LOCUS       NM_144994               2584 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 23 (ANKRD23), mRNA.
ACCESSION   NM_144994
VERSION     NM_144994.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2584)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2584)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2584)
  AUTHORS   Lorenzer,C., Streussnig,S., Tot,E., Winkler,A.M., Merten,H.,
            Brandl,F., Sayers,E.J., Watson,P., Jones,A.T.,
            Zangemeister-Wittke,U., Pluckthun,A. and Winkler,J.
  TITLE     Targeted delivery and endosomal cellular uptake of DARPin-siRNA
            bioconjugates: Influence of linker stability on gene silencing
  JOURNAL   Eur J Pharm Biopharm 141, 37-50 (2019)
   PUBMED   31103742
  REMARK    GeneRIF: The promise of DARPin-siRNA bioconjugates for tumor
            targeting.
REFERENCE   4  (bases 1 to 2584)
  AUTHORS   Lun,A.S., Chen,J. and Lange,S.
  TITLE     Probing muscle ankyrin-repeat protein (MARP) structure and function
  JOURNAL   Anat Rec (Hoboken) 297 (9), 1615-1629 (2014)
   PUBMED   25125175
  REMARK    GeneRIF: Report structure activity relationships for ANKRD23.
REFERENCE   5  (bases 1 to 2584)
  AUTHORS   Nagueh,S.F., Shah,G., Wu,Y., Torre-Amione,G., King,N.M.,
            Lahmers,S., Witt,C.C., Becker,K., Labeit,S. and Granzier,H.L.
  TITLE     Altered titin expression, myocardial stiffness, and left
            ventricular function in patients with dilated cardiomyopathy
  JOURNAL   Circulation 110 (2), 155-162 (2004)
   PUBMED   15238456
REFERENCE   6  (bases 1 to 2584)
  AUTHORS   Miller,M.K., Bang,M.L., Witt,C.C., Labeit,D., Trombitas,C.,
            Watanabe,K., Granzier,H., McElhinny,A.S., Gregorio,C.C. and
            Labeit,S.
  TITLE     The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a
            family of titin filament-based stress response molecules
  JOURNAL   J Mol Biol 333 (5), 951-964 (2003)
   PUBMED   14583192
REFERENCE   7  (bases 1 to 2584)
  AUTHORS   Ikeda,K., Emoto,N., Matsuo,M. and Yokoyama,M.
  TITLE     Molecular identification and characterization of a novel nuclear
            protein whose expression is up-regulated in insulin-resistant
            animals
  JOURNAL   J Biol Chem 278 (6), 3514-3520 (2003)
   PUBMED   12456686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF827606.1, BC107056.2,
            AK092564.1, AY196212.1 and AC092636.3.
            
            On Nov 22, 2018 this sequence version replaced NM_144994.7.
            
            Summary: This gene is a member of the muscle ankyrin repeat protein
            (MARP) family and encodes a protein with four tandem ankyrin-like
            repeats. The protein is localized to the nucleus, functioning as a
            transcriptional regulator. Expression of this protein is induced
            during recovery following starvation. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279873.1184.1, BC107056.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318357.9/ ENSP00000321679.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BF827606.1         42-46
            6-996               BC107056.2         1-991
            997-2577            AK092564.1         871-2451
            2578-2582           AY196212.1         2152-2156
            2583-2584           AC092636.3         91158-91159         c
FEATURES             Location/Qualifiers
     source          1..2584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2584
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /note="ankyrin repeat domain 23"
                     /db_xref="GeneID:200539"
                     /db_xref="HGNC:HGNC:24470"
                     /db_xref="MIM:610736"
     exon            1..56
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..947
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /note="muscle ankyrin repeat protein 3; diabetes related
                     ankyrin repeat protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 23"
                     /protein_id="NP_659431.5"
                     /db_xref="CCDS:CCDS2027.1"
                     /db_xref="GeneID:200539"
                     /db_xref="HGNC:HGNC:24470"
                     /db_xref="MIM:610736"
                     /translation="MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAV
                     AREKLKLEEEKKKKLERFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQ
                     SQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLV
                     NKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV
                     RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAAS
                     VTPVQLARDWQRGIREALQAHVAHPRTRC"
     exon            57..203
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..329
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..455
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..554
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..653
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..752
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..851
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            852..2584
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /note="hexamer: ATTAAA"
     polyA_site      2584
                     /gene="ANKRD23"
                     /gene_synonym="DARP; MARP3"
                     /note="major polyA site"
ORIGIN      
        1 actggggggt gtgaggaaca ggggggacca tggacttcat cagcattcag cagttggtaa
       61 gtggagaaag agttgaaggg aaagtgttgg gatttggaca tggagttcct gaccctggag
      121 cctggcctag tgactggagg aggggccccc aagaggctgt ggcccgggag aagctgaaat
      181 tggaagaaga gaagaagaag aaacttgaaa gatttaacag taccagattt aatctggata
      241 acctggctga cttggaaaac ttggttcaaa gacggaaaaa gcgactgaga cacagagtcc
      301 cccccaggaa acctgagccc ctggttaagc cgcagtccca ggcccaggtg gagcctgtgg
      361 gcctggagat gttcctgaag gcagctgctg agaaccagga gtacctgatt gacaagtact
      421 tgacagacgg aggggacccc aatgcccatg acaagctcca ccgcaccgcc ttgcactggg
      481 cctgtctgaa gggtcacagc cagctggtga acaagctgct ggtggcaggt gccacagtgg
      541 acgcgcgaga cttgctggac aggacacctg tgttctgggc ctgccgcgga ggacatctgg
      601 tcatcctcaa acagctgctt aaccagggag cccgggtcaa tgcccgggac aagatcggga
      661 gcacccccct gcacgtggca gtgcgcaccc ggcaccccga ctgcctggag cacctcatcg
      721 agtgtggcgc ccacctgaac gcacaggata aggaagggga cacggctctg cacgaggccg
      781 tgcggcacgg cagctacaaa gccatgaagc tactgctgct ctatggggcc gagctggggg
      841 tgcggaacgc ggcctccgtg accccggtgc agctggctcg agactggcag cgcggcatcc
      901 gggaggccct gcaggcccac gtggcgcatc cccgcacccg gtgctgaccg cagcaccgcc
      961 ccccgccgcg cctttcgcac tgccaccatt ccatcctgtg ccccgccccc gcgtctgcac
     1021 ctctgtggtt cctgccctca gccctggttc ctccctctct ggcctgtgcc gcctcagcag
     1081 ccctggcaga actgaagagc ggcaccgggc ccagcaggca aagagagagg cctccctggc
     1141 ttcgagtgtc aggggagccg cgttccctcc cagggctgga gcagaggacc acaaggcagc
     1201 agaaagcgcg ggtccagatg agggccagga aggggaggag agtgagggcc aagaacgagc
     1261 cttaagggag cagtcccaag ctggagccac ccagggctgg gtctgggagt cctcagtgtc
     1321 cacttgtccc aggttagggg gcttgccttg ctctctccag ggccagtctg tgtgtgtggg
     1381 gactcagccc gtggccggca gatgccatcc aggatgtaca aggtgcagcc aaggcaggcc
     1441 atgcaggggc cgggcctgtc tgcagctggt ggatgcctgt gggcatggct ttctctgggg
     1501 accccattcc tgtcagtagc aaccctggca gtgtccggag cggctctaga caactttggt
     1561 cataggaact ctggaggtgg gttctggtca tctgaggtgg ctactcaaca ggtttgaggc
     1621 cccacagcaa cagaagtcca ggacccacta ggttgcctca gaagccctaa gactgatgag
     1681 ctggagcgcg catttgagag aagcctcgca cccactgtgt actggccccg ctcaggccgg
     1741 cctggcacac cgttgcctgc tggcggctct catggggaag cgcctgggca ctggggattg
     1801 cttgtggccc actcaactct tggggcagtg gcccgtaacc ctagtttgcc tgaggccctt
     1861 atgtcccctt atgttcctgg tactggagct tgagctcttg cctggaacgc tgcagctgca
     1921 cccaccctgc ttgatcccac ctgggaggcc aggacactga ggagctctga acccagccca
     1981 cagggaagca gaggaaggtg agcccccgcc gccccccagc ccttcccatc ccttccctgc
     2041 tccctggtgg tctaaggacc caagctccct agacttcctc ttccaccgtc tgtacgtttc
     2101 aaattacact ggtgtaggcc tgtactgctg gtggggctgg gcccctaaac gccagaaagt
     2161 gaatcttaag aagctctgcc ctaaactgag aaccacatgc tgagggaagg gctgaaaggt
     2221 gaaggctcag cctccctcac atgggtcctg ggttacatta ggtaccgggc tgattgatag
     2281 gcatttggcc atggttcctt ttcgtctacc tttgggggcc ttctcaggcc cagaacaagg
     2341 ctgttgttac tatgtggaaa agctgaccag tgctgcacac taggggcaca cacctttcca
     2401 tgagcagctc ctgccctgtg gcgacagcca gcgtgcaccc agacgctggt gccatggcga
     2461 agcaggcgtt caagaccatg gagaagacaa ctcctcatct agaaaatgag gacacctcag
     2521 tgacaaacac acctttttat accaatcagt atcctctgtt cattaaaact ggctatccat
     2581 taca
//
