LOCUS       NM_001393611            4160 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat domain 18B (ANKRD18B), transcript
            variant 2, mRNA.
ACCESSION   NM_001393611
VERSION     NM_001393611.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4160)
  AUTHORS   Liu,W.B., Han,F., Jiang,X., Yin,L., Chen,H.Q., Li,Y.H., Liu,Y.,
            Cao,J. and Liu,J.Y.
  TITLE     Epigenetic regulation of ANKRD18B in lung cancer
  JOURNAL   Mol Carcinog 54 (4), 312-321 (2015)
   PUBMED   24249358
  REMARK    GeneRIF: ANKRD18B mRNA expression was significantly decreased or
            silenced in lung cancer tissues and cell lines associated with
            hypermethylation of the ANKRD18B region.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139008.10.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000684830.1/ ENSP00000510683.1
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AL139008.10        29065-29509
            446-560             AL139008.10        33541-33655
            561-734             AL139008.10        33814-33987
            735-841             AL139008.10        38253-38359
            842-979             AL139008.10        39184-39321
            980-1047            AL139008.10        41692-41759
            1048-1101           AL139008.10        44263-44316
            1102-1236           AL139008.10        44892-45026
            1237-1317           AL139008.10        45961-46041
            1318-1388           AL139008.10        47999-48069
            1389-2306           AL139008.10        52752-53669
            2307-2456           AL139008.10        55244-55393
            2457-2569           AL139008.10        60522-60634
            2570-2699           AL139008.10        62872-63001
            2700-2981           AL139008.10        71033-71314
            2982-3193           AL139008.10        71917-72128
            3194-3416           AL139008.10        73485-73707
            3417-3462           AL139008.10        76060-76105
            3463-4160           AL139008.10        77130-77827
FEATURES             Location/Qualifiers
     source          1..4160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4160
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /note="ankyrin repeat domain 18B"
                     /db_xref="GeneID:441459"
                     /db_xref="HGNC:HGNC:23644"
                     /db_xref="MIM:618930"
     exon            1..445
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..3581
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ankyrin repeat domain-containing protein 18B"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 18B
                     isoform 2"
                     /protein_id="NP_001380540.1"
                     /db_xref="CCDS:CCDS94397.1"
                     /db_xref="GeneID:441459"
                     /db_xref="HGNC:HGNC:23644"
                     /db_xref="MIM:618930"
                     /translation="MRKLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIK
                     GDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNR
                     TPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANI
                     EALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTL
                     LLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQEAAAMKN
                     ESFKTQGASSKVSLYHQSGVQWHDLRLLQPSPPRFKQFSCLSLPRSWDNRHMRPCPET
                     AAMKPENLKKRKKRKKLKKRKEGAKEHNLKVASEEKQERLERSENKQPQDSQSYGKKK
                     DEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEM
                     ITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEIL
                     ERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD
                     ALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELEN
                     LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLKEKLLQYE
                     KEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQVEIQP
                     EEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFS
                     CHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQ
                     EKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQ
                     KQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTELEEYKEAFAVA
                     LKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPDPELPCVENLNSIEL
                     NRKYIPKMAIRIPTSNPQTSNNCKNSLTEMELDCAEQIITETKKTFAALGPCSYLLSS
                     LESTGKPHLMKRIFNHKILRKSCMI"
     exon            446..560
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            561..734
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            735..841
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..979
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1047
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1101
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1236
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1317
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1388
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2306
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2456
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2569
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2699
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2981
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3193
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3416
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3462
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..4160
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4139..4144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /note="hexamer: AATAAA"
     polyA_site      4160
                     /gene="ANKRD18B"
                     /gene_synonym="bA255A11.3; bA255A11.5"
                     /note="major polyA site"
ORIGIN      
        1 actgggctca ctctatcgag aggtcggagg ctgcgagtgt cgctgctgaa ggctgtagtg
       61 gaccgggctg gatcgcggat tctgagctac atcgcgggtt tgggggtgca tcttggattt
      121 aggggtggat cgctgggtgg ggagggggat ctcgaatttg gagctgggtg ggggtggaaa
      181 ggccacgagg agccgcggcg tctcaggagc gggtggtggg catctgagaa gtcgccacca
      241 tgaggaagct cctcagtttt gggagacgcc tgggccaggc gctcctgagc tccatggacc
      301 aagagtatgc gggtcggggg taccacattc gggactggga actgcggaag atccacaggg
      361 cggccatcaa gggcgacgcc gcagaggtgg agcactgcct gacgcgcagg ttccgggact
      421 tggacgtccg cgacagaaaa gacaggactg ttctacattt ggcctgtgcc catggccgtg
      481 tgcaagtggt cactctcttg ctggacagaa aatgccagat caacatctgt gacagactaa
      541 acaggacacc tttaatgaag gctgtacact gccaggaaga ggcttgtgcc attattctcc
      601 tgaaacgtgg cgccaatcca aacattaagg atatctacgg caacactgct ctccattatg
      661 ccgtgtataa tgaggggact tcactggcag aaagactgct ttcccaccat gcaaatattg
      721 aagcactaaa caaggaggga aacactccac ttttgtttgc tataaattcc aggagacagc
      781 atatggtgga atttttattg aagaaccagg caaatataca tgccgttgac aatttcaaaa
      841 gaacagccct catacttgca gtacagcata acttgtcaag tatcgtcacc ctcctgcttc
      901 aacaaaatat acatatctct tctcaagaca tgtttggcca aactgccgag gattatgctt
      961 tttgttgtga tttgagaagc atccaacaac aaattttgga acataaaaat aagatgctta
     1021 aaaatcatct tcgaaatgac aatcaagaag cagcagccat gaagaatgaa agttttaaaa
     1081 cacaaggagc aagttcaaaa gtctcgctct atcaccagtc tggagtccag tggcatgatc
     1141 tcagattact gcagccttca cctcccaggt tcaagcaatt ctcctgcctc agcctcccga
     1201 ggagctggga caacaggcac atgcgaccat gcccagaaac agcagctatg aagcctgaaa
     1261 atttgaaaaa aagaaaaaaa agaaaaaaat tgaaaaaaag aaaagaaggt gcaaaagaac
     1321 acaacttaaa agtggcttca gaggaaaagc aagaaaggct tgaaagaagt gaaaataaac
     1381 agccgcagga ttctcaaagt tatggaaaaa agaaggatga gatgtttgga aattttatgt
     1441 tgaagagaga cattgccatg ctcaaagagg aattatatgc aataaaaaat gacagtctca
     1501 gaaaggaaaa gaaatatatt caggaaatta aaagtattac agaaataaat gctaactttg
     1561 aaaagagtgt aagactcaat gaagaaatga taacaaaaaa agtggcccag tattcgcaac
     1621 agcttaatga tctgaaagct gagaatgcaa ggctgaattc aaaattggag aaggaaaaac
     1681 acaacaaaga aagactagaa gctgaagttg aatccctcca ttctaacttg gccactgcta
     1741 taaatgagta caatgaaatt ttggaaagaa aagacctaga actagtttta tggagagcag
     1801 atgatgtttc tagacatgaa acaatgggtt ctaatatttc tcaactaaca gataagaatg
     1861 agttgcttac tgaacaggtc cataaagctc gggtgaagtt caatacctta aaaggtaagc
     1921 tccgtgagac aagagatgct ctcagggaaa agacattggc tttagaaagt gtacagctgg
     1981 acctaaagca agcgcagcat cgaataaagg aaatgaagca gatgcatcca aatggggaag
     2041 ctaaagaaag tcaatccatt ggaaagcaga actcttcaga ggagagaata cgtcaacgag
     2101 aacttgaaaa tctcttgctt gaacgacaac tagaggatgc tcgtaaggaa ggtgataata
     2161 aagagatagt cattaatatc cacagagact gtcttgagaa tggaaaggaa gatcttctag
     2221 aagaaagaaa taaggaatta atgaatgaat ataattattt aaaagaaaaa ctgcttcagt
     2281 atgaaaaaga aaaagcagaa agagaagtga ttgtgagaga atttcaagaa gaactggtcg
     2341 atcatcttaa aaaattttca atgtcagagt ctccactgga aggtacatca cattgtcata
     2401 ttaatttgga tgagacatgg acttcaaaga agaaattatt tcaagtagaa attcaacctg
     2461 aagaaaaaca tgaagaattc agaaaagttt ttgaattaat atcattactg aactatactg
     2521 cggatcaaat aagaaagaaa aatcgtgaat tagaagaaga ggcaactgga tataagaaat
     2581 gcctagaaat gacaataaat atgttaaatg catttgcaaa tgaagacttc agttgccatg
     2641 gagacttaaa tacagaccaa ctgaaaatgg atattctgtt taagaagcta aaacagaagt
     2701 ttgatgatct tatggccgag aaggaagctg tatcttcaaa atgtgtcaat ttggccaaag
     2761 acaatgaagt tcttcatcag gagttattat ctatgggaaa agtacaagag aaatgtgaaa
     2821 aacttgagaa ggataaaaag atgttggaag aaaaagtatt aaatcttaag acacatatgg
     2881 aaaaagatat ggtagaactt ggtaaagtac aagaatataa atcggagctg gatgaaaggg
     2941 caatgcaggc aatagaaaaa ttagaagaaa tccatttaca gaaacaagca gaatatgaaa
     3001 aacaattaga gcagttaaac aaggataata cggcttcact aaaaaagaag gaactcacac
     3061 ttaaagatgt ggaatgtaaa ttctccaaaa tgaaaacagc ttatgaagat gttacaactg
     3121 aattagaaga gtataaggaa gcctttgcag tagcattgaa agctaacagt tccatgtcag
     3181 aaaaaataac gaaatcggat aagaaaatag ctgtgatcag caccaagctc tttatggaga
     3241 aagagcggat ggaatatttt ctcagcactc ttcctatgag gccagaccca gagttacctt
     3301 gtgttgaaaa tcttaatagt atagaactca acagaaaata tattcccaaa atggccataa
     3361 gaattcctac ttcaaaccca cagacttcaa ataactgcaa gaactccttg actgagatgg
     3421 agctggactg tgcagaacaa ataattacag aaacaaagaa aacttttgct gcgttgggcc
     3481 cttgctccta tctactttct tctctagaat ccactggtaa gccacatcta atgaagagaa
     3541 tatttaacca taaaatctta aggaaaagtt gtatgattta aaagatcata aaactttatt
     3601 actgggctat ttacatgaaa ttttaattgt ttctcataaa atataaaaca tcacaatctt
     3661 tactaaagta gaatattttc atatcatatg atgtatattt atatgttatt ttaaatgatt
     3721 tttttagcct ccttaagttt taagtggatc ttgcaaatga acaccagtgt tattgagttt
     3781 gacctactca aattgcctga atgtcagctg tttaaacagc caaacaacca agtcatcatt
     3841 gatactgtag taaaggtcat ctttgcattt tacacttttt attaccatat atagtaggag
     3901 acttaaagag tatctgccag gtttgtccat actagtgtta tgattttctt tttgtagttc
     3961 aatagtattt tgtgtggaga tactttgaag ctctgtaaat atctggttac tcctcaaaac
     4021 ccactagatt tagcatttca tggatgactt gtgtttgaac aagtattact gtgatggttg
     4081 ccagatgatt atttttctta ttttcttctt tgttctacat ggagaaataa aaccaataaa
     4141 taaaggagaa gggaaagtca
//
