LOCUS       NM_144590               3858 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ankyrin repeat domain 22 (ANKRD22), mRNA.
ACCESSION   NM_144590
VERSION     NM_144590.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3858)
  AUTHORS   Wu,Y., Chen,W., Zhang,B. and Liu,H.
  TITLE     ANKRD22 knockdown suppresses papillary thyroid cell carcinoma
            growth and migration and modulates the Wnt/beta-catenin signaling
            pathway
  JOURNAL   Tissue Cell 84, 102193 (2023)
   PUBMED   37586180
  REMARK    GeneRIF: ANKRD22 knockdown suppresses papillary thyroid cell
            carcinoma growth and migration and modulates the Wnt/beta-catenin
            signaling pathway.
REFERENCE   2  (bases 1 to 3858)
  AUTHORS   Liu,X., Zhao,J., Wu,Q., Wang,L., Lu,W. and Feng,Y.
  TITLE     ANKRD22 promotes glioma proliferation, migration, invasion, and
            epithelial-mesenchymal transition by upregulating E2F1-mediated
            MELK expression
  JOURNAL   J Neuropathol Exp Neurol 82 (7), 631-640 (2023)
   PUBMED   37164633
  REMARK    GeneRIF: ANKRD22 promotes glioma proliferation, migration,
            invasion, and epithelial-mesenchymal transition by upregulating
            E2F1-mediated MELK expression.
REFERENCE   3  (bases 1 to 3858)
  AUTHORS   Utsumi,T., Hosokawa,T., Shichita,M., Nishiue,M., Iwamoto,N.,
            Harada,H., Kiwado,A., Yano,M., Otsuka,M. and Moriya,K.
  TITLE     ANKRD22 is an N-myristoylated hairpin-like monotopic membrane
            protein specifically localized to lipid droplets
  JOURNAL   Sci Rep 11 (1), 19233 (2021)
   PUBMED   34584137
  REMARK    GeneRIF: ANKRD22 is an N-myristoylated hairpin-like monotopic
            membrane protein specifically localized to lipid droplets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3858)
  AUTHORS   Pan,T., Liu,J., Xu,S., Yu,Q., Wang,H., Sun,H., Wu,J., Zhu,Y.,
            Zhou,J. and Zhu,Y.
  TITLE     ANKRD22, a novel tumor microenvironment-induced mitochondrial
            protein promotes metabolic reprogramming of colorectal cancer cells
  JOURNAL   Theranostics 10 (2), 516-536 (2020)
   PUBMED   31903135
  REMARK    GeneRIF: ANKRD22, a novel tumor microenvironment-induced
            mitochondrial protein promotes metabolic reprogramming of
            colorectal cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3858)
  AUTHORS   Yin,J., Fu,W., Dai,L., Jiang,Z., Liao,H., Chen,W., Pan,L. and
            Zhao,J.
  TITLE     ANKRD22 promotes progression of non-small cell lung cancer through
            transcriptional up-regulation of E2F1
  JOURNAL   Sci Rep 7 (1), 4430 (2017)
   PUBMED   28667340
  REMARK    GeneRIF: ANKRD22 exhibits oncogene activity that promotes tumor
            progression in NSCLC through the transcriptional regulation of
            E2F1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3858)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3858)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 3858)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA672161.1, BM785517.1, BC021671.1, AL353113.7 and N95187.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144590.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.221031.1,
                                           SRR5189667.203426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371930.5/ ENSP00000360998.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA672161.1         132-157
            27-697              BM785517.1         1-671
            698-1185            BC021671.1         616-1103
            1186-3540           AL353113.7         15004-17358         c
            3541-3855           N95187.1           8-322               c
            3856-3858           AL353113.7         14686-14688         c
FEATURES             Location/Qualifiers
     source          1..3858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..3858
                     /gene="ANKRD22"
                     /note="ankyrin repeat domain 22"
                     /db_xref="GeneID:118932"
                     /db_xref="HGNC:HGNC:28321"
     exon            1..258
                     /gene="ANKRD22"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..813
                     /gene="ANKRD22"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 22"
                     /protein_id="NP_653191.2"
                     /db_xref="CCDS:CCDS7390.1"
                     /db_xref="GeneID:118932"
                     /db_xref="HGNC:HGNC:28321"
                     /translation="MGILYSEPICQAAYQNDFGQVWRWVKEDSSYANVQDGFNGDTPL
                     ICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLIILLMPVLLI
                     GYFLMVSKTKQNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARAD
                     PTIKNKHGESSLDIARRLKFSQIELMLRKAL"
     exon            259..450
                     /gene="ANKRD22"
                     /inference="alignment:Splign:2.1.0"
     exon            451..558
                     /gene="ANKRD22"
                     /inference="alignment:Splign:2.1.0"
     exon            559..636
                     /gene="ANKRD22"
                     /inference="alignment:Splign:2.1.0"
     exon            637..735
                     /gene="ANKRD22"
                     /inference="alignment:Splign:2.1.0"
     exon            736..3858
                     /gene="ANKRD22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD22"
                     /note="hexamer: AATAAA"
     polyA_site      1503
                     /gene="ANKRD22"
                     /note="major polyA site"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD22"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="ANKRD22"
                     /note="major polyA site"
     regulatory      3837..3842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD22"
                     /note="hexamer: AATAAA"
     polyA_site      3858
                     /gene="ANKRD22"
ORIGIN      
        1 acacatgaca ccagtgcctt tgtttcattg ggctgggctc tctggaaggt gtgctgctgc
       61 ctgagctgct ggaaaagcac tgacaggtgt ttgctagaaa agcactcctg gagcttgcca
      121 ccagcttgga cttctaggga ctttcctctc agccaggaag gattttgata ttcatcagaa
      181 atacctccag aagattcaag gagctgtaga ggtgaagtaa gcctgtgaag gaccagcatg
      241 ggaatcctat actctgagcc catctgccaa gcagcctatc agaatgactt tggacaagtg
      301 tggcggtggg tgaaagaaga cagcagctat gccaacgttc aagatggctt taatggagac
      361 acgcccctga tctgtgcttg caggcgaggg catgtgagaa tcgtttcctt ccttttaaga
      421 agaaatgcta atgtcaacct caaaaaccag aaagagagaa cctgcttgca ttatgctgtg
      481 aagaaaaaat ttaccttcat tgattatcta ctaattatcc tcttaatgcc tgttctgctt
      541 attgggtatt tcctcatggt atcaaagaca aagcagaatg aggctcttgt acgaatgcta
      601 cttgatgctg gcgtcgaagt taatgctaca gattgttatg gctgtaccgc attacattat
      661 gcctgtgaaa tgaaaaacca gtctcttatc cctctgctct tggaagcccg tgcagacccc
      721 acaataaaga ataagcatgg tgagagctca ctggatattg cacggagatt aaaattttcc
      781 cagattgaat taatgctaag gaaagcattg taatccttgt gaccacaccg atggagatac
      841 agaaaaagtt aacgactgga ttctatcttc attttagact tttggtctgt gggccattta
      901 acctggatgc caccatttta tggggataat gatgcttacc atggttaatg ttttggaaga
      961 gctttttatt tatagcattg tttactcagt caagttcacc atggccgtaa tccttctaag
     1021 ggaaacacta aagttgttgt agtctccact tcagtcagaa actgatgttt cagctaggca
     1081 cagtggtaca tgcctgtaat cccagctact tgggaggctg aggtgggagg atcacttgaa
     1141 ctcaggagtt tgagagcagc cagggcaaca cagcgagacc ctgtctcaaa aaaaaaaaaa
     1201 aaaaaaaaag ccctggtgtt ccaaactcag tctttcctga agaagaggat ctgagttatc
     1261 ttctgaaaca gcgttctccc ttcccagttg tatcactctt ataaaaagac tgtccagtct
     1321 atgtcatgcc ctaggagaca aactgttcct cccagccccc tttgagtatt gagcagaaga
     1381 atcaaattat taaatacgta tgtttgtaca gaatggtatt tgtgtatgtg tgtgggctta
     1441 gagattcaca agtaaatatt cctttggtga aggaatttca ataaaaacat ctatcaagtg
     1501 tcagcggtga gtgtgtttac accacagaaa ttggcaaatt gacaaatcag agtttgtttt
     1561 tgtttttttg ttttttactt tccataaagt tcgtttacca gcataccact agagatttcg
     1621 gtttacaaat aaaagccatc ttggtttgag caagactatg caactatgaa aatgttcgtt
     1681 taaaaaaatc ttcatgatcc ttttgtaaat acaaggtggt tgccaagctt gttagttttg
     1741 tttattttat tgatagatgt aaaatattat tgtaacttat ttggataaag ttcttcaaaa
     1801 gaaacagagc tatacaatga ggtaggatct ggattatttg tctaagtgag agattgcgaa
     1861 tatcaaaata tctgtctcac ttcttctgtg aatgacacag agtagaaata aattcacttt
     1921 aaaaatatga ctgaattttg aaaatcaaga ctgaatctca catagctgca gacaggaact
     1981 aagccagcct ctttgtatgt ggtaacaagt acagtataag aatgaaagat ttaccatcct
     2041 tgaaagctct aatgaaaatc aaatccagca atatatattc aactgtgtac aggatttaag
     2101 aaacttattt tatgaaggaa gtaatagtgt gtagatatag attctgaagt ctttaaacgt
     2161 gtcttaataa attaagattc actggcattg agctgagcta ccaggtgacc cttggggaca
     2221 aaaaacccac acaagtgaat ttcacacacc agtatacctt caacaatata cttttgacac
     2281 acacaaacct ttgatttggt ttcagagatt ttgcaaaata gtaccaatgt aatttacaac
     2341 tgtcatcttt gaaattgtgt aaaagtggaa taattttctg aagaaataaa tcatggtttg
     2401 tcaatgagtt gcagagactg tctgacatta actttgtcaa gattaaagga taaagtatat
     2461 gacaatttgt ttcatcatgc tcatgacatt atgcaatttt ctccctagct tttaattttt
     2521 ggaggcagaa aattgagcca gaaattttta gtcattaggt ctcctagcaa caagctgtaa
     2581 accttccaac aagcttggac tagaatctag acactgaaat gcacatacat gctttatgta
     2641 atgcagaatg catttattgg agaactcata aacatcctat aaaattttct tccctgagat
     2701 gcaactataa aacttggcct tattctgaga atgcttaaca tagatttcat ccatactgta
     2761 acactgattt tgttgttgtt gtccttaaag cagctcagct tcctgaggta gtgttatgtc
     2821 tctgtggcaa caaggtgaaa atgtctagct tattttgtca aagtcaacaa taatccacag
     2881 actccagacc tcaatatctg tcccaatttg ccattttact ttagtgctcc aaaaatatgg
     2941 cttatagaaa aaacaatagg tgttttaaag agatttacct gaatgatata gagaatgtct
     3001 agatattttc tggctatcag gtaaaaccta cccttcaaga tggtagaata tataatagca
     3061 tacaaaacct ctatttacct aataagtact ttaatttaca gaaaaaaaat gtaaatgtaa
     3121 gtgtcggatt tagtgccaag tgcagggaat ctgaaaaatg tatactaggt ctctgctctc
     3181 cgtaattctg ccttcatggg tcctagcccc atccctcagg aggttgtcct aagatcgtca
     3241 gtgtcagatg cttcacaata cggcctcaca ccgtccctgg gaaaggttgg tctcctcctg
     3301 ctgcatcaga tggatgattt cattgtacat acggtgagga gcatccaaac cccagatgaa
     3361 atccacgtga gcccattcag gaatattctt atggtagatg aggttggtca cctcagagag
     3421 cagcattttc acgtcttctg gatttgaaag ccagtcctga cctcctgtcc acattgctgt
     3481 agggaccgtc atatctctga ctctgtacct tacaggagtt ggctagagaa aaggaatagt
     3541 tcttaactct aggtaacatt tggactttca ggctcataat ttatgtttca aatagacata
     3601 ataaacatgc catctgttgt ggtgaagggt acatgggtgt tagagccaca caactctgtt
     3661 aagaatttct gttcccgccc ttactttaag gtaaaattac ttaacattat tgaacctcag
     3721 tttcttcttc tgtgactggg gataatatct gtaataactt gctagatcaa atgacaaaac
     3781 acataaaaac atgtaatgcc ttgtatttct tttttcttcc tattaaatat tttgtaaata
     3841 aattgttttt aaaaataa
//
