LOCUS       NM_001195099            6070 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 28 (ANKRD28), transcript variant
            3, mRNA.
ACCESSION   NM_001195099
VERSION     NM_001195099.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6070)
  AUTHORS   Song,S., Shi,Y., Zeng,D., Xu,J., Yang,Y., Guo,W., Zheng,Y. and
            Tang,H.
  TITLE     circANKRD28 inhibits cisplatin resistance in non-small-cell lung
            cancer through the miR-221-3p/SOCS3 axis
  JOURNAL   J Gene Med 25 (4), e3478 (2023)
   PUBMED   36740786
  REMARK    GeneRIF: circANKRD28 inhibits cisplatin resistance in
            non-small-cell lung cancer through the miR-221-3p/SOCS3 axis.
REFERENCE   2  (bases 1 to 6070)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6070)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6070)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6070)
  AUTHORS   Ding,L., Feng,M.J., Liu,C.L., Wang,L., Song,Z.C., Yang,Q., Li,X.X.,
            Song,L., Gao,W. and Wang,J.T.
  TITLE     [Effect of hnRNP K and its interaction with HPV16 on cervical
            intraepithelial neoplasia]
  JOURNAL   Zhonghua Liu Xing Bing Xue Za Zhi 39 (12), 1630-1635 (2018)
   PUBMED   30572391
  REMARK    GeneRIF: HPV16 infection and over-expression of hnRNP K protein
            were associated with the increased risk of cervical intraepithelial
            neoplasia. There might be interaction between hnRNP K protein
            overexpression and HPV16 infection existed on the progress of CIN/
            [ cervical intraepithelial neoplasia II/III].
REFERENCE   6  (bases 1 to 6070)
  AUTHORS   Stefansson,B., Ohama,T., Daugherty,A.E. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 regulatory subunits composed of ankyrin
            repeat domains
  JOURNAL   Biochemistry 47 (5), 1442-1451 (2008)
   PUBMED   18186651
REFERENCE   7  (bases 1 to 6070)
  AUTHORS   Lee,P.T., Liao,P.C., Chang,W.C. and Tseng,J.T.
  TITLE     Epidermal growth factor increases the interaction between nucleolin
            and heterogeneous nuclear ribonucleoprotein K/poly(C) binding
            protein 1 complex to regulate the gastrin mRNA turnover
  JOURNAL   Mol Biol Cell 18 (12), 5004-5013 (2007)
   PUBMED   17928403
REFERENCE   8  (bases 1 to 6070)
  AUTHORS   Kwiek,N.C., Thacker,D.F. and Haystead,T.A.
  TITLE     Dual kinase-mediated regulation of PITK by CaMKII and GSK3
  JOURNAL   Cell Signal 19 (3), 593-599 (2007)
   PUBMED   17023142
  REMARK    GeneRIF: CaMKII and GSK3 mediate regulation of PITK.
REFERENCE   9  (bases 1 to 6070)
  AUTHORS   Kwiek,N.C., Thacker,D.F., Datto,M.B., Megosh,H.B. and Haystead,T.A.
  TITLE     PITK, a PP1 targeting subunit that modulates the phosphorylation of
            the transcriptional regulator hnRNP K
  JOURNAL   Cell Signal 18 (10), 1769-1778 (2006)
   PUBMED   16564677
  REMARK    GeneRIF: These findings provide a putative mechanism by which
            transcriptional activity of hnRNP K can be discretely controlled
            through the regulation of PP1 activity.
REFERENCE   10 (bases 1 to 6070)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY367056.1, AK293770.1, BQ423818.1 and AC090950.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001195099.1.
            
            Transcript Variant: This variant (3), as well as variants 2 and 10,
            encodes isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY367056.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-751               AY367056.1         5-755
            752-1385            AK293770.1         1066-1699
            1386-2161           BQ423818.1         71-846
            2162-3422           AY367056.1         2165-3425
            3423-6070           AC090950.3         60671-63318         c
FEATURES             Location/Qualifiers
     source          1..6070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..6070
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="ankyrin repeat domain 28"
                     /db_xref="GeneID:23243"
                     /db_xref="HGNC:HGNC:29024"
                     /db_xref="MIM:611122"
     exon            1..64
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            65..135
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            136..336
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..3036
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="isoform b is encoded by transcript variant 3;
                     protein phosphatase 6 ankyrin repeat subunit A;
                     phosphatase interactor targeting K protein;
                     serine/threonine-protein phosphatase 6 regulatory ankyrin
                     repeat subunit A; PP6-ARS-A; ankyrin repeat
                     domain-containing protein 28; phosphatase interactor
                     targeting protein hnRNP K; serine/threonine-protein
                     phosphatase 6 regulatory subunit ARS-A; protein
                     phosphatase 1, regulatory subunit 65"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory ankyrin repeat subunit A isoform b"
                     /protein_id="NP_001182028.1"
                     /db_xref="CCDS:CCDS74908.1"
                     /db_xref="GeneID:23243"
                     /db_xref="HGNC:HGNC:29024"
                     /db_xref="MIM:611122"
                     /translation="MVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE
                     VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVN
                     ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA
                     LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG
                     MFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD
                     FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCL
                     EYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD
                     NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN
                     QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL
                     NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR
                     TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ
                     EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHV
                     ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL
                     HLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV
                     LAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTV
                     SFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY"
     exon            337..424
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            425..567
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            568..780
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            781..859
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            860..974
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1057
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1121
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1190
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1331
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1443
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1470
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1545
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1747
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1835
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1953
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2173
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2261
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2345
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2491
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2574
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2657
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2749
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..6070
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4675..4680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="hexamer: AATAAA"
     polyA_site      4707
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="major polyA site"
     regulatory      6047..6052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="hexamer: AATAAA"
     polyA_site      6070
                     /gene="ANKRD28"
                     /gene_synonym="CFAP79; FAP79; PITK; PPP1R65"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcttcac aacgttagac ctctcttcag ctgcattgct ggctgcctag agccctagac
       61 taatgagcta gagttaatgc caaagacagc aaatggttga cacctttaca cagagcagtt
      121 gcatcttgta gtgaggaagc agttcaggta cttttgaagc attctgcaga tgttaatgct
      181 cgagacaaaa attggcaaac ccctttacat atagctgctg ctaataaagc tgtaaagtgt
      241 gctgaagctt tggtacctct tctgagtaat gtaaacgtat ctgatcgagc agggaggact
      301 gcattacatc atgcagcttt cagtggacat ggtgagatgg tcaaactact cttgtctaga
      361 ggtgccaata ttaatgcttt tgacaagaaa gataggcgtg ctatccattg ggcagcatat
      421 atgggtcaca ttgaagtagt gaaattgctt gtgtcgcatg gagctgaagt gacatgcaag
      481 gataaaaagt cttatacacc tcttcatgca gcagcctcta gtggaatgat cagcgtagtc
      541 aagtaccttc tagatcttgg agttgatatg aatgaaccaa atgcctatgg aaatacacct
      601 cttcatgtag cctgctataa tggacaagat gttgtagtga atgaacttat agactgtggt
      661 gctattgtga atcaaaagaa tgaaaaagga tttactcctt tgcactttgc tgctgcatca
      721 acacatggag cattgtgttt agagcttcta gttggcaatg gggccgatgt caatatgaag
      781 agtaaagatg ggaaaacccc actacacatg actgctctcc acggtagatt ctcccgatca
      841 caaaccatta tccagagtgg agctgtaatc gactgtgagg ataagaatgg aaatacccct
      901 ttgcacatag cagcacggta tggccatgag ctgctgatca acactcttat tacaagtggt
      961 gctgacactg caaagcgtgg catacatgga atgttccccc tccatttggc agccttaagc
     1021 ggcttttcag attgctgcag aaaacttctt tcttcaggat ttgatataga taccccagat
     1081 gattttggca ggacttgtct acatgcagct gcagctggag ggaatttgga gtgcctaaac
     1141 cttctgctga atactggtgc agactttaat aaaaaggaca aatttgggag atctccactg
     1201 cactacgctg ctgccaactg caattaccag tgcctgtttg ctcttgtggg atcaggagca
     1261 agtgtgaatg accttgatga aagaggctgc acacccctgc actatgcagc tacatcagac
     1321 acagatggca agtgcctgga atacttatta agaaacgatg caaatccagg gatccgtgat
     1381 aagcaaggat acaacgcagt tcattattca gctgcttatg gtcaccgtct atgtcttcag
     1441 ctgattgcaa gtgaaactcc tctagatgtt ttaatggaaa cctcaggaac agacatgctg
     1501 agtgattcag ataatagagc aacaataagc cctttacact tggctgccta tcatggtcac
     1561 catcaagcac tggaagtgtt ggtacagtct ttgttagatc ttgatgtcag aaatagtagt
     1621 ggaagaacac ccctagatct tgcagctttt aagggccatg ttgaatgtgt ggatgtactc
     1681 attaatcagg gagcctcaat cttagtaaaa gattacattt tgaagaggac acctattcat
     1741 gcagcagcaa caaatggtca ttcagaatgc ttacggctat taataggaaa tgcagaacca
     1801 cagaatgcag tggatattca agatggaaat ggacagacgc ctctgatgct atctgttctc
     1861 aacgggcaca cagactgtgt ttactcattg ctgaacaaag gagcaaatgt agatgccaaa
     1921 gataagtggg gaaggacagc gttgcataga ggggcagtta caggccatga agaatgtgta
     1981 gatgcattac ttcaacatgg tgctaagtgc ttacttcggg atagcagggg ccggacgcct
     2041 atacacctgt ctgctgcctg tggacacatt ggtgttcttg gagccctttt gcagtcagca
     2101 gcatctatgg atgcaaatcc agccacagca gacaatcatg gatatacggc acttcactgg
     2161 gcttgctaca atggtcacga gacatgtgta gaactgcttt tagaacagga agttttccag
     2221 aaaacggaag gaaatgcttt tagtccattg cattgtgccg tgataaatga caacgaaggt
     2281 gctgctgaga tgttaattga tacattaggt gccagcattg tgaacgccac agattcaaaa
     2341 ggaagaactc ctctccatgc agccgccttc acagaccatg tagagtgttt acagctgctg
     2401 ctcagccata atgctcaagt caattctgtg gactctacag ggaaaacacc tcttatgatg
     2461 gctgcagaaa atggacaaac aaatacagtt gagatgctgg ttagcagtgc tagtgcagaa
     2521 ctgactttac aagataacag taaaaatact gccctccatt tggcttgtag caagggtcat
     2581 gaaactagtg ccttgttaat actggaaaag ataacagata gaaacctcat caatgcaacc
     2641 aacgcagcct tgcaaacacc tctgcatgtt gctgcccgaa atgggctaac aatggtggtt
     2701 caggaacttt tgggaaaagg agcaagtgtg cttgcagtag atgaaaatgg ctatacccca
     2761 gctttggcct gtgctcccaa taaggatgtg gctgattgcc tggctctcat tttggccacc
     2821 atgatgcctg tctcatcaag tagtccttta tcatccttaa cattcaatgc cattaaccgt
     2881 tataccaaca cctcaaaaac agtcagcttt gaagctttgc ccatcatgag gaatgaacct
     2941 agctcctatt gcagtttcaa taacattgga ggggaacagg agtacttata cactgacgtg
     3001 gatgagctca acgactccga ttctgagacc tactgagagg ctgaggagga gggagttctc
     3061 acagtaaagc ttcaaactgt gctttttcag gaaaaaggca ctttgatatt cacgtagaaa
     3121 ttcaacctaa gaggaaagat cccacagtga gccaatgtta agagatctga tggcattagg
     3181 aggaagagtt ttaaaggcaa gttttacaaa aggaacttct agaatcttga aatagacctg
     3241 actgaggaaa acacattgat gtcagaattc tttgtggaat tgtttaattt ggttttgcag
     3301 tgccaggaac aattggggac actgtgcact ctaacctgct tacacaagca acactattgt
     3361 aacagaagaa ataaagacac tagatttaaa ttttatcaat aaaattacaa ctaaatttaa
     3421 aggcaataaa agtttggtac agtaggcatt atgtgcacag caaattgcaa aaggaccaaa
     3481 taactgaaag gtttttttaa taaaatgcca ttttgtggaa actggagtag attaaatgaa
     3541 acattaccta aaccaaactg caatatttct ggaaatgaag ctgagatttg gttttaaatg
     3601 ttgagttttt ttgggttttg tttttttttt aagaaaacat ctgaaagcct tccaatgctg
     3661 tattaaacca tgagagaaag cagatgtatt tttacatttt tttcttttac agaactattt
     3721 caaatttcca atttttatac tattagaatt aaaaaccagc tgactgggtg caatacgggt
     3781 gaaaatactt gtgacataga cattgagatg gattggggtc aggctgttgc cctgttttga
     3841 atggtttggg tttaaaatag tactattttt gtttgaaaat gtaaagaatt tcctagaaaa
     3901 aaattcatga aatcaaaaag tagactattt caccctattg cagctaagtg gtcctggggc
     3961 atggagtctt caacctctct atgaatggca caccttagtc acttatgtta cttttgtgtc
     4021 cccaccatgg gttgggggat tttttgttta ttctgatcta tgagttttga aaaagtgaat
     4081 aatcaaaagg aaaataattc cttgttgttc ataaattaag catcactaaa gtctcttgaa
     4141 aggcatttct gtattgggca agatttaaaa tactaaagcc ttaggtccta ttcatattta
     4201 aagtagcatg tttgtaacct gttactattt ggagagagaa gcagttgcct gccaaattga
     4261 agactacctt tcaaatagca aaagagagag agaaggctga tatttcggct tttaaataaa
     4321 gatttgtgtg gttctgcttt tactgtaact gtcactttcc cagtgaaaat gatttcatat
     4381 acattgaggg tcttacaggt atgggtaaag ttctataaat tgcaacaaaa tgatacccaa
     4441 tttcatttta tcctttttgt attgtgaaac tggaaacttt atgacattgt aaattatcag
     4501 ctggtttttc tgaatataaa gtgtgaaaac acagaacagt attttgatct atttgataat
     4561 tttgtgggtt ttttgaagaa ttaatgagca tgtacataga aatagtgact gcttgaatac
     4621 tgtatttact tgcactcttt cagtacatca agattcctgt atattttaga gtataataaa
     4681 acacagatgt gagttgtatt taatgaataa tgtatttgta tctgtgcata ttatctacaa
     4741 atctataaag tttctagggc attgactact agattttaag cattttttct aaaatattta
     4801 cagaaattat aaatctaatc ccccatcttt tctttataat ataaagaagt cataatgaac
     4861 ccttcctaat tattagtagt aggaaggtga atatgcattt taatgacagt ggactacatt
     4921 ttctattgta ccttttgaaa aaaaaaaaaa tcaagcagat tctaaaagta tacatatgtg
     4981 tgctttctct ttccttttag gaattctctt ctgaattccc tgagggaatt ttctagaatc
     5041 tcagaattga aagagacctg aggttcatcc agtctctaac ctcttaacaa atgcaggagt
     5101 cccttctaca agggtgatct ttccaccttg aacacttcca agtgactcta cctcaccaag
     5161 cagtccattc agttgttgag cagctctaac tgttagaaag gtcttcctta gatggagttg
     5221 aagcctccct cccggtaact tctgtctttg ggcctgggtc tgtcctccaa gagaaccctg
     5281 agaatgttgg aaggatgaat ctcgcacatt ctgccatgtc ttctctttta caggctgttt
     5341 gacttctctg ctgaagtgat ttccagaagg actcatttga cacactatta gatttaccac
     5401 atctaatgaa atccaaggtg tagctataaa gtgacaagct gtttttaatt tatcacatac
     5461 accagaactt ctatcctgca tcacttatat gtaaatgatg ctgttaccaa aaacattaag
     5521 gtagttcttg cgaatgccac cccactaaga aaactatttc attacttttg taatccatct
     5581 gtgagagtct gccccccagc ttaaccactt cctttggtct gcacccaatg aagggaaacc
     5641 ccaaagtact gtctcaaatg gtatttgaac tacgccagta ttgttggaat aagtacatta
     5701 attacttgaa tgaatgaaca cagcaccgta gaaatttcct ttatggttac accttgtatg
     5761 tctaaagcat tcaggccctg ttctgtagtg tttcttatcc tcacacagag tagaaaagcc
     5821 tgtttgcttt atttaactta tacataaaag atgacatctg aaatatctga tgtgtattat
     5881 aataccagct tctgctctag aactactttg ggtgaaatgg tggtaatagc aaatgacctc
     5941 ctttaacaag acactcatct caaacaatgc catttagttc aggagatctc taagtgtagc
     6001 tgtaaatttt ggggttaatt tggcttatat tggacctttt aaaagaaata aagtttttta
     6061 atgcaataaa
//
