LOCUS       NM_001349278            7744 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 28 (ANKRD28), transcript variant
            5, mRNA.
ACCESSION   NM_001349278 XM_005264996
VERSION     NM_001349278.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7744)
  AUTHORS   Song,S., Shi,Y., Zeng,D., Xu,J., Yang,Y., Guo,W., Zheng,Y. and
            Tang,H.
  TITLE     circANKRD28 inhibits cisplatin resistance in non-small-cell lung
            cancer through the miR-221-3p/SOCS3 axis
  JOURNAL   J Gene Med 25 (4), e3478 (2023)
   PUBMED   36740786
  REMARK    GeneRIF: circANKRD28 inhibits cisplatin resistance in
            non-small-cell lung cancer through the miR-221-3p/SOCS3 axis.
REFERENCE   2  (bases 1 to 7744)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7744)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7744)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7744)
  AUTHORS   Ding,L., Feng,M.J., Liu,C.L., Wang,L., Song,Z.C., Yang,Q., Li,X.X.,
            Song,L., Gao,W. and Wang,J.T.
  TITLE     [Effect of hnRNP K and its interaction with HPV16 on cervical
            intraepithelial neoplasia]
  JOURNAL   Zhonghua Liu Xing Bing Xue Za Zhi 39 (12), 1630-1635 (2018)
   PUBMED   30572391
  REMARK    GeneRIF: HPV16 infection and over-expression of hnRNP K protein
            were associated with the increased risk of cervical intraepithelial
            neoplasia. There might be interaction between hnRNP K protein
            overexpression and HPV16 infection existed on the progress of CIN/
            [ cervical intraepithelial neoplasia II/III].
REFERENCE   6  (bases 1 to 7744)
  AUTHORS   Stefansson,B., Ohama,T., Daugherty,A.E. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 regulatory subunits composed of ankyrin
            repeat domains
  JOURNAL   Biochemistry 47 (5), 1442-1451 (2008)
   PUBMED   18186651
REFERENCE   7  (bases 1 to 7744)
  AUTHORS   Lee,P.T., Liao,P.C., Chang,W.C. and Tseng,J.T.
  TITLE     Epidermal growth factor increases the interaction between nucleolin
            and heterogeneous nuclear ribonucleoprotein K/poly(C) binding
            protein 1 complex to regulate the gastrin mRNA turnover
  JOURNAL   Mol Biol Cell 18 (12), 5004-5013 (2007)
   PUBMED   17928403
REFERENCE   8  (bases 1 to 7744)
  AUTHORS   Kwiek,N.C., Thacker,D.F. and Haystead,T.A.
  TITLE     Dual kinase-mediated regulation of PITK by CaMKII and GSK3
  JOURNAL   Cell Signal 19 (3), 593-599 (2007)
   PUBMED   17023142
  REMARK    GeneRIF: CaMKII and GSK3 mediate regulation of PITK.
REFERENCE   9  (bases 1 to 7744)
  AUTHORS   Kwiek,N.C., Thacker,D.F., Datto,M.B., Megosh,H.B. and Haystead,T.A.
  TITLE     PITK, a PP1 targeting subunit that modulates the phosphorylation of
            the transcriptional regulator hnRNP K
  JOURNAL   Cell Signal 18 (10), 1769-1778 (2006)
   PUBMED   16564677
  REMARK    GeneRIF: These findings provide a putative mechanism by which
            transcriptional activity of hnRNP K can be discretely controlled
            through the regulation of PP1 activity.
REFERENCE   10 (bases 1 to 7744)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090950.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001349278.1.
            
            Transcript Variant: This variant (5) encodes isoform d.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.176379.1,
                                           SRR1803616.96332.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683139.1/ ENSP00000508086.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1575              AC090950.3         189840-191414       c
            1576-1659           AC090950.3         188658-188741       c
            1660-1738           AC090950.3         159669-159747       c
            1739-1809           AC090950.3         145185-145255       c
            1810-2010           AC090950.3         130468-130668       c
            2011-2098           AC090950.3         128845-128932       c
            2099-2241           AC090950.3         117817-117959       c
            2242-2454           AC090950.3         114350-114562       c
            2455-2533           AC090950.3         108013-108091       c
            2534-2648           AC090950.3         106962-107076       c
            2649-2731           AC090950.3         105575-105657       c
            2732-2795           AC090950.3         104646-104709       c
            2796-2864           AC090950.3         103103-103171       c
            2865-3005           AC090950.3         101359-101499       c
            3006-3117           AC090950.3         89569-89680         c
            3118-3144           AC090950.3         88623-88649         c
            3145-3219           AC090950.3         88174-88248         c
            3220-3421           AC090950.3         83454-83655         c
            3422-3509           AC090950.3         79657-79744         c
            3510-3627           AC090950.3         79437-79554         c
            3628-3847           AC090950.3         78661-78880         c
            3848-3935           AC090950.3         72911-72998         c
            3936-4019           AC090950.3         72736-72819         c
            4020-4165           AC090950.3         71644-71789         c
            4166-4248           AC090950.3         70915-70997         c
            4249-4331           AC090950.3         70409-70491         c
            4332-4423           AC090950.3         69333-69424         c
            4424-7744           AC090950.3         60671-63991         c
FEATURES             Location/Qualifiers
     source          1..7744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..7744
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="ankyrin repeat domain 28"
                     /db_xref="GeneID:23243"
                     /db_xref="HGNC:HGNC:29024"
                     /db_xref="MIM:611122"
     exon            1..1575
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     CDS             1459..4710
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="isoform d is encoded by transcript variant 5;
                     protein phosphatase 6 ankyrin repeat subunit A;
                     phosphatase interactor targeting K protein;
                     serine/threonine-protein phosphatase 6 regulatory ankyrin
                     repeat subunit A; PP6-ARS-A; ankyrin repeat
                     domain-containing protein 28; phosphatase interactor
                     targeting protein hnRNP K; serine/threonine-protein
                     phosphatase 6 regulatory subunit ARS-A; protein
                     phosphatase 1, regulatory subunit 65"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory ankyrin repeat subunit A isoform d"
                     /protein_id="NP_001336207.1"
                     /db_xref="CCDS:CCDS93222.1"
                     /db_xref="GeneID:23243"
                     /db_xref="HGNC:HGNC:29024"
                     /db_xref="MIM:611122"
                     /translation="MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLPSLVQ
                     AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDS
                     KWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL
                     SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV
                     VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA
                     CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK
                     DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG
                     ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC
                     LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA
                     ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMET
                     SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG
                     HVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGN
                     GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA
                     KCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGH
                     ETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTP
                     LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELT
                     LQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV
                     QELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAI
                     NRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY"
     exon            1576..1659
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1738
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1809
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2010
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2098
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2241
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2454
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2533
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2648
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2731
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2795
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2864
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3005
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3117
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3144
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3219
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3421
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3509
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3627
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3847
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3935
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4019
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4165
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4248
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4331
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..4423
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..7744
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6349..6354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="hexamer: AATAAA"
     polyA_site      6381
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="major polyA site"
     regulatory      7721..7726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="hexamer: AATAAA"
     polyA_site      7744
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="major polyA site"
ORIGIN      
        1 agatctctgg taagtgtaac atgtgagcat tactaggcat ttcatcctgt gggtctgcag
       61 tctttgctct tcagactgtt gctccgttgg aatgcttctg tgggactgat actgaggttc
      121 tatagatatt ttttaaggac ctactcattt ggggatgtca gtggtgtttt gcaagatcat
      181 ctgaggaaca ggaaagcatt tgaaatctga aaaggataac tgtggcggtt ttcacagtgg
      241 aaggaaacta tattggcaaa gaggcagatg actgaataaa gtagttggct caaagaagat
      301 gcacagtctg ctattttttt ctctgaatga agactgttta atggaagctg tattcatgtg
      361 gagatcaaag gaaacactgg aatgatacac tactatgttt ttcccccccc tttttttttt
      421 taaagaaaac aaaaagcctg aagcagtaat ttgagctcaa atgccttcta attccttcac
      481 agcctgcttg ttctactagg attctccact aacaccattt ctgcctggtg cctgtgccct
      541 tttgctggag cagccacaga caactgcctg atggagaaag aatgaacgct ctgccttgct
      601 tatgctatcg atgggaataa agctaactgt gtttcttcta ttatatggga aacctggatt
      661 aatcaagctg tattctagta ccaagagtcg tattgtctct tgtggtctga ctcatcacat
      721 gtaaacgtac tgcagctttg ctattaatgc agagtggttt tttttttttt gtttttgttt
      781 tttgcccctt tcccaaacac tgaaagaatt gttaacctct gagcttcatt ttcaggattt
      841 gtgctgagct ctagatcttt tttctgtgaa tagtatctgc attaaaccag tgatgaagaa
      901 atgaagacaa attagaagtg gaaacagaat agtgagattt tattttttat tttcaattat
      961 aagcaaaaca gctactggta actatatgac cttgcaggca agagtgggta tcgctgtgat
     1021 catctctgtc acagcagttg tttctcattt cattctatat tgtgtggtgt tgtgtcacca
     1081 aaaacaatga ttgttttgtg caagtaaatt tcagagatag agcaataaga ctattttggt
     1141 agaggaaaaa tatttttaaa tgagcttgga ctcagtttta gttattgaca tgttggtgtg
     1201 aaatttcttc ttaagtattg cagtaatcca acagaaataa tagaatttcg ttatatttag
     1261 gaagttacaa attatgtagt cataatttta aacttgtttt tccagtagta cttattaact
     1321 ttaaaaaaaa aaaaaaccca gctgtgctgt tcagagaatg tttgtaagtg ttgtacagaa
     1381 gaggaggaaa aactacttgt gctcttccaa ctgtgacttt tatcacatag cttggaattt
     1441 agtgttttaa aagatcgaat gagtcgagtg tgtattgttg ttttggagga ggtagaagat
     1501 gaatctcctg cattcatttc taaattgcca caggaaaata aatccctaca ttctccacct
     1561 tctggaaatg tattgccatc actggtgcaa gctatattta acggagatcc tgatgaagtt
     1621 cgagcactaa tatttaagaa agaagatgtt aactttcagg acaatgaaaa gcgaacccca
     1681 ttgcacgccg cagcttacct tggagatgca gaaatcattg aacttcttat tttatctgga
     1741 gctagagtta atgccaaaga cagcaaatgg ttgacacctt tacacagagc agttgcatct
     1801 tgtagtgagg aagcagttca ggtacttttg aagcattctg cagatgttaa tgctcgagac
     1861 aaaaattggc aaaccccttt acatatagct gctgctaata aagctgtaaa gtgtgctgaa
     1921 gctttggtac ctcttctgag taatgtaaac gtatctgatc gagcagggag gactgcatta
     1981 catcatgcag ctttcagtgg acatggtgag atggtcaaac tactcttgtc tagaggtgcc
     2041 aatattaatg cttttgacaa gaaagatagg cgtgctatcc attgggcagc atatatgggt
     2101 cacattgaag tagtgaaatt gcttgtgtcg catggagctg aagtgacatg caaggataaa
     2161 aagtcttata cacctcttca tgcagcagcc tctagtggaa tgatcagcgt agtcaagtac
     2221 cttctagatc ttggagttga tatgaatgaa ccaaatgcct atggaaatac acctcttcat
     2281 gtagcctgct ataatggaca agatgttgta gtgaatgaac ttatagactg tggtgctatt
     2341 gtgaatcaaa agaatgaaaa aggatttact cctttgcact ttgctgctgc atcaacacat
     2401 ggagcattgt gtttagagct tctagttggc aatggggccg atgtcaatat gaagagtaaa
     2461 gatgggaaaa ccccactaca catgactgct ctccacggta gattctcccg atcacaaacc
     2521 attatccaga gtggagctgt aatcgactgt gaggataaga atggaaatac ccctttgcac
     2581 atagcagcac ggtatggcca tgagctgctg atcaacactc ttattacaag tggtgctgac
     2641 actgcaaagc gtggcataca tggaatgttc cccctccatt tggcagcctt aagcggcttt
     2701 tcagattgct gcagaaaact tctttcttca ggatttgata tagatacccc agatgatttt
     2761 ggcaggactt gtctacatgc agctgcagct ggagggaatt tggagtgcct aaaccttctg
     2821 ctgaatactg gtgcagactt taataaaaag gacaaatttg ggagatctcc actgcactac
     2881 gctgctgcca actgcaatta ccagtgcctg tttgctcttg tgggatcagg agcaagtgtg
     2941 aatgaccttg atgaaagagg ctgcacaccc ctgcactatg cagctacatc agacacagat
     3001 ggcaagtgcc tggaatactt attaagaaac gatgcaaatc cagggatccg tgataagcaa
     3061 ggatacaacg cagttcatta ttcagctgct tatggtcacc gtctatgtct tcagctgatt
     3121 gcaagtgaaa ctcctctaga tgttttaatg gaaacctcag gaacagacat gctgagtgat
     3181 tcagataata gagcaacaat aagcccttta cacttggctg cctatcatgg tcaccatcaa
     3241 gcactggaag tgttggtaca gtctttgtta gatcttgatg tcagaaatag tagtggaaga
     3301 acacccctag atcttgcagc ttttaagggc catgttgaat gtgtggatgt actcattaat
     3361 cagggagcct caatcttagt aaaagattac attttgaaga ggacacctat tcatgcagca
     3421 gcaacaaatg gtcattcaga atgcttacgg ctattaatag gaaatgcaga accacagaat
     3481 gcagtggata ttcaagatgg aaatggacag acgcctctga tgctatctgt tctcaacggg
     3541 cacacagact gtgtttactc attgctgaac aaaggagcaa atgtagatgc caaagataag
     3601 tggggaagga cagcgttgca tagaggggca gttacaggcc atgaagaatg tgtagatgca
     3661 ttacttcaac atggtgctaa gtgcttactt cgggatagca ggggccggac gcctatacac
     3721 ctgtctgctg cctgtggaca cattggtgtt cttggagccc ttttgcagtc agcagcatct
     3781 atggatgcaa atccagccac agcagacaat catggatata cggcacttca ctgggcttgc
     3841 tacaatggtc acgagacatg tgtagaactg cttttagaac aggaagtttt ccagaaaacg
     3901 gaaggaaatg cttttagtcc attgcattgt gccgtgataa atgacaacga aggtgctgct
     3961 gagatgttaa ttgatacatt aggtgccagc attgtgaacg ccacagattc aaaaggaaga
     4021 actcctctcc atgcagccgc cttcacagac catgtagagt gtttacagct gctgctcagc
     4081 cataatgctc aagtcaattc tgtggactct acagggaaaa cacctcttat gatggctgca
     4141 gaaaatggac aaacaaatac agttgagatg ctggttagca gtgctagtgc agaactgact
     4201 ttacaagata acagtaaaaa tactgccctc catttggctt gtagcaaggg tcatgaaact
     4261 agtgccttgt taatactgga aaagataaca gatagaaacc tcatcaatgc aaccaacgca
     4321 gccttgcaaa cacctctgca tgttgctgcc cgaaatgggc taacaatggt ggttcaggaa
     4381 cttttgggaa aaggagcaag tgtgcttgca gtagatgaaa atggctatac cccagctttg
     4441 gcctgtgctc ccaataagga tgtggctgat tgcctggctc tcattttggc caccatgatg
     4501 cctgtctcat caagtagtcc tttatcatcc ttaacattca atgccattaa ccgttatacc
     4561 aacacctcaa aaacagtcag ctttgaagct ttgcccatca tgaggaatga acctagctcc
     4621 tattgcagtt tcaataacat tggaggggaa caggagtact tatacactga cgtggatgag
     4681 ctcaacgact ccgattctga gacctactga gaggctgagg aggagggagt tctcacagta
     4741 aagcttcaaa ctgtgctttt tcaggaaaaa ggcactttga tattcacgta gaaattcaac
     4801 ctaagaggaa agatcccaca gtgagccaat gttaagagat ctgatggcat taggaggaag
     4861 agttttaaag gcaagtttta caaaaggaac ttctagaatc ttgaaataga cctgactgag
     4921 gaaaacacat tgatgtcaga attctttgtg gaattgttta atttggtttt gcagtgccag
     4981 gaacaattgg ggacactgtg cactctaacc tgcttacaca agcaacacta ttgtaacaga
     5041 agaaataaag acactagatt taaattttat caataaaatt acaactaaat ttaaaggcaa
     5101 taaaagtttg gtacagtagg cattatgtgc acagcaaatt gcaaaaggac caaataactg
     5161 aaaggttttt ttaataaaat gccattttgt ggaaactgga gtagattaaa tgaaacatta
     5221 cctaaaccaa actgcaatat ttctggaaat gaagctgaga tttggtttta aatgttgagt
     5281 ttttttgggt tttgtttttt ttttaagaaa acatctgaaa gccttccaat gctgtattaa
     5341 accatgagag aaagcagatg tatttttaca tttttttctt ttacagaact atttcaaatt
     5401 tccaattttt atactattag aattaaaaac cagctgactg ggtgcaatac gggtgaaaat
     5461 acttgtgaca tagacattga gatggattgg ggtcaggctg ttgccctgtt ttgaatggtt
     5521 tgggtttaaa atagtactat ttttgtttga aaatgtaaag aatttcctag aaaaaaattc
     5581 atgaaatcaa aaagtagact atttcaccct attgcagcta agtggtcctg gggcatggag
     5641 tcttcaacct ctctatgaat ggcacacctt agtcacttat gttacttttg tgtccccacc
     5701 atgggttggg ggattttttg tttattctga tctatgagtt ttgaaaaagt gaataatcaa
     5761 aaggaaaata attccttgtt gttcataaat taagcatcac taaagtctct tgaaaggcat
     5821 ttctgtattg ggcaagattt aaaatactaa agccttaggt cctattcata tttaaagtag
     5881 catgtttgta acctgttact atttggagag agaagcagtt gcctgccaaa ttgaagacta
     5941 cctttcaaat agcaaaagag agagagaagg ctgatatttc ggcttttaaa taaagatttg
     6001 tgtggttctg cttttactgt aactgtcact ttcccagtga aaatgatttc atatacattg
     6061 agggtcttac aggtatgggt aaagttctat aaattgcaac aaaatgatac ccaatttcat
     6121 tttatccttt ttgtattgtg aaactggaaa ctttatgaca ttgtaaatta tcagctggtt
     6181 tttctgaata taaagtgtga aaacacagaa cagtattttg atctatttga taattttgtg
     6241 ggttttttga agaattaatg agcatgtaca tagaaatagt gactgcttga atactgtatt
     6301 tacttgcact ctttcagtac atcaagattc ctgtatattt tagagtataa taaaacacag
     6361 atgtgagttg tatttaatga ataatgtatt tgtatctgtg catattatct acaaatctat
     6421 aaagtttcta gggcattgac tactagattt taagcatttt ttctaaaata tttacagaaa
     6481 ttataaatct aatcccccat cttttcttta taatataaag aagtcataat gaacccttcc
     6541 taattattag tagtaggaag gtgaatatgc attttaatga cagtggacta cattttctat
     6601 tgtacctttt gaaaaaaaaa aaaatcaagc agattctaaa agtatacata tgtgtgcttt
     6661 ctctttcctt ttaggaattc tcttctgaat tccctgaggg aattttctag aatctcagaa
     6721 ttgaaagaga cctgaggttc atccagtctc taacctctta acaaatgcag gagtcccttc
     6781 tacaagggtg atctttccac cttgaacact tccaagtgac tctacctcac caagcagtcc
     6841 attcagttgt tgagcagctc taactgttag aaaggtcttc cttagatgga gttgaagcct
     6901 ccctcccggt aacttctgtc tttgggcctg ggtctgtcct ccaagagaac cctgagaatg
     6961 ttggaaggat gaatctcgca cattctgcca tgtcttctct tttacaggct gtttgacttc
     7021 tctgctgaag tgatttccag aaggactcat ttgacacact attagattta ccacatctaa
     7081 tgaaatccaa ggtgtagcta taaagtgaca agctgttttt aatttatcac atacaccaga
     7141 acttctatcc tgcatcactt atatgtaaat gatgctgtta ccaaaaacat taaggtagtt
     7201 cttgcgaatg ccaccccact aagaaaacta tttcattact tttgtaatcc atctgtgaga
     7261 gtctgccccc cagcttaacc acttcctttg gtctgcaccc aatgaaggga aaccccaaag
     7321 tactgtctca aatggtattt gaactacgcc agtattgttg gaataagtac attaattact
     7381 tgaatgaatg aacacagcac cgtagaaatt tcctttatgg ttacaccttg tatgtctaaa
     7441 gcattcaggc cctgttctgt agtgtttctt atcctcacac agagtagaaa agcctgtttg
     7501 ctttatttaa cttatacata aaagatgaca tctgaaatat ctgatgtgta ttataatacc
     7561 agcttctgct ctagaactac tttgggtgaa atggtggtaa tagcaaatga cctcctttaa
     7621 caagacactc atctcaaaca atgccattta gttcaggaga tctctaagtg tagctgtaaa
     7681 ttttggggtt aatttggctt atattggacc ttttaaaaga aataaagttt tttaatgcaa
     7741 taaa
//
