LOCUS       NM_017664               2495 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ankyrin repeat domain 10 (ANKRD10), transcript variant
            1, mRNA.
ACCESSION   NM_017664
VERSION     NM_017664.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000100.1, AK094222.1 and AL157875.27.
            
            On Nov 22, 2018 this sequence version replaced NM_017664.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000100.1, SRR3476690.677112.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267339.6/ ENSP00000267339.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               AK000100.1         1-661
            662-1061            AK094222.1         700-1099
            1062-2495           AL157875.27        121213-122646       c
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..2495
                     /gene="ANKRD10"
                     /note="ankyrin repeat domain 10"
                     /db_xref="GeneID:55608"
                     /db_xref="HGNC:HGNC:20265"
     exon            1..345
                     /gene="ANKRD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1398
                     /gene="ANKRD10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 10"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 10
                     isoform 1"
                     /protein_id="NP_060134.2"
                     /db_xref="CCDS:CCDS9520.1"
                     /db_xref="GeneID:55608"
                     /db_xref="HGNC:HGNC:20265"
                     /translation="MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQ
                     TPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFG
                     GHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLT
                     AADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLED
                     SEDFGVKKARTEAQSLDSAVPLTNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTN
                     GCVINGHLDFPSTTPLSGMESRNGQCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEP
                     EKTLRANPELCGSLHLNGSPSSCIASRPSWVEDIGDNLYYGHYHGFGDTAESIPELNS
                     VVEHSKSVKVQERYDSAVLGTMHLHHGS"
     exon            346..498
                     /gene="ANKRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            499..590
                     /gene="ANKRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            591..826
                     /gene="ANKRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            827..922
                     /gene="ANKRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            923..2495
                     /gene="ANKRD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD10"
                     /note="hexamer: AATAAA"
     polyA_site      2495
                     /gene="ANKRD10"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgctccg ctcggcagcc tgtgggacgc gaccgcggcg ctagtctcgt tcctttgtgc
       61 tgcggcggcg gcttctcgag tcctccccga cgcgtcctct aggccagcga gccccgcgct
      121 ctccggtgac ggaccatgtc ggcggcggga gcgggcgcgg gcgtagaggc gggcttctcc
      181 agcgaggagc tgctctcgct ccgtttcccg ctgcaccgcg cctgccgcga cggggacctg
      241 gccacgctct gctcgctgct gcagcagaca ccccacgccc acctggcctc tgaggactcc
      301 ttctatggct ggacgcccgt gcactgggcc gcgcatttcg gcaagttgga gtgcttagtg
      361 cagttggtga gagcgggagc cacactcaac gtctccacca cacggtacgc gcagacgcca
      421 gcccacattg cagcctttgg gggacatcct cagtgcctgg tctggctgat tcaagcagga
      481 gccaacatta acaaaccgga ttgtgagggt gaaactccca ttcacaaggc agctcgctct
      541 gggagcctag aatgcatcag tgcccttgtg gcgaatgggg ctcacgtcga cctgagaaat
      601 gccagtggcc tgacagcagc agacattgca caaacccagg gtttccaaga gtgtgcccag
      661 tttctcttga acctccagaa ttgtcatctg aaccatttct ataacaatgg catcttaaat
      721 gggggtcatc agaatgtatt tcctaatcat attagtgtgg gaacaaatcg aaagagatgc
      781 ttggaagact cagaagactt tggagtaaag aaagctagaa ctgaagctca aagcttggat
      841 tctgccgtgc cactcacgaa tggcgacaca gaagacgatg ctgacaaaat gcacgttgat
      901 agggagtttg ctgttgtaac agatatgaaa aacagtagct ccgtatcgaa tacattgaca
      961 aatggatgtg tcatcaatgg acatttggac ttcccctcca cgaccccgct cagtgggatg
     1021 gaaagcagga atggccagtg cttgacagga actaacggaa ttagcagtgg attagcccca
     1081 ggacagccgt ttccgagtag ccagggttct ctctgcatta gtgggactga ggagccagag
     1141 aagaccctga gagctaaccc tgagttgtgc ggttctctgc acctgaacgg gagtccaagt
     1201 agctgcatag ccagtaggcc ttcctgggtg gaagacattg gggataacct gtactatgga
     1261 cactaccacg ggtttgggga cactgctgaa agcatcccag aactgaacag tgtggtcgag
     1321 cattccaagt ccgtgaaggt gcaggagcgg tacgacagtg ccgtgctggg caccatgcac
     1381 ctgcaccacg gctcctagag acgctgacct ggctctcgga aacgcaggag tccttcctgg
     1441 tagccagctc agaataccca tgtagcagca acttgaacga atgtcacaac ttgtacgttt
     1501 tttatatact tcaactttct gaaaaagtaa acttcgacaa gttcccagca actgcttgtt
     1561 tgtgcatgag tagggcttac taagtgcata gatgtttcta cagtgaggtg tcctttttat
     1621 aaggtgcact tttggagttt ttctgatgcc aatctcaaca ttgtcttttt aatactgtca
     1681 ccagatattg ccatttttct ttttgttaaa agattatatg atcaagataa attggggtgg
     1741 taaatcaggt gcctggtaat ttatctcttt gcacatgggc atcattttaa aaagcttgct
     1801 tccactcttt tctgtagaat ttgacggaac acagctattt ccctatgcaa ggtacagcct
     1861 tacaaagatt tctgcagtga tttgtgtgaa gaagagaacg tttgtctttt tcaatgaagc
     1921 tttgcagatc accatgtggt tgaaggtttt agttgtggac acagtggtcc ctccttaatg
     1981 atgaagatca ctgccttggg cttcatggaa aacaggccca gcctggggct gcgtttggat
     2041 ttattgtttt tattccacac ttcctacttg gtctctggaa gttttaccac atgtaacaga
     2101 ttcctttata tgtagtggaa atcactattt gtagaaactg tcaggtcaaa atatttaact
     2161 gactgttgac atgtattttc ttttttcctt gtttttgttt tttggggttt tctgctttaa
     2221 gatatatacc actatgtata tccagttaac tgagagaatt ttgactctct taataaaact
     2281 gcattaagtt tttgattttg tagaaattag cttttgtcta ggcaactagt ggttatactc
     2341 tgcaaatatt gtaatgaatt tttacttttt tgatttttgt aataaaaatt ggtgcagata
     2401 aaatgtcaaa tgaacaaacc agtgttctaa gagtgttact aacattttgt tctaaaactg
     2461 tccttcacaa attgaataaa aaactctcac actca
//
