LOCUS       NM_013275               9301 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ankyrin repeat domain containing 11 (ANKRD11),
            transcript variant 2, mRNA.
ACCESSION   NM_013275
VERSION     NM_013275.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9301)
  AUTHORS   He,D., Zhang,M., Li,Y., Liu,F. and Ban,B.
  TITLE     Insights into the ANKRD11 variants and short-stature phenotype
            through literature review and ClinVar database search
  JOURNAL   Orphanet J Rare Dis 19 (1), 292 (2024)
   PUBMED   39135054
  REMARK    GeneRIF: Insights into the ANKRD11 variants and short-stature
            phenotype through literature review and ClinVar database search.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9301)
  AUTHORS   Chen,M., Yang,X., Liu,H. and Wan,J.
  TITLE     Identification and functional characterization of a bipartite
            nuclear localization signal in ANKRD11
  JOURNAL   Biochem Biophys Res Commun 670, 117-123 (2023)
   PUBMED   37290286
  REMARK    GeneRIF: Identification and functional characterization of a
            bipartite nuclear localization signal in ANKRD11.
REFERENCE   3  (bases 1 to 9301)
  AUTHORS   Yuan,M., Barefoot,M.E., Peterson,K., Campbell,M.J., Blancato,J.K.,
            Chen,M., Schmidt,M.O., Kiliti,A.J., Fang,H.B., Wellstein,A.,
            Riegel,A.T. and Sharif,G.M.
  TITLE     Loss of ANCO1 Expression Regulates Chromatin Accessibility and
            Drives Progression of Early-Stage Triple-Negative Breast Cancer
  JOURNAL   Int J Mol Sci 24 (14), 11505 (2023)
   PUBMED   37511268
  REMARK    GeneRIF: Loss of ANCO1 Expression Regulates Chromatin Accessibility
            and Drives Progression of Early-Stage Triple-Negative Breast
            Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9301)
  AUTHORS   Borja,N., Zafeer,M.F., Rodriguez,J.A., Morel Swols,D., Thorson,W.,
            Bademci,G. and Tekin,M.
  TITLE     Deletion of first noncoding exon in ANKRD11 leads to KBG syndrome
  JOURNAL   Am J Med Genet A 191 (4), 1044-1049 (2023)
   PUBMED   36628575
  REMARK    GeneRIF: Deletion of first noncoding exon in ANKRD11 leads to KBG
            syndrome.
            Review article
REFERENCE   5  (bases 1 to 9301)
  AUTHORS   Wang,L., Li,J., Xu,J., Xu,Y., Wang,J., Feng,Y. and Kong,X.
  TITLE     [Clinical and genetic analysis of three children with KBG syndrome
            due to novel variants of ANKRD11 gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (1), 1-6 (2023)
   PUBMED   36584991
  REMARK    GeneRIF: [Clinical and genetic analysis of three children with KBG
            syndrome due to novel variants of ANKRD11 gene].
REFERENCE   6  (bases 1 to 9301)
  AUTHORS   Willemsen,M.H., Fernandez,B.A., Bacino,C.A., Gerkes,E., de
            Brouwer,A.P., Pfundt,R., Sikkema-Raddatz,B., Scherer,S.W.,
            Marshall,C.R., Potocki,L., van Bokhoven,H. and Kleefstra,T.
  TITLE     Identification of ANKRD11 and ZNF778 as candidate genes for autism
            and variable cognitive impairment in the novel 16q24.3
            microdeletion syndrome
  JOURNAL   Eur J Hum Genet 18 (4), 429-435 (2010)
   PUBMED   19920853
  REMARK    GeneRIF: ANKRD11 is a candidate gene for autism and variable
            cognitive impairment in the novel 16q24.3 microdeletion syndrome.
REFERENCE   7  (bases 1 to 9301)
  AUTHORS   Neilsen,P.M., Cheney,K.M., Li,C.W., Chen,J.D., Cawrse,J.E.,
            Schulz,R.B., Powell,J.A., Kumar,R. and Callen,D.F.
  TITLE     Identification of ANKRD11 as a p53 coactivator
  JOURNAL   J Cell Sci 121 (Pt 21), 3541-3552 (2008)
   PUBMED   18840648
  REMARK    GeneRIF: ANKRD11 has a role as a p53 coactivator and may be
            involved in a regulatory feedback loop with p53
REFERENCE   8  (bases 1 to 9301)
  AUTHORS   Zhang,A., Li,C.W. and Chen,J.D.
  TITLE     Characterization of transcriptional regulatory domains of ankyrin
            repeat cofactor-1
  JOURNAL   Biochem Biophys Res Commun 358 (4), 1034-1040 (2007)
   PUBMED   17521611
  REMARK    GeneRIF: Together, these results indicate that the transcriptional
            potential of ANCO-1 may be modulated by a combination of repression
            and activation signals.
REFERENCE   9  (bases 1 to 9301)
  AUTHORS   Zhang,A., Yeung,P.L., Li,C.W., Tsai,S.C., Dinh,G.K., Wu,X., Li,H.
            and Chen,J.D.
  TITLE     Identification of a novel family of ankyrin repeats containing
            cofactors for p160 nuclear receptor coactivators
  JOURNAL   J Biol Chem 279 (32), 33799-33805 (2004)
   PUBMED   15184363
REFERENCE   10 (bases 1 to 9301)
  AUTHORS   Morel Swols,D. and Tekin,M.
  TITLE     KBG Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29565525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY373756.1, BC017437.1,
            AY533563.1 and DA172996.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013275.5.
            
            Summary: This locus encodes an ankryin repeat domain-containing
            protein. The encoded protein inhibits ligand-dependent activation
            of transcription. Mutations in this gene have been associated with
            KBG syndrome, which is characterized by macrodontia, distinctive
            craniofacial features, short stature, skeletal anomalies, global
            developmental delay, seizures and intellectual disability.
            Alternatively spliced transcript variants have been described.
            Related pseudogenes exist on chromosomes 2 and X. [provided by
            RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY533563.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301030.10/ ENSP00000301030.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AY373756.1         1-31
            32-2573             BC017437.1         1-2542
            2574-3232           AY533563.1         2402-3060
            3233-3373           DA172996.1         341-481
            3374-9301           AY533563.1         3202-9129
FEATURES             Location/Qualifiers
     source          1..9301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..9301
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /note="ankyrin repeat domain containing 11"
                     /db_xref="GeneID:29123"
                     /db_xref="HGNC:HGNC:21316"
                     /db_xref="MIM:611192"
     exon            1..317
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            318..402
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            403..548
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..8453
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /note="nasopharyngeal carcinoma susceptibility protein;
                     ankyrin repeat-containing cofactor 1; ankyrin repeat
                     domain 11; ankyrin repeats containing cofactor 1"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 11"
                     /protein_id="NP_037407.4"
                     /db_xref="CCDS:CCDS32513.1"
                     /db_xref="GeneID:29123"
                     /db_xref="HGNC:HGNC:21316"
                     /db_xref="MIM:611192"
                     /translation="MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLER
                     GDGGKEVRERASKRKLPFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGL
                     SGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDK
                     VNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAK
                     QLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANS
                     PTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNP
                     EPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYT
                     KNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKE
                     KNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLV
                     LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLS
                     DSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDK
                     EGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTEN
                     KLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSN
                     KAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKED
                     KEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGED
                     SWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLD
                     KNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAH
                     REELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKE
                     KSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKE
                     KAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRT
                     DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEK
                     HKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDK
                     EHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAF
                     LEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGE
                     DYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSERE
                     PSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLR
                     HHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGN
                     DKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEK
                     LRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKL
                     HPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPS
                     CSADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLS
                     TNLYRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPLPPVPAEK
                     FACLSPGYYSPDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLV
                     PSLEGALPPDLDTSEDQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQAL
                     ASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYP
                     APPASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPE
                     APLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFAGPEDDLD
                     LGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVINGGDVSTVVAEEPPAL
                     PPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGDPDSSVEPAPVPPEQ
                     RPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPAEGP
                     PGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPPSEKECAPTPA
                     PVTRAKARGSEDDDAQAQHPRKRRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAI
                     KLDAIEPYHSDRANPYFEYLQIRKKIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDG
                     KPLSKLHIPVIAPPPSLAEPLKELFRQQEAVRGKLRLQHSIEREKLIVSCEQEILRVH
                     CRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDD
                     KYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLCVNEVPSFYVPMVDV
                     NDDFVLLPA"
     exon            549..687
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            688..858
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1062
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1205
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1353
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..7931
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            7932..8030
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            8031..8174
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            8175..8267
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     exon            8268..9301
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9286..9291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /note="hexamer: AATAAA"
     polyA_site      9301
                     /gene="ANKRD11"
                     /gene_synonym="ANCO-1; ANCO1; LZ16; T13"
                     /note="major polyA site"
ORIGIN      
        1 agaggccgcc ctgagacggt gcgcgatgga ccgagggccc cagccgggga ggcgccgccg
       61 ccgagcccgc ggccagacgc cccatcagta gcgtccgcac cgggagccgc ggctctcgcc
      121 cgagccgtgg gcgcgcccga ggggcgggct cgcctcccgc cgtccctcgc agctctgccg
      181 ggcccgagcc cgcgccgccg ccgccgccgc cttgccgctc gggccgcgcg gcccgggaaa
      241 cgcggccgcg ggctgcatgg gcagcgcccg cgccccgccg ctgagccgtc gcggagccgc
      301 gcagccctcg gagcacgaat atatacagcc ctgctctggg acacacctcc attggattta
      361 aaagacagtc ctcgtcagca ctgactttca gctatggaat cgcagacggt tgatgatgaa
      421 gcgccggccg tgtaaatgaa gatcgggtga ggagcaggac gatgcccaag ggtgggtgcc
      481 ctaaagcacc acagcaggaa gagcttcccc tcagcagcga catggtggag aagcagactg
      541 ggaaaaagga taaagataaa gtttctctaa ccaagacccc aaaactggag cgtggcgatg
      601 gcgggaagga ggtgagggag cgagccagca agcggaagct gcccttcacc gcgggcgcca
      661 atggggagca gaaggactcg gacacagaga agcagggccc tgagcggaag aggattaaga
      721 aggagcctgt cacccggaag gccgggctgc tgtttggcat ggggctgtct ggaatccgag
      781 ccggctaccc cctctccgag cgccagcagg tggcccttct catgcagatg acggccgagg
      841 agtctgccaa cagcccagtg gacacaacac caaagcaccc ctcccagtct acagtgtgtc
      901 agaagggaac gcccaactct gcctcaaaaa ccaaagataa agtgaacaag agaaacgagc
      961 gtggagagac ccgcctgcac cgagccgcca tccgcgggga cgcccggcgc atcaaagagc
     1021 tcatcagcga gggggcagac gtcaacgtca aggacttcgc aggctggacg gcgctgcacg
     1081 aggcctgtaa ccggggctac tacgacgtcg cgaagcagct gctggctgca ggtgcggagg
     1141 tgaacaccaa gggcctagat gacgacacgc ctttgcacga cgctgccaac aacgggcact
     1201 acaaggtggt gaagctgctg ctgcggtacg gagggaaccc gcagcagagc aacaggaaag
     1261 gcgagacgcc gctgaaagtg gccaactccc ccacgatggt gaacctcctg ttaggcaaag
     1321 gcacttacac ttccagcgag gagagctcga cggagagctc agaagaggaa gacgcaccat
     1381 ccttcgcacc ttccagttca gtcgacggca acaacacgga ctccgagttc gaaaaaggcc
     1441 tcaagcacaa ggccaagaac ccagagccac agaaggccac ggcccccgtc aaggacgagt
     1501 atgagtttga tgaggacgac gagcaggaca gggttcctcc ggtggacgac aagcacctat
     1561 tgaaaaagga ctacagaaaa gaaacgaaat ccaatagttt tatctctata cccaaaatgg
     1621 aggttaaaag ttacactaaa aataacacga ttgcaccaaa gaaagcgtcc catcgtatcc
     1681 tgtcagacac gtcggacgag gaggacgcga gtgtcaccgt ggggacagga gagaagctga
     1741 gactctcggc acatacgata ttgcctggta gtaagacacg agagccttct aatgccaagc
     1801 agcagaagga aaaaaataaa gtgaaaaaga agcgaaagaa agaaacaaaa ggcagagagg
     1861 ttcgcttcgg aaagcggagc gacaagttct gctcctcgga gtcggagagc gagtcctcag
     1921 agagtgggga ggatgacagg gactctctgg ggagctctgg ctgcctcaag gggtccccgc
     1981 tggtgctgaa ggacccctcc ctgttcagct ccctctctgc ctcctccacc tcgtctcacg
     2041 ggagctctgc cgcccagaag cagaacccca gccacacaga ccagcacacc aagcactggc
     2101 ggacagacaa ttggaaaacc atttcttccc cggcttggtc agaggtcagt tctttatcag
     2161 actccacaag gacgagactg acaagcgagt ctgactactc ctctgagggc tccagtgtgg
     2221 aatcgctgaa gccagtgagg aagaggcagg agcacaggaa gcgagcctcc ctgtcggaga
     2281 agaagagccc cttcctgtcc agcgcggagg gcgctgtccc caaactggac aaggagggga
     2341 aagttgtcaa aaaacataaa acaaaacaca aacacaaaaa caaggagaag ggacagtgtt
     2401 ccatcagcca agagctgaag ttgaaaagtt ttacttacga atatgaggac tccaagcaga
     2461 agtcagataa ggctatactg ttagagaatg atctttccac tgaaaacaag ctaaaagtgt
     2521 taaagcacga tcgcgaccac tttaaaaaag aagagaaact tagcaaaatg aaattagaag
     2581 aaaaagaatg gctctttaaa gatgaaaaat cactgaagag aatcaaagac acaaacaaag
     2641 acatcagcag gtctttccga gaagagaaag accgttcgaa taaagcagaa aaggagagat
     2701 cgctgaagga aaagtctccg aaagaagaaa aactgagact gtacaaagag gagagaaaga
     2761 agaaatcaaa agaccggccc tcaaaattag agaagaagaa tgatttaaaa gaggacaaaa
     2821 tttcaaaaga gaaggagaag atttttaaag aagataaaga aaaactcaaa aaagaaaagg
     2881 tttataggga agattctgct tttgacgaat attgtaacaa aaatcagttt ctggagaatg
     2941 aagacaccaa atttagcctt tctgacgatc agcgagatcg gtggttttct gacttgtccg
     3001 attcatcctt tgatttcaaa ggggaggaca gctgggactc gccagtgaca gactacaggg
     3061 acatgaagag cgactctgtg gccaagctca tcttggagac ggtgaaggag gacagcaagg
     3121 agaggaggcg ggacagccgg gcccgggaga agcgagacta cagagagccc ttcttccgaa
     3181 agaaggacag ggactatttg gataaaaact ctgagaagag gaaagagcag accgaaaagc
     3241 ataaaagtgt ccctggctac ctttcggaaa aggacaagaa gaggagagag tccgcagagg
     3301 ccgggcggga cagaaaggac gccctggaga gctgcaagga gcgcagggac ggcagggcca
     3361 agcccgagga ggcgcaccgg gaggagctga aggagtgtgg ctgcgagagt ggcttcaagg
     3421 acaagtccga cggcgacttt gggaagggcc tggagccgtg ggaacggcac cacccagcac
     3481 gagagaagga gaagaaggat ggccccgata aggaaaggaa ggagaagaca aaaccagaaa
     3541 gatacaaaga gaaatccagt gacaaggaca aaagtgagaa atcaatcctg gaaaaatgtc
     3601 agaaggacaa agaatttgat aaatgtttta aagagaaaaa agataccaag gaaaaacata
     3661 aagacacaca tggcaaagac aaagaaagga aagcgtctct cgaccaaggg aaagagaaga
     3721 aggagaaggc tttccctggg atcatctcag aagacttctc tgaaaaaaaa gatgacaaga
     3781 aaggcaaaga gaaaagctgg tacatcgcag acatcttcac agatgagagt gaggacgaca
     3841 gagacagctg catggggagc gggttcaaga tgggagaggc cagcgacttg ccgaggacgg
     3901 acggcctcca ggagaaggag gaaggacggg aggcctatgc ctccgacaga cacaggaagt
     3961 cttctgacaa gcagcaccct gagaggcaga aggacaagga gcccagagac aggagaaagg
     4021 accgaggggc tgccgacgcg gggagagaca aaaaagagaa agtctttgaa aagcacaagg
     4081 agaagaagga taaagagtcc acagaaaagt acaaggacag gaaggacaga gcctcagtgg
     4141 actccacgca agataagaaa aataaacaga agctccccga gaaggctgaa aagaagcacg
     4201 ctgccgaaga caaggctaaa agcaaacaca aagagaagtc ggacaaagaa cattccaagg
     4261 agaggaagtc ctcgagaagt gccgacgcgg aaaaaagcct gcttgaaaag ttggaagaag
     4321 aggctctcca tgagtacaga gaagactcca acgataaaat cagcgaggtc tcctctgaca
     4381 gcttcacgga ccgagggcag gagccggggc tgactgcctt cctggaggtc tctttcacgg
     4441 agccacctgg agacgacaag ccgagggaga gcgcctgcct ccctgagaag ctgaaagaga
     4501 aggagaggca cagacactcc tcatcttcat ccaagaagag ccacgaccga gagcgagcca
     4561 agaaagagaa ggccgagaag aaagagaagg gcgaagatta caaggagggc ggtagcagga
     4621 aggactccgg ccagtacgaa aaggacttcc tggaggcgga tgcttacgga gtttcttaca
     4681 acatgaaagc tgacatagaa gatgagctag ataaaaccat tgaattgttt tctaccgaaa
     4741 agaaagataa aaatgattcc gagagagaac cttccaagaa aatagaaaag gaactaaagc
     4801 cttatggatc tagtgccatc aacatcctaa aagagaagaa gaagagagag aaacacaggg
     4861 agaaatggag agacgagaag gagaggcacc gggacaggca tgcggatggg ctgctgcggc
     4921 atcacaggga cgagctcctg cggcatcaca gggacgagca gaagcccgcc accagggaca
     4981 aggacagccc gccccgcgtg ctcaaagaca agtccaggga cgagggcccg aggctcggcg
     5041 atgccaaact gaaggagaaa ttcaaggacg gtgcagagaa agaaaagggc gacccagtga
     5101 agatgagcaa cgggaatgat aaggtagcgc catccaaaga cccaggcaag aaagacgcca
     5161 ggcccaggga gaagctcctg ggggacggcg acctgatgat gaccagcttc gagaggatgc
     5221 tgtcccagaa ggacctggag atcgaggagc gccacaagcg gcacaaggag aggatgaagc
     5281 aaatggagaa gctgaggcac cggtccggag accccaagct caaggagaag gcgaagccgg
     5341 cagacgacgg gcggaagaag ggtctggaca ttcctgctaa gaaaccgccg gggctggacc
     5401 ctccatttaa agacaaaaag ctcaaagagt cgactcctat tccacctgcc gcggaaaata
     5461 agctacaccc agcatcaggt gcagactcca aagactggct ggcaggccct cacatgaaag
     5521 aggtcctgcc tgcgtccccc aggcctgacc agagccggcc cactggcgtg cccaccccta
     5581 cgtcggtgct atcctgcccc agctacgagg aggtgatgca cacgcccagg accccgtcct
     5641 gcagcgccga tgactacgcg gacctcgtgt tcgactgcgc cgactcgcag cactccacgc
     5701 ccgtgcccac cgctcccacc agcgcctgct ccccctcctt tttcgacagg ttctccgtgg
     5761 cttcaagtgg gctttcggaa aacgccagcc aggctcctgc caggcctctc tccacaaacc
     5821 tttaccgctc ggtctctgtc gacattagga ggacccccga ggaagaattc agcgtcggag
     5881 acaagctctt caggcagcag agcgttcctg ctgcctccag ctacgactct cccatgccac
     5941 cctcgatgga agacagggcg cccctgcccc cggttcccgc ggagaagttt gcctgcttgt
     6001 cgccagggta ctactcccca gactatggcc tcccgtcgcc caaagtcgac gctttgcact
     6061 gcccaccggc tgccgttgtc actgtcaccc cgtctccaga gggcgtcttc tcaagtttac
     6121 aagcaaaacc ttccccttcc cccagagccg agctgctggt tccttccctc gaaggggccc
     6181 ttcccccgga cctggacacc tccgaggacc agcaggcgac ggccgccatc atccccccgg
     6241 agcccagcta cctggagccg ctggacgagg gtcccttcag cgccgtcatc accgaggagc
     6301 ccgttgagtg ggcccacccc tccgagcagg cgcttgcctc tagcctgatc gggggcacct
     6361 ctgaaaaccc tgtgagctgg cctgtgggct cggacctcct gctgaagtct ccacagagat
     6421 tccccgagtc cccaaagcgt ttctgccccg cggaccccct ccactctgcc gccccagggc
     6481 ccttcagcgc ctcggaggcg ccgtaccccg cccctcccgc ctctcctgcc ccgtacgctc
     6541 tgcccgtcgc tgagccgggg ctggaggacg tcaaggacgg agtggacgcc gtccccgccg
     6601 ccatctccac ctcagaggcg gctccctacg cccctccctc cgggctggag tccttcttca
     6661 gcaactgcaa gtcacttccg gaagccccgc tggacgtggc ccccgagccc gcctgtgtag
     6721 ccgctgtggc tcaggtggag gctctggggc ccctggaaaa tagcttcctg gacggcagcc
     6781 gcggcctgtc tcacctcggc caggtggagc cggtgccctg ggcggacgcc ttcgccggcc
     6841 ccgaggacga cctggacctg gggcccttct ccctgccgga gcttcccctg cagactaaag
     6901 atgccgcaga tggtgaagcg gaacccgtgg aagaaagtct tgctcctcca gaagagatgc
     6961 ctccaggggc ccccggggtc ataaacggtg gggatgtttc caccgtagtg gctgaggagc
     7021 cgccggcact gcctcctgac caggcctcca cccggctccc tgcagagctc gagcctgagc
     7081 cctcagggga gccaaagctg gacgtggctc tagaagctgc ggtggaggcg gagacggtgc
     7141 cggaagagag ggcccgtggg gatccggact ccagcgtgga gcccgcgccc gttcccccag
     7201 aacagcgccc actggggagc ggagaccagg gggctgaggc tgaaggcccc cccgccgcgt
     7261 ccctctgtgc ccctgacggc cccgccccga acactgtggc acaagctcag gccgcagacg
     7321 gtgccggccc cgaggacgac actgaggcct cccgtgccgc cgccccagcc gaaggccctc
     7381 ctggcggcat ccagccggaa gccgcagaac caaaacccac ggccgaagcc ccgaaggccc
     7441 cccgagtgga ggagatccct cagcgcatga ccaggaaccg ggcgcagatg ctcgcgaacc
     7501 agagcaagca gggcccgccc ccctccgaga aggagtgcgc ccccacccct gccccggtca
     7561 ccagggccaa ggcccgcggc tccgaggacg acgacgccca ggcccagcat ccgcgcaaac
     7621 gccgctttca gcgctccacc cagcagctgc agcagcagct gaacacgtcc acgcagcaga
     7681 cgcgggaggt gatccagcag acgctggccg ccatcgtgga cgccatcaag ctggatgcca
     7741 tcgagcccta ccacagcgac agggccaacc cctacttcga atacctgcag atcaggaaga
     7801 agatcgagga gaagcgcaag atcctgtgct gtatcacgcc gcaggcgccc cagtgctacg
     7861 ccgagtacgt cacctacacg ggctcctacc tcctggacgg caagccgctc agcaagctcc
     7921 acatccccgt gatcgcaccc cctccctccc tggcggagcc cctgaaggag ctgttcaggc
     7981 agcaggaggc cgtccgggga aagctgcgtc tacagcacag catcgagcgg gagaagctga
     8041 tcgtatcctg tgagcaggag attctgcggg ttcactgccg ggcggccagg accatcgcca
     8101 accaggcagt gccattcagc gcctgcacga tgctgctgga ctccgaggtc tacaacatgc
     8161 ccctggagag ccagggtgac gagaacaagt cagtgcgcga ccgtttcaac gcccgccagt
     8221 tcatctcctg gctccaggac gtggatgaca agtatgaccg catgaagact tgcctcctca
     8281 tgcggcagca gcacgaggcc gcggccctga acgccgtgca gaggatggag tggcagctga
     8341 aggtgcagga actggacccc gccgggcaca agtccctgtg cgtgaacgag gtgccctcct
     8401 tctacgtgcc catggtcgac gtcaacgacg actttgtatt gttgccggca tgacaccgcg
     8461 ggacggccgc aggacgcagg cgagggccgc acggctgccc aggactgctg ctgagcccca
     8521 ggggcggagg agggagcgcc ctgtccaccc gggcggggag agaccccgag agagactgca
     8581 cttggccaca gcgcctccat cccttccaga ctggtccaga cgtcggggag gtgaaacacg
     8641 tctcttctct accagctgcc gcggcggggg caaagccccc agagcctcac tggccccggc
     8701 gggatgagga gaccatgccg ggcgcgcaca cacggcagct tctgtttgaa aacggcgacc
     8761 ttcgggccct tttctccagc aactgcagag gcatttcagg agttggagaa cggagtacat
     8821 ttttaaaatt ttttgttcca ttctgatcaa ctaaagaaaa ttaaggtgtc cacctctcac
     8881 aaacagtgac ctgcaggtcg gaggggcagg agccccatcc cagccgtggt tctgttgccg
     8941 ccgagctgcg acggcctcag actgggcttc agacctggtg cggagccagg cggagggaca
     9001 cagagccagg actcccagcc gtattgaaat ggagtcaaat ccgcgtggtt tgtatcttct
     9061 ttcctttaat cttgggcatt ttgtttctct ttctgagaac gtaacttgaa acactacaga
     9121 gccaataatc atataaaaag tgtatccgta aacgctgtac agttttatat accttcacaa
     9181 tgtacttttg ctgccttcta gataatttat tttgcaacac attactgcac agttgtaaat
     9241 aacttatgta ctgtaacatc actttcagtt atgtgtaaag aaataaataa attaattaaa
     9301 a
//
