LOCUS       NM_015208              11284 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ankyrin repeat domain 12 (ANKRD12), transcript variant
            1, mRNA.
ACCESSION   NM_015208
VERSION     NM_015208.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11284)
  AUTHORS   Karedath,T., Ahmed,I., Al Ameri,W., Al-Dasim,F.M., Andrews,S.S.,
            Samuel,S., Al-Azwani,I.K., Mohamoud,Y.A., Rafii,A. and Malek,J.A.
  TITLE     Silencing of ANKRD12 circRNA induces molecular and functional
            changes associated with invasive phenotypes
  JOURNAL   BMC Cancer 19 (1), 565 (2019)
   PUBMED   31185953
  REMARK    GeneRIF: These results suggest that circANKRD12 could be involved
            in a diverse set of functions ranging from cell cycle arrest, tumor
            invasion to immune modulation. Manipulating the levels of
            circANKRD12 can regulate molecular functions by altering different
            signaling pathways and modifies the phenotype of the cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11284)
  AUTHORS   Bai,R., Li,D., Shi,Z., Fang,X., Ge,W. and Zheng,S.
  TITLE     Clinical significance of Ankyrin repeat domain 12 expression in
            colorectal cancer
  JOURNAL   J Exp Clin Cancer Res 32 (1), 35 (2013)
   PUBMED   23718802
  REMARK    GeneRIF: Study revealed that ANKRD12 mRNA were down regulated in
            CRC tumor tissues and low ANKRD12 expression was correlated with
            liver metastasis and poor survival of CRC patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11284)
  AUTHORS   Li,C.W., Dinh,G.K., Zhang,A. and Chen,J.D.
  TITLE     Ankyrin repeats-containing cofactors interact with ADA3 and
            modulate its co-activator function
  JOURNAL   Biochem J 413 (2), 349-357 (2008)
   PUBMED   18377363
  REMARK    GeneRIF: ADA3 is a newly identified target of the ANCO proteins,
            which may modulate co-activator function in a
            transcription-factor-specific manner
REFERENCE   4  (bases 1 to 11284)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 11284)
  AUTHORS   Tompkins,V., Hagen,J., Zediak,V.P. and Quelle,D.E.
  TITLE     Identification of novel ARF binding proteins by two-hybrid
            screening
  JOURNAL   Cell Cycle 5 (6), 641-646 (2006)
   PUBMED   16582619
REFERENCE   6  (bases 1 to 11284)
  AUTHORS   Zhang,A., Yeung,P.L., Li,C.W., Tsai,S.C., Dinh,G.K., Wu,X., Li,H.
            and Chen,J.D.
  TITLE     Identification of a novel family of ankyrin repeats containing
            cofactors for p160 nuclear receptor coactivators
  JOURNAL   J Biol Chem 279 (32), 33799-33805 (2004)
   PUBMED   15184363
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP230422.1, AY373757.1,
            AY533564.2, AP001033.6 and BM992146.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015208.4.
            
            Summary: This gene encodes a member of the ankyrin
            repeats-containing cofactor family. These proteins may inhibit the
            transcriptional activity of nuclear receptors through the
            recruitment of histone deacetylases. The encoded protein interacts
            with p160 coactivators and also represses transcription mediated by
            the coactivator alteration/deficiency in activation 3 (ADA3).
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY373757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262126.9/ ENSP00000262126.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BP230422.1         29-94
            67-746              AY373757.1         45-724
            747-8165            AY533564.2         804-8222
            8166-11193          AP001033.6         79303-82330
            11194-11284         BM992146.1         18-108              c
FEATURES             Location/Qualifiers
     source          1..11284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.22"
     gene            1..11284
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /note="ankyrin repeat domain 12"
                     /db_xref="GeneID:23253"
                     /db_xref="HGNC:HGNC:29135"
                     /db_xref="MIM:610616"
     exon            1..185
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            186..323
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..6425
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 12; ankyrin
                     repeat-containing cofactor 2; ankyrin repeats containing
                     cofactor 2"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 12
                     isoform 1"
                     /protein_id="NP_056023.3"
                     /db_xref="CCDS:CCDS11843.1"
                     /db_xref="GeneID:23253"
                     /db_xref="HGNC:HGNC:29135"
                     /db_xref="MIM:610616"
                     /translation="MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIE
                     RSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSE
                     KEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQT
                     TPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAG
                     WTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN
                     PFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSE
                     TEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE
                     AEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETS
                     NSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG
                     LDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTC
                     LSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKI
                     KDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSA
                     KELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKH
                     VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIG
                     LHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD
                     KLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE
                     KPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINI
                     TNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKER
                     DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD
                     LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEV
                     TDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSV
                     SMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERE
                     LDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT
                     KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASN
                     SKYVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFIC
                     PNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSF
                     PSQSLSDAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLG
                     DVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLT
                     YKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQD
                     PKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDK
                     TENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHP
                     RKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHI
                     RKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLK
                     ELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLD
                     AEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALN
                     AVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI"
     exon            324..471
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            472..540
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            541..687
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            688..888
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1031
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1179
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..5900
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            5901..5999
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6143
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            6144..6239
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     exon            6240..11284
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9036..9041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /note="hexamer: AATAAA"
     polyA_site      9065
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /note="major polyA site"
     regulatory      11259..11264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
                     /note="hexamer: AATAAA"
     polyA_site      11284
                     /gene="ANKRD12"
                     /gene_synonym="ANCO-2; ANCO1; GAC-1; Nbla00144"
ORIGIN      
        1 gcggggcgac gctgtcctgg gagcgaggag gctgtggtga gagacggacc gagaccggag
       61 atgttttcaa gcccggctcc ggcggcttta caggcggctg cagcggcgac gaagacaacg
      121 acagcgacgg ctacgccgaa gcactcgttc cgggggtgaa gcctcctgcg ccggccttgc
      181 ctcggatcca ggatgagaag actgataaaa gaagaagcta gctgaacagc tgtaaaatgc
      241 ccaaatctgg gttcacaaaa ccaattcaga gtgaaaattc tgacagtgac agcaatatgg
      301 tagagaaacc atatggaaga aagagtaaag acaagattgc atcctacagc aaaactccaa
      361 aaattgaacg aagtgatgtg agcaaggaga tgaaagagaa atcatccatg aaacgtaaac
      421 ttccttttac tattagccca tcaagaaatg aagaacgaga ttcagacaca gattcagatc
      481 caggacatac aagtgaaaat tggggggaga gacttatatc ttcttacagg acatactcag
      541 agaaagaagg tccagaaaag aagaagacaa aaaaggaagc tggaaataag aaatccacac
      601 cagttagcat tctttttggt tatccactct ctgagcgaaa acagatggca cttcttatgc
      661 agatgacagc aagagacaac agtccagatt ccacaccaaa tcatccatca caaacaacgc
      721 ctgcccaaaa gaaaactccc agttcttcat ctcgacagaa agataaagtt aataaaagaa
      781 atgaacgtgg tgaaactcct ttacacatgg ctgctattcg aggagatgtg aaacaagtta
      841 aagaattaat aagtttaggg gcaaatgtga atgtgaaaga ttttgcaggt tggacaccac
      901 tgcatgaagc ttgcaatgtt ggatattacg atgttgctaa gatacttata gcagctggag
      961 cagatgttaa cacacaagga ttagatgatg acactccact ccatgattct gctagtagtg
     1021 ggcacagaga tatagtaaag ctgttacttc gtcacggtgg aaatccattt caagctaata
     1081 aacatgggga gcgtccagtg gatgtagcag aaacagagga gttggagttg ctactaaaaa
     1141 gagaggtgcc tttatctgat gatgatgaaa gttacacaga ttccgaagag gctcaatctg
     1201 taaatccttc tagtgttgat gaaaatattg actctgaaac agagaaagac tctctcatct
     1261 gtgaaagtaa acagatactt cccagtaaaa cacctcttcc atctgccctt gatgagtatg
     1321 agttcaaaga tgatgatgat gaagaaatta ataagatgat tgatgatagg catattctta
     1381 ggaaagaaca acgaaaagaa aatgaacctg aagcagaaaa aactcattta tttgcaaaac
     1441 aggagaaagc cttctatcct aaatcattta aaagtaaaaa acaaaagcca tctagggtct
     1501 tatattcaag tactgaaagt tctgatgaag aagctcttca gaataaaaag atttctactt
     1561 catgttccgt catccctgaa acatcaaatt ctgatatgca aaccaaaaag gaatatgtag
     1621 tttcaggtga acacaaacag aaaggcaaag ttaaaagaaa attgaaaaat cagaataaaa
     1681 ataaagagaa ccaagagcta aagcaagaaa aggaaggaaa agaaaataca agaataacaa
     1741 acttgacagt aaatactgga ctagattgtt cagaaaagac cagagaggag gggaacttta
     1801 ggaaatcttt tagcccaaaa gatgatactt cattacattt atttcatatt tccactggta
     1861 aatctcccaa acattcttgt ggattaagtg aaaaacagtc aacaccacta aaacaagaac
     1921 atactaaaac atgtttatca ccaggaagtt ctgaaatgtc attacagcct gatcttgttc
     1981 ggtatgataa tacagaatct gaattcttgc cagaaagttc aagtgtaaaa tcttgtaagc
     2041 ataaggaaaa aagcaaacat cagaaagatt tccacttaga atttggtgaa aaatcaaatg
     2101 ccaaaataaa ggatgaagat catagtccaa catttgaaaa ttcagattgc acactgaaaa
     2161 aaatggataa agaaggtaaa acattaaaaa aacataaatt gaagcataaa gagagggaaa
     2221 aagaaaagca taaaaaagaa attgaaggtg aaaaggaaaa atacaaaact aaggatagtg
     2281 ccaaagaact gcagaggagt gtggaatttg atagagaatt ttggaaagag aattttttta
     2341 aaagtgatga aactgaagat ctctttttaa atatggaaca tgaatcctta acattagaaa
     2401 aaaaatcaaa attggaaaaa aacatcaaag atgataaatc aaccaaggaa aagcatgtgt
     2461 caaaagagag gaactttaaa gaggaacgag acaagattaa aaaggaaagc gagaaatctt
     2521 ttagggagga aaaaataaaa gatctaaaag aagagagaga aaacataccc acagataaag
     2581 actcagaatt tacttctttg ggtatgagtg ccattgagga atctataggg cttcatttag
     2641 tggaaaagga aatagacatt gaaaaacaag aaaagcatat aaaggaaagt aaagaaaaac
     2701 ctgagaagcg atctcaaatt aaagaaaagg acattgagaa gatggaaaga aaaacctttg
     2761 aaaaagaaaa gaagataaaa catgagcata agtcagaaaa agacaaatta gatcttagtg
     2821 aatgtgttga taaaataaaa gaaaaggaca agctatattc gcatcacaca gaaaaatgcc
     2881 ataaagaagg tgagaagagc aaaaatactg ctgctattaa aaaaactgac gacagagaga
     2941 aaagtagaga aaagatggat aggaaacatg acaaagaaaa gcctgaaaaa gagaggcatc
     3001 tagcagaaag caaagaaaag cacttgatgg agaaaaaaaa taaacaatca gataatagtg
     3061 aatacagtaa atcagaaaaa ggcaaaaata aagaaaaaga cagggagcta gataaaaagg
     3121 aaaaatctag agataaagaa agtataaata taactaactc caaacacata caggaagaaa
     3181 aaaaatcaag tatagtagac ggtaataaag cacaacatga aaaaccctta tcccttaaag
     3241 aaaaaacaaa agatgaacct ttgaaaactc cagatggaaa agaaaaagat aaaaaagata
     3301 aagatataga tagatacaaa gaacgagaca aacataaaga taaaattcaa ataaatagct
     3361 tactcaaact aaaatctgaa gcagataagc ctaaacctaa gtcatcacca gcatcaaaag
     3421 atacccgacc taaagaaaag aggttagtga atgatgattt aatgcagaca agttttgaac
     3481 gaatgctaag ccttaaagac ctagaaatag aacagtggca caaaaaacat aaggaaaaaa
     3541 ttaagcaaaa agaaaaggaa cggttgagaa accgaaactg tttagaactt aaaataaaag
     3601 ataaagaaaa aacaaagcat acaccaactg aatccaaaaa taaagaactt actaggtcaa
     3661 agagttcaga agtgactgat gcatatacca aggagaaaca acctaaagat gctgtaagta
     3721 acagatcaca atctgttgac accaaaaatg taatgacttt agggaagtca tcttttgttt
     3781 cagataatag cttaaacagg tctcctagat cagaaaatga aaagccgggt ctcagctcca
     3841 gatctgtatc catgatttct gttgctagtt cagaagattc ctgccatact acagtgacaa
     3901 ccccaaggcc tccagttgag tatgactctg actttatgtt agagagttca gaatcccaaa
     3961 tgtccttttc ccagtcacct tttttgtcaa ttgccaaatc tcctgctctt catgaaaggg
     4021 aattggacag cctggctgac ttgccggagc ggattaaacc accatatgca aacagacttt
     4081 caacatccca tcttaggtca tcttctgtag aagatgttaa actaattata agcgagggga
     4141 gacctaccat agaagttcga agatgtagca tgccttctgt catttgtgaa cataccaaac
     4201 aattccaaac aatatcagaa gagagcaatc aaggtagctt attaactgtg ccaggagata
     4261 ctagtccttc tcccaaacct gaggtattct caaatgtgcc tgaaagagac ctttcaaatg
     4321 tatctaacat acattccagt tttgcaactt ctccaactgg agcttcaaac agcaagtatg
     4381 tttcagctga tagaaatctc atcaagaata ctgccccagt gaacactgta atggacagtc
     4441 cagtgcattt agagccatct agtcaggttg gtgtgatcca gaataaatca tgggagatgc
     4501 ctgttgatag actagagaca ttaagcacca gagactttat ctgcccaaat tctaacatac
     4561 ctgatcaaga atcctctctt cagagttttt gtaattctga aaataaggta ttgaaagaaa
     4621 atgctgattt tttatccctg cgccagactg aactgccagg aaactcttgt gctcaggatc
     4681 cggcatcctt tatgcctcca cagcagcctt gctctttccc cagccaatca ctttcagatg
     4741 ctgaatcgat ttctaaacat atgtctttgt catatgttgc taatcaagag ccaggtattt
     4801 tacaacaaaa aaatgcagtt cagattatta gttctgcttt agatactgat aatgaatcta
     4861 caaaagatac agaaaatact tttgtcctag gagatgttca aaaaacagat gcctttgtcc
     4921 cagtgtactc tgacagcact attcaagaag catcaccaaa ctttgagaaa gcttatactt
     4981 tacctgtgtt accatcagaa aaggacttta atggaagtga tgcctctacc cagctaaata
     5041 cacattatgc atttagcaaa ctaacttaca agtcttccag tggccatgaa gttgagaata
     5101 gcacaactga tactcaggtc atttcacatg aaaaagaaaa caaactggag agtttggttt
     5161 taactcattt gagtaggtgt gattctgatt tatgtgaaat gaatgcaggg atgccaaaag
     5221 gaaacctaaa tgaacaagat ccaaaacatt gtcctgaaag tgaaaagtgt ttgctttcca
     5281 tagaagatga ggaatctcaa caaagcattt tatcaagtct ggaaaaccat tcacagcagt
     5341 caactcaacc agaaatgcat aaatatggtc agttagttaa agtagaatta gaagaaaatg
     5401 ccgaagatga taaaactgaa aaccaaatcc ctcaaagaat gactagaaac aaagcaaata
     5461 caatggcaaa tcaaagcaaa cagattcttg ctagctgtac actattatca gaaaaagaca
     5521 gtgaatcctc atctcctaga ggaagaataa gattaactga agatgacgat cctcaaattc
     5581 accatccacg gaaaaggaaa gtgtcacgtg tacctcagcc tgtgcaagtg agtccctctt
     5641 tactacaagc aaaagagaaa actcagcaat ctctggcagc cattgtagat tctctaaaac
     5701 tagatgagat tcagccatac agttcagaga gagcaaatcc atattttgaa tacttgcaca
     5761 taaggaaaaa aatagaagaa aaacgcaaat tactgtgtag tgtgattcct caagcacctc
     5821 agtactatga cgaatatgta acatttaacg gatcatatct cctggatgga aaccccttaa
     5881 gcaagatttg tattcccaca attacaccac caccttcact gtcagatcca cttaaagagc
     5941 tttttcgaca acaggaagtt gtaaggatga aactacgttt gcaacacagt attgaaaggg
     6001 aaaaactcat tgtatccaac gaacaagaag ttttgcgagt tcattacaga gctgcaagaa
     6061 cattggcaaa tcaaacactg ccatttagtg cttgtactgt tttgctggat gccgaagtat
     6121 acaatgtacc attggactct cagtctgatg acagtaaaac ttctgtgagg gatcgcttta
     6181 atgcaagaca attcatgtct tggttacaag atgtggatga taaatttgac aaattaaaga
     6241 cctgtctttt aatgaggcaa caacatgaag ctgcggcttt aaatgctgtc cagaggttag
     6301 aatggcagct caaactccag gaacttgatc ctgccaccta taaatctatc agcatttacg
     6361 aaatccagga gttttatgtt ccccttgttg atgttaacga cgactttgaa ttgactccta
     6421 tatagcagtc agtacttcct gatggtattg tcctaaactg gtgatgctca agcattatac
     6481 tgtggaatac tgccttttga caaaaatact catgccttta caattgttag taaagttcga
     6541 ttatagttgg ttatgtagta aacactgtca ttttataaaa aatgagaatt attttggatc
     6601 ttagatccaa acacagtttc taatagaaaa ctattattta tattgggaaa ggtaactatt
     6661 gcattagagc atgttggcag actggtaggt atttaaaaag ttgagaatct gctaacagcg
     6721 ctggaagttg ttagcgctct aagtaataag ataaccacta gtattcaaat ctctttcagg
     6781 ttttattaaa aaatatatat caataaacta aaaggttcaa ttcctaccaa atagtttcta
     6841 atgtgggaga aaaacttggc acaaaatttc ttcagtttat tatctgtaaa ttgtacagtt
     6901 ttctttttga aagttttaat attgtcttcc tttttaataa cttattttat acatattgtg
     6961 cagatgtaaa tcttgtaatt aatggtcaaa ctgtataaag ggattggtag tcaaaacatg
     7021 tacaaagaaa tacctgtaaa actgttttgt ctcatgtttt attggaccaa agttgtggtt
     7081 tgtatggagt gtagtagtag tgtgtacagg tagaaaactt ttaaatacag catgcaggtg
     7141 tttcagttag cttgttttca tcaccataac tgcaaagatg tggcttagtt gtattgcatg
     7201 cttcctataa tttaactctc cataattgat gcctgcagta gtgtaaggca tttcatacta
     7261 gtctcctcta gtagacctgt gacttactgt gttggacata ttatttagac ttagtcatac
     7321 aaagaaactt agctcttttt tcatctcaca gtaaagccta tttccccagg aaaaaaataa
     7381 atgcctttga atgaaaattc tgaaattgta aatgtctatt ttaatattca cctatgaaag
     7441 aatctgtgaa tatatgtaaa tacgtttaat aaattttatt ggtcatgtta aatcattgta
     7501 aaactttttt acattgctta atgttttaag cttaatagcc tttgcacttt taaaataaaa
     7561 accaagtatg caaatcaaag atatttggta gtcaaaataa gtaaaagaaa tataggaata
     7621 ttccagtcaa tctctgaaat gtttatgaaa aacaggttaa tatgttgtat ttttttcctt
     7681 gtatcaagat gcaaaacata atttgcaaaa ttttataatt gaaataaaac ttggtatgct
     7741 gttttataat aaattagcaa tatactttaa aaaaaatcca gtttctccta taacatgatg
     7801 taaattaaat attcaggaat atttcaggtc tgaaatctgc tgctgaactt gttagacatt
     7861 tttgaaagga aaattaggtt agcgtacaat ttatcataaa tatatgaggt aaaatttgca
     7921 aaactttcca cagtactttc ttgaattata atactgaatg ttttctgttc cgatagagaa
     7981 aagtgaagca aatatgtgag gaatgaagtg atctagtgca agttggtaat tccagctaat
     8041 gggagagaat gtaaatgtgc aaaggtacat attaagctta gggatttttg aatttttacg
     8101 tcagtttata ttttaattct tactgtactt ggcatgcgca ataaagcagc acatgtaaaa
     8161 aaaaaataca cagtgcaagg actttattat aaaggttgga tgtagttttc cttagaaatt
     8221 taggtgagag attttggcct tttttattgg ataaattggg ccagaaaggc agggtagatt
     8281 tcgaagcact ggttctgttg aagttaagtt tattaagcct gggaacatta aaagctaatt
     8341 tataaaagca atacttttta atatgaaaac ttactgcaaa gtttgtttat acttttgcct
     8401 aaaaaggaaa ttggatggga tactgtggca aatcataaaa aaccagataa ttgaactttg
     8461 aagttataga aaatcagaga ggggtaagtt tatagggcat tttgttctga tggttcaacc
     8521 agaggtctgg gaaatagcac tgttggccca aacagaacag gcttttagaa gataaaagcg
     8581 acaagaagga atctggtgaa ttttagtcat cccagctttt tagtcttaac cacagttctc
     8641 actctcttaa atggtacctc aaaaagctgg agcctctctg ccatgattat gcttctacaa
     8701 atttctttta taaagagact caaagctaat gatagcttaa aagaaaagtt aatgccttct
     8761 cattggaaat gtataatcaa ataagtagtt aagggctttt ggtattaaag atattctgaa
     8821 gctctgaaat gctagaaaaa aatttggaat ggagtatatg cctgaaaagg ttttggattc
     8881 agaaagaaaa aggatggtta gtttaatcag tgattctttt taaactcttc aaatatcatg
     8941 aacaagatac taaattgtac ctaaggattt gtatttcttt acaatttgtt ctaaatatct
     9001 gtttaatgac tagttgatat ttgtgcatgt tatttaataa agagttatat ttttatagaa
     9061 aaaaagagtg aaatgtgtgc taactgtttt tttacttaat tttacttggg cagctagcaa
     9121 aattgcagaa atatgcatcc tgggaaaaga aacagccttt gaagaattag cctttcaagt
     9181 tcaaatctat ttaataatga gaagtctcac aagtgaattt ttaagtacag gcatacctca
     9241 gacgtacttt aggttccaga ccatctcagt aaagcaaata ccacaacaaa gcgagtcagg
     9301 aggaattttt tggtttccca gtgcatataa aagttttgtt tatactatat taagtgtgca
     9361 atagcattat gtctaaaaat atgtacataa gtttaaaaat attttattgc taaaaatggt
     9421 aacaaagtga gcacatgctg ttggaaaaag agcaccaata gacttgcttg aagcagggtt
     9481 gccacaaacc ttcaatttgt aaaaaacgcc aatatgtaca aagcacaata aagcaaagca
     9541 caatagaaca ggattgcctg tattagacat gctacaaact tcataactgg aaacatctca
     9601 aagaccccat gaagctcatt tgaatgggac ttaacaatta gacagttatt ttagaaattg
     9661 agtgcagacc taaatacata gttttccaaa aagaaaatta ttgtctctga tatcttaaaa
     9721 cataaaaacc caaaatttta tatagaagaa attgactctg taaaacgcaa tgaaatagtc
     9781 ctctttttaa acagtttaaa ggaagcattt tcaccgtttg taaaaattat ttttaaatat
     9841 ttagggcaaa atttttgtta gataataatg gaaaagcttg tgtgagttta gtggttaaaa
     9901 tatcttgtaa ttcatcatta tttaagtgac ttcttgggag ccgtctttgt acctaaaatg
     9961 gagttttttt ttaagcctcc acagagatag tcacccaaag tatttccagt cagtaaaagt
    10021 agaattcata gaaaaaactg aggcaaatta aaacaattcc attaatcaaa atggctttaa
    10081 acaaattaag tattagcata aaaatagcaa aaagtacaac taaaaaaatg gttgggtttt
    10141 cccagtggtt aaatgctata taataactgc aaataaaagt ttttttgtac atggacagcg
    10201 tcctcataaa agaaaatagg ccaggccagg cgcagtggct cgcgcctgta atcccagcac
    10261 tttgggaggc caaggcgggc ggatcacgag gtcaggagat cgagaccatc ctggctaaca
    10321 cggtgaaacc ccgtctctac taaacaaaat gcaaaaaatc agccgggtgt ggccgcgggc
    10381 gcctgtagtt ccagctactc gggaggctga ggcaggagaa tggcgtgagc ctgggaggcg
    10441 gagcttgcag tgagccgaga tcgtgccact gcactccagc ctgggcgaca gagcgagact
    10501 ccgtctcaaa aaaaaaaaaa aagaaagaaa agaaaatagg ccaatatggt gaaacccttt
    10561 ctctactaaa aatacaaaaa ttagccaagc gtgacggtgc ctgcctgtag tcctagctac
    10621 ttgggaggtt gagacaggag aatcgcttga agcctggagg cggaggttgc agtgagctca
    10681 cgccactgca ccccagcctg ggcaacaaga gtgaaactct gtctccaaaa aaaaaaaaaa
    10741 aaaaaaaaag tatatcacat atgtagcatg tgtttacaag tttaaaaggc accacctatg
    10801 cactcatcac tcaagagaat atcaataact ttctcagttt tttttcattg ttatagtctg
    10861 tattcaataa aattacccag atcttaacta ggcagtttga taaatcctga caaatgtaaa
    10921 cactcatgtt accatcaccc aaattaagat attgtaaaac attttcatta ctctagaaag
    10981 ttcactcatg cctctctcca gtcactaccc ctgaggcagc cactgtgctg atttcccatc
    11041 accatacatt agttgtacct agccttgaac ttcatagaaa tagagtcata catacttcct
    11101 tgtctgcctt gtttctcaac atgatgtttt gaaattcatc catgttgcac ctaacagtaa
    11161 tgagtcgtaa tttattaatg agtagtagtg tattgtacaa atttgtttat tcgttctctt
    11221 gttggtattt ggattgtttc cagtttggga ctattgttaa taaacctgtg aatctgcaag
    11281 ccta
//
