LOCUS       NM_173505               3387 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 29 (ANKRD29), transcript variant
            1, mRNA.
ACCESSION   NM_173505
VERSION     NM_173505.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Zhao,H., Wang,Y., He,Y., Zhang,P., Zeng,C., Du,T., Shen,Q. and
            Zhao,S.
  TITLE     ANKRD29, as a new prognostic and immunological biomarker of
            non-small cell lung cancer, inhibits cell growth and migration by
            regulating MAPK signaling pathway
  JOURNAL   Biol Direct 18 (1), 28 (2023)
   PUBMED   37277814
  REMARK    GeneRIF: ANKRD29, as a new prognostic and immunological biomarker
            of non-small cell lung cancer, inhibits cell growth and migration
            by regulating MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Fogh,I., Ratti,A., Gellera,C., Lin,K., Tiloca,C., Moskvina,V.,
            Corrado,L., Soraru,G., Cereda,C., Corti,S., Gentilini,D.,
            Calini,D., Castellotti,B., Mazzini,L., Querin,G., Gagliardi,S., Del
            Bo,R., Conforti,F.L., Siciliano,G., Inghilleri,M., Sacca,F.,
            Bongioanni,P., Penco,S., Corbo,M., Sorbi,S., Filosto,M.,
            Ferlini,A., Di Blasio,A.M., Signorini,S., Shatunov,A., Jones,A.,
            Shaw,P.J., Morrison,K.E., Farmer,A.E., Van Damme,P., Robberecht,W.,
            Chio,A., Traynor,B.J., Sendtner,M., Melki,J., Meininger,V.,
            Hardiman,O., Andersen,P.M., Leigh,N.P., Glass,J.D., Overste,D.,
            Diekstra,F.P., Veldink,J.H., van Es,M.A., Shaw,C.E., Weale,M.E.,
            Lewis,C.M., Williams,J., Brown,R.H., Landers,J.E., Ticozzi,N.,
            Ceroni,M., Pegoraro,E., Comi,G.P., D'Alfonso,S., van den Berg,L.H.,
            Taroni,F., Al-Chalabi,A., Powell,J. and Silani,V.
  CONSRTM   SLAGEN Consortium and Collaborators
  TITLE     A genome-wide association meta-analysis identifies a novel locus at
            17q11.2 associated with sporadic amyotrophic lateral sclerosis
  JOURNAL   Hum Mol Genet 23 (8), 2220-2231 (2014)
   PUBMED   24256812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010853.11, BC030622.1, AK057782.1, BM680506.1 and AI073766.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173505.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.153677.1,
                                           SRR1660809.46250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592179.6/ ENSP00000468354.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC010853.11        8497-8522
            27-515              BC030622.1         6-494
            516-882             AK057782.1         420-786
            883-1913            BC030622.1         862-1892
            1914-2300           BM680506.1         16-402              c
            2301-3001           AC010853.11        71396-72096
            3002-3387           AI073766.1         11-396              c
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..3387
                     /gene="ANKRD29"
                     /note="ankyrin repeat domain 29"
                     /db_xref="GeneID:147463"
                     /db_xref="HGNC:HGNC:27110"
     exon            1..202
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1087
                     /gene="ANKRD29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 29"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 29
                     isoform 1"
                     /protein_id="NP_775776.2"
                     /db_xref="CCDS:CCDS11879.1"
                     /db_xref="GeneID:147463"
                     /db_xref="HGNC:HGNC:27110"
                     /translation="MCRMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDS
                     HGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFG
                     ASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDV
                     IRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKA
                     ANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKAN
                     ELPAELTKNERILRLLRSKEGPRKS"
     exon            203..313
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            314..412
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            413..511
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            512..610
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            611..709
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            710..808
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            809..904
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1003
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3387
                     /gene="ANKRD29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD29"
                     /note="hexamer: AATAAA"
     polyA_site      2079
                     /gene="ANKRD29"
                     /note="major polyA site"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD29"
                     /note="hexamer: AATAAA"
     polyA_site      3387
                     /gene="ANKRD29"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgcccc ttcggcccgg ccctgtgtgc ggcggctgct gccgggccgg gcggcgggag
       61 cgcgcggcgt cggaggccgc ccctctgcgg aacgccgaga gccccgggag agtgaagggc
      121 cggggaggac aaggcgcccc gggcccaaag cgcgccggct cccgctcggg cggccgcgga
      181 catgtgcagg atgtccttca agaaggaaac tccacttgcc aatgctgcat tctgggcagc
      241 caggagagga aacctggcgc tgctgaagct gctgttgaac agcggccggg tggacgtgga
      301 ctgcagagac agccatggca ccacactcct gatggttgct gcctacgctg gccacataga
      361 ctgtgtgagg gaactggttc tgcaaggagc agacatcaat ctccagagag agtcaggtac
      421 aactgcccta ttctttgccg cccagcaagg ccataatgat gtcgtgagat ttctctttgg
      481 atttggagca tccactgaat ttaggaccaa agacgggggc accgccctgt tggctgccag
      541 tcagtacggg cacatgcagg tggtggagac cttgctgaag cacggagcaa acatccatga
      601 ccaactttat gatggagcca ctgccctctt cctagctgcc caaggtggtt acttggatgt
      661 tattcgatta ctgctggctt caggagcaaa agtcaaccag ccaaggcagg acgggacagc
      721 gcccctgtgg atcgcgtccc agatgggcca cagcgaggtg gtgcgggtga tgctgctgcg
      781 cggagccgac cgcgacgctg cgcggaacga tggcacaaca gcattattga aagcagccaa
      841 caaagggtat aatgatgtca taaaagagtt gcttaaattc tcacccactc ttggtatttt
      901 gaagaatggg acatcagcgc tccatgcagc agtgctcagt ggaaacatta aaacagttgc
      961 gctgctccta gaagcagggg cagacccatc cctgagaaac aaggccaatg aacttccggc
     1021 agaactaacc aaaaatgaac gtatattgcg tctcctgaga agtaaagaag gtcccagaaa
     1081 gagctaactt agctccatat ttgacagaaa gatagaaagc ttaaccacat tgtccaaaaa
     1141 gaaattgcat ttcaagcagt gttggaaatt cttttatgaa aaaaaaagat gcccagaatg
     1201 cccatcctgt gggtccctga caaagaagag ctacgctctg tgcacgaagt caagaaccaa
     1261 acagctcagg gaccctcttg ccccttcacc atggacttct catggtgtcc tgtaactcat
     1321 ctcccggggg gcctggcatg ttcacagatt ccacagaaac tcattttcaa caatgctaac
     1381 ttggacctgt cagttaaact ctaaggtgga cagggttctc agtactaagc aaggagacag
     1441 aatgctttgt tcctttaaaa gactgaaaag ctgaccttca atggattgag gcacttttgc
     1501 ttttgtgtta aatgtagatg tgctaaaata tatagatcta tcatatttta cctacatatg
     1561 tatgtcattc cagtataaaa cattctcctc tacccaagaa ccatagccat gattgttata
     1621 aatcaatgaa gtgtaaacat acattattaa aaaaccactt ctgacattcc attatgtgct
     1681 attcaaagat ggactattga actatagaaa agacagactg tgcatttgtt cgttgatcct
     1741 catcttattc ctgacatgta aaaatcaatt ttacgtagag tcaacattgt aggtaggtta
     1801 aaataccagt ggcaaatttg gaaattcaga aacttataaa ccacgagaaa tatataggct
     1861 tgtctctttg gtcttttatt ttggctctat tgttgggaat ctatttccta ttctataagt
     1921 aagtatacct aacatgctgt ggaatcttga gtttccaaca ccgtgctgct tgatagaatg
     1981 actttgaggt ccttggataa aatgtgatat atgcaagtac agtatgttgc tattactatt
     2041 gcaggaatat aaataataaa agactgttat tagcacttag taagtcttca tctatgcatg
     2101 tttttgagtt gactgattcc aagaatgaaa tatgaggttt attgaattat tcctttgaaa
     2161 gggatcaaaa cttatattca atgcacttta taattaatgg tgtctaaatg cctcagtcag
     2221 tgcctaactg cacatacaaa aataaaacct tctttctgta atctaccaaa ataaacgcaa
     2281 tggtatttct gctatttaaa cacatcttta gcttatttct tcatgttctg ctctggtttt
     2341 cagtcagtgt ctatgtaaag acacttttag aggaaaatgt tgtaatccca aaagaatttt
     2401 tgtttaacca actttcagag ttactaaaag gattatcttt aattcagtaa ataatagaat
     2461 ataatcttca aaattagaag atattctctt aaaatttata acaattaatg caacaaaaat
     2521 cagcatattt tgataaatgt ctcaagcaaa tgagcaactc acaggcccca caggtgccta
     2581 cagcctgacc agctatacaa aaagcctgca acctgattct aggataaaat attagaaagc
     2641 tctctgttgc taaaacatcc agatataaac attttggtgg ctaaaatcaa tgccatttcc
     2701 tcattgacat tcttttattc agcaaatttg tacaaatata cattttctcc tgtgcgaatt
     2761 tcaaaaagct atattcattt tgaagaggaa aataatatgg cattaaatgc tttgtatttt
     2821 ccccttagtt agcccttatg gcaaaaatag ttgctaatca ctgatacaaa gcaaaacgtt
     2881 atgggtactg ataacaaagt tccaaaagcc aaaatgggat gaatcacaaa cttactgttt
     2941 ttcactaaaa catgtaattg gcctattaca tcaatagttt taagtgggta atgttcttga
     3001 acaatattag agccataaaa ttgaagccag tagcttgaac aatatggagg ccttcttact
     3061 gtagggaaga ggtgtctagc ttagaaggat cacatttgat ctagatgaga ttacccatag
     3121 cagggaaaat gaatcatcac ctaccaaaga ctgtacggaa aggtgtgtta ttttcaaaat
     3181 tgcattttag tttgcacaca tgtaaatgat tattctatgt taatctaatt gacaattcag
     3241 ttagctccgc atcctaagac ttaaaactag caattcctat gcaaatcatc tgcttaactg
     3301 aactacaaac gtttttcatt aattcattct ttgatgacat attccatgtt atataataat
     3361 tcaaaataaa gttaatatac tacccca
//
