LOCUS       NM_207354               2128 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat domain 13D (ANKRD13D), transcript
            variant 1, mRNA.
ACCESSION   NM_207354 XM_941948 XM_945557 XM_945561 XM_945565 XM_945567
            XM_945571
VERSION     NM_207354.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Zhou,W., Huang,Y., Liu,J., Liu,Y., Liu,Y. and Yu,C.
  TITLE     Identification of ANKRD13D as a potential target in renal cell
            carcinomas
  JOURNAL   Int J Biol Markers 39 (2), 149-157 (2024)
   PUBMED   38449090
  REMARK    GeneRIF: Identification of ANKRD13D as a potential target in renal
            cell carcinomas.
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Tsunoda,T., Riku,M., Yamada,N., Tsuchiya,H., Tomita,T., Suzuki,M.,
            Kizuki,M., Inoko,A., Ito,H., Murotani,K., Murakami,H., Saeki,Y. and
            Kasai,K.
  TITLE     ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that
            is downregulated in breast cancer
  JOURNAL   EMBO Rep 23 (2), e51182 (2022)
   PUBMED   34927784
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Mattioni,A., Boldt,K., Auciello,G., Komada,M., Rappoport,J.Z.,
            Ueffing,M., Castagnoli,L., Cesareni,G. and Santonico,E.
  TITLE     Ring Finger Protein 11 acts on ligand-activated EGFR via the direct
            interaction with the UIM region of ANKRD13 protein family
  JOURNAL   FEBS J 287 (16), 3526-3550 (2020)
   PUBMED   31985874
REFERENCE   6  (bases 1 to 2128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 2128)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 2128)
  AUTHORS   Tanno,H., Yamaguchi,T., Goto,E., Ishido,S. and Komada,M.
  TITLE     The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor
            endocytosis from the plasma membrane
  JOURNAL   Mol Biol Cell 23 (7), 1343-1353 (2012)
   PUBMED   22298428
  REMARK    GeneRIF: overexpression of wild-type as well as truncated-mutant
            Ankrd 13A, 13B and 13D proteins strongly inhibited rapid
            endocytosis of ubiquitinated EGFR from the surface in EGF-treated
            cells
REFERENCE   9  (bases 1 to 2128)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2128)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB460018.1, BC110419.1,
            AP001885.4 and BC044239.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 1, 2019 this sequence version replaced NM_207354.2.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat domain (ANKRD) 13 family, which currently consists
            of four proteins containing ubiquitin-interacting motifs. These
            proteins are integral membrane proteins that bind specifically to
            Lys-63-linked ubiquitin chains on membrane-bound proteins,
            targeting those proteins for rapid internalization. [provided by
            RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110419.1, AK096277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000511455.7/ ENSP00000427130.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DB460018.1         13-27
            16-1495             BC110419.1         1-1480
            1496-1496           AP001885.4         154936-154936
            1497-1882           BC110419.1         1482-1867
            1883-2128           BC044239.1         866-1111
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2128
                     /gene="ANKRD13D"
                     /note="ankyrin repeat domain 13D"
                     /db_xref="GeneID:338692"
                     /db_xref="HGNC:HGNC:27880"
                     /db_xref="MIM:615126"
     exon            1..248
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1976
                     /gene="ANKRD13D"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 13D; ankyrin
                     repeat domain 13 family, member D"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 13D
                     isoform 1"
                     /protein_id="NP_997237.2"
                     /db_xref="CCDS:CCDS31616.2"
                     /db_xref="GeneID:338692"
                     /db_xref="HGNC:HGNC:27880"
                     /db_xref="MIM:615126"
                     /translation="MAGPGPTFPLHRLVWANRHRELEAALHSHQHDIEQEDPRGRTPL
                     ELAVSLGNLESVRVLLRHNANVGKENRQGWAVLQEAVSTGDPEMVQLVLQYRDYQRAT
                     QRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSL
                     LGFEHMTWQRGRRSFIFKGQEAGALVMEVDHDRQVVHVETLGLTLQEPETLLAAMRPS
                     EEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELV
                     TRTRTEHLSDQDKSRSKAGKTPFQSFLGMAQQHSSHTGAPVQQAASPTNPTAISPEEY
                     FDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFA
                     KLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPLSSVWVPAPSSAVAASG
                     NPFPCEVDPTVFEVPNGYSVLGMERNEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVW
                     EALTNTRPGARPPPQATVYEEQLQLERALQESLQLSTEPRGPGSPPRTPPAPGPPSFE
                     EQLRLALELSSREQEERERRGQQEEEDLQRILQLSLTEH"
     exon            249..384
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            385..509
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            510..555
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            556..699
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            700..889
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            890..956
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1038
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1100
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1231
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1389
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1506
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1670
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1762
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..2128
                     /gene="ANKRD13D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2108..2113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD13D"
                     /note="hexamer: AATAAA"
     polyA_site      2128
                     /gene="ANKRD13D"
                     /note="major polyA site"
ORIGIN      
        1 gccctccctg ccgcccgcgc tgccgccgcc gccgccgccg ccgctactgc tgcgggggcc
       61 gcggggggcg cagctggggc gcggctcgga ggggaggcta gggggccgtg ccaggcccga
      121 agccgaggcg gggccgggat gcggcgctga ggcccagcat ggccggcccg ggccccacct
      181 tcccgctgca ccggctcgtc tgggcgaacc ggcatcgcga actggaggcc gcactgcaca
      241 gccaccagca cgacattgaa caggaggacc cccgcgggcg gaccccactg gagctggccg
      301 tgtctctggg aaacctggag tctgtgagag tgctccttcg acacaatgcc aacgtgggca
      361 aagagaaccg ccagggctgg gcagtcctgc aggaggcagt cagcactgga gaccccgaga
      421 tggtgcagct ggtgctccag tatcgggact accagagggc cacgcagagg ctggcgggca
      481 ttccggaact gctcaacaaa cttcgccagg cccccgattt ctacgttgag atgaagtggg
      541 agttcaccag ctgggtgccc cttgtgtcta agatgtgccc aagcgatgtg taccgcgtgt
      601 ggaagcgggg tgagagcctg cgagtagaca ccagtctcct gggcttcgag cacatgacct
      661 ggcagcgggg ccggaggagc ttcatcttca agggccagga ggcaggagcc ctggtgatgg
      721 aagtggacca tgaccggcag gtggtgcatg tggagacact ggggctcact ctgcaggagc
      781 ccgaaacact gctggccgcc atgcggccca gcgaggagca tgtggccagt cgcctcacct
      841 ctcctatcgt ctccacccac ctggacactc gtaatgtggc ctttgagagg aacaaatgtg
      901 gtatctgggg ctggcggtct gagaagatgg aaactgttag cggctacgag gccaaggtgt
      961 acagtgccac caacgtggag ctggtgacac gcacacgcac ggagcacctc tctgatcagg
     1021 acaagtcgag gagcaaagcg gggaagactc cattccagtc cttcctgggg atggcgcagc
     1081 agcattcctc ccacaccggg gcccccgtgc agcaggcagc cagccccacc aaccccacag
     1141 ccatctcccc tgaggagtac ttcgacccca acttcagcct ggagtcacgg aacattggcc
     1201 gccccatcga gatgtccagc aaagtacaga ggttcaaggc aacactgtgg ctgagtgaag
     1261 agcacccgct ctccctgggt gaccaggtga cccccatcat cgacctaatg gccatcagca
     1321 acgctcactt tgccaagctg cgcgacttca tcactctgcg ccttccacct ggcttccccg
     1381 tcaaaattga gattcccctt ttccacgtgc tcaatgcccg catcaccttc agcaacctgt
     1441 gtggctgtga tgagcccctg agctccgtgt gggtgccggc ccccagctct gctgttgccg
     1501 catcagggaa ccctttcccg tgcgaggtgg accccaccgt gtttgaagtg cccaacgggt
     1561 acagcgtgct gggcatggag cgcaacgagc ccctccggga cgaggacgat gacctcctgc
     1621 agttcgccat ccagcagagc ctgcttgaag cgggcactga ggcggagcag gtgaccgtct
     1681 gggaagccct gaccaacacc cggcccggtg cccgccctcc tccccaggcc acggtttatg
     1741 aggaacagct tcagctggag cgggccctcc aggaaagcct gcagctgtcc acagagccca
     1801 ggggcccagg atcccctccc aggacacccc cagcccccgg tccacccagc tttgaagagc
     1861 agctgcgcct ggccctggag ttgtcttcac gggagcagga ggagcgggag cggcgcgggc
     1921 agcaggagga ggaggactta cagcggatcc tgcagctgtc actcactgag cactgagcca
     1981 tagccccggg agggctggcc aggccactcc ctgcccgctt ttgtaattta tttatttata
     2041 aactctctgc tgctgagctt ggggcctgga gccccaggaa tgagcaggca ggggagactg
     2101 agatggaaat aaagagactg tcgcagca
//
