LOCUS       NM_014391               1790 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ankyrin repeat domain 1 (ANKRD1), mRNA.
ACCESSION   NM_014391
VERSION     NM_014391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Han,S., Guo,J., Kong,C., Li,J., Lin,F., Zhu,J., Wang,T., Chen,Q.,
            Liu,Y., Hu,H., Qiu,T., Cheng,F. and Zhou,J.
  TITLE     ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting
            TRIM25-mediated ubiquitination of ACSL3
  JOURNAL   Clin Transl Med 14 (9), e70024 (2024)
   PUBMED   39285846
  REMARK    GeneRIF: ANKRD1 aggravates renal ischaemia-reperfusion injury via
            promoting TRIM25-mediated ubiquitination of ACSL3.
REFERENCE   2  (bases 1 to 1790)
  AUTHORS   Xie,R., Yuan,S., Hu,G., Zhan,J., Jin,K., Tang,Y., Fan,J., Zhao,Y.,
            Wang,F., Chen,C., Wang,D.W. and Li,H.
  TITLE     Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1
            transcription in failing hearts
  JOURNAL   Mol Ther 32 (5), 1578-1594 (2024)
   PUBMED   38475992
  REMARK    GeneRIF: Nuclear AGO2 promotes myocardial remodeling by activating
            ANKRD1 transcription in failing hearts.
REFERENCE   3  (bases 1 to 1790)
  AUTHORS   Milosevic,E., Novkovic,M., Cenni,V., Bavelloni,A., Kojic,S. and
            Jasnic,J.
  TITLE     Molecular characterization of ANKRD1 in rhabdomyosarcoma cell
            lines: expression, localization, and proteasomal degradation
  JOURNAL   Histochem Cell Biol 161 (5), 435-444 (2024)
   PUBMED   38396247
  REMARK    GeneRIF: Molecular characterization of ANKRD1 in rhabdomyosarcoma
            cell lines: expression, localization, and proteasomal degradation.
REFERENCE   4  (bases 1 to 1790)
  AUTHORS   Xu,X., Zhong,D., Wang,X., Luo,F., Zheng,X., Feng,T., Chen,R.,
            Cheng,Y., Wang,Y. and Ma,G.
  TITLE     Pan-cancer integrated analysis of ANKRD1 expression, prognostic
            value, and potential implications in cancer
  JOURNAL   Sci Rep 14 (1), 5268 (2024)
   PUBMED   38438492
  REMARK    GeneRIF: Pan-cancer integrated analysis of ANKRD1 expression,
            prognostic value, and potential implications in cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1790)
  AUTHORS   Zolk,O., Frohme,M., Maurer,A., Kluxen,F.W., Hentsch,B., Zubakov,D.,
            Hoheisel,J.D., Zucker,I.H., Pepe,S. and Eschenhagen,T.
  TITLE     Cardiac ankyrin repeat protein, a negative regulator of cardiac
            gene expression, is augmented in human heart failure
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1377-1382 (2002)
   PUBMED   12054667
  REMARK    GeneRIF: Cardiac ankyrin repeat protein, a negative regulator of
            cardiac gene expression, is augmented in human heart failure.
REFERENCE   6  (bases 1 to 1790)
  AUTHORS   Bang,M.L., Mudry,R.E., McElhinny,A.S., Trombitas,K., Geach,A.J.,
            Yamasaki,R., Sorimachi,H., Granzier,H., Gregorio,C.C. and Labeit,S.
  TITLE     Myopalladin, a novel 145-kilodalton sarcomeric protein with
            multiple roles in Z-disc and I-band protein assemblies
  JOURNAL   J Cell Biol 153 (2), 413-427 (2001)
   PUBMED   11309420
REFERENCE   7  (bases 1 to 1790)
  AUTHORS   Kanai,H., Tanaka,T., Aihara,Y., Takeda,S., Kawabata,M.,
            Miyazono,K., Nagai,R. and Kurabayashi,M.
  TITLE     Transforming growth factor-beta/Smads signaling induces
            transcription of the cell type-restricted ankyrin repeat protein
            CARP gene through CAGA motif in vascular smooth muscle cells
  JOURNAL   Circ Res 88 (1), 30-36 (2001)
   PUBMED   11139470
REFERENCE   8  (bases 1 to 1790)
  AUTHORS   Chu,W., Burns,D.K., Swerlick,R.A. and Presky,D.H.
  TITLE     Identification and characterization of a novel cytokine-inducible
            nuclear protein from human endothelial cells
  JOURNAL   J Biol Chem 270 (17), 10236-10245 (1995)
   PUBMED   7730328
REFERENCE   9  (bases 1 to 1790)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
REFERENCE   10 (bases 1 to 1790)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X83703.1, BC018667.1 and
            AL590622.7.
            
            On Dec 27, 2019 this sequence version replaced NM_014391.2.
            
            Summary: The protein encoded by this gene is localized to the
            nucleus of endothelial cells and is induced by IL-1 and TNF-alpha
            stimulation. Studies in rat cardiomyocytes suggest that this gene
            functions as a transcription factor. Interactions between this
            protein and the sarcomeric proteins myopalladin and titin suggest
            that it may also be involved in the myofibrillar stretch-sensor
            system. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891465.1, BC018667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154361, SAMEA2155550
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371697.4/ ENSP00000360762.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               X83703.1           190-459
            271-1579            BC018667.1         275-1583
            1580-1700           X83703.1           1771-1891
            1701-1786           BC018667.1         1701-1786
            1787-1790           AL590622.7         40500-40503         c
FEATURES             Location/Qualifiers
     source          1..1790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..1790
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /note="ankyrin repeat domain 1"
                     /db_xref="GeneID:27063"
                     /db_xref="HGNC:HGNC:15819"
                     /db_xref="MIM:609599"
     exon            1..87
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1020
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /note="cardiac ankyrin repeat protein; liver ankyrin
                     repeat domain 1; cytokine-inducible gene C-193 protein;
                     cytokine-inducible nuclear protein; ankyrin repeat domain
                     1 (cardiac muscle); epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 1"
                     /protein_id="NP_055206.2"
                     /db_xref="CCDS:CCDS7412.1"
                     /db_xref="GeneID:27063"
                     /db_xref="HGNC:HGNC:15819"
                     /db_xref="MIM:609599"
                     /translation="MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQED
                     LKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKT
                     KVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRA
                     CLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL
                     LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGA
                     DLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF"
     exon            88..267
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            268..405
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            406..513
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            514..612
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            613..711
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            712..810
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            811..909
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1790
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1768..1773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /note="hexamer: AATAAA"
     polyA_site      1790
                     /gene="ANKRD1"
                     /gene_synonym="ALRP; bA320F15.2; C-193; CARP; CVARP;
                     MCARP"
                     /note="major polyA site"
ORIGIN      
        1 agggccaact ccagggattc cttccacgac agaaaaacat acaagactcc ttcagccaac
       61 atgatggtac tgaaagtaga ggaactggtc actggaaaga agaatggcaa tggggaggca
      121 ggggaattcc ttcctgagga tttcagagat ggagagtatg aagctgctgt tactttagag
      181 aagcaggagg atctgaagac acttctagcc caccctgtga ccctggggga gcaacagtgg
      241 aaaagcgaga aacaacgaga ggcagagctc aaaaagaaaa aactagaaca aagatcaaag
      301 cttgaaaatt tagaagacct tgaaataatc attcaactga agaaaaggaa aaaatacagg
      361 aaaactaaag ttccagttgt aaaggaacca gaacctgaaa tcattacgga acctgtggat
      421 gtgcctacgt ttctgaaggc tgctctggag aataaactgc cagtagtaga aaaattcttg
      481 tcagacaaga acaatccaga tgtttgtgat gagtataaac ggacagctct tcatagagca
      541 tgcttggaag gacatttggc aattgtggag aagttaatgg aagctggagc ccagatcgaa
      601 ttccgtgata tgcttgaatc cacagccatc cactgggcaa gccgtggagg aaacctggat
      661 gttttaaaat tgttgctgaa taaaggagca aaaattagcg cccgagataa gttgctcagc
      721 acagcgctgc atgtggcggt gaggactggc cactatgagt gcgcggagca tcttatcgcc
      781 tgtgaggcag acctcaacgc caaagacaga gaaggagata ccccgttgca tgatgcggtg
      841 agactgaacc gctataagat gatccgactc ctgattatgt atggcgcgga tctcaacatc
      901 aagaactgtg ctgggaagac gccgatggat ctggtgctac actggcagaa tggaaccaaa
      961 gcaatattcg acagcctcag agagaactcc tacaagacct ctcgcatagc tacattctga
     1021 ggcaaacgac agactcttaa tcagtaaatg ttcactggca ttttgaaggc atggcccaag
     1081 agaagagaca ctagccataa aatctagttt ctatttatca acgtgttgtg aagatgtacc
     1141 taatgaagtt ttgagaaagc acagggttat aggtgtttaa atttccttta gtgaaactct
     1201 tatttatttt tatgtattcc tgtttattta tttactgcca cgctactgat attcagacct
     1261 tcatgatcat ccatctggtg agcagagctt catttgtata taacactttc agagccttcc
     1321 cacccatagg tagttcttaa accaggtgaa agagcaaagt tcaagtgcct acttatgtgt
     1381 cattcgctca tgtaagagtt tttaagagag ggctgattat cacagccctc ttttctcctg
     1441 aatttttaat gcagaagttt gaatgaagca agggaaggca tgtagggaca ggaaaggaaa
     1501 caatggaagg aaagtgattc tgtgaaaagg acagtgaagc cagctatttt acccccaggc
     1561 tggatttttt tttttttttt tttttttttt ttttaccgag tacacagagt acccaagtga
     1621 agagaacgtc atgagtgtaa gtgcaaatca gtggaaggag cggcaaactg ggacatgcag
     1681 aattgaattt gctcaaaaaa gatgaaagga aatgcaaact gtaaatgtat aaatgtatat
     1741 tgtattgtat gtacatttta tattcataat aaaggcaatc aaactctaaa
//
