacaa aatttggtaa atccaagcat
     2281 aaacaatcaa ctcttgacca gatatactct acaggactca gaaagggcaa tctccataac
     2341 gtcaaagatc ccaacacaaa cgtaccaaaa ggtataggaa gaagaaaaac acaacataaa
     2401 aggacccaag tagatgatgt agactgtaat ccaagaaaga tactagctgt ctctccttcc
     2461 aggagaataa acagattggt tacctatcag cagcatattc cagaaactca taatgacctt
     2521 ccagaagaat tgtgtgaacc ttccagctta actctgtcaa gcctgagaaa tggattagat
     2581 agcagtactg aggcttgttc agtttccaaa gagaaacaca tccagaacct ggatttatca
     2641 gatagtcaag aagttcaatg cttggaatta gaatctgttg accaaactga agctgtttct
     2701 ttcccagggc ttttattaca taaagaaatc aagttaccag ttgttactac agataagcag
     2761 cctcacactc tccaggaaca acaccatgta ctttataaat ctcatgaaaa cagtaacttg
     2821 gtcccaaaag atgagagatt taacaaatgg gaaaattctt tcctatcctt tgtaaaggaa
     2881 aattctgata atgatgatga tgatgattgc tctacctctg agaaggctat aacatctaaa
     2941 aaggtgttgt gttctacagg tggcaaaaaa cactataatt ttaaggagaa tttaacaaat
     3001 aaaaaagaaa tgggtttcca acagttttta ctttctgaag atcatctttc acaggaaaat
     3061 gagttaaaag cagtcagcct aaccacactt ccagaacagg aagctgttaa tttttcttat
     3121 tcagataatg cagttatttc tgaacatgtt gcaaattatg aacaatgcat atttggacct
     3181 tcttttgatc actcaaatgg caatcctgag caaaattccc tggcttgtat gagaacactt
     3241 ttgacacatg aggcttcaaa gttgactaat catgtggagc tattcaaaaa gccacaggat
     3301 tatattccca gagcaccaac ttttttaatg aatcaaacag atacacatat tgtggaaaag
     3361 atggcaaaga attgtgacac tgagaggaat tacattgaca gagaccaaaa aataatttat
     3421 tcaaatgagc ctttatccat agttgctcat tctcaagtaa tagaaacaac taaagttgaa
     3481 aaaaggagac aaaaccatct agaaagtgag actatacaca atatagattc tcattccact
     3541 gacaatatga gtaaagaatt ggccaacatc tcaaaactta gtcaaagaga aaagaaggaa
     3601 atttctcaca aaccagatga ggaattaact aataacatca gtggagatga aataactata
     3661 agaaattgtg aggagataaa agaaaaaacg gagtcagaaa ttcacatgcc tactaatagc
     3721 caagaacaca aaacagttca gaatttcaga aaaagacaaa gtttcttaaa aactacctgc
     3781 aacctaggaa tgaaagcagg taggatcaac aagaggaatg ccagagggga aagccagctt
     3841 catttagctg tcagaagagg aaatctgccc ctagtgaaag ccctgataga atctggagca
     3901 gatgtgaatc taaatgataa tgcaggttgg acaccacttc atgaggcatc taatgaagga
     3961 tctattgata taattgtaga gttattaaaa gctggtgcta aggttaattg tgaaaatata
     4021 gatggaattc tgcccttaca tgatgctgtt gcaaacaatc atttaaaggc agctgagatt
     4081 ctactacaaa atggagcaaa ccctaatcaa aaagatcaaa aacagaagag tgctttggat
     4141 gaagcagatg atgaaaaaat gaaagaatta ctaagatctt atggtgctat tgagactgtt
     4201 aatagagatg agagtgatgc tatagtcaat gaaaaaattc ctgctgtccg gtctaaaaga
     4261 cataaacagt gtttttgtga tgatggcaaa actattgact catcttccct ttcacaccaa
     4321 gaaagatcaa gagaaagcct ttctgtgcat cagaccctca gtgccattct acaagatata
     4381 gaagaaaaac aagaatattt attagagttt gaaataagaa accctgaaga tgcagaacaa
     4441 tacattgaaa agatgttaaa gataaaaaag attatggata atgtgcttgc caagcagaaa
     4501 gcagaaaggg atgatctggc taaaaaatac agggtatcca tagagtcatt taagcatgga
     4561 gccctgagag aacaattggc caacttggct gcaagacaga agagcctttt agttgtggca
     4621 aaaaaacaga aaaaaataag cctgaaaatt caaaactgta ggaatgttac atcattgcct
     4681 tgtcttagtt taaggaagct cccacccaga tcagaaatct ctagtgaaaa agacagccaa
     4741 gagctcacta gtctggaaaa tttagagcat ccccaatcag gttcactttc tcctgtttct
     4801 ggaagcatgc aggaaacaca attgtctctg gaaacttgga actacagcca aaataccaac
     4861 atttgtctaa attcagaggc agtgagaagg ggagaatttt ctggaaatga tatgaattct
     4921 aaacaaaatg gcagtgattg taccttggat ggttttccaa aatccagaca ttcagatggc
     4981 acagagaaga ataaattacc atcccaacct gttgctttta ttggtcaaac agaatattca
     5041 cagaaagaga atgatcttac agaagctaca gacaaagacc atgaattcta tgtttcttcc
     5101 ccagtaatcg gcaaattaaa tatttcagaa actgcaagtg tccttgccga aaatgctgcc
     5161 catccatcaa atattatttg tgatcaggac ctttccaatt atgatcccaa aagaggaaac
     5221 agaaaaacaa gttcccagca atcacctaca ggggcatcag aatctctggc acatcaaggg
     5281 attgctgtct taggcagtga tacagtgcat cagatgaaac catatcttaa aaaatcagtt
     5341 tctgttgttc catgtgcaga tgacagtcag atctcctctt cctctggatc tgggcaacaa
     5401 gatacaataa aaaaggcttt aaactacagt acagctccta aaaagaaatg tattcagata
     5461 aaagatttga tattactagg aagaattaac ccaggaaata acattctgga attcaaaaca
     5521 caggagacta cccacaaagc cagtatttta ttgaatggta aacttaaggt agaaagtggt
     5581 cagatttata aaaacccagt cacctggctc aaggatcttc tgggaggcaa cagttatgtg
     5641 acctggaatt atgcttggag taaggtaacg tatcttggga aggagctttt aaggtatgtt
     5701 tctgaggatg cacccatact tccagaacca aactcagtac ctcagcaata tcaaccttgt
     5761 cttccagaag ttgcttgttt agatgaccca gtacaggaac caaacaaatc aatgtttgag
     5821 aaaacaaaat ttggacaagg aacttccaga gagtcaatgc aaagcagccc acgttatcta
     5881 caaataaatg aaatactatt aatcagtgat caagaatttc tcccatgcca cataatggat
     5941 cagcattgga agttttgtgt ggaatgtgag gaactaacac cctaaaacct tggtttctta
     6001 atattttatt ggatatttgt tcaaattacc aacaaacatt tatatttcat cttgtataat
     6061 ctggtgggcc tattttaaca tacactttat gagttgctat ttaggatgta tgtttactgt
     6121 tcttaagatg tatgtaactg ttcaacaatt atataagatt aatgcttttt tgccattgaa
     6181 ataaaggcac atttgaacta gaccata
//
