LOCUS       NM_001393985            3838 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 24 (ANKRD24), transcript variant
            7, mRNA.
ACCESSION   NM_001393985
VERSION     NM_001393985.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3838)
  AUTHORS   Krey,J.F., Liu,C., Belyantseva,I.A., Bateschell,M., Dumont,R.A.,
            Goldsmith,J., Chatterjee,P., Morrill,R.S., Fedorov,L.M., Foster,S.,
            Kim,J., Nuttall,A.L., Jones,S.M., Choi,D., Friedman,T.B.,
            Ricci,A.J., Zhao,B. and Barr-Gillespie,P.G.
  TITLE     ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points
  JOURNAL   J Cell Biol 221 (4) (2022)
   PUBMED   35175278
  REMARK    GeneRIF: ANKRD24 organizes TRIOBP to reinforce stereocilia
            insertion points.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006930.1 and AC005578.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000318934.9/
                                                ENSP00000321731.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC006930.1         8479-8530
            53-124              AC006930.1         12180-12251
            125-211             AC006930.1         25473-25559
            212-342             AC006930.1         25665-25795
            343-431             AC006930.1         25873-25961
            432-496             AC006930.1         27816-27880
            497-554             AC006930.1         28659-28716
            555-625             AC006930.1         33032-33102
            626-732             AC006930.1         33291-33397
            733-920             AC006930.1         33571-33758
            921-958             AC006930.1         34554-34591
            959-1039            AC006930.1         35848-35928
            1040-1147           AC006930.1         36055-36162
            1148-1186           AC006930.1         38265-38303
            1187-1285           AC006930.1         38390-38488
            1286-1358           AC005578.1         8654-8726
            1359-1477           AC005578.1         8960-9078
            1478-3091           AC005578.1         9226-10839
            3092-3259           AC005578.1         12267-12434
            3260-3385           AC005578.1         15346-15471
            3386-3451           AC005578.1         16803-16868
            3452-3838           AC005578.1         17104-17490
FEATURES             Location/Qualifiers
     source          1..3838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3838
                     /gene="ANKRD24"
                     /note="ankyrin repeat domain 24"
                     /db_xref="GeneID:170961"
                     /db_xref="HGNC:HGNC:29424"
                     /db_xref="MIM:620234"
     exon            1..52
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            53..124
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..3529
                     /gene="ANKRD24"
                     /note="isoform b is encoded by transcript variant 7;
                     ankyrin repeat domain-containing protein 24"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 24
                     isoform b"
                     /protein_id="NP_001380914.1"
                     /db_xref="CCDS:CCDS45925.1"
                     /db_xref="GeneID:170961"
                     /db_xref="HGNC:HGNC:29424"
                     /db_xref="MIM:620234"
                     /translation="MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQD
                     WGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMI
                     AHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGC
                     LSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL
                     MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPP
                     SALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERG
                     RLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQ
                     SRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAV
                     LTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQ
                     ALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEA
                     AGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTG
                     AQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGM
                     ESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQRE
                     REAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDL
                     RDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQ
                     LATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVV
                     PASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVG
                     TLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGL
                     RTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALR
                     DQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQGR
                     "
     exon            125..211
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            212..342
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            343..431
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            432..496
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            497..554
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            555..625
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            626..732
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            733..920
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            921..958
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1039
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1147
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1186
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1285
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1358
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1477
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..3091
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3259
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3385
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3451
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3838
                     /gene="ANKRD24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3815..3820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD24"
                     /note="hexamer: AATAAA"
     polyA_site      3838
                     /gene="ANKRD24"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcgaca tgttatctgc tgtcagaagg aagcctgcct ctttgcatgc aggtggcctg
       61 tggagaggag aaacacaggg caccaactat gaagactctc agggcgcgat ttaagaagac
      121 agagctgcgg ctcagcccca ctgaccttgg ctcctgcccg ccctgcggcc cctgccccat
      181 cccgaagccg gcagccagag gcaggcgcca gagtcaagac tggggcaaga gtgacgagag
      241 gctgctacaa gccgtggaaa acaacgatgc acctcgggtg gccgccctca tcgcccgcaa
      301 ggggctggtg cccacgaagc tagaccccga gggcaagtcc gcgttccacc tggcggccat
      361 gcggggtgcg gccagctgtc tggaggtgat gatagctcat ggcagcaatg tcatgagcgc
      421 ggacggggca ggttacaatg ccctccacct ggccgccaaa tacgggcacc cacagtgctt
      481 gaagcaacta ctgcaggctt cctgcgtggt ggacgtcgtg gacagcagcg ggtggactgc
      541 cctacaccat gcagcggctg gtggctgtct ctcctgctca gaggtgctct gctcctttaa
      601 ggcacatcta aacccccaag atcggtcagg cgcaacaccc ctcattatag cagctcagat
      661 gtgtcacaca gacctgtgcc gtctcctact gcagcaaggg gctgccgcga acgatcagga
      721 cctgcaaggc aggacggccc tgatgctggc ctgtgagggg gccagccccg aaacagtgga
      781 ggtcctgctg cagggcggag cccagccggg catcaccgat gcgctggggc aggacgcggc
      841 tcactatggc gccctggcgg gggacaaact catcctgcac cttctgcaag aggcggccca
      901 gcgcccctcc ccacccagcg ccctcacaga ggatgattca ggcgaggcgt catctcagaa
      961 ctctatgtcc agccatggaa agcagggggc ccccaagaag cggaaggcgc ctccacctcc
     1021 cgccagcatt cccatgccgg atgatcgaga tgcctatgag gagatcgtga ggctgcggca
     1081 ggagaggggc cgcctcctgc agaagatccg gggcctggaa cagcacaagg aacggaggca
     1141 gcaggagtcc ccggaggcca gctccctgca catcctggag agacaggtgc aagagctaca
     1201 gcagttgctg gtggagagac aagaggagaa ggagagcctg ggacgggagg tggagagttt
     1261 gcagagccgg ctgtccctgc tggagaacga gcgggagaat actagctatg acgtaaccac
     1321 cctgcaggat gaggagggtg agctgcctga ccttccaggg gccgaggtgc tgctgtccag
     1381 acaactcagt ccgtcggccc aggaacacct ggcctcgctg caggaacagg tggctgtgct
     1441 caccagacag aaccaggaac tgatggagaa ggtccagatc ctggagaact ttgagaagga
     1501 cgagacacag atggaagtgg aagctttggc agaggtcatc cctcttgccc tctatgactc
     1561 tctccgggcc gagtttgacc agctacgcag gcagcacgct gaggccctgc aggccctgag
     1621 gcagcaggag acacgagagg tccccagaga agagggggca gcctgtgggg agagtgaggt
     1681 tgctggagcc acggccacca aaaacgggcc aacccacatg gagctaaatg gctcagtggc
     1741 tccagaaacc aaagttaacg gagccgagac catagatgag gaggctgcag gagatgaaac
     1801 catggaagcc aggactatgg aagctgaggc cacgggagcc gaggccacgg gagctgaggc
     1861 cacaggagcc aaggtcacag aaacaaaacc cacaggggct gaggtcagag aaatggagac
     1921 cacagaagaa gaagcaaaca tggaaactaa gcccacagga gctcaggcca cagacacaga
     1981 gaccacggga gtggaggcca tgggggtgga ggccacaaaa acaaaagcag aggaagcaga
     2041 aatgcaggcc tacggagtgg gtgctgggca agcagagccc ccagtcacag ggaccacaaa
     2101 catggaggcc acgggctcta gggccacagg gatggaatcc acaggagtca gtgccacagg
     2161 tgtggagaac ccaggggtag aggccacggt cccggggatc tctgctggcc ccatcctaca
     2221 tcctggtgcc gcagaggcct cggaaaagct tcaagtagag ctggagacca ggatccgtgg
     2281 cttggaggag gctctccggc agcgggagcg ggaggcagct gcggagctgg aggcggccct
     2341 ggggaagtgc gaggccgcgg aggccgaggc aggccggctg cgagagcgtg tccgcgaggc
     2401 cgagggcagc ggggccagcg ggggcggtgg cggtgacacc acacagctgc gggcggccct
     2461 ggagcaggcc cgggaggacc tccgagaccg ggactcccgc ctgcgggagc tggaggcggc
     2521 ctcggcctgc ctggatgagg ctcgggccag ccggctgctg gcggaggagg aggcgcgggg
     2581 cctgcgggcc gagctggccc agcgggagga ggcgcggctg gagcagagcc gggagctgga
     2641 ggttctgcgg gagcagctgg ccacggccag ggccacgggg gagcagcagc gcacggcggc
     2701 cgcggaactg ggccgggcac gggacgccgc tgaggcccga gtggctgagc tgcctgcggc
     2761 ctgcgaggag gcgcggcagg gcctggccga gctgcgggag gcctccgagg ccctccgcca
     2821 gtccgtggtg ccggcctctg agcaccgccg gctgcaggag gaggccctgg agctgcgggg
     2881 ccgggcagcc agtctggagc aggaggtggt ggccacgggc aaggaggccg cccggctgcg
     2941 cgcggagctg gagcgggagc gtgtgtgcag cgtggcgctc tcggagcacg aacgcatcgt
     3001 gggcaccctg caggccaacg tggcccagct ggaggggcag ctggaggagc tgggacggcg
     3061 gcatgagaag accagcgcag aggtcttcca ggtgcagcgt gaggccctgt tcatgaagag
     3121 tgagcgacac gcagccgagg cacagctggc cacagcagag cagcagctac gggggctacg
     3181 gaccgaggcg gaaagggctc gccaggccca gagccgggcc caggaggctc tggacaaggc
     3241 caaggagaag gacaagaaga tcacagaact ctccaaagaa gtcttcaatc ttaaggaagc
     3301 cttgaaggag cagccggccg ccctcgccac ccctgaggtg gaggctctcc gtgaccaggt
     3361 gaaggattta cagcagcagc tgcaggaagc tgccagggac cactccagcg tggtggcttt
     3421 gtacagaagc cacctcctat atgccattca gggccagatg gatgaagatg tgcagcggat
     3481 tctcagccag attctgcaga tgcagagact ccaggctcag ggccgctgag aaaggccagg
     3541 cccagtggct acactgacca cacccacgca gggacctcac ccccctgcag gccccttgca
     3601 gaccggcttc acttggcttc acttggccct atccaggccc atgcacttgg agaccagcct
     3661 ggttccctgc ccgaccaccc ccagctggct ccatcacccc acctggtctc tgcacgcaca
     3721 cactggtcag tctggacccg ggccgtgact gcccctcccc caccaccgga gactgtgatt
     3781 ccctgtgtcc tccacatcca gacgccagcc caggaataaa ggcattctgt gcacaggg
//
