LOCUS       NM_019046               2734 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ankyrin repeat domain 16 (ANKRD16), transcript variant
            1, mRNA.
ACCESSION   NM_019046
VERSION     NM_019046.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Vo,M.N., Terrey,M., Lee,J.W., Roy,B., Moresco,J.J., Sun,L., Fu,H.,
            Liu,Q., Weber,T.G., Yates,J.R. 3rd, Fredrick,K., Schimmel,P. and
            Ackerman,S.L.
  TITLE     Publisher Correction: ANKRD16 prevents neuron loss caused by an
            editing-defective tRNA synthetase
  JOURNAL   Nature 560 (7720), E35 (2018)
   PUBMED   29925958
  REMARK    Correction to:[Nature. 2018 May;557(7706):510-515. doi:
            10.1038/s41586-018-0137-8.. PMID: 29769718]
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Vo,M.N., Terrey,M., Lee,J.W., Roy,B., Moresco,J.J., Sun,L., Fu,H.,
            Liu,Q., Weber,T.G., Yates,J.R. 3rd, Fredrick,K., Schimmel,P. and
            Ackerman,S.L.
  TITLE     ANKRD16 prevents neuron loss caused by an editing-defective tRNA
            synthetase
  JOURNAL   Nature 557 (7706), 510-515 (2018)
   PUBMED   29769718
  REMARK    Erratum:[Nature. 2018 Aug;560(7720):E35. doi:
            10.1038/s41586-018-0271-3.. PMID: 29925958]
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Turnbull,C., Ahmed,S., Morrison,J., Pernet,D., Renwick,A.,
            Maranian,M., Seal,S., Ghoussaini,M., Hines,S., Healey,C.S.,
            Hughes,D., Warren-Perry,M., Tapper,W., Eccles,D., Evans,D.G.,
            Hooning,M., Schutte,M., van den Ouweland,A., Houlston,R., Ross,G.,
            Langford,C., Pharoah,P.D., Stratton,M.R., Dunning,A.M., Rahman,N.
            and Easton,D.F.
  CONSRTM   Breast Cancer Susceptibility Collaboration (UK)
  TITLE     Genome-wide association study identifies five new breast cancer
            susceptibility loci
  JOURNAL   Nat Genet 42 (6), 504-507 (2010)
   PUBMED   20453838
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137186.18, BC017324.1, BC062346.1, AL137614.1 and AL596094.2.
            
            On Nov 22, 2018 this sequence version replaced NM_019046.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017324.1, SRR5189667.207171.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380094.10/ ENSP00000369436.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-607               AL137186.18        22990-23596         c
            608-1186            BC017324.1         8-586
            1187-1597           BC062346.1         677-1087
            1598-2441           AL137614.1         457-1300
            2442-2596           AL596094.2         100937-101091       c
            2597-2624           AL137614.1         1445-1472
            2625-2734           AL596094.2         100799-100908       c
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..2734
                     /gene="ANKRD16"
                     /note="ankyrin repeat domain 16"
                     /db_xref="GeneID:54522"
                     /db_xref="HGNC:HGNC:23471"
                     /db_xref="MIM:618017"
     exon            1..853
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..1625
                     /gene="ANKRD16"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 16"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 16
                     isoform a"
                     /protein_id="NP_061919.1"
                     /db_xref="CCDS:CCDS31136.1"
                     /db_xref="GeneID:54522"
                     /db_xref="HGNC:HGNC:23471"
                     /db_xref="MIM:618017"
                     /translation="MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCA
                     ARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK
                     ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC
                     PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI
                     DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLT
                     ALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDS
                     EDITGTLAQQLPRRADVLQGSGHSAMT"
     exon            854..1074
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1117
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1226
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1388
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1467
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1658
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..2734
                     /gene="ANKRD16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD16"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="ANKRD16"
                     /note="major polyA site"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD16"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="ANKRD16"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggccc tgaggacgcg tgcggggcag gtcacgcttg ggcctggctg cctcaggagc
       61 caccctgcac ggcgccgggc gaggctgtgc gcgccctccc ggaccctcca ctttggggct
      121 ttgcggtgta gcggcgcgcc ccactccctt acgtgttcag tcccgaatca cgtacgggcc
      181 gctgcagctc caggacggcg gacgccagcg ctctcggatc cccaggcccc tccgtgctca
      241 tcccggaccg ctccgtccct gaggaaaaac cgccccgtgc ccggaaccgc ggcttctccc
      301 acgcggggca ggccggggct gtgagggggc agcccgcctg cggactaggc cgggggtttg
      361 aggaggcggc tctgccgggg acaaagccgg gggcgtgagg ggcggttctg ccgggttcgg
      421 ggcgcgcggg gcaggttgcg tgaagaggcg gaaagtccca ctcgccctcg gcttctccct
      481 gcccggccgc cggtgtcccg cccgccgcct ccccgcgcag cccggcccga cccgcggcga
      541 tggcccagcc cggggacccg cggcgcctct gcaggctggt gcaggagggc cggctgcgcg
      601 ccctgaagga ggagctgcag gcggccgggg gctgcccggg gccggccggg gataccctcc
      661 tgcactgcgc cgcgcgccac gggcatcggg acgtgctggc ctatctggcc gaggcctggg
      721 gcatggacat cgaggccacc aaccgagact acaagcggcc tctgcacgag gcggcctcca
      781 tgggccaccg agactgcgtg cgctacctgc tgggccgggg ggcagcggtc gactgcctga
      841 agaaggccga ctggactcct ctgatgatgg cctgcacaag gaagaacctg ggggtgatcc
      901 aggagctggt ggaacatggc gccaatccac tcctgaagaa caaagatggc tggaacagtt
      961 tccacattgc cagtcgagaa ggcgaccctc tgatcctcca gtacctgctc actgtttgcc
     1021 caggtgcctg gaagacagag agcaaaatta gaaggactcc tctgcatact gcagcaatgc
     1081 atggccattt ggaggcagtc aaggtgcttc ttaagaggtg ccaatatgaa ccagactaca
     1141 gagacaactg tggcgtcacc gccttgatgg acgcaatcca gtgtgggcac atcgacgtcg
     1201 ctaggctgct cctcgatgaa catggggctt gcctttcagc agaagacagc ctgggtgccc
     1261 aggctctgca cagggcagct gtcacagggc aggacgaagc catccgattc ttggtctctg
     1321 aacttggcgt cgatgtagat gtgagagcca catcaaccca cctcacagca cttcattatg
     1381 cagctaagga aggacataca agtacaattc agactctctt atccttggga gctgacatca
     1441 attctaaaga tgaaaaaaat cgatcagccc tgcatctggc ctgtgcaggt cagcacttgg
     1501 cctgtgccaa gtttctcctg cagtcgggac tgaaggattc tgaagacatc acgggcaccc
     1561 tggctcagca gctcccaagg agagcagatg tccttcaggg ctctggccat agcgcaatga
     1621 cataaggatg tttccaagag gaggcaataa agtgcatgag ttgctgggag cctgagcacc
     1681 tttcgttttt cggctcagag aaagccaagt gcaacttgct tcagtcatcc tgaacctgag
     1741 ttcaaccaac cgcagccacc tacgtttgac cccagcgaga tcaaagttgt atatctgagg
     1801 tgtaccagtg gtgaagtcag tgccacatct gcactggccc ccaaggtcag ctccctgggt
     1861 ctgtctccaa aaatggttgc tgatgacatc accaaccatt gactggaaga gtctgaggat
     1921 gatagtgaaa ctgaccagcc acagcagaca ggcccagatt gaggtggtgc cttctgcctc
     1981 tgccctgatc gtcacaaccc tcaggaacca ccgacagaaa gaaagaaaca caaaaacatg
     2041 aaacacagtg gtagcaccac ttctgatgag attgtcaaca ttgcctaaca gatgcagcag
     2101 cagtctttag ccagagaact ctctggaacc attaaagaat tcctgggggc cggttgcggt
     2161 ggctcatgcc tgtaatccca gcactttggg aggccgaggc gggaggatca tgaggtcagg
     2221 agatcgagac catcctggct aacgtggtga aaccccgtct cttactaaaa atacaaaaaa
     2281 attagccagg catggtggtg ggcgcctgta gtcccagcta ctcaggaggc tgaggcagga
     2341 gaatgctgtg aaccctggag gcagagcttg cagtgagccg aatatgcgcc actgcactcc
     2401 agcctgggca acagagcaag actccgtctc caaaaaaaaa aaaaaaaaaa aagaattcct
     2461 ggggcctgcc cagtctgtga gctgccatgt tgatagtatc acagatgata ccaacagtga
     2521 agctgtggaa tgcccagcta gttaaagaat gcaaaggaaa atattttcac aaagggttat
     2581 ctgataacca aaaaaaaaaa agacatttca tctaagccac ttaacaccgt gtctgatgtg
     2641 tagtaaataa taaatgtcaa tgattctcaa agaacccagg aatagaaaaa gcatttaata
     2701 aaaattagct cttggcataa tctcttcatc caca
//
