LOCUS       NM_023039               2161 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ankyrin repeat family A member 2 (ANKRA2), mRNA.
ACCESSION   NM_023039
VERSION     NM_023039.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Gao,J. and Xu,C.
  TITLE     Structural basis for the recognition of RFX7 by ANKRA2 and RFXANK
  JOURNAL   Biochem Biophys Res Commun 523 (1), 263-266 (2020)
   PUBMED   31864703
  REMARK    GeneRIF: Structural basis for the recognition of RFX7 by ANKRA2 and
            RFXANK.
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Nie,J., Xu,C., Jin,J., Aka,J.A., Tempel,W., Nguyen,V., You,L.,
            Weist,R., Min,J., Pawson,T. and Yang,X.J.
  TITLE     Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M
            syndrome protein CCDC8
  JOURNAL   Structure 23 (4), 700-712 (2015)
   PUBMED   25752541
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Xu,C., Jin,J., Bian,C., Lam,R., Tian,R., Weist,R., You,L., Nie,J.,
            Bochkarev,A., Tempel,W., Tan,C.S., Wasney,G.A., Vedadi,M.,
            Gish,G.D., Arrowsmith,C.H., Pawson,T., Yang,X.J. and Min,J.
  TITLE     Sequence-specific recognition of a PxLPxI/L motif by an ankyrin
            repeat tumbler lock
  JOURNAL   Sci Signal 5 (226), ra39 (2012)
   PUBMED   22649097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Wang,A.H., Gregoire,S., Zika,E., Xiao,L., Li,C.S., Li,H.,
            Wright,K.L., Ting,J.P. and Yang,X.J.
  TITLE     Identification of the ankyrin repeat proteins ANKRA and RFXANK as
            novel partners of class IIa histone deacetylases
  JOURNAL   J Biol Chem 280 (32), 29117-29127 (2005)
   PUBMED   15964851
  REMARK    GeneRIF: ANKRA, RFXANK, and CIITA are novel targets of class IIa
            HDACs which may deacetylases play a role in regulating MHCII
            expression
REFERENCE   8  (bases 1 to 2161)
  AUTHORS   Rader,K., Orlando,R.A., Lou,X. and Farquhar,M.G.
  TITLE     Characterization of ANKRA, a novel ankyrin repeat protein that
            interacts with the cytoplasmic domain of megalin
  JOURNAL   J Am Soc Nephrol 11 (12), 2167-2178 (2000)
   PUBMED   11095640
REFERENCE   9  (bases 1 to 2161)
  AUTHORS   Rader,K., Boyer,A.D., Farquhar,M.G. and Arden,K.C.
  TITLE     Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to
            human chromosome 5q12-->q13 by radiation hybrid mapping and somatic
            cell hybrid PCR
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 164-165 (2000)
   PUBMED   10965114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL558295.3, BC012917.1, DB543368.1 and AC010279.5.
            
            On Nov 22, 2018 this sequence version replaced NM_023039.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.106596.1,
                                           SRR3476690.56682.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296785.8/ ENSP00000296785.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL558295.3         48-183
            137-492             AL558295.3         185-540
            493-2016            BC012917.1         406-1929
            2017-2151           DB543368.1         344-478
            2152-2161           AC010279.5         89345-89354         c
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..2161
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /note="ankyrin repeat family A member 2"
                     /db_xref="GeneID:57763"
                     /db_xref="HGNC:HGNC:13208"
                     /db_xref="MIM:605787"
     exon            1..508
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            509..901
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             613..1554
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /note="RFXANK-like protein 2; ankyrin repeat, family A
                     (RFXANK-like), 2"
                     /codon_start=1
                     /product="ankyrin repeat family A protein 2"
                     /protein_id="NP_075526.1"
                     /db_xref="CCDS:CCDS4020.1"
                     /db_xref="GeneID:57763"
                     /db_xref="HGNC:HGNC:13208"
                     /db_xref="MIM:605787"
                     /translation="MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGS
                     AQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIH
                     TSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQG
                     EMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA
                     LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI
                     ETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE"
     exon            902..1060
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1126
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1224
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1350
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1417
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1498
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..2161
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /note="major polyA site"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="ANKRA2"
                     /gene_synonym="ANKRA"
ORIGIN      
        1 gcttcctctg ctctggtgac ccagaaccgt caactgaaat gaccctgtct gtgtagtact
       61 ccggcaggat gggcctcgga gcgtaaaggc ggcaaaaaca aaaatattaa aaaaaaggag
      121 agagggacaa aaaaaagaaa acccgaaagt ttcagctgca ttgctgcgga acgtttttta
      181 gccagaaggc gaaagaagaa atcggaagtg acgtcgcggc caaaacaagc ccgggcttgg
      241 aggcctgtac tgaagctggc ctcagatggg aaggcccgac tcgctgtctg ctgtcgtcgg
      301 tggtcgcgag accttgcact ctcaccgggt cggcctccag cccctgtgcc cgggatccgc
      361 tcgccgcgga tgagcgagag tttcttcctg ggacttttcg ggcacagctg gccggtggcg
      421 acagaacgga ctttctttcc tgcaagagtc tcccctccag cgggagacag cgggctcctg
      481 tctcgggacg ctgggacacc tgtcgcctat ttttaaatat ccagattcca agaacacact
      541 ggatactgct cttacaaaac caagaggaaa tcatgaagaa atgttttagt tattgaaact
      601 acagttgaaa tcatggatac atcaacaaat ctggatattg gagcccagct tatcgtggaa
      661 gagtgtccca gcacttatag cctaactggc atgccagaca ttaaaataga acatccactg
      721 gacccaaatt cagaagaagg gtcagctcag ggtgttgcca tgggaatgaa attcatattg
      781 cctaaccgat ttgatatgaa tgtgtgttct cgatttgtga agtccttaaa tgaagaagat
      841 agtaaaaata ttcaagatca ggttaactct gacctggagg tggcatctgt cctatttaaa
      901 gctgaatgca atatccatac atctccttct ccgggaattc aagtaaggca tgtctacacc
      961 ccctctacaa caaagcattt ctcacccata aaacagtcaa ccactttaac caacaaacac
     1021 agaggaaatg aggtctctac cacacctctg ttagcaaatt ctttgtctgt tcaccagttg
     1081 gctgctcagg gagagatgct ctatctggct actcgtatcg aacaagaaaa tgttatcaat
     1141 cacacggatg aagaaggatt tactcctctg atgtgggctg cagcacacgg gcaaatagct
     1201 gtggtagagt tcctacttca gaatggtgct gatccccaac ttttaggaaa aggtcgagaa
     1261 agtgcactgt cgttggcctg tagtaaaggc tacacagata ttgtcaaaat gctgcttgat
     1321 tgtggagttg atgtaaatga atatgattgg aatggaggaa cacctctgct ttatgctgta
     1381 catggaaatc atgtgaaatg tgtaaagatg ctcttagaaa gtggggctga tccaacaatt
     1441 gaaactgact ctggatataa ttctatggat ctagctgtag ccctaggcta tagaagtgtt
     1501 caacaggtta ttgagtcaca tttgttgaag ctgcttcaaa atatcaagga gtagacacag
     1561 tcatcagaaa atgtctgccc ttttgtttac ttcttggtcc ttataaatga tagttttgtt
     1621 tacttataaa tttttacctc agttgcaata tttactggtt tttagtaggt tttaataaat
     1681 atttctctga gtaattcact ggtttataat aaatgtaata ctctttttat aactatgttt
     1741 tactgtatat ttaaaattat aaattaatgt tttcgtggca tgtaaatttt tatggtacag
     1801 atagttatca tcagtctttg tatcaagtgc tgtaatttga cattttcaga aattattcta
     1861 ccctagtcat cttcactcgt gtattaagtc attcacttta tatagggttt gctataaatc
     1921 cctagaaaaa aattgttctt attgttgaat aaaaaagtgc acagtgtgat tgtttacaaa
     1981 atgatattat aaataaataa aatacttctt ctgtcagttt gcatactact tttttaagta
     2041 tataagatta ttaaagattt ctttcagatt tttaatttca cccttctgtc ctgccgtaac
     2101 acttcattag atcaaacaat atatgtaatt aaaataaact gaatctaagt caatcaacaa
     2161 a
//
