LOCUS       NM_033121               4241 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat domain 13A (ANKRD13A), mRNA.
ACCESSION   NM_033121 XM_027116
VERSION     NM_033121.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4241)
  AUTHORS   Won,M., Park,K.A., Kim,S., Ju,E., Ko,Y., Yoo,H., Ro,H., Lee,J.,
            Oh,J., Lee,E.G., Kim,S.Y., Nam,S.W., Shen,H.M., Yeo,M.K., Kim,J.M.
            and Hur,G.M.
  TITLE     ANKRD13a controls early cell-death checkpoint by interacting with
            RIP1 independent of NF-kappaB
  JOURNAL   Cell Death Differ 29 (6), 1152-1163 (2022)
   PUBMED   34839354
  REMARK    GeneRIF: ANKRD13a controls early cell-death checkpoint by
            interacting with RIP1 independent of NF-kappaB.
REFERENCE   2  (bases 1 to 4241)
  AUTHORS   Zhou,W., Xu,S., Deng,T., Zhou,R. and Wang,C.
  TITLE     LncRNA USP30-AS1 promotes the survival of acute myeloid leukemia
            cells by cis-regulating USP30 and ANKRD13A
  JOURNAL   Hum Cell 35 (1), 360-378 (2022)
   PUBMED   34694569
  REMARK    GeneRIF: LncRNA USP30-AS1 promotes the survival of acute myeloid
            leukemia cells by cis-regulating USP30 and ANKRD13A.
REFERENCE   3  (bases 1 to 4241)
  AUTHORS   Burana,D., Yoshihara,H., Tanno,H., Yamamoto,A., Saeki,Y., Tanaka,K.
            and Komada,M.
  TITLE     The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins
            Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal
            Trafficking of Caveolin 1
  JOURNAL   J Biol Chem 291 (12), 6218-6231 (2016)
   PUBMED   26797118
  REMARK    GeneRIF: The Ankrd13 family of ubiquitin-interacting motif
            (UIM)-containing proteins are novel VCP-interacting molecules in
            the endosome.
REFERENCE   4  (bases 1 to 4241)
  AUTHORS   Satpathy,S., Wagner,S.A., Beli,P., Gupta,R., Kristiansen,T.A.,
            Malinova,D., Francavilla,C., Tolar,P., Bishop,G.A., Hostager,B.S.
            and Choudhary,C.
  TITLE     Systems-wide analysis of BCR signalosomes and downstream
            phosphorylation and ubiquitylation
  JOURNAL   Mol Syst Biol 11 (6), 810 (2015)
   PUBMED   26038114
  REMARK    GeneRIF: We validated ANKRD13A as a novel constituent of BCR
            signalosome and showed that BCR-induced phosphorylation of RAB7A at
            S72 regulates its association with its effector proteins and with
            endo-lysosomal compartments.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4241)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   6  (bases 1 to 4241)
  AUTHORS   Avellino,R., Carrella,S., Pirozzi,M., Risolino,M., Salierno,F.G.,
            Franco,P., Stoppelli,P., Verde,P., Banfi,S. and Conte,I.
  TITLE     miR-204 targeting of Ankrd13A controls both mesenchymal neural
            crest and lens cell migration
  JOURNAL   PLoS One 8 (4), e61099 (2013)
   PUBMED   23620728
  REMARK    GeneRIF: the microRNA miR-204 promotes both mesenchymal neural
            crest and lens cell migration and elongation by the direct
            targeting of the Ankrd13A gene.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4241)
  AUTHORS   Tanno,H., Yamaguchi,T., Goto,E., Ishido,S. and Komada,M.
  TITLE     The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor
            endocytosis from the plasma membrane
  JOURNAL   Mol Biol Cell 23 (7), 1343-1353 (2012)
   PUBMED   22298428
  REMARK    GeneRIF: overexpression of wild-type as well as truncated-mutant
            Ankrd 13A, 13B and 13D proteins strongly inhibited rapid
            endocytosis of ubiquitinated EGFR from the surface in EGF-treated
            cells
REFERENCE   8  (bases 1 to 4241)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 4241)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057817.1, BC032833.2, AF155103.1 and AC007546.6.
            
            On May 17, 2019 this sequence version replaced NM_033121.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032833.2, SRR1803613.135765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261739.9/ ENSP00000261739.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-684               BC057817.1         1-684
            685-1145            BC032833.2         526-986
            1146-1493           AF155103.1         88-435
            1494-3910           BC032833.2         1335-3751
            3911-4241           AC007546.6         28906-29236
FEATURES             Location/Qualifiers
     source          1..4241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..4241
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /note="ankyrin repeat domain 13A"
                     /db_xref="GeneID:88455"
                     /db_xref="HGNC:HGNC:21268"
                     /db_xref="MIM:615123"
     exon            1..355
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2032
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /note="NY-REN-25 antigen"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 13A"
                     /protein_id="NP_149112.1"
                     /db_xref="CCDS:CCDS9140.1"
                     /db_xref="GeneID:88455"
                     /db_xref="HGNC:HGNC:21268"
                     /db_xref="MIM:615123"
                     /translation="MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTL
                     LHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNT
                     SMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDIT
                     LLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKP
                     KSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNV
                     ITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDE
                     YFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHF
                     ARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSA
                     SHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGP
                     ASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELE
                     EWELRLQEEEAELQQVLQLSLTDK"
     exon            356..488
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            489..613
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            614..659
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            660..803
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            804..993
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1060
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1142
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1204
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1335
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1493
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1607
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1768
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1836
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..4241
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3874..3879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /note="hexamer: AATAAA"
     polyA_site      3910
                     /gene="ANKRD13A"
                     /gene_synonym="ANKRD13; NY-REN-25"
                     /note="major polyA site"
ORIGIN      
        1 agaagtctgt ccgcgagctg tcagcgcggg cgggaacgcc gcggggcgcg gggtgggcgc
       61 ggccgacctg gtccctgagc cggccggcga ccccggacct cccgcgcgcc ccgcacccga
      121 ccggctcagc cggccggcag cgtaacacgc cctacgctcg cttgctcgcc ggcctcaggg
      181 caggcaggcg ggcgcgggag accccgccgg ggccgagact tggggcgggc gacgaggacc
      241 aggttacggc ctcctcgcca tgtcctcggc ctgcgacgcg ggcgaccact accccctgca
      301 cctcctagtc tggaaaaacg actaccggca gctcgagaag gagctgcagg gccagaatgt
      361 ggaggctgtg gacccacgag gtcgaacatt attgcatctt gctgtttcct tgggacattt
      421 ggaatctgct cgagtcttac tccgacataa agcagatgtg acaaaagaaa atcgccaggg
      481 atggacagtt ttacatgagg ctgtgagcac tggcgatcct gagatggtgt acacagttct
      541 ccaacatcga gactaccaca acacatccat ggcccttgag ggagttcctg agctgctcca
      601 aaaaattctc gaggctccgg atttctatgt gcagatgaaa tgggaattca ccagctgggt
      661 gcccttggtt tctagaatat gcccaaatga tgtctgtcgc atctggaaaa gtggtgccaa
      721 actgcgcgtc gatatcacat tgctgggatt tgaaaacatg agctggataa gagggaggcg
      781 tagttttata tttaagggag aagacaactg ggcggagtta atggaagtca accatgatga
      841 caaagtggtc accaccgaac gcttcgacct ttcccaagaa atggagcgcc tcactctgga
      901 cttgatgaag ccaaaaagca gggaagttga gcggcggctc acaagccctg tcattaacac
      961 cagcctcgat actaaaaata ttgcttttga aagaactaaa tccggattct ggggctggag
     1021 gacagataaa gcagaagttg ttaatggtta cgaagcaaag gtttacacag taaacaatgt
     1081 gaatgtgatc accaaaatac gcacagaaca tctgaccgag gaggaaaaaa agagatataa
     1141 agcagacagg aacccgctgg aatctttgct gggaactgtg gaacaccaat ttggtgcaca
     1201 aggggacctc accacggaat gtgctactgc aaacaacccc acagccatca cgcctgatga
     1261 gtacttcaat gaagagtttg atctgaaaga cagggacatt ggaaggccga aagagctgac
     1321 gattagaaca cagaagttta aagcaatgtt gtggatgtgt gaagagtttc ccctctctct
     1381 ggtggagcag gtcattccca tcattgacct aatggctcga acgagtgctc attttgcaag
     1441 actgagagat ttcatcaaat tggaattccc acctggattt cctgtcaaaa tagaaattcc
     1501 cttgtttcat gtcttaaatg cacggattac atttggaaat gttaatggct gtagcactgc
     1561 cgaagaatct gtatctcaaa atgtggaagg gacccaggct gattcagctt cccacatcac
     1621 aaactttgag gttgatcaat ctgtgtttga aattcccgaa tcttactatg ttcaagacaa
     1681 tggcagaaat gtgcatttgc aagatgaaga ttacgagata atgcagtttg ccatccagca
     1741 aagtctgctg gagtccagca ggagccagga actttcagga ccagcttcga atggagggat
     1801 cagccagaca aacacctatg acgcccagta tgagagggcc atccaggaga gcctcctcac
     1861 cagcacagaa ggcctgtgcc ccagcgccct gagcgagaca agccgttttg ataatgactt
     1921 gcagctagcc atggagctct ctgccaaaga gctggaggaa tgggagctcc ggctccagga
     1981 ggaagaggct gagctccagc aagtcttaca gctgtcactc actgacaaat agacctttca
     2041 gcctgtgagc ctctgcacaa agcagaggct gtgggctgtc acagatgctg tgtcaaccag
     2101 ggccctaggg ctaagggcct gcaccttgcg tgcatgcagc aggcaacaac tgccccttct
     2161 ttatgcagag gtgcagaacc agggactcct gggcccatcc aggctgctcc ctggggtgga
     2221 gaagggacca gggattgcag gccccatctc caggctaagg ggaggagagc atcatcactt
     2281 tccattagct gtattggctt gcaggtcaca tttttactac cagctttaga caaaacccca
     2341 atccccgcag gtttgtagat aaatttttat caaggagtga taacaagaca agttattgca
     2401 gagtcagggt gcttttatat ataagagcag cagccgcctt tgtaaagtgt gatctatgag
     2461 aattggagac acttctttac tgttcaccaa agaaatgggt aatctgtgct gatctcctta
     2521 tttttacctt tttacagggt ttctaggaca ttgtcattat tcttcctcca tctatctgat
     2581 tccattcctt ccacacccag ctaaagttag aggagataca tatagaatct attttagatt
     2641 attgttaact atttgcatca aattaagata cacaaatggc catggatgtt gccttagcct
     2701 taaacattac taatagtttc acatcacctc actgcacgca tcgaaggatc tgatttgaat
     2761 ttgtaaaggc aattcttttg agagcaggat tctccaggct aaatcaaagg cagctaatcc
     2821 tgtccctgaa ggagcagcta ggggaacctg aggcttgttc ttgaagtggg caagctggcc
     2881 aaaatattgg aacacacaga accaaaccag gtgtgttcta cacctgcatg agtgaaggat
     2941 ttccacgtag acacctagga agagcccgca tgccctagac tcactccaga ggaaggattg
     3001 atttgcaacc agaaagggag ctgaaaacca cggagctcca tggctcttca ttcaaaaggg
     3061 aaaataatga ttccacgttg ctttttagag ttcaaatcaa catctttctg gataaatcta
     3121 ttttttaaca atctttttat tatttgtaaa agatataaaa acaactccca tcagtagcaa
     3181 tacaaggtta tacattttaa ccagattttc tcaggccttt tttggatacc tttagtagtt
     3241 aactctcttt tgtcaaaccc tcttgtatat aaccatcgca caacatacag aaccctgggg
     3301 aatacagcca agggcactgc tcactgtggc ccgtgtattc attcccacag gctgcactga
     3361 aataacctgg taaacaacac cctcctccat tttgcgtcta tttcttctat tgtgcttctt
     3421 tggggatagg aagagaaaca taactactgt tccaggtaac gtctgtatca tacagttagt
     3481 gttgccagtg aaacgttccc agatacaaag aattgtgctt ttaattccat ttcacaatct
     3541 gttttgtttt ttttttttgt cattgtctga ccaaaattcc ttctgcacat gaggccagta
     3601 taggcaacgt cacatttgtt tgtttcaaat atgcagtgtg gtattttgtt tactttgcat
     3661 ttaccgtgag caaagatact tcttggaatg gctgcagtga ggccgtgtca ttggctcaca
     3721 aaagtgactc ataggtaatt tctgtgtttg cattccactg ctctgctccc taaggtcctt
     3781 gactttctcc ccaggaattc acttaaaaag ggactgagca ttgtgtcaac ctgttgcagt
     3841 gtttttcata tatgtgttca ctctaaaaat gcaaataaag actgcttcct tagagggtgc
     3901 tcatacaaaa ttccagtctt tgagtctttt tccttttcag ttttttctag tcactggatg
     3961 tacccacact tcctgttacg tatgtcagta gaacattaga atgcctcact tcgctcagtt
     4021 catcactgca aaggtggcat gctcctccca gccttcctgc ccaggttaac aagccccatg
     4081 ctgcttgttt caaatggcaa ctaaaagcaa gccagtgttg ggctgttctg acacctctgt
     4141 ggtcctcctg gaggggaact ggctcttgtg gggtaaggga agcccagcca acatcaaagc
     4201 tctgcatcaa tgctatccct tgaagccaac tgctttgtga g
//
