LOCUS       NM_147195               3971 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat domain 18A (ANKRD18A), transcript
            variant 2, mRNA.
ACCESSION   NM_147195 XM_001713970 XM_001717620 XM_001726105
VERSION     NM_147195.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3971)
  AUTHORS   Liu,W.B., Han,F., Jiang,X., Yang,L.J., Li,Y.H., Liu,Y., Chen,H.Q.,
            Ao,L., Cui,Z.H., Cao,J. and Liu,J.Y.
  TITLE     ANKRD18A as a novel epigenetic regulation gene in lung cancer
  JOURNAL   Biochem Biophys Res Commun 429 (3-4), 180-185 (2012)
   PUBMED   23131552
  REMARK    GeneRIF: These results suggest that ANKRD18A hypermethylation and
            consequent mRNA alterations might be a vital molecular mechanism in
            lung cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056266.1, AB095935.1 and AL591543.22.
            
            On Nov 22, 2018 this sequence version replaced NM_147195.3.
            
            Transcript Variant: This variant (2) lacks two in-frame exons
            compared to variant 1. The encoded isoform (2) is shorter than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB095935.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399703.6/ ENSP00000382610.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               BC056266.1         69-767
            700-1588            AB095935.1         412-1300
            1589-1589           AL591543.22        28892-28892         c
            1590-2490           AB095935.1         1302-2202
            2491-2491           AL591543.22        19080-19080         c
            2492-3000           AB095935.1         2204-2712
            3001-3010           AL591543.22        9925-9934           c
            3011-3969           AB095935.1         2723-3681
            3970-3971           AL591543.22        4194-4195           c
FEATURES             Location/Qualifiers
     source          1..3971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.1"
     gene            1..3971
                     /gene="ANKRD18A"
                     /note="ankyrin repeat domain 18A"
                     /db_xref="GeneID:253650"
                     /db_xref="HGNC:HGNC:23643"
                     /db_xref="MIM:620259"
     exon            1..517
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..3290
                     /gene="ANKRD18A"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ankyrin repeat domain-containing protein 18A"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 18A
                     isoform 2"
                     /protein_id="NP_671728.2"
                     /db_xref="CCDS:CCDS55311.1"
                     /db_xref="GeneID:253650"
                     /db_xref="HGNC:HGNC:23643"
                     /db_xref="MIM:620259"
                     /translation="MRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIK
                     GDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNR
                     TPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANI
                     EALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTL
                     LLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP
                     ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDI
                     AMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLN
                     DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRAD
                     DVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQ
                     LDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKE
                     GDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREF
                     QEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFEL
                     ISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMD
                     ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKML
                     EEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLN
                     KDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMK
                     SDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIP
                     TSNPQTSNNCKNFLTEVLLC"
     exon            518..632
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            633..806
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            807..913
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1051
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1119
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1173
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1247
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..2165
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2315
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2428
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2558
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2840
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3052
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3275
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3971
                     /gene="ANKRD18A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3471..3476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD18A"
                     /note="hexamer: ACTAAA"
     polyA_site      3495
                     /gene="ANKRD18A"
                     /note="major polyA site"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD18A"
                     /note="hexamer: AATAAA"
     polyA_site      3965
                     /gene="ANKRD18A"
ORIGIN      
        1 actcggtctg agagttcgga gcgctgaggt tcaggcgcgc gcctaacggc ttagctgggc
       61 tcactcggtc tgagaggtcg gagtctgcga gtgtcgctgc tgaaggctgt ggtggaccgg
      121 gctggatcgc ggattctgag ctacattgcg ggtttggggg tggatcttgg atttgggggt
      181 ggatcgcggg ttgcgggggg gatcgcgggt tgcgggggag atcgcggatt tggggcggag
      241 tgggggtgga aaggccacga ggagccgccg cggctcagga gcgggtggtg ggcgtctgag
      301 aagtcgccac catgaggaag ctcttcagct tcgggagacg cctgggccag gcgctcctga
      361 gctccatgga ccaagagtat gcgggtccgg gttacgacat tcgggactgg gaactgcgga
      421 agatccacag ggctgccatc aagggcgacg ccgcggaggt ggagcgctgc ctgacgcgca
      481 ggttccggga cttggacgcc cgcgacagaa aagacaggac tgttctacat ttggcctgtg
      541 cccatggccg tgtgcaagtg gtcactctct tgctgcacag aagatgccag atcgacatct
      601 gtgacagact aaacaggaca cctttaatga aggctgtaca cagccaggaa gaggcttgtg
      661 ccatcgttct cctggaatgt ggcgccaatc caaacattga ggatatctac ggcaacactg
      721 ctctccatta tgccgtgtat aataagggga cttcactggc agaaagactg ctttcccacc
      781 atgcaaatat tgaagcacta aacaaggagg gaaacactcc acttttgttt gctataaatt
      841 ccaggagaca gcatatggtg gaatttttat tgaagaacca ggcaaatata catgccgttg
      901 acaatttcaa aagaacagcc ctcatacttg cagtacagca taacttgtca agtatcgtca
      961 ccctcctgct tcaacaaaat atacgtatct cttctcaaga catgtttggc caaactgccg
     1021 aggattatgc tctttgttct gatttgagaa gcatccgaca acaaattttg gaacataaaa
     1081 ataaaatgct taaaaatcat cttcgaaatg acaatcaaga aacagcagct atgaagcctg
     1141 caaatttgaa aaaaagaaaa gaacgtgcaa aagcagaaca caacctaaaa gtggcttcag
     1201 aggaaaagca agaaaggctc caaagaagtg aaaataaaca gccacaggat tctcaaagtt
     1261 acggaaaaaa gaaggatgcg atgtatggaa attttatgtt gaagaaagac attgccatgc
     1321 tcaaagagga attatatgca ataaaaaatg acagtctcag aaaggaaaag aaatatattc
     1381 aggaaattaa aagcattaca gaaataaatg ctaactttga aaagagtgta agactcaatg
     1441 aaaaaatgat aacaaaaaca gtggcccggt attcgcaaca gcttaatgat ctgaaagctg
     1501 agaatgcaag gctgaattca gaattggaga aggaaaaaca caacaaagaa agactagaag
     1561 ctgaagttga atccctccat tctagcctgg ccactgctat aaatgagtac aatgaaattg
     1621 tggaaagaaa agacctagaa ctagttttat ggagagcaga tgatgtttct agacatgaaa
     1681 aaatgggttc taatatttct caactaacag ataagaatga gttgcttact gaacaggtcc
     1741 ataaagctcg ggtgaagttc aataccttaa aaggtaagct ccgtgagaca agagatgctc
     1801 tcagggaaaa gacattggct ttaggaagtg tacagctgga cctaaggcaa gcacagcatc
     1861 gaataaagga aatgaagcag atgcatccaa atggagaagc taaagaaagt caatccattg
     1921 gaaagcagaa ctctttagag gagagaatac gtcaacaaga acttgaaaat ctcttgcttg
     1981 aacgacaact agaggatgct cgtaaggaag gcgataataa agagatagtc attaatatcc
     2041 acagagactg tcttgagaat ggaaaggaag atcttctaga agaaagaaat aaggaattaa
     2101 tgaaagaata taattattta aaagaaaaac tgcttcagtg tgaaaaagaa aaagcagaaa
     2161 gagaagtgat tgtgagagaa tttcaagaag aactggtcga tcaccttaaa acattttcaa
     2221 tatcagagtc tccactggaa ggtacatcac attgtcatat taatttgaat gagacatgga
     2281 cttcaaagaa gaaattattt caagtagaaa ttcaacctga agaaaaacat gaagaattca
     2341 gaaaactttt tgaattaata tcattactga actatactgc ggaccaaata agaaagaaaa
     2401 atcgtgaatt agaagaagag gcaactggat ataagaaatg cctagaaatg acaataaata
     2461 tgttaaatgc atttgcaaat gaggacttca gttgccatgg agacttaaat acagaccaac
     2521 tgaaaatgga tattctgttt aagaagctaa aacagaagtt taatgatctt gtggccgaga
     2581 aggaagctgt gtcttcagaa tgtgtcaatt tggccaaaga caatgaagtt cttcatcagg
     2641 agttattatc tatgagaaat gtacaagaga aatgtgaaaa acttgagaag gataaaaaga
     2701 tgttggaaga agaagtatta aatcttaaga cacatatgga aaaagatatg gtagaacttg
     2761 gtaaactaca agaatataaa tcggagctgg atgaaagggc agtgcaggaa atagaaaaat
     2821 tagaagaaat ccatttacag aaacaagcag aatatgaaaa acaattagag cagttaaaca
     2881 aggataatac ggcttcacta aaaaagaagg aactcacact taaagatgtg gaatgtaaat
     2941 tctccaaaat gaaaactgct tatgaagagg ttacaactga attagaagaa tttaaggaag
     3001 cctttgcagg agcagtgaaa gctaacaatt ccatgtcaaa aaaattaatg aaatcggata
     3061 agaaaatagc agtgatcagc accaagctct ttacggagaa acagcggatg aaatattttc
     3121 tcagcactct tcctacaagg ccagaaccag agttaccttg tgttgaaaat cttaatagta
     3181 tagaactcaa cagaaaatat attcccaaaa cggccataag aattcctact tcaaacccac
     3241 agacttcaaa taactgcaag aacttcttga ctgaggtttt gctatgttga gcacttgctc
     3301 ccgtctactt tcttttgtag aatccactgg taagccacat ctaatgaaga gattaaccat
     3361 aaaatcttaa ggaaaagttg tatgatttaa aagatcataa aactttatta ctgggctatt
     3421 tacatgaaat tttaattgtt tctcatataa tataaaacat cataatcttt actaaagtag
     3481 aatattttca tgtcacatat ggtgtatatt tatatgttat tttaaatgat gttttttagc
     3541 ctccttaagt tttaagtgga tcttgcaaat gaacaccagc gttattgagt ttggcctact
     3601 caaattgcct gaatgtcagc tgtttaaaca gccaaacaac caagtcatca ttgatacttt
     3661 agtaaaggtc atcgagggct tctttgcatt ttacagtttt tattaccata tgtagtagga
     3721 gacttaaaga gtatctgcca ggtttgtcca tactagtgtt acggttttct tcttgtagct
     3781 caatagtatt ttgtgtggag atactttgaa gctctgtaaa tatctggtta ctcctcaaaa
     3841 cccactagat ttagcatttc atggatgact tgtgtttgaa caagtattac tgtgatggtt
     3901 gccagatgat tgtttttctt attttcttct ttgttctaca tggagaaata aaaccaataa
     3961 ataaaggaga a
//
