LOCUS       NM_014915               6775 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ankyrin repeat domain containing 26 (ANKRD26),
            transcript variant 1, mRNA.
ACCESSION   NM_014915 XM_374779
VERSION     NM_014915.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6775)
  AUTHORS   Trizuljak,J., Likavcova,P., Stano Kozubik,K., Vrzalova,Z.,
            Hynst,J., Deissova,T., Stika,J., Radova,L., Prudkova,M.,
            Vaculova,J., Blahakova,I., Smejkal,P., Kamelander,J.,
            Pospisilova,S. and Doubek,M.
  TITLE     Impact of thrombocytopenia-associated c.-118C>T and c.-140C>G
            ANKRD26 5'UTR variants in three-generational pedigree
  JOURNAL   Platelets 35 (1), 2388103 (2024)
   PUBMED   39212265
  REMARK    GeneRIF: Impact of thrombocytopenia-associated c.-118C>T and
            c.-140C>G ANKRD26 5'UTR variants in three-generational pedigree.
REFERENCE   2  (bases 1 to 6775)
  AUTHORS   Dunstan-Harrison,C., Morison,I.M. and Ledgerwood,E.C.
  TITLE     Inherited thrombocytopenia associated with a variant in the FLI1
            binding site in the 5' UTR of ANKRD26
  JOURNAL   Clin Genet 106 (3), 315-320 (2024)
   PUBMED   38757516
  REMARK    GeneRIF: Inherited thrombocytopenia associated with a variant in
            the FLI1 binding site in the 5' UTR of ANKRD26.
REFERENCE   3  (bases 1 to 6775)
  AUTHORS   Homan,C.C., Scott,H.S. and Brown,A.L.
  TITLE     Hereditary platelet disorders associated with germ line variants in
            RUNX1, ETV6, and ANKRD26
  JOURNAL   Blood 141 (13), 1533-1543 (2023)
   PUBMED   36626254
  REMARK    GeneRIF: Hereditary platelet disorders associated with germ line
            variants in RUNX1, ETV6, and ANKRD26.
REFERENCE   4  (bases 1 to 6775)
  AUTHORS   Ovsyannikova,G.S., Fedorova,D.V., Tesakov,I.P., Martyanov,A.A.,
            Ignatova,A.A., Ponomarenko,E.A., Zharkov,P.A., Pavlova,A.V.,
            Raykina,E.V., Maschan,M.A., Panteleev,M.A., Novichkova,G.A.,
            Sveshnikova,A.N. and Smetanina,N.S.
  TITLE     Platelet functional abnormalities and clinical presentation in
            pediatric patients with germline RUNX1, ANKRD26, and ETV6 mutations
  JOURNAL   Haematologica 107 (10), 2511-2516 (2022)
   PUBMED   35796010
  REMARK    GeneRIF: Platelet functional abnormalities and clinical
            presentation in pediatric patients with germline RUNX1, ANKRD26,
            and ETV6 mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6775)
  AUTHORS   Sullivan,M.J., Palmer,E.L. and Botero,J.P.
  TITLE     ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid
            Neoplasms
  JOURNAL   Curr Hematol Malig Rep 17 (5), 105-112 (2022)
   PUBMED   35751752
  REMARK    GeneRIF: ANKRD26-Related Thrombocytopenia and Predisposition to
            Myeloid Neoplasms.
            Review article
REFERENCE   6  (bases 1 to 6775)
  AUTHORS   Noris,P., Perrotta,S., Seri,M., Pecci,A., Gnan,C., Loffredo,G.,
            Pujol-Moix,N., Zecca,M., Scognamiglio,F., De Rocco,D., Punzo,F.,
            Melazzini,F., Scianguetta,S., Casale,M., Marconi,C., Pippucci,T.,
            Amendola,G., Notarangelo,L.D., Klersy,C., Civaschi,E.,
            Balduini,C.L. and Savoia,A.
  TITLE     Mutations in ANKRD26 are responsible for a frequent form of
            inherited thrombocytopenia: analysis of 78 patients from 21
            families
  JOURNAL   Blood 117 (24), 6673-6680 (2011)
   PUBMED   21467542
  REMARK    GeneRIF: The ANKRD26-related thrombocytopenia has to be taken into
            consideration in the differential diagnosis of isolated
            thrombocytopenias.
REFERENCE   7  (bases 1 to 6775)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   8  (bases 1 to 6775)
  AUTHORS   Pippucci,T., Savoia,A., Perrotta,S., Pujol-Moix,N., Noris,P.,
            Castegnaro,G., Pecci,A., Gnan,C., Punzo,F., Marconi,C.,
            Gherardi,S., Loffredo,G., De Rocco,D., Scianguetta,S., Barozzi,S.,
            Magini,P., Bozzi,V., Dezzani,L., Di Stazio,M., Ferraro,M.,
            Perini,G., Seri,M. and Balduini,C.L.
  TITLE     Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26
            gene, cause an autosomal-dominant form of inherited
            thrombocytopenia, THC2
  JOURNAL   Am J Hum Genet 88 (1), 115-120 (2011)
   PUBMED   21211618
  REMARK    GeneRIF: mutations in the 5' UTR of ANKRD26 are implicated in
            thrombocytopenia 2.
REFERENCE   9  (bases 1 to 6775)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 6775)
  AUTHORS   Perez Botero,J., Dugan,S.N. and Anderson,M.W.
  TITLE     ANKRD26-Related Thrombocytopenia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29927566
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA712092.1, CD626319.1,
            AK001137.1, DB228067.1, AB028997.1 and AL137351.1.
            
            On Dec 12, 2019 this sequence version replaced NM_014915.2.
            
            Summary: This gene encodes a protein containing N-terminal ankyrin
            repeats which function in protein-protein interactions. Mutations
            in this gene are associated with autosomal dominant
            thrombocytopenia-2. Pseudogenes of this gene are found on
            chromosome 7, 10, 13 and 16. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.187283.1,
                                           SRR14038197.2294305.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376087.5/ ENSP00000365255.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               DA712092.1         5-230
            227-415             CD626319.1         197-385
            416-1803            AK001137.1         414-1801
            1804-2014           DB228067.1         368-578
            2015-5381           AB028997.1         1994-5360
            5382-6775           AL137351.1         1204-2597
FEATURES             Location/Qualifiers
     source          1..6775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..6775
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="ankyrin repeat domain containing 26"
                     /db_xref="GeneID:22852"
                     /db_xref="HGNC:HGNC:29186"
                     /db_xref="MIM:610855"
     exon            1..410
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..5301
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 26;
                     GNS/ANKRD26/NCKAP1L fusion; ankyrin repeat domain 26"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 26
                     isoform 1"
                     /protein_id="NP_055730.2"
                     /db_xref="CCDS:CCDS41499.1"
                     /db_xref="GeneID:22852"
                     /db_xref="HGNC:HGNC:29186"
                     /db_xref="MIM:610855"
                     /translation="MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRD
                     RDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDR
                     KCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDIS
                     VATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLI
                     SEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKP
                     SLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFS
                     HPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENGIDIIESAPLEQTNNDNLTY
                     VDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGN
                     EQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPN
                     KAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHD
                     GATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRT
                     SKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMD
                     DVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLE
                     LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQE
                     EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQ
                     ERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKN
                     SMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTIS
                     QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKREL
                     ELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR
                     EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLL
                     RQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLK
                     ERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKK
                     LGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLL
                     NANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE
                     NGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLS
                     MKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKL
                     KEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTEL
                     EKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPP
                     CVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAA
                     AELESGSIASPLGSTDESNLNQDLVWKASREYVQVLKKNYMI"
     exon            411..525
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..699
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..806
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..877
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..908
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..981
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1042
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1245
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1375
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1437
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1531
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1630
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1659
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1732
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1803
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1982
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2153
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2187
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2329
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2543
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2727
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2865
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3822
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3975
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4046
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4140
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4253
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4383
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4674
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4892
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..5121
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5122..5167
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5168..6775
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5359..5364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="hexamer: AATATA"
     regulatory      5379..5384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="hexamer: ATTAAA"
     polyA_site      5379
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="major polyA site"
     polyA_site      5405
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="major polyA site"
     regulatory      5779..5784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="hexamer: AACAAG"
     polyA_site      5803
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="major polyA site"
     regulatory      6561..6566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="hexamer: ATTAAA"
     polyA_site      6584
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
     regulatory      6750..6755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="hexamer: AATACA"
     polyA_site      6775
                     /gene="ANKRD26"
                     /gene_synonym="bA145E8.1; THC2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtctagcg ggatcgcttg cttggtaacc cggagggaga gattggaaac cgcggagttt
       61 cctttgggag gctgcggcca gccggggctg acttgttatg ttgggctccg gaggccgtta
      121 agagccgaga gagacatgag gtgtctctga agcccggtcg cctgggccat gaagaagatt
      181 tttagtaaga agggcgagtc gcccttgggc tccttcgcgc ggcggcagag gagcagcgcg
      241 ggaggcgggg gcgagccggg ggagggcgcc tactcgcagc ccggctacca cgtccgagac
      301 cgagatctcg gcaagatcca caaagctgcc agcgcgggta atgtggcgaa agtgcagcag
      361 atccttttgc tcaggaagaa tggcttgaac gatagagaca agatgaacag gacggctcta
      421 catttggcct gtgccaatgg tcatccagaa gtagtaactc tcctggtgga cagaaaatgc
      481 cagctcaatg tctgtgacaa cgaaaacagg acagctctga tgaaggctgt acaatgccag
      541 gaagagaaat gtgcaactat tctgctagaa catggtgctg atccaaatct tgcggatgtc
      601 catggcaaca ctgctcttca ctatgctgtc tataatgagg acatatcagt agcaacaaag
      661 ctgcttttgt atgatgcaaa tattgaagca aaaaacaagg atgacctcac accactttta
      721 cttgcagtaa gtggaaaaaa gcagcaaatg gtggaatttt taataaagaa aaaagcaaat
      781 gtaaatgcag tagataagtt ggaaagcagt caccaactaa tttcagaata taaagaagaa
      841 aggataccta aacattcttc tcaaaatagt aattcagtgg atgaaagctc tgaagactcc
      901 ttaagcaggc tttctggcaa accgggtgtt gatgattcat ggcctacctc agatgacgaa
      961 gacctcaatt ttgatactaa gaatgtccca aaaccaagct tagcaaagct aatgactgct
     1021 tctcagcaat ccaggaaaaa tttagaagca acatatggca ctgtgagaac aggaaataga
     1081 actttgtttg aggatagaga ttccgatagt caagatgaag ttgtggttga aagccttcct
     1141 acaacatcaa tcaaagtcca gtgcttttct catcctacct atcaatcacc tgaccttctt
     1201 ccaaaacctt cccacaagtc gttagcaaac cctggtctta tgaaggaaga accaacaaag
     1261 ccaggcattg caaaaaaaga aaatggtatt gatattattg aaagtgctcc actagagcaa
     1321 acaaataatg acaatttgac ttatgttgat gaagtgcaca aaaataatag aagtgatatg
     1381 atgtccgcat taggattagg acaagaggaa gatatagaat caccttggga ttctgagagt
     1441 atctctgaga attttccaca gaagtatgtt gatcctttag ctggggctgc agacggaaaa
     1501 gaaaaaaata taggaaatga acaagcagaa gatgtgtttt atataccttc ttgcatgagt
     1561 ggatcaagaa actttaagat ggctaaacta gaggatacaa gaaatgtagg catgccagta
     1621 gcccacatgg agtctcctga gagatatctt cacttgaagc ctaccattga aatgaaagat
     1681 tctgttccaa ataaagcagg aggaatgaag gatgtacaaa catccaaagc agctgaacat
     1741 gacttagaag tagcatcaga agaagagcaa gaaagggaag ggagtgaaaa taaccagcca
     1801 caggttgaag aagaaaggaa aaaacacaga aataatgaaa tggaagtatc agcaaacata
     1861 catgatggtg ctactgatga tgctgaagat gatgatgatg atgatggatt aattcaaaaa
     1921 agaaagagtg gagaaactga tcatcagcaa tttcccagga aggaaaataa agagtatgct
     1981 agtagtggtc ctgccttgca aatgaaggaa gtaaagagca ctgaaaaaga aaaacggacc
     2041 tcgaaagaat ctgtgaattc accagtgttt gggaaggcca gtttactaac tggtggcctg
     2101 ctacaagtgg atgatgacag cagtttaagt gaaatagatg aggatgaagg aaggcctact
     2161 aagaaaacat ctaatgaaaa gaacaaggtc aaaaaccaaa tacagtctat ggatgatgtt
     2221 gatgacttaa ctcagtcatc tgaaacagcc tcagaggatt gtgagctacc ccactctagt
     2281 tacaagaatt ttatgttgct cattgaacaa cttggaatgg agtgtaaaga ttctgttagc
     2341 ctattgaaaa tccaggatgc agctctttca tgtgaaagat tattagaact taaaaaaaat
     2401 cactgtgaac tacttacagt aaaaattaaa aaaatggaag acaaggttaa tgtactacaa
     2461 agggagctat ctgaaacaaa agaaataaaa tcacagttag agcatcaaaa agttgaatgg
     2521 gaacgagaac tgtgctcttt gagatttagc ttaaaccaag aagaagagaa gagaagaaat
     2581 gctgatacgt tgtatgaaaa aattagggaa cagttaagaa gaaaagaaga gcaatatagg
     2641 aaagaagttg aagtgaaaca acagcttgaa ctgagtctcc aaacactgga gatggaattg
     2701 aggactgtaa aaagtaattt gaatcaggtc gttcaagagc gaaatgacgc tcagaggcaa
     2761 ctttctcgag aacagaatgc cagaatgtta caagatggaa ttctgaccaa tcacctttcc
     2821 aaacaaaagg agattgaaat ggctcaaaag aaaatgaatt ctgagaattc tcatagtcat
     2881 gaagaagaaa aagacctatc gcataaaaat agcatgttgc aggaagaaat tgctatgcta
     2941 agactagaaa tagacacaat aaaaaatcaa aaccaggaaa aagaaaagaa atgttttgag
     3001 gaccttaaaa ttgtaaaaga aaagaatgaa gaccttcaga agactataaa acagaatgag
     3061 gaaacattaa cacaaacaat atcccagtat aatggacggc ttagtgttct gacagctgag
     3121 aatgcaatgc taaattctaa actggagaat gaaaagcaaa gcaaggaaag actggaagca
     3181 gaagttgaat cataccattc tagattggct gctgctatac atgatcgtga tcaaagtgag
     3241 acatcaaaaa gagaactaga acttgctttc cagagagcaa gagatgaatg ttctcgttta
     3301 caggacaaaa tgaattttga tgtgtctaac ctaaaagata acaatgagat tctttctcaa
     3361 caactattta aaactgaaag taaactcaat agcctagaaa ttgagttcca tcacacgaga
     3421 gatgccctca gagaaaagac tttgggttta gaacgggtac aaaaggacct aagccaaaca
     3481 cagtgtcaaa tgaaggaaat ggaacaaaag tatcaaaatg aacaagttaa agtgaataaa
     3541 tacattggaa agcaggagtc tgtagaggag agattgtctc aactacaaag tgagaatatg
     3601 ttgcttcgac aacaactgga tgatgcccac aacaaggctg acaataaaga gaagacagtg
     3661 attaatatcc aagaccagtt tcatgctatt gtgcaaaaac ttcaagctga gagtgaaaag
     3721 caaagtcttc tgctagaaga aagaaataag gagttaatca gtgaatgtaa tcacttaaaa
     3781 gaaagacagt atcaatatga aaatgaaaag gcagaaagag aagttgttgt gagacaactt
     3841 caacaagaac tagctgatac cctaaaaaaa caatctatgt cagaggcttc actggaggtt
     3901 acgtcacgtt atcgtattaa tttagaagat gagacacagg atttaaagaa gaaattaggt
     3961 caaatcagaa atcaattgca agaagcacag gatcgacata cagaagctgt cagatgtgct
     4021 gagaagatgc aagatcacaa gcaaaagctt gaaaaagata atgccaagtt aaaagttaca
     4081 gtcaaaaagc aaatggacaa aattgaggag cttcagaaaa acctgttaaa tgcaaatttg
     4141 tctgaagatg aaaaggaaca attaaagaaa cttatggaat taaaacagtc actggaatgt
     4201 aatttggatc aagaaatgaa gaaaaatgtt gaattagaaa gagagataac tggatttaag
     4261 aacctcttaa aaatgacaag aaagaagtta aatgaatatg aaaatggaga atttagtttc
     4321 catggagatt taaaaactag tcaatttgaa atggatattc agattaataa gctaaaacat
     4381 aagattgatg atcttacagc agaactggag actgcaggtt caaaatgtct acatctggat
     4441 acaaagaacc aaattcttca agaggagttg ttatctatga aaacagtaca aaagaaatgt
     4501 gaaaaactac agaagaataa aaagaagttg gaacaagaag tgatcaacct gagaagtcat
     4561 atagaaagga atatggtaga acttggtcaa gtcaaacagt ataaacagga gattgaagaa
     4621 agagcaagac aggaaatagc agaaaaatta aaagaagtca atctattttt acaggcacaa
     4681 gcagcatctc aagaaaactt agagcagttt agagagaata attttgcttc aatgaaaagt
     4741 cagatggaac tcagaattaa agatctggaa tctgaactct ccaaaataaa aacttctcaa
     4801 gaagacttta ataaaaccga actggaaaaa tataagcaac tctatctaga agaattaaaa
     4861 gttagaaaat ctttgtcaag taaactaacc aaaactaatg agaggctagc agaggtcaac
     4921 accaaacttc ttgtggaaaa acagcagagc agatctttgt tcaccactct cactaccagg
     4981 ccagtcatgg agccaccttg tgtgggaaat cttaataata gtttagatct caacagaaaa
     5041 cttattccaa gagaaaactt agtgatctct acctcaaatc cacgggcttc aaataatagc
     5101 atggagaact acttgagcaa gatgcagcag gagttggaaa aaaatataac tagagaactc
     5161 aaagaagctg ctgctgaatt ggaatctgga tcaatagctt cccctctagg gtctactgat
     5221 gagtcaaatc taaatcaaga tctagtttgg aaagcatcaa gagaatatgt acaggtttta
     5281 aagaaaaatt atatgatctg aaagataaga ttttattact gggctgttta tgtgacattt
     5341 tgtttctcat taaatattaa tatatgacat gtaaaaatat taaaggaacg tatttttgta
     5401 tcatatatgt cagatcaaaa tttatatagt attttaaaca atgttacttg gcttctttaa
     5461 cttttaagtg gattttgcca atgaaaacca ggaatattga gttttacata ctcaaactgc
     5521 ccaaatgtga gctgtttaaa cagccaaacc actaagttgt cattaatact ttagtgcagt
     5581 taattgatgg cttatttgta ttttgtaatt tttatcacta tatgtagtgg tagatgtcta
     5641 attggactta gacatcattt tgttgtgcag gaactgtggt cattgttcat gtttggatgt
     5701 attacaattg ttacagtgcc atcaaattta cataatttta attttaagca ctgatttata
     5761 tagctgttct cagggagaaa caagatttgc ctgattcacc ttttctgttt gtttatttat
     5821 ttttaattaa ccttttggaa atagccttca gtttagagaa aatttcgaag ttttagtaca
     5881 aagactttct cctccgaaca atttgagagt aaattgctga cattatgtca tcacccctga
     5941 ttactttagt gggcattcct acaagtcagg acattctaca taactacagt gcaaaccttg
     6001 caatcagaaa gtcaacatta atacattcta gtttgttact tctctgtaat gtcctttata
     6061 gcaaaaggat cccattctaa tccatggctt gtatttagtt gttgtatctg ttagatcttt
     6121 cagtctggaa cagttcctca gtctttcctt gaccttcatg accttgaata ttttgaagag
     6181 taaagtctgg taatataaga atgtccctca attgggtttc atggtgatta gatttagatt
     6241 atatgatttt ttggcaggag tatcacagaa gtgacccagt gatcttctca ttgcatctta
     6301 cctgtgaccc tacagttttg atttgccctg ttactggtaa tgttagcatt gatcactaac
     6361 agtggtatct gctgaatttc tcctctgtaa tgttattttt tcaccttgtg gttaattagt
     6421 attttacagg gaggtaattt gagactatgt acatatctct actccccatc gaaccctcaa
     6481 tttattcatt tgcttgtatc aaataaacca tggattcatg gtttatttta ttcagtgagt
     6541 tataattcat taatattgtt attaaaaatt tgtttttctt ttaagaaatg ttatattttg
     6601 acaacttcag acttacagaa agattataag aggtagtaca aataattttt ggatattatt
     6661 ccccaaatgt taacatttta ctgcatttac tttatccttt ctcccccttc tcctcctgtc
     6721 tttctagatg aatatgaata taggtactta atacagattt tttttctaaa ctgtt
//
